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Hepsera (Adefovir Dipivoxil) - Multiple Fractures - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Multiple Fractures (25)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Hepsera (Adefovir Dipivoxil) where reactions include multiple fractures. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Hepsera side effects in 56 year old male

Reported by a physician from Japan on 2012-08-07

Patient: 56 year old male

Reactions: Renal Tubular Disorder, Protein Urine Present, Pelvic Fracture, Metabolic Acidosis, Osteoporosis, Pain in Extremity, Fanconi Syndrome Acquired, Multiple Fractures, Hypophosphataemia, Osteonecrosis, Renal Impairment, Spinal Compression Fracture, Aminoaciduria, Gait Disturbance, Urine Phosphorus Decreased, RIB Fracture

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Start date: 2006-03-28
    End date: 2010-03-18

Hepsera
    Dosage: 10 mg, qd
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2006-03-28
    End date: 2010-03-18

Hepsera
    Administration route: Oral
    Start date: 2010-02-23
    End date: 2010-03-19

Lamivudine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-10-17
    End date: 2010-02-23

Other drugs received by patient: Gaster / 00706001 /; Neurovitan / 00280501 /; Urso / 00465701 /



Possible Hepsera side effects in male

Reported by a physician from Japan on 2012-05-29

Patient: male

Reactions: Urine Phosphorus Increased, Pain, Blood Uric Acid Decreased, Aminoaciduria, Urine Uric Acid Increased, Fibula Fracture, Blood Creatinine Increased, RIB Fracture, Blood Alkaline Phosphatase Increased, Metabolic Acidosis, Fanconi Syndrome, Fanconi Syndrome Acquired, Multiple Fractures, Glucose Urine Present, Osteomalacia, Nephrosclerosis, Urine Calcium Increased, Renal Impairment, Limb Discomfort, Blood Phosphorus Decreased, Arthralgia, Tibia Fracture

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-09-01
    End date: 2011-11-01

Lamivudine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2001-10-01
    End date: 2011-11-01

Lamivudine
    Dosage: 100mg per day
    Administration route: Oral

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Start date: 2004-09-01
    End date: 2011-11-01

Lamivudine
    Dosage: 100 mg, qd
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2001-10-01
    End date: 2011-11-01

Other drugs received by patient: Etodolac; Etodolac; Antagostin; Etodolac; Losartan Potassium; Antagostin; Losartan Potassium; Losartan Potassium; Antagostin



Possible Hepsera side effects in male

Reported by a physician from Japan on 2012-05-22

Patient: male

Reactions: Urine Phosphorus Increased, Pain, Anti-SS-A Antibody Negative, Bence Jones Protein Urine Present, Blood Uric Acid Decreased, Aminoaciduria, Urine Uric Acid Increased, Fibula Fracture, Blood Creatinine Increased, RIB Fracture, Blood Alkaline Phosphatase Increased, Metabolic Acidosis, Anti-SS-B Antibody Negative, Fanconi Syndrome, Multiple Fractures, Glucose Urine Present, Osteomalacia, Nephrosclerosis, Urine Calcium Increased, Limb Discomfort, Renal Impairment, Blood Phosphorus Decreased, Arthralgia, Tibia Fracture

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-09-01
    End date: 2011-11-01

Lamivudine (Epivir Hbv)
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2001-10-01
    End date: 2011-11-01

Other drugs received by patient: Antagostin; Losartan Potassium; Etodolac



Possible Hepsera side effects in male

Reported by a physician from France on 2012-05-14

Patient: male, weighing 75.0 kg (165.0 pounds)

Reactions: Bedridden, Movement Disorder, Renal Tubular Disorder, Blood Phosphorus Decreased, Bone Pain, Multiple Fractures, Bone Disorder

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Lamivudine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2003-01-01
    End date: 2012-03-25

Hepsera
    Dosage: 10mg in the morning
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01
    End date: 2012-03-25

Other drugs received by patient: Lantus; Acenocoumarol; Valsartan; Sectral; Calcidose VIT D



Possible Hepsera side effects in male

Reported by a health professional (non-physician/pharmacist) from France on 2012-05-09

Patient: male

Reactions: Renal Tubular Disorder, Blood Phosphorus Decreased, Multiple Fractures

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01
    End date: 2012-03-25

Lamivudine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2003-01-01
    End date: 2012-03-25

Other drugs received by patient: Lantus; Acenocoumarol; Calcidose Vitamin D; Sectral; Valsartan



Possible Hepsera side effects in male

Reported by a health professional (non-physician/pharmacist) from France on 2012-05-08

Patient: male

Reactions: Renal Tubular Disorder, Blood Phosphorus Decreased, Multiple Fractures

