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Emend (Aprepitant) - Drug Interaction - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Drug Interaction (16)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Emend (Aprepitant) where reactions include drug interaction. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Emend side effects in

Reported by a physician from France on 2012-08-01

Patient:

Reactions: Renal Failure, Lung Disorder, Toxic Encephalopathy, Drug Interaction, Pancytopenia, Septic Shock

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Emend

Other drugs received by patient possibly interacting with the suspect drug:
Cyclophosphamide
    Dosage: unk
    Indication: Sarcoma
    Start date: 2012-03-22

Cyclophosphamide
    Dosage: unk
    Start date: 2012-04-23

Cyclophosphamide
    Dosage: unk

Other drugs received by patient: Calciparine; Granocyte; Zofran



Possible Emend side effects in 45 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-06-11

Patient: 45 year old male

Reactions: Drug Interaction, Encephalopathy

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ifosfamide
    Indication: Epithelioid Sarcoma Metastatic
    Start date: 2012-03-06
    End date: 2012-03-08

Ifosfamide
    Start date: 2012-04-05
    End date: 2012-04-07

Emend
    Administration route: Oral
    Start date: 2012-03-06
    End date: 2012-03-08

Emend
    Administration route: Oral
    Indication: Premedication
    Start date: 2012-04-05
    End date: 2012-04-07

Other drugs received by patient: Metoclopramide Hydrochloride; Metoclopramide Hydrochloride; Methylprednisolone Sodium Succinate; Mesna; Methylprednisolone Sodium Succinate



Possible Emend side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-04-23

Patient: 65 year old female

Reactions: Encephalopathy, Drug Interaction

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ifosfamide
    Start date: 2012-02-09
    End date: 2012-02-11

Emend
    Administration route: Oral
    Start date: 2012-02-09
    End date: 2012-02-11

Other drugs received by patient: Paroxetine Hydrochloride; Ondansetron; Tenormin; Acetaminophen; Levothyroxine Sodium; Nitroderm; Mesna; Primperan TAB; Insulin; Aspirin; Oxycodone



Possible Emend side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-03-19

Patient: 65 year old female

Reactions: Encephalopathy, Drug Interaction

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ifosfamide
    Start date: 2012-02-09
    End date: 2012-02-11

Emend
    Start date: 2012-02-09
    End date: 2012-02-11

Other drugs received by patient: Oxycodone; Insulin; Ondansetron; Tenormin; Levothyroxine Sodium; Acetaminophen; Primperan TAB; Nitroderm; Aspirin; Paroxetine Hydrochloride



Possible Emend side effects in 28 year old male

Reported by a pharmacist from France on 2012-02-22

Patient: 28 year old male

Reactions: Drug Interaction, Lipase Increased, Metastases To Pancreas

Drug(s) suspected as cause:
Emend
    Administration route: Oral
    Start date: 2011-12-01
    End date: 2011-12-02

Irinotecan HCL
    Start date: 2012-02-01

Emend
    Administration route: Oral
    Start date: 2011-12-28
    End date: 2011-12-28

Emend
    Administration route: Oral
    Start date: 2011-11-30
    End date: 2011-11-30

Emend
    Administration route: Oral
    Start date: 2011-12-29
    End date: 2011-12-30

Irinotecan HCL
    Indication: Colorectal Cancer
    Start date: 2011-08-01
    End date: 2012-01-11

Emend
    Administration route: Oral
    Start date: 2011-12-15
    End date: 2011-12-16

Emend
    Administration route: Oral
    Start date: 2012-01-11
    End date: 2012-01-11

Emend
    Administration route: Oral
    Start date: 2011-12-14
    End date: 2011-12-14

Other drugs received by patient: Folic Acid; Atropine; Fluorouracil



Possible Emend side effects in 28 year old male

Reported by a pharmacist from France on 2012-02-20

Patient: 28 year old male

Reactions: Drug Interaction, Lipase Increased, Metastases To Pancreas

Drug(s) suspected as cause:
Emend
    Administration route: Oral
    Start date: 2011-12-15
    End date: 2011-12-16

Emend
    Administration route: Oral
    Start date: 2011-12-14
    End date: 2011-12-14

Emend
    Administration route: Oral
    Start date: 2011-12-29
    End date: 2011-12-30

Emend
    Administration route: Oral
    Start date: 2011-12-28
    End date: 2011-12-28

Irinotecan HCL
    Indication: Colorectal Cancer
    Start date: 2011-08-01
    End date: 2012-01-11

Emend
    Administration route: Oral
    Start date: 2012-01-11
    End date: 2012-01-11

Emend
    Administration route: Oral
    Start date: 2011-11-30
    End date: 2011-11-30

Irinotecan HCL
    Start date: 2012-02-01

Emend
    Administration route: Oral
    Start date: 2011-12-01
    End date: 2011-12-02

Other drugs received by patient: Fluorouracil; Folic Acid; Atropine



Possible Emend side effects in 56 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-02-06

