Diazepam and Neuroleptic Malignant Syndrome - Suspected Cause

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Diazepam where reactions include neuroleptic malignant syndrome. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Diazepam side effects in 82 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-03

Reactions: Hyperthermia, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Convulsion

Drug(s) suspected as cause:
Carvedilol
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Clarithromycin
Administration route: Oral
Indication: Product Used FOR Unknown Indication

Paroxetine
    Dosage: 40 mg, unk
    Administration route: Oral
    Indication: Depression
    Start date: 2009-01-27
    End date: 2009-03-09

Salmeterol Xinafoate
Dosage: unk
Indication: Product Used FOR Unknown Indication

Possible Diazepam side effects in male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-01

Reactions: Abdominal Pain, Agitation, Akathisia, Dizziness Postural, Libido Disorder, Erectile Dysfunction, Gynaecomastia, Disinhibition, Malaise, Balance Disorder, Sedation, Breast Discharge, Abnormal Behaviour, Tremor, Irritability, Rash Maculo-Papular, Sleep Apnoea Syndrome, Hypersensitivity, Dyskinesia, Somnolence, Fatigue, Excessive Masturbation, Anger, Neuroleptic Malignant Syndrome, Lethargy, Decreased Appetite, Dyspnoea, Vomiting, Nausea, Rash, Amnesia, Dysarthria, Withdrawal Syndrome, Colour Blindness Acquired, Memory Impairment, Drug Dependence, Influenza Like Illness

Drug(s) suspected as cause:
Clopixol
Indication: Product Used FOR Unknown Indication
Start date: 2012-05-22

Sulpiride
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-01

Valproate Sodium
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-22

Possible Diazepam side effects in male

Reactions: Agitation, Akathisia, Abdominal Pain, Libido Disorder, Impulsive Behaviour, Erectile Dysfunction, Gynaecomastia, Disinhibition, Malaise, Balance Disorder, Sedation, Breast Pain, Breast Discharge, Abnormal Behaviour, Aggression, Tremor, Irritability, Reflexes Abnormal, Rash Maculo-Papular, Hypersensitivity, Dyskinesia, Somnolence, Abdominal Pain Upper, Speech Disorder, Fatigue, Concussion, Excessive Masturbation, Anger, Dizziness, Neuroleptic Malignant Syndrome, Decreased Appetite, Vomiting, Dyspnoea, Nausea, Drug Effect Increased, Rash, Dysarthria, Anxiety, Visual Impairment, Memory Impairment, Drug Dependence, Influenza Like Illness

Drug(s) suspected as cause:
Diazepam
Dosage: 10 mg; bid
Start date: 2012-04-22

Possible Diazepam side effects in male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-17

Reactions: Agitation, Akathisia, Abdominal Pain, Dizziness Postural, Libido Disorder, Erectile Dysfunction, Gynaecomastia, Disinhibition, Malaise, Balance Disorder, Sedation, Breast Discharge, Abnormal Behaviour, Tremor, Irritability, Rash Maculo-Papular, Sleep Apnoea Syndrome, Hypersensitivity, Dyskinesia, Somnolence, Fatigue, Excessive Masturbation, Anger, Neuroleptic Malignant Syndrome, Lethargy, Decreased Appetite, Vomiting, Dyspnoea, Nausea, Rash, Amnesia, Dysarthria, Colour Blindness Acquired, Memory Impairment, Withdrawal Syndrome, Drug Dependence, Influenza Like Illness

Drug(s) suspected as cause:
Clopixol
Indication: Product Used FOR Unknown Indication
Start date: 2012-05-22

Sulpiride
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-01

Valproate Sodium
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-22

Possible Diazepam side effects in male

Reported by a consumer/non-health professional from United Kingdom on 2012-07-17

Reactions: Abdominal Pain, Akathisia, Agitation, Dizziness Postural, Libido Disorder, Erectile Dysfunction, Gynaecomastia, Disinhibition, Malaise, Balance Disorder, Sedation, Breast Discharge, Abnormal Behaviour, Tremor, Irritability, Rash Maculo-Papular, Sleep Apnoea Syndrome, Hypersensitivity, Dyskinesia, Somnolence, Fatigue, Excessive Masturbation, Anger, Neuroleptic Malignant Syndrome, Decreased Appetite, Lethargy, Dyspnoea, Vomiting, Nausea, Rash, Amnesia, Dysarthria, Withdrawal Syndrome, Colour Blindness Acquired, Memory Impairment, Drug Dependence, Influenza Like Illness

