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Doxil (Doxorubicin) - Pancytopenia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Pancytopenia (9)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Doxil (Doxorubicin) where reactions include pancytopenia. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Doxil side effects in 49 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-06

Patient: 49 year old female

Reactions: Neoplasm Malignant, Swelling, Pancytopenia, Rash, Neurological Symptom, Generalised Oedema

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Carboplatin
    Dosage: 1df=auc5 also auc4
    Indication: Peritoneal Carcinoma Metastatic

Cytarabine
    Indication: Peritoneal Carcinoma Metastatic

Methotrexate
    Indication: Peritoneal Carcinoma Metastatic

Mitomycin
    Dosage: inj
    Indication: Peritoneal Carcinoma Metastatic

Cyclophosphamide
    Dosage: cyclophosphamide hydrate day1 also 600mg/m2
    Indication: Peritoneal Carcinoma Metastatic

Prednisolone
    Indication: Peritoneal Carcinoma Metastatic

Doxil
    Indication: Peritoneal Carcinoma Metastatic

Irinotecan HCL
    Dosage: on day 1, 15
    Indication: Peritoneal Carcinoma Metastatic

Epirubicin Hydrochloride
    Dosage: day1
    Indication: Peritoneal Carcinoma Metastatic

Nedaplatin
    Dosage: also 60mg/m2,12mg/m2(days1-15),120mg/m2
    Indication: Peritoneal Carcinoma Metastatic

Paclitaxel
    Indication: Peritoneal Carcinoma Metastatic

Docetaxel
    Indication: Peritoneal Carcinoma Metastatic



Possible Doxil side effects in 49 year old female

Reported by a consumer/non-health professional from Japan on 2012-06-25

Patient: 49 year old female

Reactions: Neoplasm Malignant, Swelling, Pancytopenia, Rash, Neurological Symptom, Generalised Oedema

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Mitomycin
    Dosage: inj
    Indication: Peritoneal Carcinoma Metastatic

Nedaplatin
    Dosage: also 60mg/m2,12mg/m2(days1-15),120mg/m2
    Indication: Peritoneal Carcinoma Metastatic

Irinotecan HCL
    Dosage: on day 1, 15
    Indication: Peritoneal Carcinoma Metastatic

Cytarabine
    Indication: Peritoneal Carcinoma Metastatic

Doxil
    Indication: Peritoneal Carcinoma Metastatic

Epirubicin Hydrochloride
    Dosage: day1
    Indication: Peritoneal Carcinoma Metastatic

Docetaxel
    Indication: Peritoneal Carcinoma Metastatic

Methotrexate
    Indication: Peritoneal Carcinoma Metastatic

Prednisolone
    Indication: Peritoneal Carcinoma Metastatic

Carboplatin
    Dosage: 1df=auc5 also auc4
    Indication: Peritoneal Carcinoma Metastatic

Paclitaxel
    Indication: Peritoneal Carcinoma Metastatic

Cyclophosphamide
    Dosage: cyclophosphamide hydrate day1 also 600mg/m2
    Indication: Peritoneal Carcinoma Metastatic



Possible Doxil side effects in 85 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-30

Patient: 85 year old male, weighing 82.1 kg (180.6 pounds)

Reactions: Diabetes Mellitus, Oral Candidiasis, Interstitial Lung Disease, Acute Respiratory Distress Syndrome, Blood Creatinine Increased, Blood Urea Increased, Vomiting, Blood Chloride Decreased, Aortic Calcification, Atrial Fibrillation, Pancytopenia, Hyponatraemia, Mitral Valve Calcification, Brain Natriuretic Peptide Increased, Pernicious Anaemia, Dehydration, Mitral Valve Incompetence, Hypothyroidism, Asthenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Revlimid
    Dosage: 10 mg/daily/po
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2011-01-31
    End date: 2011-02-13

Decadron
    Dosage: 40 mg/wky/
    Indication: Multiple Myeloma
    Start date: 2011-01-31
    End date: 2011-02-10

Doxil
    Dosage: 8 mg
    Indication: Multiple Myeloma
    Start date: 2011-01-31
    End date: 2011-02-10