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Lamivudine
    Dosage: 100 mg, qd
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2003-01-01
    End date: 2012-03-25

Hepsera
    Dosage: 10 mg, qd
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01
    End date: 2012-03-25

Other drugs received by patient: Minisintrom; Lantus; Sectral; Valsartan; Calcidose Vitamine D



Possible Hepsera side effects in male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-05-03

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Fanconi Syndrome, Urine Phosphorus Increased, Muscular Weakness, Osteomalacia, Multiple Fractures, Chest Pain, Aminoaciduria, Gait Disturbance

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Lamivudine (Epivir Hbv)
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Other drugs received by patient: Lexin / 00052501 /; Amlodipine; Lioresal; Gaster / 00706001 /; Loxoprofen; Lioresal; Rilutek; Lioresal; Gaster / 00706001 /; Gaster / 00706001 /; ATP / 00090104 /; Loxoprofen; Loxoprofen; Lioresal; Amlodipine; Amlodipine



Possible Hepsera side effects in male

Reported by a physician from Japan on 2012-05-03

Patient: male

Reactions: Renal Impairment, Fanconi Syndrome Acquired, Electrolyte Imbalance, Osteomalacia, Multiple Fractures

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg alternate days
    Administration route: Oral
    Start date: 2010-09-30
    End date: 2011-07-09

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2005-10-27
    End date: 2010-09-29

Other drugs received by patient: Vitamin B12; Promacta; Neurotropin; Lamivudine (Epivir Hbv); Rabeprazole Sodium; Depas; Magnesium Oxide; Aldactone; Lactitol; Furosemide; Livact; Aminoleban EN; Actonel



Possible Hepsera side effects in 45 year old male

Reported by a physician from France on 2012-04-23

Patient: 45 year old male

Reactions: Off Label Use, Drug Ineffective, Multiple Fractures, Hyperphosphaturia

Drug(s) suspected as cause:
Hepsera



Possible Hepsera side effects in male

Reported by a consumer/non-health professional from Japan on 2012-03-21

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Urine Phosphorus Increased, Fanconi Syndrome, Muscular Weakness, Multiple Fractures, Osteomalacia, Chest Pain, Aminoaciduria, Gait Disturbance

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Lamivudine (Epivir Hbv)
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Other drugs received by patient: Lexin / 00052501 /; Lioresal; Gaster / 00706001 /; Gaster / 00706001 /; Gaster / 00706001 /; ATP / 00090104 /; Amlodipine; Lioresal; Lioresal; Loxoprofen; Loxoprofen; Amlodipine; Rilutek; Loxoprofen; Lioresal; Amlodipine



Possible Hepsera side effects in 45 year old male

Reported by a physician from France on 2012-02-17

Patient: 45 year old male

Reactions: Off Label Use, Drug Ineffective, Multiple Fractures, Hyperphosphaturia

Drug(s) suspected as cause:
Hepsera



Possible Hepsera side effects in male

Reported by a physician from Japan on 2012-01-20

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Fanconi Syndrome Acquired, Osteomalacia, Multiple Fractures, Blood Phosphorus Decreased, Blood Uric Acid Decreased, Arthralgia, Tibia Fracture, Fibula Fracture, Blood Creatinine Increased, RIB Fracture

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lamivudine
    Dosage: 100mg per day
    Administration route: Oral

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-09-01
    End date: 2011-11-01

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Start date: 2004-09-01
    End date: 2011-11-01

Lamivudine
    Dosage: 100 mg, qd
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2001-10-01
    End date: 2011-11-01

Other drugs received by patient: Antagostin; Losartan Potassium; Etodolac; Antagostin; Losartan Potassium; Etodolac



Possible Hepsera side effects in male

Reported by a consumer/non-health professional from Japan on 2012-01-18

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Chest Pain, Osteomalacia, Multiple Fractures

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Zefix
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Other drugs received by patient: Gaster / 00706001 /; Gaster / 00706001 /; Lexin / 00052501 /; Rilutek; Lioresal; Gaster / 00706001 /; ATP / 00090104 /; Loxoprofen; Amlodipine; Loxoprofen; Lioresal; Amlodipine; Lioresal



Possible Hepsera side effects in male

Reported by a physician from Japan on 2012-01-18

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Fanconi Syndrome, Osteomalacia, Multiple Fractures, Blood Phosphorus Decreased, Arthralgia, Blood Uric Acid Decreased, Tibia Fracture, Fibula Fracture, Blood Creatinine Increased, RIB Fracture

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-09-01
    End date: 2011-11-01

Lamivudine, Stavudine, and Nevirapine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2001-10-01
    End date: 2011-11-01

