This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Diprivan (Propofol) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (217)
Death (30)
Life Threatening Events (119)
Disability (3)
Reports by Reaction Type
Anaphylactic Shock (73),
Bronchospasm (19),
Erythema (17),
Cardiac Arrest (14),
Hypotension (13),
Circulatory Collapse (12),
Bradycardia (12),
Shock (12),
Blood Pressure Decreased (11),
Tachycardia (10),
Cardio-Respiratory Arrest (10),
Cytolytic Hepatitis (10)
Below are a few examples of reports where side effects / adverse reactions may be related to Diprivan (Propofol). For a complete list or a specific selection of reports, please use the links above.
Possible Diprivan side effects in 45 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-27
Patient: 45 year old male
Reactions: Hypotension, Urticaria, Anaphylactic Reaction, Skin Test Negative, Oxygen Saturation Decreased
Drug(s) suspected as cause:
Augmentin '500'
Dosage: single
Indication: Tooth Extraction
Start date: 2011-11-15
End date: 2011-11-15
Diprivan
Dosage: single
Indication: General Anaesthesia
Start date: 2011-11-15
End date: 2011-11-15
Solu-Medrol
Dosage: single
Indication: Tooth Extraction
Start date: 2011-11-15
End date: 2011-11-15
Sufentanil Citrate
Dosage: single
Indication: General Anaesthesia
Start date: 2011-11-15
End date: 2011-11-15
Other drugs received by patient: Pantoprazole Sodium; Sevoflurane; Symbicort
Possible Diprivan side effects in
Reported by a individual with unspecified qualification from France on 2012-08-23
Patient:
Reactions: Cardio-Respiratory Arrest, Anaphylactic Shock, Circulatory Collapse
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Dosage: 200 mg, once
Indication: General Anaesthesia
Start date: 2012-03-20
End date: 2012-03-20
Rocuronium Bromide
Dosage: 40 mg, once
Indication: General Anaesthesia
Start date: 2012-03-20
End date: 2012-03-20
Ultiva
Dosage: 50 ?g, once
Indication: General Anaesthesia
Start date: 2012-03-20
End date: 2012-03-20
Possible Diprivan side effects in 37 year old female
Reported by a physician from Japan on 2012-08-21
Patient: 37 year old female
Reactions: Acidosis, Respiratory Depression, Delayed Recovery From Anaesthesia, Convulsion, Respiration Abnormal
Drug(s) suspected as cause:
Buprenorphine HCL
Dosage: unit dose unknown
Indication: Analgesic Therapy
Start date: 2012-06-28
End date: 2012-06-28
Diprivan
Dosage: unit dose unknown
Indication: Sedation
Start date: 2012-06-28
End date: 2012-06-28
Ultiva
Dosage: unit dose unknown
Indication: Analgesic Therapy
Start date: 2012-06-28
End date: 2012-06-28
Other drugs received by patient: Zonisamide; Phenytoin
Possible Diprivan side effects in male
Reported by a physician from France on 2012-08-20
Patient: male
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Augmentin '500'
Start date: 2012-07-02
End date: 2012-07-02
Diprivan
Indication: General Anaesthesia
Start date: 2012-07-02
End date: 2012-07-02
Sevoflurane
Indication: General Anaesthesia
Start date: 2012-07-02
End date: 2012-07-02
Sufentanyl Mylan
Indication: General Anaesthesia
Start date: 2012-07-02
End date: 2012-07-02
Tracrium
Indication: General Anaesthesia
Start date: 2012-07-02
End date: 2012-07-02
Possible Diprivan side effects in 37 year old female
Reported by a physician from Japan on 2012-08-17
Patient: 37 year old female
Reactions: Respiratory Depression, Acidosis, Delayed Recovery From Anaesthesia, Convulsion, Respiration Abnormal
Drug(s) suspected as cause:
Buprenorphine HCL
Dosage: unit dose unknown
Indication: Analgesic Therapy
Start date: 2012-06-28
End date: 2012-06-28
Diprivan
Dosage: unit dose unknown
Indication: Sedation
Start date: 2012-06-28
End date: 2012-06-28
Ultiva
Dosage: unit dose unknown
Indication: Analgesic Therapy
Start date: 2012-06-28
End date: 2012-06-28
Other drugs received by patient: Phenytoin; Zonisamide
Possible Diprivan side effects in female
Reported by a physician from France on 2012-08-16
Patient: female
Reactions: Tachycardia, Circulatory Collapse, Erythema
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Celocurine
Dosage: once/single administration
Indication: Induction of Anaesthesia
Start date: 2012-03-27
End date: 2012-03-27
Diprivan
Dosage: once/single administration
Indication: Induction of Anaesthesia
Start date: 2012-03-27
