This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Glucovance (Glyburide / Metformin) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (27)
Death (2)
Life Threatening Events (2)
Disability (1)
Reports by Reaction Type
Hepatic Cirrhosis (5),
Lactic Acidosis (3),
Myalgia (3),
Blood Glucose Increased (3),
Disseminated Intravascular Coagulation (2),
Coma (2),
Multi-Organ Failure (2),
Pyelonephritis (2),
Renal Failure Acute (2),
Hepatic Fibrosis (2),
Incorrect Dose Administered (2),
Toxicity To Various Agents (2)
Possible Glucovance side effects in 86 year old female
Reported by a consumer/non-health professional from Germany on 2012-08-10
Patient: 86 year old female
Reactions: Incorrect Dose Administered, Pollakiuria, Cerebrovascular Accident
Drug(s) suspected as cause:
Glucovance
Other drugs received by patient: Atenolol; Aspirin; Vicog
Possible Glucovance side effects in 59 year old male
Reported by a consumer/non-health professional from United States on 2012-08-03
Patient: 59 year old male, weighing 81.0 kg (178.2 pounds)
Reactions: Photosensitivity Reaction, Dyspepsia, Feeling Hot
Drug(s) suspected as cause:
Avapro
Administration route: Oral
Indication: Hypertension
Start date: 2003-05-28
Lipitor
Lantus
Dosage: 1 dosage form= 54 units also on 64units
Glucovance
Dosage: 1 dosage form= 2.5/500mg.
Administration route: Oral
Indication: Diabetes Mellitus
Start date: 2003-05-28
Aspirin
Protonix
Metformin HCL
Lovastatin
Dosage: 2tab in night
Other drugs received by patient: Loratadine; Lyrica; Naproxen
Possible Glucovance side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-03
Patient: male, weighing 63.0 kg (138.6 pounds)
Reactions: Blood Glucose Increased
Drug(s) suspected as cause:
Glucovance
Possible Glucovance side effects in 65 year old female
Reported by a consumer/non-health professional from United States on 2012-08-03
Patient: 65 year old female, weighing 66.0 kg (145.2 pounds)
Reactions: Protein Urine Present, Hypoaesthesia Oral, Abnormal Sensation in Eye, DRY Eye
Drug(s) suspected as cause:
Glucovance
Possible Glucovance side effects in 71 year old female
Reported by a consumer/non-health professional from France on 2012-08-03
Patient: 71 year old female
Reactions: Blood Glucose Increased
Drug(s) suspected as cause:
Glucovance
Lantus
Dosage: 1df:10 units inj solution 100 in/ml
Indication: Diabetes Mellitus
Start date: 2011-11-01
Byetta
Possible Glucovance side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-03
Patient: female
Reactions: Abdominal Pain, Diarrhoea
Drug(s) suspected as cause:
Glucovance
Possible Glucovance side effects in 69 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-27
Patient: 69 year old female
Reactions: Metabolic Acidosis, Pneumonia Aspiration, Hypothermia, Incorrect Dose Administered, Disseminated Intravascular Coagulation, Coma, Continuous Haemodiafiltration, Lactic Acidosis, Toxicity To Various Agents, Multi-Organ Failure, Shock, Renal Failure Acute
Adverse event resulted in: death
Drug(s) suspected as cause:
Glucovance
Dosage: 60 tablets
Indication: Product Used FOR Unknown Indication
Alprazolam
Dosage: 0.50 mg, 60 tabs
Indication: Product Used FOR Unknown Indication
Tercian (Cyamemazine)
Dosage: 25 mg, 60 tabs
Indication: Product Used FOR Unknown Indication
Lithium Carbonate
Dosage: 400 mg, 60 tabs
Indication: Product Used FOR Unknown Indication
Metfformin Hydrochloride
Dosage: 30 gm
Indication: Product Used FOR Unknown Indication
Effexor
Dosage: 75 mg, 30 tablets
Indication: Product Used FOR Unknown Indication
Possible Glucovance side effects in 69 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-23
Patient: 69 year old female