Other drugs received by patient: Losartan Potassium; Etodolac; Antagostin



Possible Hepsera side effects in male

Reported by a physician from Japan on 2012-01-16

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Fanconi Syndrome, Urine Phosphorus Increased, Muscular Weakness, Multiple Fractures, Osteomalacia, Aminoaciduria, Chest Pain, Gait Disturbance

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Lamivudine, Stavudine, and Nevirapine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Other drugs received by patient: Famotidine; Lexin; Loxoprofen; Lioresal; ATP; Amlodipine; Rilutek



Possible Hepsera side effects in male

Reported by a physician from Japan on 2011-12-21

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Chest Pain, Osteomalacia, Multiple Fractures

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Lamivudine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Other drugs received by patient: Amlodipine; Rilutek; Lioresal; ATP / 00090104 /; Loxoprofen; Lioresal; Lexin / 00052501 /; Amlodipine; Lioresal; Gaster / 00706001 /; Gaster / 00706001 /; Gaster / 00706001 /; Loxoprofen



Possible Hepsera side effects in male

Reported by a physician from Japan on 2011-12-20

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Chest Pain, Multiple Fractures, Osteomalacia

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Lamivudine, Stavudine, and Nevirapine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Other drugs received by patient: Lexin; ATP; Amlodipine; Rilutek; Famotidine; Lioresal; Loxoprofen



Possible Hepsera side effects in male

Reported by a physician from Japan on 2011-12-16

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Chest Pain, Hyperphosphatasaemia, Multiple Fractures, Osteomalacia

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Zefix
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Other drugs received by patient: Amlodipine; Loxoprofen; Gaster / 00706001 /; Gaster / 00706001 /; Lexin / 00052501 /; Lioresal; Loxoprofen; Amlodipine; Rilutek; Lioresal; Lioresal; ATP / 00090104 /; Gaster / 00706001 /



Possible Hepsera side effects in male

Reported by a pharmacist from Japan on 2011-12-13

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Chest Pain, Hyperphosphatasaemia, Osteomalacia, Multiple Fractures

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Lamivudine, Stavudine, and Nevirapine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Other drugs received by patient: Rilutek; Lexin; ATP; Amlodipine; Lioresal; Famotidine; Loxoprofen



Possible Hepsera side effects in male

Reported by a physician from Japan on 2011-12-06

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Chest Pain, Multiple Fractures, Osteomalacia

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Lamivudine, Stavudine, and Nevirapine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Other drugs received by patient: Loxoprofen; Lioresal; Famotidine; Famotidine; Lioresal; Lexin; Rilutek; ATP; Amlodipine



Possible Hepsera side effects in male

Reported by a physician from Japan on 2011-12-02

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Chest Pain, Multiple Fractures, Osteomalacia

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Lamivudine, Stavudine, and Nevirapine
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Other drugs received by patient: Famotidine; Loxoprofen; Lexin; ATP; Amlodipine; Lioresal; Rilutek



Possible Hepsera side effects in

Reported by a physician from Japan on 2011-10-19

Patient:

Reactions: Renal Impairment, Fanconi Syndrome Acquired, Osteomalacia, Multiple Fractures, Electrolyte Imbalance

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2005-10-27
    End date: 2010-09-29

Hepsera
    Dosage: 10mg alternate days
    Administration route: Oral
    Start date: 2010-09-30
    End date: 2011-07-09

Other drugs received by patient: Methycobal; Depas; Aminoleban EN; Actonel; Promac; Lactitol; Furosemide; Livact; Lamivudine; Rabeprazole Sodium; Neurotropin; Aldactone; Magnesium Oxide



Possible Hepsera side effects in male

Reported by a physician from Japan on 2011-07-20

Patient: male

Reactions: Blood Alkaline Phosphatase Increased, Chest Pain, Multiple Fractures, Osteomalacia

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Lamivudine (Epivir Hbv)
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Other drugs received by patient: Famotidine; Lexin; Amlodipine; Lioresal; ATP; Loxoprofen; Rilutek



Possible Hepsera side effects in male

Reported by a physician from Japan on 2011-07-08

Patient: male

Reactions: Chest Pain, Multiple Fractures

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2005-05-30

Lamivudine (Epivir Hbv)
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis B
    Start date: 2004-01-01

Other drugs received by patient: Lexin; Loxoprofen; Famotidine; Amlodipine; Lioresal; ATP; Rilutek



Possible Hepsera side effects in 56 year old male

Reported by a pharmacist from Japan on 2011-07-01

Patient: 56 year old male

Reactions: Multiple Fractures

Drug(s) suspected as cause:
Hepsera
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hepatitis B

Lamivudine (Epivir Hbv)
    Administration route: Oral

Other drugs received by patient: Rilutek; Famotidine; Lioresal

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