Drug(s) suspected as cause:
Chinese Medication
Indication: Cyclothymic Disorder

Diazepam
Dosage: in the morning at 10am and in the evening at 10pm
Start date: 2012-04-22

Sulpiride
Dosage: (liquid 1.4g per day) 8am in the morning and 10pm in the evening
Start date: 2012-04-01

Valproate Sodium
Dosage: once at 8am in the morning and then again at 10pm in the evening.
Start date: 2012-04-22

Possible Diazepam side effects in male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-17

Reactions: Abdominal Pain, Akathisia, Agitation, Libido Disorder, Dizziness Postural, Erectile Dysfunction, Gynaecomastia, Disinhibition, Malaise, Balance Disorder, Sedation, Breast Discharge, Abnormal Behaviour, Tremor, Irritability, Sleep Apnoea Syndrome, Rash Maculo-Papular, Hypersensitivity, Dyskinesia, Somnolence, Fatigue, Excessive Masturbation, Anger, Neuroleptic Malignant Syndrome, Decreased Appetite, Lethargy, Vomiting, Dyspnoea, Nausea, Rash, Amnesia, Dysarthria, Withdrawal Syndrome, Colour Blindness Acquired, Memory Impairment, Drug Dependence, Influenza Like Illness

Drug(s) suspected as cause:
Clopixol
Indication: Product Used FOR Unknown Indication
Start date: 2012-05-22

Sulpiride
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-01

Valproate Sodium
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-22

Possible Diazepam side effects in male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-16

Reactions: Agitation, Akathisia, Dizziness Postural, Libido Disorder, Erectile Dysfunction, Gynaecomastia, Disinhibition, Malaise, Balance Disorder, Sedation, Breast Pain, Breast Discharge, Hypotension, Abnormal Behaviour, Drug Withdrawal Syndrome, Tremor, Aggression, Irritability, Swelling, Rash Erythematous, Rash Maculo-Papular, Reflexes Abnormal, Sleep Apnoea Syndrome, Hypersensitivity, Dyskinesia, Pain, Somnolence, Abdominal Pain Upper, Fatigue, Excessive Masturbation, Anger, Neuroleptic Malignant Syndrome, Lethargy, Hypersomnia, Decreased Appetite, Vomiting, Dyspnoea, Nausea, Amnesia, Dysarthria, Anxiety, Visual Impairment, Memory Impairment, Drug Dependence, Influenza Like Illness

Drug(s) suspected as cause:
Chinese Medication
Indication: Cyclothymic Disorder

Possible Diazepam side effects in 71 year old female

Drug(s) suspected as cause:
Depakene
Administration route: Oral
Indication: Bipolar Disorder

Possible Diazepam side effects in 42 year old male

Reported by a health professional (non-physician/pharmacist) from Croatia (Local Name: Hrvatska) on 2012-02-27

Drug(s) suspected as cause:
Clozapine
Dosage: 25 mg/day
Indication: Schizoaffective Disorder

Diazepam
    Dosage: up to 60 mg/day
    Administration route: Oral
    Indication: Schizoaffective Disorder

Possible Diazepam side effects in 36 year old male

Reported by a health professional (non-physician/pharmacist) from Croatia (Local Name: Hrvatska) on 2012-02-22

Drug(s) suspected as cause:
Clozapine
Dosage: 200 mg, daily, unknown
Indication: Mania

Possible Diazepam side effects in 34 year old male

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-02-16

Drug(s) suspected as cause:
Clonazepam
Dosage: unk
Indication: Schizophrenia

Possible Diazepam side effects in 51 year old female

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-02-16

Drug(s) suspected as cause:
Carbamazepine
Dosage: unk
Indication: Multiple Sclerosis

Possible Diazepam side effects in 51 year old female

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-02-11

Reactions: Autonomic Nervous System Imbalance, Hyperthermia, Mental Status Changes, Neuroleptic Malignant Syndrome, Muscle Rigidity

