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Herceptin (Trastuzumab) - Neutropenia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Neutropenia (74)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Herceptin (Trastuzumab) where reactions include neutropenia. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 74   Next >>

Possible Herceptin side effects in

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-08-20

Patient:

Reactions: Abdominal Pain, Vomiting, Hypersensitivity, Nausea, Skin Toxicity, Mucosal Inflammation, Fatigue, Diarrhoea, Hepatotoxicity, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lapatinib
    Dosage: arm b
    Administration route: Oral
    Indication: Breast Cancer

Cyclophosphamide
    Indication: Breast Cancer

Lapatinib
    Dosage: arm c
    Administration route: Oral

Herceptin
    Dosage: loading dose
    Indication: Breast Cancer

Herceptin
    Dosage: maintenance dose

Fluorouracil
    Indication: Breast Cancer

Paclitaxel
    Indication: Breast Cancer

Epirubicin
    Indication: Breast Cancer



Possible Herceptin side effects in female

Reported by a physician from United Kingdom on 2012-08-07

Patient: female, weighing 93.7 kg (206.0 pounds)

Reactions: Diarrhoea, Neutropenic Sepsis, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Herceptin
    Dosage: last dose prior to sae: 29 july 2011, last dose 546 mg

Docetaxel
    Dosage: dose decreased, date of last dose prior to sae: 11/nov/2011
    Indication: Breast Cancer

Docetaxel
    Dosage: dose decreased,last dose on 29 july 2011, last dose taken 75 mg
    Start date: 2011-07-29
    End date: 2011-11-11

Herceptin
    Dosage: dose held.
    Indication: Breast Cancer



Possible Herceptin side effects in female

Reported by a physician from Philippines on 2012-08-03

Patient: female, weighing 52.0 kg (114.4 pounds)

Reactions: Gastrointestinal Ulcer, Cardio-Respiratory Arrest, Pneumonia, Febrile Neutropenia, Duodenal Ulcer, Hepatic Failure, Neutropenia

Adverse event resulted in: death, life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Docetaxel
    Dosage: dose level:100 mg/m2; last dose prior to sae 26 oct 2010, permanently discontinued on 16 nov 2010
    Indication: Breast Cancer
    Start date: 2010-10-26
    End date: 2010-11-16

Herceptin
    Dosage: last dose prior to sae : 26 oct 2010, permanently discontinued on 16 nov 2010
    Indication: Breast Cancer
    Start date: 2010-10-26
    End date: 2010-11-16

Other drugs received by patient: Mucosta; Fluconazole; Acetaminophen; Tinzaparin; Tranexamic Acid; Omeprazole; Ciprofloxacin; Vitamin K TAB



Possible Herceptin side effects in 48 year old male

Reported by a physician from Germany on 2012-08-02

Patient: 48 year old male, weighing 85.0 kg (187.0 pounds)

Reactions: Agranulocytosis, Neoplasm Malignant, Neutropenia, Upper Gastrointestinal Haemorrhage, Skin Infection

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Herceptin

Other drugs received by patient: Fluorouracil; Docetaxel; Cisplatin



Possible Herceptin side effects in female

Reported by a physician from Germany on 2012-07-19

Patient: female

Reactions: Weight Decreased, Pulmonary Embolism, Pyrexia, Hyperhidrosis, Cardiac Disorder, Intestinal Perforation, Dyspepsia, Proteinuria, Epistaxis, Gingival Bleeding, Anaemia, Cardiomyopathy, Neutropenia, Hypersensitivity, Bone Pain, Pain, Chills, Skin Reaction, Abdominal Pain Upper, Polyneuropathy, Myalgia, Fatigue, Oedema, Dizziness, Myocardial Infarction, Nail Toxicity, Thrombocytopenia, Decreased Appetite, Vomiting, Dyspnoea, Nausea, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Cerebrovascular Accident, Dysgeusia, Mucosal Inflammation, Anxiety, Diarrhoea, Impaired Healing, Arthralgia, Hypertension, Asthenia, Leukopenia

Drug(s) suspected as cause:
Avastin
    Indication: Breast Cancer

Herceptin
    Indication: Breast Cancer

Xeloda
    Indication: Breast Cancer



Possible Herceptin side effects in

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-07-19

Patient:

Reactions: Stomatitis, Alanine Aminotransferase Increased, Febrile Neutropenia, Fatigue, Aspartate Aminotransferase Increased, Neutropenia, Thrombocytopenia, Leukopenia, Decreased Appetite

