This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Disulfiram and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (28)
Death (11)
Life Threatening Events (2)
Reports by Reaction Type
Completed Suicide (9),
Respiratory Arrest (7),
Cardiac Arrest (7),
Toxicity To Various Agents (4),
Jaundice (3),
Drug Interaction (3),
Poisoning (3),
Flushing (3),
Alcohol Interaction (3),
Infection (2),
Intentional Overdose (2),
Tachycardia (2)
Possible Disulfiram side effects in 36 year old male
Reported by a physician from United States on 2012-08-01
Patient: 36 year old male
Reactions: Hyperammonaemic Encephalopathy, Drug Interaction, Arrhythmia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Lithium Carbonate
Dosage: 450 mg;qd
Indication: Product Used FOR Unknown Indication
Topiramate
Dosage: 300 mg;qd
Indication: Product Used FOR Unknown Indication
Divalproex Sodium
Dosage: 1000 mg
Indication: Product Used FOR Unknown Indication
Clonazepam
Dosage: 3 mg;qd
Indication: Product Used FOR Unknown Indication
Clozapine
Dosage: 300 mg;qd
Indication: Product Used FOR Unknown Indication
Risperidone
Dosage: 3 mg;qd
Indication: Product Used FOR Unknown Indication
Disulfiram
Dosage: 250 mg;qd
Indication: Product Used FOR Unknown Indication
Possible Disulfiram side effects in
Reported by a individual with unspecified qualification from Montenegro on 2012-07-31
Patient:
Reactions: Acute Polyneuropathy
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Disulfiram
Possible Disulfiram side effects in female
Reported by a health professional (non-physician/pharmacist) from Denmark on 2012-05-09
Patient: female
Reactions: Jaundice, Asterixis, Hepatic Failure, Encephalopathy, Hepatitis Toxic, Liver Disorder
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Progesterone
Administration route: Oral
Indication: Hormone Replacement Therapy
Escitalopram
Indication: Major Depression
Disulfiram
Indication: Alcoholism
Start date: 2011-05-01
End date: 2011-06-01
Other drugs received by patient: Levothyroxine Sodium; Milnacipran; Oxazepam; Estradiol
Possible Disulfiram side effects in female
Reported by a health professional (non-physician/pharmacist) from France on 2012-05-09
Patient: female
Reactions: Jaundice, Asterixis, Encephalopathy, Hepatic Failure, Hepatitis Toxic, Liver Disorder
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Progesterone
Administration route: Oral
Indication: Hormone Replacement Therapy
Escitalopram
Indication: Major Depression
Disulfiram
Indication: Alcoholism
Start date: 2011-05-01
End date: 2011-06-01
Other drugs received by patient: Oxazepam; Levothyroxine Sodium; Estradiol; Milnacipran
Possible Disulfiram side effects in 29 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-04-09
Patient: 29 year old female
Reactions: Agranulocytosis, Viral Upper Respiratory Tract Infection, Asthenia, Infection
Drug(s) suspected as cause:
Disulfiram
Dosage: 500 mg;po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2011-10-20
End date: 2011-11-22
Escitalopram
Dosage: po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2011-06-01
End date: 2011-11-22
Estradiol Valerate / Dienogest
Dosage: 1 df;qd;po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2011-05-01
End date: 2011-11-20
Celestamine TAB
Dosage: 1 df;qd;po
Administration route: Oral
Indication: Rhinitis
Start date: 2011-11-14
End date: 2011-11-16
Other drugs received by patient: Desloratadine; Augmentin '125'
Possible Disulfiram side effects in
Reported by a individual with unspecified qualification from Belgium on 2012-04-06
Patient:
Reactions: Weight Decreased, Posterior Reversible Encephalopathy Syndrome, Abnormal Behaviour, Toxicity To Various Agents, Radiculopathy
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Disulfiram
Other drugs received by patient: Thiamine HCL
Possible Disulfiram side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-06
Patient:
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Disulfiram
Possible Disulfiram side effects in 40 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-02
Patient: 40 year old female
Reactions: Completed Suicide, Respiratory Arrest, Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Bupropion HCL
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Hydroxyzine
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Disulfiram
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Lorazepam
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Sumatriptan Succinate
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Disulfiram side effects in