Velcade
    Dosage: 2 mg
    Indication: Multiple Myeloma
    Start date: 2011-01-31
    End date: 2011-02-13

Other drugs received by patient: Procrit; Aspirin; Neurontin; Zometa; Ciprofloxacin; Thioctic Acid; Synthroid; Dflucan; Calcium (Unspecified); Levoxyl; Acyclovir



Possible Doxil side effects in 44 year old female

Reported by a physician from United States on 2012-04-13

Patient: 44 year old female, weighing 119.5 kg (262.9 pounds)

Reactions: White Blood Cell Count Decreased, Type 2 Diabetes Mellitus, Diabetes Mellitus, Lymphatic Disorder, Hyperglycaemia, Anaemia, Pancytopenia, Febrile Neutropenia, Cardiac Disorder, Diarrhoea, Blood Disorder, Platelet Count Decreased, Hypertension, Gastrooesophageal Reflux Disease

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Pegfilgrastim
    Indication: Product Used FOR Unknown Indication

Cyclophosphamide
    Indication: Breast Cancer
    Start date: 2011-03-24

Doxil
    Indication: Breast Cancer
    Start date: 2011-03-24

Bevacizumab
    Indication: Breast Cancer
    Start date: 2011-03-24

Paclitaxel
    Indication: Breast Cancer
    Start date: 2011-03-24

Other drugs received by patient: Tylenol (Caplet); Prochlorperazine; Toprol-XL; Cefepime; Mucinex; Diflucan; Bacitracin; Ambien; Pepcid; Tessalon



Possible Doxil side effects in female

Reported by a pharmacist from Japan on 2012-04-10

Patient: female, weighing 57.0 kg (125.4 pounds)

Reactions: Hepatic Function Abnormal, Restlessness, Disseminated Intravascular Coagulation, Pancytopenia, Pyrexia, Fatigue, Malaise, Cardiac Failure, Interstitial Lung Disease, Dehydration, Bone Marrow Failure, Blood Pressure Decreased, Decreased Appetite, Anuria, Deep Vein Thrombosis

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Doxil
    Start date: 2010-11-24
    End date: 2010-11-24

Doxil
    Start date: 2010-11-24
    End date: 2010-11-24

Doxil
    Indication: Malignant Peritoneal Neoplasm
    Start date: 2010-12-22
    End date: 2010-12-22

Doxil
    Indication: Ovarian Cancer Recurrent
    Start date: 2010-12-22
    End date: 2010-12-22

Cisplatin W / Docetaxel
    Indication: Malignant Peritoneal Neoplasm

Cyclophosphamide
    Indication: Malignant Peritoneal Neoplasm

Zosyn
    Indication: Interstitial Lung Disease
    Start date: 2011-01-14
    End date: 2011-02-06

Minocycline Hydrochloride
    Indication: Infection
    Start date: 2011-01-29
    End date: 2011-01-31

Minocycline Hydrochloride
    Indication: Pyrexia
    Start date: 2011-01-29
    End date: 2011-01-31

Taxotere
    Indication: Malignant Peritoneal Neoplasm

Other drugs received by patient: Methycobal; Futhan; Recomodulin; Norvasc; Elaspol; Pentamidine Isethionate; Gosha-Jinki-GAN; Bactrim; Solu-Medrol; Zithromax; Predopa; Dalteparin Sodium; Reminaron; Bactrim; Solu-Medrol; Solu-Medrol; Mucosta; DAI-Kenchu-TO; Futhan; Dalteparin Sodium; Prodif; Humulin R; Magnesium Oxide; Midazolam HCL; Midazolam HCL; Vancomycin Hydrochloride; Pentamidine Isethionate; Predopa; Vancomycin Hydrochloride; Dalteparin Sodium; Prednisolone; Concentrated Human Blood Platelets



Possible Doxil side effects in female

Reported by a physician from United States on 2012-03-23

Patient: female

Reactions: Neuropathy Peripheral, Pancytopenia

Drug(s) suspected as cause:
Revlimid
    Dosage: 5 mg, 1 in 1 d, po
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2010-07-19
    End date: 2011-03-01