Drug(s) suspected as cause:
Gemcitabine Hydrochloride
    Dosage: on days 1 and 8 every 21 days
    Indication: Breast Cancer

Herceptin
    Dosage: within 2 weeks after curative surgery until 52 weeks of therapy was completed

Paclitaxel
    Dosage: over 1 h on days 1 and 8 every 21 days
    Indication: Breast Cancer

Herceptin
    Dosage: over 90 min on day 1
    Indication: Breast Cancer

Herceptin
    Dosage: over 30 min weekly



Possible Herceptin side effects in female

Reported by a physician from Belgium on 2012-07-19

Patient: female, weighing 66.0 kg (145.2 pounds)

Reactions: Tonsillitis, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Taxotere
    Dosage: 100mg cyclic
    Indication: Breast Cancer
    Start date: 2012-06-06

Herceptin
    Dosage: 130mg cyclic
    Indication: Breast Cancer
    Start date: 2012-06-06

Lapatinib
    Dosage: 1000mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-06-06



Possible Herceptin side effects in

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-07-18

Patient:

Reactions: Stomatitis, Alanine Aminotransferase Increased, Febrile Neutropenia, Fatigue, Aspartate Aminotransferase Increased, Neutropenia, Thrombocytopenia, Decreased Appetite, Leukopenia

Drug(s) suspected as cause:
Paclitaxel
    Indication: Breast Cancer

Paclitaxel
    Dosage: dosages were modified to one step lower than the previous level after withholding treatment

Gemcitabine Hydrochloride
    Indication: Breast Cancer

Herceptin
    Dosage: over 90 min on day 1, followed by 2 mg/kg over 30 min weekly, for a total of 18 doses
    Indication: Breast Cancer

Herceptin
    Dosage: after curative surgery until 52 weeks of therapy was completed.

Gemcitabine Hydrochloride
    Dosage: dosages were modified to one step lower than the previous level after withholding treatment



Possible Herceptin side effects in female

Reported by a physician from China on 2012-07-17

Patient: female, weighing 63.0 kg (138.6 pounds)

Reactions: Suicide Attempt, Neutropenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Avastin
    Dosage: last dose: 21 jul 2010
    Indication: Breast Cancer
    Start date: 2010-03-16
    End date: 2010-08-30

Carboplatin
    Dosage: last dose: 30 jun 2010
    Indication: Breast Cancer
    Start date: 2010-03-16

Docetaxel
    Dosage: last dose: 30 jun 2010
    Indication: Breast Cancer
    Start date: 2010-03-16

Herceptin
    Dosage: last dose: 21 jul 2010
    Indication: Breast Cancer
    Start date: 2010-03-16
    End date: 2010-08-30

Clonazepam
    Indication: Product Used FOR Unknown Indication



Possible Herceptin side effects in 55 year old female

Reported by a physician from Colombia on 2012-07-09

Patient: 55 year old female, weighing 69.0 kg (151.8 pounds)

Reactions: Neutropenia, Unevaluable Event

Drug(s) suspected as cause:
Herceptin



Possible Herceptin side effects in 77 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-06-22

Patient: 77 year old female

Reactions: Neutropenic Colitis, Diarrhoea, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Xeloda
    Administration route: Oral
    Start date: 2012-02-29
    End date: 2012-03-14

Cisplatin
    Indication: Breast Cancer
    Start date: 2012-02-08

Cisplatin
    Indication: Gastric Cancer
    Start date: 2012-02-08

Cisplatin
    Start date: 2012-02-29

Herceptin
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-02-29

Cisplatin
    Start date: 2012-02-29

Emend
    Administration route: Oral
    Start date: 2012-02-08
    End date: 2012-03-02

Xeloda
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-02-08
    End date: 2012-02-22

Emend
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2012-02-08
    End date: 2012-03-02

Xeloda
    Administration route: Oral
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-02-22

Xeloda
    Administration route: Oral
    Start date: 2012-02-29
    End date: 2012-03-14

Herceptin
    Indication: Breast Cancer
    Start date: 2012-02-08
    End date: 2012-02-29

Other drugs received by patient: Iperten; Allopurinol; Xenetix; Lovenox; Magnesium Sulfate; Cordarone; Bisoprolol Fumarate and Hydrochlorothiazide; Lorazepam; Potassium Chloride; Nexium; Acetaminophen; Tramadol HCL; Zofran