Reactions: Hypotension, Disseminated Intravascular Coagulation, Coma, Lactic Acidosis, Toxicity To Various Agents, Multi-Organ Failure, Hypoxia, Bradycardia, Shock, Renal Failure Acute
Adverse event resulted in: death
Drug(s) suspected as cause:
Alprazolam
Dosage: 0.50 mg, 60 tabs
Tercian
Dosage: 25 mg, 60 tabs
Lithium Carbonate
Dosage: 400 mg, 60 tabs
Glucovance
Dosage: 60 tablets
Metformin HCL
Dosage: 30 g, unk
Effexor
Dosage: 75 mg, 30 tablets
Possible Glucovance side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-29
Patient: female
Reactions: Nausea, Flatulence, Cystitis Noninfective, Ulcer, Abdominal Pain Upper, Hepatomegaly, Product Taste Abnormal, Bladder Disorder, Calculus Urinary, Blood Glucose Increased, Eye Pruritus
Drug(s) suspected as cause:
Glucovance
Other drugs received by patient: Multi-Vitamin; Vitamin D; Vitamin B-12
Possible Glucovance side effects in 79 year old female
Reported by a consumer/non-health professional from United States on 2012-06-15
Patient: 79 year old female, weighing 78.0 kg (171.6 pounds)
Reactions: White Blood Cell Count Decreased, Hypersensitivity, Feeling Abnormal, Blood Glucose Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Glucovance
Possible Glucovance side effects in 71 year old female
Reported by a physician from United States on 2012-05-25
Patient: 71 year old female, weighing 74.4 kg (163.7 pounds)
Reactions: Hypoglycaemia, Mental Status Changes, Hypertension
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Glucovance
Pazopanib
Dosage: 800mg per day
Administration route: Oral
Indication: Uterine Cancer
Start date: 2011-12-16
Other drugs received by patient: Imodium; Ambien; Diovan HCT
Possible Glucovance side effects in
Reported by a consumer/non-health professional from United States on 2012-04-17
Patient:
Reactions: Incorrect Storage of Drug
Drug(s) suspected as cause:
Avapro
Plavix
Reyataz
Hydrea
Avalide
Sustiva
Sprycel
Zerit
Coumadin
Videx
Glucovance
Onglyza
Azactam
Dosage: powdered vial
Abilify
Kombiglyze XR
Kenalog-40
Possible Glucovance side effects in 67 year old male
Reported by a consumer/non-health professional from Ecuador on 2012-03-16
Patient: 67 year old male, weighing 54.5 kg (119.9 pounds)
Reactions: Myalgia
Drug(s) suspected as cause:
Amaryl
Dosage: half at morning and half at night
Administration route: Oral
Amaryl
Dosage: half at morning and half at night
Administration route: Oral
Start date: 2010-01-01
Glucovance
Dosage: one at morning and one at night
Administration route: Oral
Start date: 2010-01-01
Possible Glucovance side effects in 75 year old male
Reported by a pharmacist from United States on 2012-03-09
Patient: 75 year old male
Reactions: Myalgia, Drug Intolerance, Asthenia, LOW Density Lipoprotein Increased
Drug(s) suspected as cause:
Lipitor
Dosage: 80 mg, per day
Glucovance
Dosage: unk
Indication: Diabetes Mellitus
Lipitor
Dosage: unk
Indication: Blood Cholesterol
Lipitor
Dosage: 40 per day, one 80 mg every other night
Lipitor
Dosage: 60 mg per day
Possible Glucovance side effects in 36 year old male
Reported by a consumer/non-health professional from United States on 2012-02-24
Patient: 36 year old male
Reactions: Pancreatitis, Lactic Acidosis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Metformin HCL
Administration route: Oral
Glucovance
Other drugs received by patient: Insulin
Possible Glucovance side effects in 67 year old male
Reported by a consumer/non-health professional from Kazakhstan on 2012-01-30
Patient: 67 year old male, weighing 54.5 kg (119.9 pounds)
Reactions: Myalgia
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Amaryl
Dosage: half at morning and half at night
Administration route: Oral