Patient: 56 year old male

Reactions: Drug Interaction, Encephalopathy

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ondansetron
    Start date: 2009-08-17
    End date: 2009-08-20

Ondansetron
    Start date: 2009-09-07

Emend
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2009-08-17
    End date: 2009-08-17

Emend
    Administration route: Oral
    Start date: 2009-09-07

Metoclopramide HCL
    Start date: 2009-08-17
    End date: 2009-08-22

Doxorubicin Hydrochloride
    Indication: Teratoma
    Start date: 2009-08-17
    End date: 2009-08-18

Mesna
    Start date: 2009-08-17
    End date: 2009-08-20

Emend
    Administration route: Oral
    Start date: 2009-08-18
    End date: 2009-08-19

Ifosfamide
    Indication: Teratoma
    Start date: 2009-08-17
    End date: 2009-08-19

Methylprednisolone Sodium Succinate
    Start date: 2009-09-07

Mesna
    Start date: 2009-09-07

Ifosfamide
    Start date: 2009-09-07

Doxorubicin HCL
    Start date: 2009-09-07

Methylprednisolone Sodium Succinate
    Start date: 2009-08-17
    End date: 2009-08-20

Metoclopramide HCL
    Start date: 2009-09-07

Other drugs received by patient: Tinzaparin Sodium



Possible Emend side effects in 56 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-02-01

Patient: 56 year old male

Reactions: Drug Interaction, Encephalopathy

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Metoclopramide Hydrochloride
    Start date: 2009-08-17
    End date: 2009-08-22

Doxorubicin Hydrochloride
    Indication: Teratoma
    Start date: 2009-08-17
    End date: 2009-08-18

Mesna
    Start date: 2009-09-07

Ifosfamide
    Start date: 2009-09-07

Methylprednisolone Sodium Succinate
    Start date: 2009-09-07

Emend
    Administration route: Oral
    Start date: 2009-08-18
    End date: 2009-08-19

Mesna
    Start date: 2009-08-17
    End date: 2009-08-20

Emend
    Administration route: Oral
    Start date: 2009-09-07

Ifosfamide
    Indication: Teratoma
    Start date: 2009-08-17
    End date: 2009-08-19

Methylprednisolone Sodium Succinate
    Start date: 2009-08-17
    End date: 2009-08-20

Doxorubicin Hydrochloride
    Start date: 2009-09-07

Metoclopramide Hydrochloride
    Start date: 2009-09-07

Emend
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2009-08-17
    End date: 2009-08-17

Ondansetron
    Start date: 2009-08-17
    End date: 2009-08-20

Ondansetron
    Start date: 2009-09-07

Other drugs received by patient: Tinzaparin Sodium



Possible Emend side effects in 28 year old male

Reported by a pharmacist from France on 2012-01-27

Patient: 28 year old male

Reactions: Pancreatitis, Drug Interaction

Drug(s) suspected as cause:
Emend
    Administration route: Oral
    Start date: 2011-12-01
    End date: 2011-12-02

Emend
    Administration route: Oral
    Start date: 2011-12-28
    End date: 2011-12-28

Emend
    Administration route: Oral
    Start date: 2012-01-11
    End date: 2012-01-11

Emend
    Administration route: Oral
    Start date: 2011-12-14
    End date: 2011-12-14

Emend
    Administration route: Oral
    Start date: 2011-11-30
    End date: 2011-11-30

Emend
    Administration route: Oral
    Start date: 2011-12-15
    End date: 2011-12-16

Emend
    Administration route: Oral
    Start date: 2011-12-29
    End date: 2011-12-30

Irinotecan HCL
    Indication: Colorectal Cancer
    Start date: 2011-08-01
    End date: 2012-01-11

Other drugs received by patient: Fluorouracil; Folic Acid; Atropine



Possible Emend side effects in

Reported by a pharmacist from France on 2012-01-20

Patient:

Reactions: Drug Interaction, Epilepsy

Drug(s) suspected as cause:
Emend
    Administration route: Oral

Valproic Acid
    Administration route: Oral



Possible Emend side effects in 44 year old male

Reported by a physician from Netherlands on 2012-01-20

Patient: 44 year old male

Reactions: Renal Disorder, Dehydration, Drug Interaction, Inhibitory Drug Interaction, Somnolence

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Emend
    Administration route: Oral

Emend
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting

Emend
    Administration route: Oral

Quetiapine Fumarate
    Administration route: Oral
    Indication: Anxiety

Other drugs received by patient: Dexamethasone; Ondansetron; Citalopram; Cisplatin



Possible Emend side effects in 67 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-12-30

Patient: 67 year old male

Reactions: Drug Interaction, Encephalopathy

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Emend
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2010-07-06
    End date: 2010-07-06

Ifosfamide
    Indication: Neuroendocrine Tumour
    Start date: 2010-07-06
    End date: 2010-07-08