Doxil
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Fexofenadine (Fexofenadine) (Tablets); Simvastatin; Valacyclovir Hydrochloride; Seroquel; Protonix; Aspirin; Lyrica; Celebrex; Potassium Chloride; Valtrex (Valaciclovir Hydrochloride) (Tablets); Mobic



Possible Doxil side effects in female

Reported by a pharmacist from United States on 2012-01-18

Patient: female, weighing 64.4 kg (141.7 pounds)

Reactions: Asthma, Weight Decreased, Abdominal Pain, Metastases To Liver, Fungal Sepsis, Pyrexia, Chronic Obstructive Pulmonary Disease, Iron Deficiency Anaemia, Poisoning, Immunosuppression, Hydronephrosis, Hiatus Hernia, Fistula, Anaemia, Hyperglycaemia, Malnutrition, Pancytopenia, Left Ventricular Hypertrophy, Intestinal Obstruction, Malignant Neoplasm of Uterine Adnexa, Hepatic Steatosis, Cholelithiasis, Hepatic Cyst, Dehydration, Abscess, Metastases To Kidney, Neutropenia, Scar, Confusional State, Jaundice, Bone Pain, Pain, Chills, Mental Status Changes, Short-Bowel Syndrome, Constipation, Fall, Laryngitis, Hypokalaemia, Pancreatic Duct Dilatation, Fatigue, Postoperative Wound Infection, Chest Pain, Hydroureter, Pleural Effusion, Dizziness, Oedema, Electrolyte Imbalance, Depression, Decreased Appetite, Abdominal Pain Lower, Vomiting, Dyspnoea, Nausea, Urinary Tract Infection, Post Gastric Surgery Syndrome, Muscular Weakness, Anxiety, Intestinal Haemorrhage, Diarrhoea, Arthralgia, Spinal Osteoarthritis, Hypertension, Ovarian Cancer

Adverse event resulted in: death

Drug(s) suspected as cause:
Estraderm
    Dosage: unk
    Indication: Hormone Replacement Therapy
    Start date: 1985-01-01
    End date: 2003-01-01

Taxol

Carboplatin

Compazine

Topotecan

Estradiol
    Dosage: unk
    Indication: Hormone Replacement Therapy
    Start date: 1985-01-01
    End date: 2003-01-01

Doxil

Neulasta
    Dosage: unk

Other drugs received by patient: Nitrofurantoin; Methylprednisolon ^jenapharm^; Ibuprofen; Metronidazol ^alpharma^; Metrogel; Cephalexin; Roxicet; Alprazolam; Dexamethasone TAB; Zithromax; Sertraline Hydrochloride; Monopril; Adipex; Robinul Forte; Enalapril Maleate; Ambien; Biaxin; Naproxen Sodium; Tamoxifen Citrate; Cefadroxil; Promethazine; Ciprofloxacin; Cyclobenzaprine; Premarin; Cleocin Hydrochloride; Dicyclomine; Temazepam; Chemotherapeutics NOS; Morphine; Fluconazole; Miralax



Possible Doxil side effects in female

Reported by a physician from United States on 2012-01-09

Patient: female, weighing 64.4 kg (141.7 pounds)

Reactions: Asthma, Abdominal Pain, Metastases To Liver, Fungal Sepsis, Pyrexia, Chronic Obstructive Pulmonary Disease, Iron Deficiency Anaemia, Poisoning, Immunosuppression, Fistula, Hiatus Hernia, Hydronephrosis, Hyperglycaemia, Anaemia, Malnutrition, Pancytopenia, Left Ventricular Hypertrophy, Malignant Neoplasm of Uterine Adnexa, Intestinal Obstruction, Hepatic Steatosis, Cholelithiasis, Hepatic Cyst, Dehydration, Neutropenia, Abscess, Metastases To Kidney, Scar, Confusional State, Pain, Chills, Bone Pain, Mental Status Changes, Short-Bowel Syndrome, Constipation, Fall, Hypokalaemia, Laryngitis, Pancreatic Duct Dilatation, Postoperative Wound Infection, Fatigue, Chest Pain, Hydroureter, Dizziness, Pleural Effusion, Oedema, Depression, Electrolyte Imbalance, Decreased Appetite, Abdominal Pain Lower, Vomiting, Dyspnoea, Nausea, Urinary Tract Infection, Post Gastric Surgery Syndrome, Muscular Weakness, Intestinal Haemorrhage, Anxiety, Arthralgia, Diarrhoea, Spinal Osteoarthritis, Hypertension, Ovarian Cancer