Glucovance
Dosage: one at morning and one at night
Administration route: Oral
Start date: 2010-01-01
Amaryl
Dosage: half at morning and half at night
Administration route: Oral
Start date: 2010-01-01
Possible Glucovance side effects in male
Reported by a physician from Germany on 2012-01-13
Patient: male
Reactions: Gastrointestinal Disorder, Haemolytic Anaemia
Adverse event resulted in: life threatening event, disablity
Drug(s) suspected as cause:
Loperamide
Administration route: Oral
Glucovance
Administration route: Oral
Zocor
Other drugs received by patient: Repaglinide; Glyburide
Possible Glucovance side effects in 80 year old female
Reported by a physician from France on 2012-01-11
Patient: 80 year old female
Reactions: Hepatic Fibrosis
Drug(s) suspected as cause:
Methotrexate
Dosage: for more than 10 years
Administration route: Oral
End date: 2011-09-15
Arthrotec
Dosage: artotec 75 mg/0.2 mg 1df=1film-coated tablet
Administration route: Oral
End date: 2011-09-15
Irbesartan and Hydrochlorothiazide
Dosage: film coated tabs for more than 3 years 1df:1 tablet
Administration route: Oral
End date: 2011-09-15
Glucovance
Dosage: 1df=1 tabs film coated tabs more than 3 years
Administration route: Oral
End date: 2011-09-15
Lorazepam
Dosage: in the evng
Administration route: Oral
Omeprazole
Dosage: mopral 10 mg 1df:1tablet enteric coated tablet more than 3 years
Administration route: Oral
Acetaminophen
Dosage: doliprane 500mg
Administration route: Oral
Possible Glucovance side effects in female
Reported by a physician from France on 2012-01-11
Patient: female
Reactions: Hepatic Fibrosis
Drug(s) suspected as cause:
Glucovance
Administration route: Oral
End date: 2011-09-15
Irbesartan and Hydrochlorothiazide
Administration route: Oral
End date: 2011-09-15
Lorazepam
Administration route: Oral
Methotrexate
Dosage: 10 to 15 mg per week for around 10 years - estimated total dose received: more than 3 grams
Administration route: Oral
End date: 2011-09-15
Acetaminophen
Administration route: Oral
Omeprazole
Dosage: 10 mg, daily, treatment started for more than 3 years
Administration route: Oral
Arthrotec
Administration route: Oral
End date: 2011-09-15
Possible Glucovance side effects in 80 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-01-10
Patient: 80 year old female
Reactions: Hepatic Cirrhosis, Pyelonephritis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Methotrexate Sodium
Dosage: 12.5 mg, weekly
Administration route: Oral
End date: 2011-09-15
Arthrotec
Dosage: 75/0.2mg, 2x/day
Administration route: Oral
End date: 2011-09-15
Irbesartan and Hydrochlorothiazide
Dosage: 300mg/25mg, 1 dfx/1 day
Administration route: Oral
End date: 2011-09-15
Omeprazole
Dosage: 10 mg, 1x/day
Administration route: Oral
Acetaminophen
Dosage: 1 g, 3x/day
Administration route: Oral
Glucovance
Dosage: 500mg/5mg, 1dfx/3day
Administration route: Oral
End date: 2011-09-15
Lorazepam
Dosage: 1 mg, 1x/day
Administration route: Oral
Possible Glucovance side effects in 80 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2011-12-29
Patient: 80 year old female
Reactions: Hepatic Cirrhosis, Pyelonephritis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Lorazepam
Dosage: 1 mg, 1x/day
Administration route: Oral
Acetaminophen
Dosage: 1 g, 3x/day
Administration route: Oral
Irbesartan and Hydrochlorothiazide
Dosage: 300mg/25mg, 1 dfx/1 day
Administration route: Oral
End date: 2011-09-15
Glucovance
Dosage: 500mg/5mg, 1dfx/3day
Administration route: Oral
End date: 2011-09-15
Methotrexate Sodium
Dosage: 12.5 mg, weekly
Administration route: Oral
End date: 2011-09-15
Arthrotec
Dosage: 75/0.2mg, 2x/day
Administration route: Oral