Emend
    Administration route: Oral
    Start date: 2010-07-07
    End date: 2010-07-10

Other drugs received by patient: Doxorubicin Hydrochloride; Ondansetron; Metoclopramide Hydrochloride; Calcium Carbonate; Methylprednisolone Sodium Succinate; Mesna; Atenolol; Hydrochlorothiazide and Irbesartan; Insulin Aspart; Irbesartan; Repaglinide; Vitamins (Unspecified)



Possible Emend side effects in 56 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-12-27

Patient: 56 year old male

Reactions: Drug Interaction, Encephalopathy

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Emend
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2009-08-17
    End date: 2009-08-17

Ifosfamide
    Indication: Teratoma
    Start date: 2009-08-17
    End date: 2009-08-19

Methylprednisolone Sodium Succinate
    Start date: 2009-08-17
    End date: 2009-08-20

Ondansetron
    Start date: 2009-09-07

Emend
    Administration route: Oral
    Start date: 2009-08-18
    End date: 2009-08-19

Mesna
    Start date: 2009-09-07

Mesna
    Start date: 2009-08-17
    End date: 2009-08-20

Emend
    Administration route: Oral
    Start date: 2009-09-07

Doxorubicin HCL
    Start date: 2009-09-07

Ondansetron
    Start date: 2009-08-17
    End date: 2009-08-20

Metoclopramide HCL
    Start date: 2009-09-07

Methylprednisolone Sodium Succinate
    Start date: 2009-09-07

Methylprednisolone Sodium Succinate
    Start date: 2009-08-17
    End date: 2009-08-22

Ifosfamide
    Start date: 2009-09-07

Doxorubicin HCL
    Indication: Teratoma
    Start date: 2009-08-17
    End date: 2009-08-18

Other drugs received by patient: Tinzaparin Sodium



Possible Emend side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2011-12-07

Patient: 65 year old female

Reactions: Drug Interaction, Muscular Weakness, Rash, Paraesthesia, Mucosal Inflammation, Neutropenia, Asthenia, Decreased Appetite

Drug(s) suspected as cause:
Emend
    Administration route: Oral
    Start date: 2011-06-09
    End date: 2011-06-09

Cyclophosphamide
    Start date: 2011-04-28
    End date: 2011-04-28

Emend
    Administration route: Oral
    Start date: 2011-06-10
    End date: 2011-06-11

Docetaxel
    Start date: 2011-04-28
    End date: 2011-04-28

Docetaxel
    Start date: 2011-05-19
    End date: 2011-05-19

Docetaxel
    Indication: Chemotherapy
    Start date: 2011-06-09
    End date: 2011-06-09

Cyclophosphamide
    Indication: Chemotherapy
    Start date: 2011-06-09
    End date: 2011-06-09

Cyclophosphamide
    Start date: 2011-05-19
    End date: 2011-05-19

Other drugs received by patient: Primperan TAB; Zofran



Possible Emend side effects in 22 year old male

Reported by a physician from France on 2011-12-06

Patient: 22 year old male

Reactions: Toxic Encephalopathy, Drug Interaction, Convulsion

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Emend
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2010-01-11
    End date: 2010-01-11

Emend
    Administration route: Oral
    Start date: 2010-01-12
    End date: 2010-01-14

Ifosfamide
    Start date: 2010-01-11
    End date: 2010-01-13

Other drugs received by patient: Doxorubicin; Mesna; Aluminum Hydroxide and Magnesium Carbonate; Ondansetron; Methylprednisolone Sodium Succinate; Clozapine; Polyethylene Glycol 4000; Metoclopramide Hydrochloride; Etoposide; Vincristine Sulfate



Possible Emend side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-25

Patient: 65 year old female

Reactions: Hepatic Neoplasm Malignant, Skin Toxicity, Drug Interaction, Neuropathy Peripheral, Tearfulness, Mucous Membrane Disorder, Decreased Appetite, Nausea, Muscular Weakness, Rash, Toxicity To Various Agents, Paraesthesia, Eye Pain, Mucosal Inflammation, Dysgeusia, Activities of Daily Living Impaired, Gait Disturbance, Neutropenia, Asthenia, Infection

Drug(s) suspected as cause:
Docetaxel
    Dosage: see image
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-06-09

Docetaxel
    Dosage: see image
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-05-19

Docetaxel
    Dosage: see image
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-04-28

Cyclophosphamide
    Dosage: see image
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-04-28

Cyclophosphamide
    Dosage: see image
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-05-19

Cyclophosphamide
    Dosage: see image
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-06-09

Emend
    Dosage: 125 mg milligram(s), unknown, oral; 80 mg milligram(s) (unknown) oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-06-09
    End date: 2011-06-09

Emend
    Dosage: 125 mg milligram(s), unknown, oral; 80 mg milligram(s) (unknown) oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-06-10
    End date: 2011-06-11

Other drugs received by patient: Primperan TAB; Ondansetron

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