Possible Herceptin side effects in

Reported by a individual with unspecified qualification from United States on 2012-06-19

Patient:

Reactions: Thrombosis, Headache, Device Related Infection, Peripheral Sensory Neuropathy, Pericardial Effusion, Malaise, Dyspepsia, Granulocytopenia, Hypoxia, Pneumonitis, Blood Alkaline Phosphatase Increased, Hypotension, Anaemia, Hyperglycaemia, Dehydration, Neutropenia, Pain, Bone Pain, Hypokalaemia, Neutropenic Infection, Postoperative Wound Infection, Fatigue, Chest Pain, Depression, Lethargy, Vomiting, Dyspnoea, Lymphopenia, Alanine Aminotransferase Increased, Muscular Weakness, Febrile Neutropenia, Hypophosphataemia, Syncope, Arthralgia, Diarrhoea, Ejection Fraction Decreased, Hypermagnesaemia, Respiratory Tract Infection, Leukopenia, Infection

Drug(s) suspected as cause:
Vinorelbine Tartrate
    Dosage: on day 8 and 15 of the 21 days cycle
    Indication: Breast Cancer Metastatic

Herceptin

Docetaxel
    Indication: Breast Cancer Metastatic

Herceptin
    Indication: Breast Cancer Metastatic



Possible Herceptin side effects in 77 year old female

Reported by a physician from France on 2012-06-15

Patient: 77 year old female

Reactions: Neutropenic Colitis, Diarrhoea, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cisplatin
    Start date: 2012-02-29

Xeloda
    Administration route: Oral
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-02-22

Xeloda
    Administration route: Oral
    Start date: 2012-02-29
    End date: 2012-03-14

Herceptin
    Start date: 2012-02-29

Emend
    Dosage: on day 1, 2 and 3 of 14 day cycle
    Indication: Vomiting
    Start date: 2012-02-08
    End date: 2012-03-02

Herceptin
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-02-29

Cisplatin
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-02-08
    End date: 2012-02-29

Other drugs received by patient: Iperten; Nexium; Allopurinol; Xenetix; Bisoprolol Fumarate and Hydrochlorothiazide; Lovenox; Kaleorid LP; Zofran; Lorazepam; Acetaminophen; Tramadol HCL; Cordarone



Possible Herceptin side effects in female

Reported by a individual with unspecified qualification from Philippines on 2012-06-15

Patient: female, weighing 52.0 kg (114.4 pounds)

Reactions: Gastrointestinal Ulcer, Cardio-Respiratory Arrest, Pneumonia, Duodenal Ulcer, Hepatic Failure, Febrile Neutropenia, Neutropenia

Adverse event resulted in: death, life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Herceptin
    Dosage: last dose prior to sae : 26 oct 2010, permanently discontinued on 16 nov 2010
    Indication: Breast Cancer
    Start date: 2010-10-26
    End date: 2010-11-16

Docetaxel
    Dosage: dose level:100 mg/m2; last dose prior to sae 26 oct 2010, permanently discontinued on 16 nov 2010
    Indication: Breast Cancer
    Start date: 2010-10-26
    End date: 2010-11-16

Other drugs received by patient: Acetaminophen; Vitamin K TAB; Fluconazole; Mucosta; Ciproflaxacin; Omeprazole; Tranexamic Acid; Tinzaparin



Possible Herceptin side effects in female

Reported by a physician from Germany on 2012-06-14

Patient: female, weighing 86.0 kg (189.2 pounds)

Reactions: Neutropenia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Herceptin
    Dosage: form: vials, dose level: 6 mg/kg,permanently discontinued
    Indication: Breast Cancer
    Start date: 2010-05-04
    End date: 2010-07-22

Carboplatin
    Dosage: form: vials, dose level 5 auc, dose reduced.
    Indication: Breast Cancer

Docetaxel
    Start date: 2010-06-15
    End date: 2010-07-22

Docetaxel
    Dosage: form: vials, dose level: 60 mg/m2, dose reduced.
    Indication: Breast Cancer

Carboplatin
    Start date: 2010-06-15
    End date: 2010-07-22

Other drugs received by patient: Emend; Bisoprolol Fumarate; Cellondan; Metoclopramide; Loperamide; Dexamethasone