End date: 2011-09-15
Omeprazole
Dosage: 10 mg, 1x/day
Administration route: Oral
Possible Glucovance side effects in 80 year old female
Reported by a physician from France on 2011-12-23
Patient: 80 year old female
Reactions: Hepatic Cirrhosis
Drug(s) suspected as cause:
Omeprazole
Dosage: mopral 10 mg 1df:1tablet enteric coated tablet more than 3 years
Administration route: Oral
Arthrotec
Dosage: artotec 75 mg/0.2 mg 1df=1film-coated tablet
Administration route: Oral
End date: 2011-09-15
Methotrexate
Dosage: for more than 10 years
Administration route: Oral
End date: 2011-09-15
Irbesartan and Hydrochlorothiazide
Dosage: film coated tabs for more than 3 years 1df:1 tablet
Administration route: Oral
End date: 2011-09-15
Lorazepam
Dosage: in the evng
Administration route: Oral
Glucovance
Dosage: 1df=1 tabs film coated tabs more than 3 years
Administration route: Oral
End date: 2011-09-15
Acetaminophen
Dosage: doliprane 500mg
Administration route: Oral
Possible Glucovance side effects in female
Reported by a physician from France on 2011-12-22
Patient: female
Reactions: Hepatic Cirrhosis
Drug(s) suspected as cause:
Omeprazole
Administration route: Oral
Methotrexate
Dosage: 10 to 15 mg per week for around 10 years
Administration route: Oral
End date: 2011-09-15
Irbesartan and Hydrochlorothiazide
Administration route: Oral
End date: 2011-09-15
Lorazepam
Administration route: Oral
Acetaminophen
Administration route: Oral
Glucovance
Administration route: Oral
End date: 2011-09-15
Arthrotec
Administration route: Oral
End date: 2011-09-15
Possible Glucovance side effects in 80 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2011-12-16
Patient: 80 year old female
Reactions: Hepatic Cirrhosis
Drug(s) suspected as cause:
Omeprazole
Dosage: 10 mg, 1x/day
Administration route: Oral
Arthrotec
Dosage: 75 mg, 2x/day
Administration route: Oral
End date: 2011-09-15
Irbesartan and Hydrochlorothiazide
Dosage: 300mg/25mg, 1 dfx/1 day
Administration route: Oral
End date: 2011-09-15
Glucovance
Dosage: 500mg/5mg, 1dfx/3day
Administration route: Oral
End date: 2011-09-15
Acetaminophen
Dosage: 1 g, 3x/day
Administration route: Oral
Lorazepam
Dosage: 1 mg, 1x/day
Administration route: Oral
Methotrexate
Dosage: 12.5 mg, weekly
Administration route: Oral
Possible Glucovance side effects in
Reported by a consumer/non-health professional from United States on 2011-11-30
Patient:
Reactions: Surgery
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Glucovance
Possible Glucovance side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-23
Patient: male, weighing 79.8 kg (175.6 pounds)
Reactions: Malaise
Drug(s) suspected as cause:
Glucovance
Dosage: 5mg
Indication: Diabetes Mellitus
Start date: 2004-01-01
Metformin HCL
Dosage: 500
Possible Glucovance side effects in 82 year old
Reported by a health professional (non-physician/pharmacist) from France on 2011-10-03
Patient: 82 year old
Reactions: Pancreatitis Chronic
Drug(s) suspected as cause:
Januvia
Administration route: Oral
Indication: Type 2 Diabetes Mellitus
Start date: 2010-04-22
End date: 2011-05-18
Tramadol HCL
Administration route: Oral
Start date: 2010-06-03
End date: 2011-04-03
Glucovance
Administration route: Oral
End date: 2011-04-12
Zestoretic
Administration route: Oral
End date: 2011-04-11
Aspirin
Administration route: Oral
End date: 2011-04-03
Pantoprazole Sodium
Administration route: Oral
End date: 2011-04-12
Levothyroxine Sodium
Administration route: Oral
Modopar
Administration route: Oral
Other drugs received by patient: Glucophage; Nexium; Zestril; Lovenox; Alfuzosin HCL; Indapamide; Atarax; Amaryl; Bactrim; Prozac
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