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Epirubicin (Epirubicin) - Neutropenia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Neutropenia (25)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Epirubicin where reactions include neutropenia. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Epirubicin side effects in

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-08-20

Patient:

Reactions: Abdominal Pain, Vomiting, Hypersensitivity, Nausea, Skin Toxicity, Mucosal Inflammation, Fatigue, Diarrhoea, Hepatotoxicity, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Breast Cancer

Epirubicin
    Indication: Breast Cancer

Fluorouracil
    Indication: Breast Cancer

Herceptin
    Dosage: loading dose
    Indication: Breast Cancer

Herceptin
    Dosage: maintenance dose

Lapatinib
    Dosage: arm b
    Administration route: Oral
    Indication: Breast Cancer

Lapatinib
    Dosage: arm c
    Administration route: Oral

Paclitaxel
    Indication: Breast Cancer



Possible Epirubicin side effects in 57 year old female

Reported by a consumer/non-health professional from Spain on 2012-07-27

Patient: 57 year old female

Reactions: Pyrexia, Neutropenia, Hidradenitis, Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Docetaxel
    Indication: Breast Cancer
    Start date: 2006-08-23
    End date: 2006-11-02

Epirubicin
    Indication: Breast Cancer
    Start date: 2006-08-23
    End date: 2006-11-02

Other drugs received by patient: Hipoartel; Simvastatin; Ceftazidime; Pantoprazole



Possible Epirubicin side effects in 58 year old female

Reported by a physician from Taiwan, Province of China on 2012-07-24

Patient: 58 year old female, weighing 57.3 kg (126.1 pounds)

Reactions: Multi-Organ Failure, Pneumonia, Coagulopathy, Central Nervous System Lesion, Acute Respiratory Distress Syndrome, Neutropenia, Acute Respiratory Failure, Renal Failure Acute

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Epirubicin
    Start date: 2010-12-28
    End date: 2010-12-28

Epirubicin
    Indication: Breast Cancer
    Start date: 2010-09-30
    End date: 2010-09-30

Taxotere
    Indication: Breast Cancer
    Start date: 2010-09-30
    End date: 2010-09-30

Taxotere
    Start date: 2010-12-28
    End date: 2010-12-28

Other drugs received by patient: Granocyte



Possible Epirubicin side effects in male

Reported by a physician from Poland on 2012-07-24

Patient: male, weighing 77.0 kg (169.4 pounds)

Reactions: Dyspnoea, Pleural Effusion, Palmar-Plantar Erythrodysaesthesia Syndrome, General Physical Health Deterioration, Neutropenia, Polyneuropathy, Disease Progression

Adverse event resulted in: death

Drug(s) suspected as cause:
Capecitabine
    Indication: Metastatic Gastric Cancer
    Start date: 2010-10-27
    End date: 2011-04-06

Epirubicin
    Indication: Metastatic Gastric Cancer
    Start date: 2010-10-27
    End date: 2011-04-06

Oxaliplatin
    Indication: Metastatic Gastric Cancer
    Start date: 2010-10-27
    End date: 2011-04-06



Possible Epirubicin side effects in 44 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-20

Patient: 44 year old female, weighing 55.5 kg (122.1 pounds)

Reactions: Abdominal Pain, Intestinal Ischaemia, Colitis Ischaemic, White Blood Cell Count Decreased, Vomiting, Blood Creatine Phosphokinase Increased, Gastrointestinal Necrosis, Pyrexia, Multi-Organ Failure, Diarrhoea, GAS Gangrene, Heart Rate Increased, Bone Marrow Failure, Neutropenia, Clostridial Infection

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 7 cycles, total 4 courses
    Indication: Breast Cancer
    Start date: 2011-07-22
    End date: 2011-09-22

Epirubicin
    Dosage: 7 cycles, total 4 courses
    Indication: Breast Cancer
    Start date: 2011-07-22
    End date: 2011-09-22

Taxotere
    Dosage: 4 cycles, total 3 courses, dose taken once daily
    Indication: Breast Cancer
    Start date: 2011-10-14
    End date: 2011-11-25

Other drugs received by patient: Leucon; Lorazepam; Decadron Phosphate; Lorazepam; Kytril; Prochlorperazine; Kytril; Cepharanthin; Decadron Phosphate; Marzulene S



Possible Epirubicin side effects in 46 year old female

Reported by a health professional (non-physician/pharmacist) from Croatia (Local Name: Hrvatska) on 2012-07-20

Patient: 46 year old female, weighing 60.0 kg (132.0 pounds)