Adverse event resulted in: death

Drug(s) suspected as cause:
Carboplatin

Estradiol
    Dosage: unk
    Indication: Hormone Replacement Therapy
    Start date: 1985-01-01
    End date: 2003-01-01

Neulasta
    Dosage: unk

Doxil

Topotecan

Estraderm
    Dosage: unk
    Indication: Hormone Replacement Therapy
    Start date: 1985-01-01
    End date: 2003-01-01

Compazine

Taxol

Other drugs received by patient: Robinul Forte; Ciprofloxacin; Zithromax; Enalapril Maleate; Metrogel; Methylprednisolon ^jenapharm^; Adipex; Alprazolam; Ibuprofen; Biaxin; Temazepam; Nitrofurantoin; Dexamethasone; Tamoxifen Citrate; Premarin; Cephalexin; Cleocin Hydrochloride; Monopril; Dicyclomine; Ambien; Fluconazole; Sertraline Hydrochloride; Cefadroxil; Chemotherapeutics NOS; Roxicet; Morphine; Metronidazol ^alpharma^; Naproxen Sodium; Cyclobenzaprine; Promethazine; Miralax



Possible Doxil side effects in female

Reported by a pharmacist from United States on 2011-11-28

Patient: female, weighing 64.4 kg (141.7 pounds)

Reactions: Asthma, Fungal Sepsis, Pyrexia, Chronic Obstructive Pulmonary Disease, Iron Deficiency Anaemia, Poisoning, Immunosuppression, Hiatus Hernia, Fistula, Hydronephrosis, Anaemia, Hyperglycaemia, Malnutrition, Left Ventricular Hypertrophy, Pancytopenia, Intestinal Obstruction, Malignant Neoplasm of Uterine Adnexa, Hepatic Steatosis, Cholelithiasis, Hepatic Cyst, Dehydration, Abscess, Neutropenia, Scar, Pain, Bone Pain, Chills, Mental Status Changes, Short-Bowel Syndrome, Constipation, Pancreatic Duct Dilatation, Hypokalaemia, Laryngitis, Postoperative Wound Infection, Fatigue, Hydroureter, Chest Pain, Oedema, Pleural Effusion, Dizziness, Depression, Electrolyte Imbalance, Decreased Appetite, Abdominal Pain Lower, Vomiting, Nausea, Urinary Tract Infection, Muscular Weakness, Intestinal Haemorrhage, Anxiety, Diarrhoea, Spinal Osteoarthritis, Hypertension, Ovarian Cancer

Adverse event resulted in: death

Drug(s) suspected as cause:
Doxil

Topotecan

Estraderm
    Dosage: unk
    Indication: Hormone Replacement Therapy
    Start date: 1985-01-01
    End date: 2003-01-01

Estradiol
    Dosage: unk
    Indication: Hormone Replacement Therapy
    Start date: 1985-01-01
    End date: 2003-01-01

Compazine

Taxol

Carboplatin

Neulasta
    Dosage: unk

Other drugs received by patient: Promethazine; Nitrofurantoin; Methylprednisolon ^jenapharm^; Cefadroxil; Adipex; Enalapril Maleate; Monopril; Robinul Forte; Alprazolam; Zithromax; Dicyclomine; Dexamethasone; Tamoxifen Citrate; Biaxin; Miralax; Morphine; Ciprofloxacin; Metronidazol ^alpharma^; Sertraline Hydrochloride; Cleocin Hydrochloride; Naproxen Sodium; Ambien; Fluconazole; Cyclobenzaprine; Premarin; Cephalexin; Temazepam; Ibuprofen; Metrogel; Roxicet; Chemotherapeutics NOS

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