Possible Herceptin side effects in female

Reported by a physician from Philippines on 2012-06-08

Patient: female, weighing 52.5 kg (115.5 pounds)

Reactions: Gastrointestinal Ulcer, Cardio-Respiratory Arrest, Pneumonia, Hepatic Failure, Duodenal Ulcer, Febrile Neutropenia, Neutropenia

Adverse event resulted in: death, life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Docetaxel
    Dosage: last dose prior to sae 26 oct 2010, permanently discontinued on 16 nov 2010
    Indication: Breast Cancer
    Start date: 2010-10-26
    End date: 2010-11-16

Herceptin
    Dosage: last dose prior to sae : 26 oct 2010, permanently discontinued on 16 nov 2010
    Indication: Breast Cancer
    Start date: 2010-10-26
    End date: 2010-11-16

Other drugs received by patient: Ciprofloxacin; Acetaminophen; Mucosta; Omeprazole; Fluconazole; Vitamin K TAB; Tinzaparin; Tranexamic Acid



Possible Herceptin side effects in female

Reported by a individual with unspecified qualification from United Kingdom on 2012-06-08

Patient: female, weighing 93.0 kg (204.6 pounds)

Reactions: Diarrhoea, Neutropenic Sepsis, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Herceptin
    Dosage: last dose prior to sae: 29 july 2011, last dose 546 mg

Docetaxel
    Dosage: dose decreased,last dose on 29 july 2011, last dose taken 75 mg
    Start date: 2011-07-29
    End date: 2011-11-11

Docetaxel
    Dosage: dose decreased,
    Indication: Breast Cancer

Herceptin
    Dosage: dose held.
    Indication: Breast Cancer



Possible Herceptin side effects in female

Reported by a individual with unspecified qualification from Philippines on 2012-06-08

Patient: female, weighing 52.5 kg (115.5 pounds)

Reactions: Gastrointestinal Ulcer, Cardio-Respiratory Arrest, Pneumonia, Duodenal Ulcer, Hepatic Failure, Febrile Neutropenia, Neutropenia

Adverse event resulted in: death, life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Herceptin
    Dosage: last dose prior to sae : 26 oct 2010, permanently discontinued on 16 nov 2010
    Indication: Breast Cancer
    Start date: 2010-10-26
    End date: 2010-11-16

Docetaxel
    Dosage: last dose prior to sae 26 oct 2010, permanently discontinued on 16 nov 2010
    Indication: Breast Cancer
    Start date: 2010-10-26
    End date: 2010-11-16

Other drugs received by patient: Ciprofloxacin; Fluconazole; Tinzaparin; Acetaminophen; Omeprazole; Mucosta; Tranexamic Acid; Vitamin K TAB



Possible Herceptin side effects in female

Reported by a physician from Philippines on 2012-06-07

Patient: female, weighing 52.5 kg (115.5 pounds)

Reactions: Gastrointestinal Ulcer, Pneumonia, Cardio-Respiratory Arrest, Hepatic Failure, Febrile Neutropenia, Duodenal Ulcer, Neutropenia

Adverse event resulted in: death, life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Docetaxel
    Dosage: last dose prior to sae 26 oct 2010, permanently discontinued on 16 nov 2010
    Indication: Breast Cancer
    Start date: 2010-10-26
    End date: 2010-11-16

Herceptin
    Dosage: last dose prior to sae : 26 oct 2010, permanently discontinued on 16 nov 2010
    Indication: Breast Cancer
    Start date: 2010-10-26
    End date: 2010-11-16

Other drugs received by patient: Omeprazole; Ciprofloxacin; Fluconazole; Acetaminophen; Tinzaparin; Vitamin K TAB; Mucosta; Tranexamic Acid



Possible Herceptin side effects in female

Reported by a individual with unspecified qualification from United States on 2012-06-05

Patient: female

Reactions: Vomiting, Wound Dehiscence, Nausea, Pain, Hyperglycaemia, Proteinuria, Ejection Fraction Decreased, Neutropenia, Hypertension, Blood Creatinine Increased, Thrombocytopenia, Infection

Drug(s) suspected as cause:
Herceptin
    Dosage: for 23 weeks

Avastin
    Dosage: for 23 weeks
    Indication: Breast Cancer

Herceptin
    Dosage: loading dose
    Indication: Breast Cancer

Herceptin
    Dosage: total 54 weeks

Paclitaxel
    Dosage: days 1, 8 and 15
    Indication: Breast Cancer

Avastin
    Dosage: total 54 weeks

Carboplatin
    Dosage: auc=6 for 6 cycles
    Indication: Breast Cancer



Possible Herceptin side effects in

Reported by a individual with unspecified qualification from Italy on 2012-06-05

Patient:

Reactions: Vomiting, Nausea, Anaemia, Palmar-Plantar Erythrodysaesthesia Syndrome, Diarrhoea, Neutropenia, Asthenia, Leukopenia, Deep Vein Thrombosis

Drug(s) suspected as cause:
Herceptin
    Dosage: loading dose on day 1 of each cycle
    Indication: Breast Cancer

Pegylated Liposomal Doxorubicin
    Dosage: on day 1
    Indication: Breast Cancer

Fluorouracil
    Dosage: 200 mg/m2 as a continuous infusion from day 1 through day 21 to be repeated every 21 days for 8 cour
    Indication: Breast Cancer

Herceptin
    Dosage: on day 2 of each cycle

Cisplatin
    Dosage: on day 1
    Indication: Breast Cancer



Possible Herceptin side effects in

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-05-30

Patient:

Reactions: Stomatitis, Alanine Aminotransferase Increased, Febrile Neutropenia, Fatigue, Aspartate Aminotransferase Increased, Neutropenia, Thrombocytopenia, Leukopenia, Decreased Appetite

Drug(s) suspected as cause:
Paclitaxel
    Dosage: dosages were modified to one step lower than the previous level after withholding treatment

Gemcitabine Hydrochloride
    Indication: Breast Cancer

Herceptin
    Dosage: over 90 min on day 1, followed by 2 mg/kg over 30 min weekly, for a total of 18 doses
    Indication: Breast Cancer

Herceptin
    Dosage: after curative surgery until 52 weeks of therapy was completed.

Paclitaxel
    Indication: Breast Cancer

Gemcitabine Hydrochloride
    Dosage: dosages were modified to one step lower than the previous level after withholding treatment



Possible Herceptin side effects in female

Reported by a consumer/non-health professional from United States on 2012-05-30

Patient: female

Reactions: Pain, Pyrexia, Somnolence, Cardiac Disorder, Fatigue, Unevaluable Event, Hepatic Pain, Rash, Alcohol Poisoning, Stress, Syncope, Neoplasm Malignant, Mastectomy, Mental Disorder, Neutropenia, Feeling Abnormal, Asthenia, Bite, Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Herceptin

Other drugs received by patient: Taxol; Oxycodone HCL



Possible Herceptin side effects in female

Reported by a physician from United Kingdom on 2012-05-29

Patient: female, weighing 93.0 kg (204.6 pounds)

Reactions: Diarrhoea, Neutropenic Sepsis, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Herceptin
    Dosage: dose held.
    Indication: Breast Cancer

Docetaxel
    Dosage: dose decreased,
    Indication: Breast Cancer

Docetaxel
    Dosage: dose decreased,last dose on 29 july 2011

Herceptin
    Dosage: last dose prior to sae: 29 july 2011



Possible Herceptin side effects in female

Reported by a physician from United Kingdom on 2012-05-28

Patient: female, weighing 93.0 kg (204.6 pounds)

Reactions: Diarrhoea, Neutropenic Sepsis, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Herceptin
    Dosage: dose held.
    Indication: Breast Cancer

Herceptin
    Dosage: last dose prior to sae: 29 july 2011

Docetaxel
    Dosage: dose decreased,last dose on 29 july 2011

Docetaxel
    Dosage: dose decreased,
    Indication: Breast Cancer



Possible Herceptin side effects in female

Reported by a physician from United States on 2012-05-23

Patient: female, weighing 112.0 kg (246.4 pounds)

Reactions: White Blood Cell Count Decreased, Cellulitis, Pain in Extremity, Urinary Tract Infection, Constipation, International Normalised Ratio, Hypokalaemia, Haemoglobin Decreased, Hypoalbuminaemia, Neutropenia, Hypertension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carboplatin
    Dosage: 900 milligram
    Indication: Breast Cancer
    Start date: 2012-03-02

Herceptin
    Dosage: 224 milligram
    Start date: 2012-04-20
    End date: 2012-04-27

Abraxane
    Dosage: 213 milligram
    Start date: 2012-04-20
    End date: 2012-04-27