Reactions: Neutropenia, Thrombocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Epirubicin
    Start date: 2012-05-17
    End date: 2012-05-18

Epirubicin
    Start date: 2012-05-17
    End date: 2012-05-18

Epirubicin
    Start date: 2012-05-17
    End date: 2012-05-18

Ifosfamide
    Start date: 2012-05-17
    End date: 2012-05-18

Mesna
    Start date: 2012-05-17
    End date: 2012-05-18



Possible Epirubicin side effects in 58 year old female

Reported by a health professional (non-physician/pharmacist) from Hong Kong on 2012-07-20

Patient: 58 year old female

Reactions: Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: (df; every three weeks intravenous drip), (df; dose reduced intravenous drip)
    Indication: Breast Cancer
    Start date: 2010-08-04
    End date: 2010-08-04

Epirubicin
    Dosage: (df; every three weeks intravenous drip), (df; dose reduced)
    Indication: Breast Cancer
    Start date: 2010-08-04
    End date: 2010-08-04

Fluorouracil
    Dosage: (df; every three weeks intravenous drip), (df; dose reduced)
    Indication: Breast Cancer
    Start date: 2010-08-04
    End date: 2010-08-04



Possible Epirubicin side effects in 63 year old male

Reported by a physician from Poland on 2012-06-27

Patient: 63 year old male

Reactions: Dyspnoea, Palmar-Plantar Erythrodysaesthesia Syndrome, Pleural Effusion, General Physical Health Deterioration, Neutropenia, Polyneuropathy, Disease Progression

Adverse event resulted in: death

Drug(s) suspected as cause:
Capecitabine
    Indication: Product Used FOR Unknown Indication

Epirubicin
    Indication: Product Used FOR Unknown Indication

Oxaliplatin
    Indication: Product Used FOR Unknown Indication



Possible Epirubicin side effects in

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-06-25

Patient:

Reactions: Neutropenia

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: (600 mg/m2 (every 3 weeks))
    Indication: Breast Cancer

Docetaxel
    Dosage: (100 mg/m2 (every 3 weeks))
    Indication: Breast Cancer

Epirubicin
    Dosage: (100 mg/m2 (every 3 weeks))
    Indication: Breast Cancer

Fluorouracil
    Dosage: (600 mg/m2 (every 3 weeks))
    Indication: Breast Cancer

Other drugs received by patient: Filgrastim



Possible Epirubicin side effects in 68 year old female

Reported by a physician from Japan on 2012-06-15

Patient: 68 year old female, weighing 39.9 kg (87.8 pounds)

Reactions: White Blood Cell Count Decreased, Dyspnoea, Nausea, Hypotension, Tachycardia, Toxic Epidermal Necrolysis, Pyrexia, Haemoglobin Decreased, Respiratory Failure, Circulatory Collapse, Neutropenia, Rash Vesicular, Oxygen Saturation Decreased, Shock

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Breast Cancer
    Start date: 2012-02-28
    End date: 2012-02-28

Epirubicin
    Indication: Breast Cancer
    Start date: 2012-02-28
    End date: 2012-02-28



Possible Epirubicin side effects in

Reported by a individual with unspecified qualification from Egypt on 2012-06-15

Patient:

Reactions: Neutropenia, Haematotoxicity

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: (500 mg/m2 (every three weeks) intravenous (not otherwise specified))
    Indication: Inflammatory Carcinoma of Breast Stage III

Epirubicin
    Dosage: (100 mg/m2 (every three weeks) intravenous (not otherwise specified))
    Indication: Inflammatory Carcinoma of Breast Stage III

Fluorouracil
    Dosage: (500 mg/m2 (every three weeks) intravenous bolus)
    Indication: Inflammatory Carcinoma of Breast Stage III



Possible Epirubicin side effects in female

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-06-15

Patient: female

Reactions: Alopecia, Neutropenia, Constipation

Drug(s) suspected as cause:
Cyclophosphamide
    Start date: 2011-06-25
    End date: 2011-09-03

Epirubicin
    Start date: 2011-06-25
    End date: 2011-09-03

Fluorouracil
    Start date: 2011-06-25
    End date: 2011-09-03

Other drugs received by patient: Levothyroxine Sodium



Possible Epirubicin side effects in

Reported by a health professional (non-physician/pharmacist) from Egypt on 2012-06-15

Patient:

Reactions: Neutropenia

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 500 mg/m2 (every three weeks) intravenous (not otherwise specified)
    Indication: Inflammatory Carcinoma of Breast Stage III