End date: 2012-03-27
Midazolam HCL
Dosage: once/single administration
Start date: 2012-03-27
End date: 2012-03-27
Sufentanil Citrate
Indication: Induction of Anaesthesia
Start date: 2012-03-27
End date: 2012-03-27
Other drugs received by patient: Levothyroxine Sodium; Atarax; Lexomil
Possible Diprivan side effects in 38 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-14
Patient: 38 year old female
Reactions: Ventricular Extrasystoles, Supraventricular Extrasystoles, Bradycardia
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Indication: Induction of Anaesthesia
Diprivan
Indication: General Anaesthesia
Other drugs received by patient: Fentanyl; Remifentanil Hydrochloride; Fentanyl; Rocuronium Bromide; Sevoflurane
Possible Diprivan side effects in 58 year old female
Reported by a physician from Japan on 2012-08-14
Patient: 58 year old female, weighing 51.0 kg (112.2 pounds)
Reactions: Ventricular Fibrillation
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Indication: Induction of Anaesthesia
Ropivacaine Hydrochloride
Indication: Epidural Anaesthesia
Other drugs received by patient: Fentanyl; Rocuronium Bromide
Possible Diprivan side effects in 30 year old female
Reported by a health professional (non-physician/pharmacist) from Netherlands on 2012-08-14
Patient: 30 year old female
Reactions: Lactic Acidosis
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Other drugs received by patient: Erythromycin; Albuterol; Aminophyllin; Ofloxacin; Methylprednisolone
Possible Diprivan side effects in male
Reported by a physician from France on 2012-08-14
Patient: male
Reactions: Electrocardiogram QRS Complex Prolonged, Anaphylactoid Reaction, Tachycardia, Bradycardia, Hypokalaemia
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Indication: General Anaesthesia
Start date: 2012-04-06
End date: 2012-04-06
Nimbex
Indication: General Anaesthesia
Start date: 2012-04-06
End date: 2012-04-06
Sufentanil Citrate
Indication: General Anaesthesia
Start date: 2012-04-06
End date: 2012-04-06
Other drugs received by patient: Midazolam HCL
Possible Diprivan side effects in male
Reported by a physician from France on 2012-08-13
Patient: male
Reactions: Electrocardiogram QRS Complex Prolonged, Tachycardia, Anaphylactoid Reaction, Bradycardia, Hypokalaemia
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Indication: General Anaesthesia
Start date: 2012-04-06
End date: 2012-04-06
Nimbex
Indication: General Anaesthesia
Start date: 2012-04-06
End date: 2012-04-06
Sufentanil Citrate
Indication: General Anaesthesia
Start date: 2012-04-06
End date: 2012-04-06
Other drugs received by patient: Midazolam HCL
Possible Diprivan side effects in 70 year old male
Reported by a physician from France on 2012-08-13
Patient: 70 year old male
Reactions: Blood Alkaline Phosphatase Increased, Gamma-Glutamyltransferase Increased, Hepatotoxicity, Haemoptysis, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Diprivan
Dosage: once/single administration
Start date: 2012-07-02
End date: 2012-07-02
Diprivan
Start date: 2012-06-29
End date: 2012-06-29
Diprivan
Indication: Anaesthesia
Start date: 2012-06-22
End date: 2012-06-22
Other drugs received by patient: Ranitidine; Xylocaine; Celocurine; Ultiva; Celocurine; Sufentanil Citrate
Possible Diprivan side effects in female
Reported by a pharmacist from Brazil on 2012-08-10
Patient: female, weighing 61.0 kg (134.2 pounds)
Reactions: Cardio-Respiratory Arrest, Drug Interaction, Bradycardia
Adverse event resulted in: death, life threatening event, disablity
Drug(s) suspected as cause:
Diprivan
Other drugs received by patient possibly interacting with the suspect drug:
Dexmedetomodine Hydrochloride
Dosage: 100mcg/ml, 63.4 mcg via continuous infusion
Indication: Sedative Therapy
Start date: 2012-06-26
End date: 2012-06-26
Other drugs received by patient: Omeprazole; Losartan Potassium; Sufentanil Citrate; Metronidazole; Dipyrone INJ; NPH Insulin; Digoxin; Lidocaine; Ciprofloxacin; Enoxaparin
Possible Diprivan side effects in 60 year old female
Reported by a physician from Japan on 2012-08-09
Patient: 60 year old female, weighing 47.0 kg (103.4 pounds)
Reactions: Posterior Reversible Encephalopathy Syndrome
Drug(s) suspected as cause:
Diprivan
Indication: Induction of Anaesthesia
Fentanyl