Herceptin
    Dosage: 224 milligram
    Indication: Breast Cancer
    Start date: 2012-03-02

Carboplatin
    Dosage: 900 milligram
    Start date: 2012-04-20
    End date: 2012-04-27

Abraxane
    Dosage: 213 milligram
    Indication: Breast Cancer
    Start date: 2012-03-02

Other drugs received by patient: Prochlorperazine; Ondansetron HCL; Ondansetron HCL; Prochlorperazine; Gentamicin; Miralax; Dexamethasone; Ambien; Potassium Chloride; Coumadin; Cozaar; Potassium Chloride; Zosyn; Vancomycin; Coumadin



Possible Herceptin side effects in female

Reported by a individual with unspecified qualification from Israel on 2012-05-08

Patient: female, weighing 55.0 kg (121.0 pounds)

Reactions: Multi-Organ Failure, Urosepsis, Neutropenia, Myocardial Infarction, Cerebral Haemorrhage

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Herceptin
    Dosage: maintenance dose. date of last dose prior to sae: 25 oct 2010, form: vial, dose level: 6 mg/kg

Carboplatin
    Dosage: date of last dose prior to sae: 25 oct 2010, form: vial, dose level: 5 auc.
    Indication: Breast Cancer

Avastin
    Dosage: date of last dose prior to sae: 25 oct 2010, form: vial, dose level: 15 mg/kg.
    Indication: Breast Cancer

Herceptin
    Dosage: loading dose: 8 mg/kg on day 1 of cycle 1 only. form: vial
    Indication: Breast Cancer

Docetaxel
    Dosage: date of last dose prior to sae: 25 oct 2010, form: vial, dose level: 75 mg/m2.
    Indication: Breast Cancer

Other drugs received by patient: Micropirin; Bondormin; Disothiazide; Simvastatin; Recital; Omeprazole; Ramipril



Possible Herceptin side effects in

Reported by a physician from United States on 2012-05-02

Patient:

Reactions: Abdominal Pain, Stomatitis, Vomiting, Dyspnoea, Nausea, Bone Pain, Palmar-Plantar Erythrodysaesthesia Syndrome, Myalgia, Fatigue, Diarrhoea, Exfoliative Rash, Dehydration, Sensory Disturbance, Nervous System Disorder, Neutropenia, Leukopenia

Drug(s) suspected as cause:
Herceptin
    Dosage: as loading dose in cycle 1 (1 cycle was of 3 weeks)
    Indication: Breast Cancer Metastatic

Xeloda
    Administration route: Oral
    Indication: Breast Cancer Metastatic

Vinorelbine Tartrate
    Indication: Breast Cancer Metastatic

Herceptin



Possible Herceptin side effects in 77 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-05-01

Patient: 77 year old female

Reactions: Neutropenic Colitis, Diarrhoea, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Xeloda
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-02-08
    End date: 2012-03-14

Emend
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2012-02-08
    End date: 2012-03-02

Herceptin
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-02-29

Xeloda
    Administration route: Oral
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-03-14

Cisplatin
    Indication: Gastric Cancer
    Start date: 2012-02-08
    End date: 2012-02-29

Herceptin
    Indication: Breast Cancer
    Start date: 2012-02-08
    End date: 2012-02-29

Emend
    Administration route: Oral
    Start date: 2012-02-08
    End date: 2012-03-02

Cisplatin
    Indication: Breast Cancer
    Start date: 2012-02-08
    End date: 2012-02-29

Other drugs received by patient: Potassium Chloride; Allopurinol; Tramadol HCL; Lovenox; Nexium; Bisoprolol Fumarate and Hydrochlorothiazide; Lorazepam; Magnesium Sulfate; Iperten; Acetaminophen; Zofran; Xenetix; Cordarone



Possible Herceptin side effects in 31 year old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-04-24

Patient: 31 year old female

Reactions: Central Nervous System Lesion, Anaemia, Headache, Herpes Zoster, Viith Nerve Paralysis, Fatigue, Neoplasm Malignant, Eyelid Ptosis, Spinal Disorder, Neutropenia, Lethargy

Drug(s) suspected as cause:
Doxorubicin HCL
    Indication: Product Used FOR Unknown Indication

Herceptin

Herceptin

Herceptin
    Indication: Product Used FOR Unknown Indication

Herceptin

Other drugs received by patient: Paclitaxel; Vinorelbine Tartrate; Thiotepa



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