Epirubicin
    Dosage: 100 mg/m2 (every three weeks) intravenous (not otherwise specified)
    Indication: Inflammatory Carcinoma of Breast Stage III

Fluorouracil
    Dosage: 500 mg/m2 (every three weeks) intravenous bolus
    Indication: Inflammatory Carcinoma of Breast Stage III



Possible Epirubicin side effects in 68 year old female

Reported by a physician from Japan on 2012-05-04

Patient: 68 year old female, weighing 39.9 kg (87.8 pounds)

Reactions: White Blood Cell Count Decreased, Dyspnoea, Nausea, Hypotension, Tachycardia, Toxic Epidermal Necrolysis, Pyrexia, Haemoglobin Decreased, Respiratory Failure, Circulatory Collapse, Neutropenia, Rash Vesicular, Oxygen Saturation Decreased, Shock

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Breast Cancer
    Start date: 2012-02-28
    End date: 2012-02-28

Epirubicin
    Indication: Breast Cancer
    Start date: 2012-02-28
    End date: 2012-02-28



Possible Epirubicin side effects in female

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-03-28

Patient: female

Reactions: Alopecia, Neutropenia, Constipation

Drug(s) suspected as cause:
Epirubicin



Possible Epirubicin side effects in female

Reported by a health professional (non-physician/pharmacist) from France on 2012-03-20

Patient: female

Reactions: Neutropenia, RIB Fracture

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: dose unit:500

Cyclophosphamide
    Dosage: dose unit:200
    Indication: Breast Cancer

Doxorubicin HCL
    Dosage: dose unit:50
    Indication: Breast Cancer

Epirubicin
    Dosage: dose unit:50
    Indication: Breast Cancer

Fluorouracil
    Dosage: dose unit:300
    Indication: Breast Cancer

Fluorouracil
    Dosage: dose unit:1500

Methotrexate
    Dosage: dose unit:10
    Indication: Breast Cancer

Therapeutic Radiopharmaceuticals
    Indication: Breast Cancer

Vincristine Sulfate
    Dosage: dose unit:0.6
    Indication: Breast Cancer



Possible Epirubicin side effects in 57 year old female

Reported by a physician from United States on 2012-02-27

Patient: 57 year old female, weighing 78.7 kg (173.1 pounds)

Reactions: Gastrointestinal Inflammation, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Bevacizumab
    Indication: Breast Cancer
    Start date: 2009-03-13

Cyclophosphamide
    Indication: Breast Cancer
    Start date: 2009-03-13
    End date: 2009-05-12

Docetaxel
    Indication: Breast Cancer
    Start date: 2009-06-11
    End date: 2009-06-30

Epirubicin
    Indication: Breast Cancer
    Start date: 2009-03-13
    End date: 2009-05-12

Epirubicin
    Start date: 2009-03-13
    End date: 2009-05-12

Fluorouracil
    Indication: Breast Cancer
    Start date: 2009-03-13
    End date: 2009-05-12

Other drugs received by patient: Mexaform; Esomeprazole Magnesium; Ibuprofen; Dexamethasone; Mersyndol; Dexamethasone



Possible Epirubicin side effects in 36 year old female

Reported by a health professional (non-physician/pharmacist) from China on 2012-01-23

Patient: 36 year old female

Reactions: Lymphadenopathy, Neutropenia

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Breast Cancer Stage III

Docetaxel
    Indication: Breast Cancer Stage III

Epirubicin
    Indication: Breast Cancer Stage III

Neupogen
    Indication: Neutropenia



Possible Epirubicin side effects in female

Reported by a individual with unspecified qualification from Japan on 2011-12-13

Patient: female

Reactions: Hyperventilation, Fatigue, Malaise, Neuropathy Peripheral, Neutropenia

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 500 mg/m2
    Indication: Metastases To Lung

Docetaxel
    Dosage: 60 mg/m2, 4 mg
    Indication: Metastases To Lung

Epirubicin
    Dosage: 60 mg/m2, 4 mg
    Indication: Metastases To Lung

Fluorouracil
    Dosage: 500 mg/m2
    Indication: Metastases To Lung

Paclitaxel
    Dosage: 210 mg/m2
    Indication: Metastases To Lung



Possible Epirubicin side effects in 71 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-23

Patient: 71 year old male, weighing 75.0 kg (165.0 pounds)