Reported by a individual with unspecified qualification from France on 2012-03-22
Patient:
Reactions: Toxic Optic Neuropathy
Drug(s) suspected as cause:
Disulfiram
Possible Disulfiram side effects in
Reported by a individual with unspecified qualification from France on 2012-03-13
Patient:
Reactions: Toxic Optic Neuropathy
Drug(s) suspected as cause:
Disulfiram
Possible Disulfiram side effects in 36 year old female
Reported by a individual with unspecified qualification from United States on 2012-02-27
Patient: 36 year old female, weighing 84.2 kg (185.2 pounds)
Reactions: Abdominal Pain, Jaundice, Vomiting, Nausea, Amphetamines Positive, Headache, Pyrexia, Malaise, Arthralgia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Disulfiram
Other drugs received by patient: OXY-Elite; Acetaminophen; Flonase; Hydoxycut
Possible Disulfiram side effects in 44 year old male
Reported by a consumer/non-health professional from United States on 2012-01-25
Patient: 44 year old male, weighing 131.5 kg (289.4 pounds)
Reactions: Flushing, Food Interaction, Confusional State, Dyspnoea, Nausea, Pain of Skin, Coordination Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Disulfiram
Possible Disulfiram side effects in
Reported by a physician from United States on 2012-01-23
Patient:
Reactions: Flushing, Intentional Overdose, Hypotension, Tachycardia, Drug Interaction, Alcohol Interaction
Drug(s) suspected as cause:
Disulfiram
Other drugs received by patient possibly interacting with the suspect drug: Ethanol
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Disulfiram side effects in
Reported by a physician from United States on 2012-01-20
Patient:
Reactions: Flushing, LIP Swelling, Intentional Overdose, Tachycardia, Hypotension, Suicide Attempt, Drug Interaction, Alcohol Interaction
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Disulfiram
Other drugs received by patient possibly interacting with the suspect drug: Ethanol
Dosage: unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Disulfiram side effects in 40 year old female
Reported by a physician from United States on 2012-01-17
Patient: 40 year old female
Reactions: Completed Suicide, Respiratory Arrest, Intentional Drug Misuse, Toxicity To Various Agents, Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Sumatriptan Succinate
Dosage: unknown
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Bupropion HCL
Dosage: unknown
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Hydroxyzine
Dosage: unknown
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Disulfiram
Dosage: unknown
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Lorazepam
Dosage: unknown
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Possible Disulfiram side effects in 40 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-17
Patient: 40 year old female
Reactions: Cardio-Respiratory Arrest, Completed Suicide
Adverse event resulted in: death
Drug(s) suspected as cause:
Disulfiram
Dosage: oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Hydroxyzine
Dosage: oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Bupropion Hydrochloride
Dosage: oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Sumatriptan Succinate
Dosage: oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Lorazepam
Dosage: oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Disulfiram side effects in 40 year old female
Reported by a physician from United States on 2012-01-12
Patient: 40 year old female
Reactions: Completed Suicide, Poisoning, Respiratory Arrest, Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Bupropion Hydrochloride
Dosage: (df oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Disulfiram
Dosage: (df oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Sumatriptan
Dosage: (df oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Hydroxyzine
Dosage: (df oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Lorazepam
Dosage: (df oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Disulfiram side effects in 40 year old female
Reported by a physician from United States on 2012-01-12
Patient: 40 year old female
Reactions: Poisoning, Completed Suicide, Respiratory Arrest, Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Sumatriptan
Dosage: df oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Bupropion Hydrochloride
Dosage: df oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Hydroxyzine
Dosage: df oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Lorazepam