Possible Diazepam side effects in 51 year old female

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-02-11

Reactions: Autonomic Nervous System Imbalance, Hyperthermia, Mental Status Changes, Neuroleptic Malignant Syndrome, Muscle Rigidity

Possible Diazepam side effects in 34 year old male

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-02-11

Reactions: Hyperthermia, Autonomic Nervous System Imbalance, Mental Status Changes, Neuroleptic Malignant Syndrome, Leukocytosis, Muscle Rigidity

Possible Diazepam side effects in

Reported by a individual with unspecified qualification from Brazil on 2012-02-10

Drug(s) suspected as cause:
Clonazepam
Dosage: unk, unknown
Indication: Schizophrenia

Possible Diazepam side effects in 34 year old male

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-02-07

Drug(s) suspected as cause:
Clonazepam
Dosage: unk
Indication: Product Used FOR Unknown Indication

Possible Diazepam side effects in 34 year old male

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-01-25

Reactions: Hyperthermia, Autonomic Nervous System Imbalance, Mental Status Changes, Neuroleptic Malignant Syndrome, Muscle Rigidity, Leukocytosis

Possible Diazepam side effects in 51 year old female

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-01-25

Reactions: Hyperthermia, Autonomic Nervous System Imbalance, Mental Status Changes, Neuroleptic Malignant Syndrome, Muscle Rigidity

Possible Diazepam side effects in 51 year old female

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-01-25

Reactions: Autonomic Nervous System Imbalance, Hyperthermia, Mental Status Changes, Neuroleptic Malignant Syndrome, Muscle Rigidity

Possible Diazepam side effects in 31 year old female

Reported by a health professional (non-physician/pharmacist) from Denmark on 2011-11-04

Reactions: Tinnitus, Pruritus, Contusion, Tachycardia, Sensory Loss, Schizophrenia, Serotonin Syndrome, Hyperhidrosis, Malaise, Incontinence, Balance Disorder, Emotional Disorder, Pupillary Reflex Impaired, Back Pain, Drooling, Restlessness, Maternal Exposure During Pregnancy, Toxicity To Various Agents, H1n1 Influenza, Delirium, Incoherent, Irritability, Sleep Disorder, Dissociation, Hypotonia, Vision Blurred, Parosmia, Pregnancy, Muscle Disorder, LIP Swelling, Drug Interaction, Somnolence, Speech Disorder, Musculoskeletal Stiffness, Depression, Decreased Appetite, Dyspnoea, Vomiting, Gastric PH Decreased, Arthralgia, Visual Impairment, Gait Disturbance, Asthenia, Agitation, Hallucination, Auditory, Depersonalisation, Headache, Hypoaesthesia Oral, Dyspepsia, Urinary Retention, Oedema Mouth, Muscle Spasms, Feeling of Despair, General Physical Health Deterioration, Drug Withdrawal Syndrome, Convulsion, Tremor, Paraesthesia, Cogwheel Rigidity, Feeling Jittery, Insomnia, Disturbance in Attention, Nervous System Disorder, Premature Delivery, Neuralgia, Confusional State, Aphasia, Dyskinesia, Pain, Restless Legs Syndrome, Disorientation, Pallor, Viith Nerve Paralysis, Suicidal Ideation, Myalgia, Mania, Fatigue, Road Traffic Accident, Neck Pain, Dizziness, Neuroleptic Malignant Syndrome, Blood Sodium Decreased, Hallucination, Hypersomnia, Nightmare, Swelling Face, Condition Aggravated, Swollen Tongue, Anxiety, Psychotic Disorder, Feeling Abnormal

Drug(s) suspected as cause:
Amitriptyline HCL
    Dosage: 25 mg;qd
    Indication: Muscle Spasms
    Start date: 2011-08-10

Clonazepam
    Dosage: po
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Codeine Sulfate
    Dosage: po
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2011-06-15
    End date: 2011-07-23

Lorazepam
    Dosage: 1 mg;po
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-03-23
    End date: 2011-06-27

Mirtazapine
    Dosage: 30 mg;qd;po
    Administration route: Oral
    Indication: Depression
    Start date: 2010-09-23
    End date: 2010-11-08

Omeprazole
    Dosage: 20 mg;qd
    Indication: Dyspepsia
    Start date: 2011-05-25