Reactions: Neutropenia, Thrombocytopenia, Leukopenia, Decreased Appetite

Drug(s) suspected as cause:
Carboplatin
    Dosage: 400 mg/m2, 4-week cycles, completed 6 cycles
    Indication: Metastatic Gastric Cancer

Epirubicin
    Dosage: 27 mg/m2, 4-week cycles, completed 6 cycles
    Indication: Metastatic Gastric Cancer

Etoposide
    Dosage: 70 mg/m2, 4-week cycles, completed 6 cycles
    Indication: Metastatic Gastric Cancer

Fluorouracil
    Dosage: 330 mg/m2, 4-week cycles, completed 6 cycles
    Indication: Metastatic Gastric Cancer



Possible Epirubicin side effects in female

Reported by a physician from Germany on 2011-11-18

Patient: female

Reactions: Drug Ineffective, Neutropenia, Leukopenia

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: unk
    Indication: Breast Cancer
    Start date: 2011-09-06
    End date: 2011-10-18

Epirubicin
    Dosage: unk
    Indication: Breast Cancer
    Start date: 2011-09-06
    End date: 2011-10-18

Fluorouracil
    Dosage: unk
    Indication: Breast Cancer
    Start date: 2011-09-06
    End date: 2011-10-18

Neulasta
    Dosage: 6 mg, unk
    Indication: Chemotherapy
    Start date: 2011-10-19

Other drugs received by patient: Mesna; Dexamethasone; Kevatril



Possible Epirubicin side effects in female

Reported by a physician from Netherlands on 2011-11-03

Patient: female, weighing 90.4 kg (198.9 pounds)

Reactions: Urosepsis, Neutropenia, Leukopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 1040 mg, unk
    Indication: Breast Cancer
    Start date: 2011-05-02

Epirubicin
    Dosage: 2.08 mg, unk
    Indication: Breast Cancer
    Start date: 2011-05-02

Fluorouracil
    Dosage: 1040 mg, unk
    Indication: Breast Cancer
    Start date: 2011-05-02

NO Treatment Received
    Dosage: no treatment
    Indication: Breast Cancer

Other drugs received by patient: Ascal; Hydrochlorothiazide; Omeprazole; Diclofenac; Ascal; Zocor; Enalapril Maleate



Possible Epirubicin side effects in 71 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-01

Patient: 71 year old male

Reactions: Neutropenia, Thrombocytopenia, Decreased Appetite, Leukopenia

Drug(s) suspected as cause:
Carboplatin
    Dosage: 400 mg/m2, 4-week cycles, completed 6 cycles
    Indication: Metastatic Gastric Cancer

Epirubicin
    Dosage: 27 mg/m2, 4-week cycles, completed 6 cycles
    Indication: Metastatic Gastric Cancer

Etoposide
    Dosage: 70 mg/m2, 4-week cycles, completed 6 cycles
    Indication: Metastatic Gastric Cancer

Fluorouracil
    Dosage: 330 mg/m2, 4-week cycles, completed 6 cycles
    Indication: Metastatic Gastric Cancer



Possible Epirubicin side effects in 50 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-18

Patient: 50 year old female

Reactions: Fatigue, Treatment Failure, Neutropenia

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 500 mg/m2, unk
    Indication: Breast Cancer Metastatic

Docetaxel
    Dosage: 60 mg/m2, unk
    Indication: Breast Cancer Metastatic

Epirubicin
    Dosage: 60 mg/m2, unk
    Indication: Breast Cancer Metastatic

Fluorouracil
    Dosage: 500 mg/m2, unk
    Indication: Breast Cancer Metastatic



Possible Epirubicin side effects in female

Reported by a health professional (non-physician/pharmacist) from France on 2011-10-05

Patient: female, weighing 54.0 kg (118.8 pounds)

Reactions: Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cisplatin
    Dosage: 160 mg, qd
    Indication: Chemotherapy
    Start date: 2011-09-01
    End date: 2011-09-01

Cyclophosphamide
    Dosage: 630 mg, qd
    Indication: Chemotherapy
    Start date: 2011-08-31
    End date: 2011-09-02

Epirubicin
    Dosage: 65 mg, qd
    Indication: Chemotherapy
    Start date: 2011-08-31
    End date: 2011-08-31

Etoposide
    Dosage: 160 mg, qd
    Indication: Chemotherapy
    Start date: 2011-08-31
    End date: 2011-09-02

Neulasta
    Dosage: 6 mg, one time dose
    Indication: Chemotherapy
    Start date: 2011-09-03
    End date: 2011-09-03

Other drugs received by patient: Antineoplastic Agents

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