Indication: General Anaesthesia
Fentanyl
Dosage: dose unknown
Ketamine HCL
Indication: General Anaesthesia
Ketamine HCL
Remifentanil Hydrochloride
Dosage: dose unknown
Sevoflurane
Dosage: dose unknown
Other drugs received by patient: Rocuronium Bromide
Possible Diprivan side effects in 70 year old male
Reported by a physician from Japan on 2012-08-09
Patient: 70 year old male
Reactions: Interstitial Lung Disease
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Ciprofloxacin HCL
Dosage: dose unknown
Diprivan
Dosage: 1%
Other drugs received by patient: Pancuronium Bromide; Adsorbed Tetanus Toxoid; Penicillin G; Midazolam
Possible Diprivan side effects in male
Reported by a physician from China on 2012-08-06
Patient: male, weighing 48.0 kg (105.6 pounds)
Reactions: Pruritus, Sleep Disorder DUE To General Medical Condition, Insomnia Type, Rash Papular
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Diprivan
Possible Diprivan side effects in male
Reported by a physician from China on 2012-08-06
Patient: male, weighing 55.0 kg (121.0 pounds)
Reactions: Drug Eruption, Tongue Oedema
Drug(s) suspected as cause:
Diprivan
Possible Diprivan side effects in female
Reported by a physician from France on 2012-08-06
Patient: female
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Augmentin '500'
Start date: 2011-11-24
Diprivan
Dosage: one single administration
Indication: Induction of Anaesthesia
Start date: 2011-11-24
Ketamine HCL
Dosage: one single administration
Indication: Induction of Anaesthesia
Start date: 2011-11-24
Nimbex
Dosage: one single administration
Indication: Induction of Anaesthesia
Start date: 2011-11-24
Sufentanil Citrate
Dosage: one single administration
Indication: Induction of Anaesthesia
Start date: 2011-11-24
Other drugs received by patient: Anti-Histamic Drugs
Possible Diprivan side effects in 37 year old female
Reported by a physician from Japan on 2012-08-03
Patient: 37 year old female
Reactions: Respiratory Depression, Acidosis, Delayed Recovery From Anaesthesia, Convulsion, Respiration Abnormal
Drug(s) suspected as cause:
Buprenorphine HCL
Dosage: unit dose unknown
Indication: Analgesic Therapy
Start date: 2012-06-28
End date: 2012-06-28
Diprivan
Dosage: unit dose unknown
Indication: Sedation
Start date: 2012-06-28
End date: 2012-06-28
Ultiva
Dosage: unit dose unknown
Indication: Analgesic Therapy
Start date: 2012-06-28
End date: 2012-06-28
Possible Diprivan side effects in 80 year old male
Reported by a physician from Japan on 2012-08-03
Patient: 80 year old male
Reactions: Atelectasis, Pneumonia, Interstitial Lung Disease, Pleural Effusion
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Diprivan
Other drugs received by patient: Midazolam; Adsorbed Tetanus Toxoid; Penicillin G; Pancuronium Bromide
Possible Diprivan side effects in male
Reported by a physician from France on 2012-08-03
Patient: male, weighing 92.0 kg (202.4 pounds)
Reactions: Arrhythmia Supraventricular, Hypokalaemia, Multi-Organ Failure, Cardio-Respiratory Arrest, Respiratory Failure, Ventricular Tachycardia, Bronchospasm, Ventricular Fibrillation, Bradycardia
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Celocurine
Indication: Endoscopy
Start date: 2012-05-30
End date: 2012-05-30
Diprivan
Indication: Endoscopy
Start date: 2012-05-30
End date: 2012-05-30
Other drugs received by patient: Zofran; Remifentanyl; Acetaminophen; Lansoprazole; Duragesic-100
Possible Diprivan side effects in
Reported by a individual with unspecified qualification from France on 2012-08-02
Patient:
Reactions: Hypotension, Hypercapnia, Anaphylactic Shock, Hyperhidrosis, Cardio-Respiratory Arrest, Respiratory Acidosis, Cyanosis, Bronchospasm, Bradycardia, Myocardial Infarction, Hypovolaemia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Atarax
Dosage: 50 mg, once
Administration route: Oral
Indication: Anaesthetic Premedication
Start date: 2010-06-17
End date: 2010-06-17
Diprivan
Dosage: 100 mg, once
Start date: 2010-06-17
End date: 2010-06-17
Diprivan
Dosage: 200 mg, once
Indication: General Anaesthesia
Start date: 2010-06-17
End date: 2010-06-17
Diprivan
Dosage: 100 mg, once
Start date: 2010-06-17
End date: 2010-06-17
Lyrica
Dosage: 150 mg, once
Administration route: Oral
Indication: Anaesthetic Premedication
Start date: 2010-06-17
End date: 2010-06-17