Paroxetine Tablets, 40mg (Aellc) (Paroxetine)
    Dosage: 40 mg;po
    Administration route: Oral
    Indication: Depression
    Start date: 1999-08-01
    End date: 2011-07-06

Procyclidine Hydrochloride 2MG TAB
    Dosage: 5 mg;tid;po
    Administration route: Oral
    Indication: Extrapyramidal Disorder
    Start date: 2011-05-03
    End date: 2011-05-10

Quetiapine Fumarate
    Dosage: 300 mg;po
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-02-24
    End date: 2011-05-06

Seroxat (NO Pref. Name)
    Dosage: 20 mg;tid;po
    Administration route: Oral
    Start date: 1999-08-01
    End date: 2011-05-01

Tramadol Hydrochloride
    Dosage: po
    Administration route: Oral
    Indication: Neck Pain
    Start date: 2008-12-01
    End date: 2010-12-10

Possible Diazepam side effects in 31 year old female

Reported by a individual with unspecified qualification from United Kingdom on 2011-11-04

Reactions: Tinnitus, Contusion, Pruritus, Tachycardia, Paralysis, Schizophrenia, Serotonin Syndrome, Hyperhidrosis, Malaise, Incontinence, Balance Disorder, Mood Swings, Emotional Disorder, Back Pain, Scratch, Pupillary Reflex Impaired, Drooling, Restlessness, Maternal Exposure During Pregnancy, Toxicity To Various Agents, H1n1 Influenza, Delirium, Incoherent, Irritability, Sleep Disorder, Hypotonia, Vision Blurred, Parosmia, Muscle Disorder, Pregnancy, LIP Swelling, Drug Interaction, Somnolence, Speech Disorder, Musculoskeletal Stiffness, Depression, Decreased Appetite, Dyspnoea, Vomiting, Gastric PH Decreased, Arthralgia, Visual Impairment, Gait Disturbance, Asthenia, Agitation, Depersonalisation, Hallucination, Auditory, Headache, Muscle Rigidity, Hypoaesthesia Oral, Cyanosis, Dyspepsia, Oedema Mouth, Urinary Retention, Muscle Spasms, Feeling of Despair, Pain in Extremity, General Physical Health Deterioration, Drug Withdrawal Syndrome, Hypoaesthesia, Convulsion, Paraesthesia, Tremor, Cogwheel Rigidity, NO Therapeutic Response, Insomnia, Feeling Jittery, Disturbance in Attention, Nervous System Disorder, Premature Delivery, Neuralgia, Confusional State, Aphasia, Pain, Restless Legs Syndrome, Dyskinesia, Pallor, Suicidal Ideation, Viith Nerve Paralysis, Myalgia, Mania, Menstruation Irregular, Fatigue, Road Traffic Accident, Neck Pain, Dizziness, Neuroleptic Malignant Syndrome, Hallucination, Blood Sodium Decreased, Hypersomnia, Swelling Face, Nightmare, Swollen Tongue, Eye Pain, Anxiety, Psychotic Disorder, Feeling Abnormal

Drug(s) suspected as cause:
Amitriptyline HCL
    Dosage: 25 mg milligram(s) 1 in 1 day
    Indication: Muscle Spasms
    Start date: 2011-08-10

Clonazepam
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Diazepam
    Dosage: 5 mg milligram(s)
    Indication: Muscle Spasms
    Start date: 2011-07-25

Lorazepam
    Dosage: 1 mg milligram(s)
    Indication: Muscle Spasms
    Start date: 2011-05-23
    End date: 2011-06-27

Mirtazapine
    Dosage: 30 mg and 15 mg at night
    Start date: 2010-09-23
    End date: 2010-11-08

Procyclidine Hydrochloride 2MG TAB
    Dosage: 5 mg milligram(s) 3 in 1 day
    Indication: Psychotic Disorder
    Start date: 2011-05-03
    End date: 2011-05-10

Quetiapine
    Dosage: 300 mg milligram(s)
    Indication: Psychotic Disorder
    Start date: 2011-02-24
    End date: 2011-05-06

Tramadol HCL
    Dosage: 15-30 mg qds
    Indication: Analgesic Therapy
    Start date: 2011-06-15