Dosage: df oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Disulfiram
Dosage: df oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Disulfiram side effects in 40 year old female
Reported by a physician from United States on 2012-01-12
Patient: 40 year old female
Reactions: Poisoning, Completed Suicide, Respiratory Arrest, Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Sumatriptan
Dosage: (df oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Hydroxyzine
Dosage: (df oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Bupropion Hydrochloride
Dosage: (df oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Disulfiram
Dosage: (df oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Lorazepam
Dosage: (df oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Disulfiram side effects in 29 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-01-05
Patient: 29 year old female
Reactions: Agranulocytosis, Sinus Headache, Rhinitis, Headache, Asthenia, Cough, Infection
Drug(s) suspected as cause:
Escitalopram
Dosage: po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2011-06-01
End date: 2011-11-22
Celestamine TAB
Dosage: 1 df;qd;po
Administration route: Oral
Indication: Rhinitis
Start date: 2011-11-14
End date: 2011-11-16
Disulfiram
Dosage: 500 mg;po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2011-10-20
End date: 2011-11-22
Estradiol Valerate / Dienogest
Dosage: 1 df;qd;po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2011-05-01
End date: 2011-11-20
Other drugs received by patient: Desloratadine; Augmentin '125'
Possible Disulfiram side effects in 40 year old female
Reported by a physician from United States on 2012-01-05
Patient: 40 year old female
Reactions: Completed Suicide, Respiratory Arrest, Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Sumatriptan Succinate
Bupropion Hydrochloride
Disulfiram
Hydroxyzine
Lorazepam
Possible Disulfiram side effects in 40 year old female
Reported by a physician from United States on 2011-12-29
Patient: 40 year old female
Reactions: Completed Suicide, Respiratory Arrest, Toxicity To Various Agents, Intentional Drug Misuse, Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Lorazepam
Sumatriptan Succinate
Bupropion HCL
Disulfiram
Hydroxyzine
Possible Disulfiram side effects in 40 year old female
Reported by a physician from United States on 2011-12-26
Patient: 40 year old female
Reactions: Death, Cardio-Respiratory Arrest, Completed Suicide
Adverse event resulted in: death
Drug(s) suspected as cause:
Buproprion HCL
Dosage: unk, unknown
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Disulfiram
Dosage: unk, unknown
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Lorazepam
Dosage: unk, unknown
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Hydroxyzine
Dosage: unk, unknown
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Sumatriptan
Dosage: unk, unknown
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Disulfiram side effects in
Reported by a physician from Italy on 2011-12-22
Patient:
Reactions: Hepatotoxicity
Drug(s) suspected as cause:
Disulfiram
Possible Disulfiram side effects in
Reported by a individual with unspecified qualification from Italy on 2011-12-08
Patient:
Reactions: Hepatotoxicity
Drug(s) suspected as cause:
Disulfiram
Possible Disulfiram side effects in
Reported by a individual with unspecified qualification from United States on 2011-12-02
Patient:
Reactions: Alcohol Interaction, Ketoacidosis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Alcohol
Dosage: 2 l of vodka on the day of adveres reaction, unknown
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Disulfiram
Dosage: unk, unknown
Indication: Alcoholism
Other drugs received by patient: Naltrexone Hydrochloride
Possible Disulfiram side effects in 39 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-20
Patient: 39 year old male
Reactions: Renal Failure, Acute Hepatic Failure, Intracranial Pressure Increased, Adverse Reaction
Adverse event resulted in: death
Drug(s) suspected as cause:
Acetaminophen
Dosage: unk, unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Disulfiram
Dosage: unk, unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Disulfiram side effects in
Reported by a individual with unspecified qualification from Belgium on 2011-10-19
Patient:
Reactions: Posterior Reversible Encephalopathy Syndrome, Toxicity To Various Agents, Radiculopathy
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Disulfiram
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