Naropin
Dosage: 20 mg, once
Indication: Neuromuscular Blockade
Start date: 2010-06-17
End date: 2010-06-17
Rocuronium Bromide
Dosage: 50 mg, once
Indication: General Anaesthesia
Start date: 2010-06-17
End date: 2010-06-17
Sufentanil Citrate
Dosage: 10 ?g, once
Start date: 2010-06-17
End date: 2010-06-17
Sufentanil Citrate
Dosage: 40 ?g, once
Indication: Gait Disturbance
Start date: 2010-06-17
End date: 2010-06-17
Other drugs received by patient: Rivotril; [composition Unspecified]; Aluminum Hydroxide (+) Magnesium Carbonate; Acetaminophen; Oxycontin; Nexium; Olmesartan Medoxomil; Desloratadine; Cymbalta
Possible Diprivan side effects in 26 year old female
Reported by a pharmacist from Japan on 2012-07-31
Patient: 26 year old female
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Other drugs received by patient: General Anesthetics
Possible Diprivan side effects in
Reported by a consumer/non-health professional from Japan on 2012-07-30
Patient:
Reactions: Pharyngeal Oedema, Cardio-Respiratory Arrest
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Dosage: 100 mg, once
Indication: Anaesthesia Procedure
Start date: 2011-11-24
End date: 2011-11-24
Rocuronium Bromide
Indication: Neuromuscular Blocking Therapy
Start date: 2011-11-24
End date: 2011-11-24
Rocuronium Bromide
Dosage: 50 mg, once
Start date: 2011-11-24
End date: 2011-11-24
Ultiva
Dosage: perpetuation administering during 0.5mcg/kg/minute
Indication: Analgesic Therapy
Start date: 2011-11-24
End date: 2011-11-24
Ultiva
Possible Diprivan side effects in female
Reported by a physician from France on 2012-07-27
Patient: female
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Alfentanil
Indication: Product Used FOR Unknown Indication
Start date: 2012-06-11
End date: 2012-06-11
Celocurine
Indication: Product Used FOR Unknown Indication
Start date: 2012-06-11
End date: 2012-06-11
Diprivan
Indication: Product Used FOR Unknown Indication
Start date: 2012-06-11
End date: 2012-06-11
Sevoflurane
Indication: Product Used FOR Unknown Indication
Start date: 2012-06-11
End date: 2012-06-11
Valium
Indication: Product Used FOR Unknown Indication
Start date: 2012-06-11
End date: 2012-06-11
Possible Diprivan side effects in
Reported by a pharmacist from Japan on 2012-07-25
Patient:
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Indication: General Anaesthesia
Rocuronium Bromide
Ultiva
Possible Diprivan side effects in 78 year old female
Reported by a physician from France on 2012-07-24
Patient: 78 year old female
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Indication: Induction of Anaesthesia
Start date: 2012-06-15
End date: 2012-06-15
Sufentanil Citrate
Indication: Induction of Anaesthesia
Start date: 2012-06-15
End date: 2012-06-15
Suxamethonium
Indication: Induction of Anaesthesia
Start date: 2012-06-15
End date: 2012-06-15
Other drugs received by patient: Ciprofloxacin Hydrochloride; Rocephin; Gentamicin
Possible Diprivan side effects in male
Reported by a physician from France on 2012-07-24
Patient: male
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Diprivan
Indication: Anaesthesia
Start date: 2012-06-12
End date: 2012-06-12
Sufentanyl Mylan
Indication: Anaesthesia
Start date: 2012-06-12
End date: 2012-06-12
Tracrium
Indication: Anaesthesia
Start date: 2012-06-12
End date: 2012-06-12
Possible Diprivan side effects in female
Reported by a physician from France on 2012-07-23
Patient: female
Reactions: Anaphylactic Shock
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Alfentanil
Indication: Induction of Anaesthesia
Start date: 2012-06-11
End date: 2012-06-11
Celocurine
Indication: Induction of Anaesthesia
Start date: 2012-06-11
End date: 2012-06-11
Diprivan
Indication: Induction of Anaesthesia
Start date: 2012-06-11
End date: 2012-06-11
Sevoflurane
Indication: Induction of Anaesthesia
Start date: 2012-06-11
End date: 2012-06-11
Valium
Indication: Induction of Anaesthesia
Start date: 2012-06-11
End date: 2012-06-11
Possible Diprivan side effects in 80 year old
Reported by a physician from Japan on 2012-07-23
Patient: 80 year old
Reactions: Renal Failure Acute
Drug(s) suspected as cause:
Carbocain
Dosage: dose unknown
Diprivan
Dosage: dose unknown
Ropivacaine Hydrochloride
Dosage: 2mg/ml
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