Possible Diazepam side effects in 31 year old

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-28

Reactions: Pruritus, Tinnitus, Contusion, Schizophrenia, Serotonin Syndrome, Hyperhidrosis, Malaise, Incontinence, Balance Disorder, Emotional Disorder, Mood Swings, Back Pain, Pupillary Reflex Impaired, Drooling, Restlessness, Maternal Exposure During Pregnancy, Toxicity To Various Agents, Delirium, H1n1 Influenza, Premature Labour, Irritability, Incoherent, Sleep Disorder, Hypotonia, Dissociation, Vision Blurred, Parosmia, Pregnancy, Muscle Disorder, LIP Swelling, Drug Interaction, Somnolence, Speech Disorder, Musculoskeletal Stiffness, Depression, Decreased Appetite, Dyspnoea, Vomiting, Gastric PH Decreased, Arthralgia, Visual Impairment, Heart Rate Increased, Gait Disturbance, Asthenia, Agitation, Depersonalisation, Hallucination, Auditory, Headache, Pyrexia, Hypoaesthesia Oral, Dyspepsia, Cyanosis, Unevaluable Event, Urinary Retention, Oedema Mouth, Muscle Spasms, Feeling of Despair, Pain in Extremity, General Physical Health Deterioration, Drug Withdrawal Syndrome, Convulsion, Paraesthesia, Tremor, Cogwheel Rigidity, NO Therapeutic Response, Feeling Jittery, Disturbance in Attention, Mental Disorder, Nervous System Disorder, Premature Delivery, Neuralgia, Confusional State, Aphasia, Dyskinesia, Restless Legs Syndrome, Disorientation, Pallor, Suicidal Ideation, Viith Nerve Paralysis, Mania, Menstruation Irregular, Myalgia, Fatigue, Road Traffic Accident, Neck Pain, Dizziness, Neuroleptic Malignant Syndrome, Hallucination, Blood Sodium Decreased, Hypersomnia, Swelling Face, Nightmare, Condition Aggravated, Swollen Tongue, Eye Pain, Anxiety, Psychotic Disorder, Feeling Abnormal

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Amitriptyline HCL
    Dosage: 25.00-mg-1.00times/per1.0days
    Indication: Muscle Spasms
    Start date: 2011-08-10

Clonazepam
    Dosage: oral
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Codeine Sulfate
    Dosage: oral
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2011-06-15
    End date: 2011-07-23

Lorazepam
    Dosage: 1.00-mg/oral
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Mirtazapine
    Dosage: oral
    Administration route: Oral
    Indication: Depression
    Start date: 2010-10-07
    End date: 2010-10-12

Omeprazole
    Dosage: 20.00-mg-1.00times per-1.0days
    Indication: Dyspepsia
    Start date: 2011-05-25

Paroxetine HCL
    Dosage: 40.00-mg/oral
    Administration route: Oral
    Indication: Post-Traumatic Stress Disorder
    Start date: 1999-08-01
    End date: 2011-07-06

Paroxetine HCL
    Dosage: 20.00-mg-3.00 times per1.0days/ oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 1999-08-01
    End date: 2011-05-01

Procyclideine(procyclidine)
    Dosage: 20.00-mg/oral
    Administration route: Oral
    Indication: Extrapyramidal Disorder
    Start date: 2011-03-24
    End date: 2011-05-06

Quetiapine Fumarate
    Dosage: 300.00-mg/oral
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-02-24
    End date: 2011-05-06

Tramadol HCL
    Dosage: oral
    Administration route: Oral
    Indication: Neck Pain
    Start date: 2008-12-01
    End date: 2010-12-10

Possible Diazepam side effects in 31 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-27

Reactions: Tinnitus, Pruritus, Contusion, Tachycardia, Schizophrenia, Sensory Loss, Paralysis, Serotonin Syndrome, Hyperhidrosis, Incontinence, Malaise, Balance Disorder, Mood Swings, Emotional Disorder, Feeling of Body Temperature Change, Back Pain, Drooling, Restlessness, Maternal Exposure During Pregnancy, Toxicity To Various Agents, Premature Labour, Delirium, H1n1 Influenza, Irritability, Limb Injury, Sleep Disorder, Hypotonia, Dissociation, Vision Blurred, Parosmia, Pregnancy, Muscle Disorder, Drug Interaction, Somnolence, Speech Disorder, Musculoskeletal Stiffness, Depression, Decreased Appetite, Dyspnoea, Vomiting, Gastric PH Decreased, Derealisation, Hallucinations, Mixed, Arthralgia, Visual Impairment, Gait Disturbance, Asthenia, Agitation, Depersonalisation, Pyrexia, Headache, Menstrual Disorder, Hypoaesthesia Oral, Dyspepsia, Cyanosis, Unevaluable Event, Urinary Retention, Muscle Spasms, Feeling of Despair, Dystonia, Hypoaesthesia, Drug Withdrawal Syndrome, Paraesthesia, Tremor, Convulsion, Cogwheel Rigidity, Feeling Jittery, NO Therapeutic Response, Nervous System Disorder, Disturbance in Attention, Premature Delivery, Neuralgia, Confusional State, Aphasia, Dyskinesia, Disorientation, Pallor, Suicidal Ideation, Mania, Myalgia, Road Traffic Accident, Fatigue, Skin Discolouration, Neck Pain, Dizziness, Neuroleptic Malignant Syndrome, Blood Sodium Decreased, Hypersomnia, Nightmare, Swelling Face, Mydriasis, Condition Aggravated, Swollen Tongue, Eye Pain, Anxiety, Psychotic Disorder, Diarrhoea

Drug(s) suspected as cause:
Amitriptyline HCL
    Dosage: 25 mg;qd
    Indication: Muscle Spasms
    Start date: 2011-08-10

Clonazepam
    Dosage: po
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Codeine Sulfate
    Dosage: po
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2011-06-15
    End date: 2011-07-23

Lorazepam
    Dosage: 1 mg;po
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-05-23
    End date: 2011-06-27

Mirtazapine
    Dosage: 30 mg;qd
    Administration route: Oral
    Indication: Depression
    Start date: 2010-09-23
    End date: 2010-11-08

Omeprazole
    Dosage: 20 mg;qd
    Indication: Dyspepsia
    Start date: 2011-05-25

Paroxetine HCL
    Dosage: 40 mg;po
    Administration route: Oral
    Indication: Post-Traumatic Stress Disorder
    Start date: 1999-08-01
    End date: 2011-07-06

Paroxetine HCL
    Dosage: 40 mg;po
    Administration route: Oral
    Indication: Depression
    Start date: 1999-08-01
    End date: 2011-07-06

Paroxetine Hydrochloride
    Dosage: 20 mg;po;tid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 1999-08-01
    End date: 2011-05-01

Procyclidine Hydrochloride 2MG TAB
    Dosage: 5 mg;tid
    Administration route: Oral
    Indication: Extrapyramidal Disorder
    Start date: 2011-05-03
    End date: 2011-05-10

Quetiapine Fumarate
    Dosage: 300 mg;po
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-02-24
    End date: 2011-05-06

Tramadol HCL
    Dosage: po
    Administration route: Oral
    Indication: Neck Pain
    Start date: 2008-12-01
    End date: 2010-12-10

Tramadol HCL
    Dosage: po
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2008-12-01
    End date: 2010-12-10

Possible Diazepam side effects in 31 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-26

Reactions: Contusion, Pruritus, Tinnitus, Tachycardia, Schizophrenia, Serotonin Syndrome, Hyperhidrosis, Incontinence, Malaise, Balance Disorder, Feeling of Body Temperature Change, Emotional Disorder, Mood Swings, Pupillary Reflex Impaired, Back Pain, Drooling, Restlessness, Maternal Exposure During Pregnancy, H1n1 Influenza, Delirium, Premature Labour, Irritability, Sleep Disorder, Hypotonia, Dissociation, Vision Blurred, Parosmia, Muscle Disorder, Pregnancy, LIP Swelling, Drug Interaction, Somnolence, Speech Disorder, Musculoskeletal Stiffness, Depression, Decreased Appetite, Dyspnoea, Vomiting, Gastric PH Decreased, Derealisation, Arthralgia, Visual Impairment, Gait Disturbance, Asthenia, Agitation, Depersonalisation, Hallucination, Auditory, Headache, Pyrexia, Hypoaesthesia Oral, Dyspepsia, Cyanosis, Poisoning, Oedema Mouth, Urinary Retention, Muscle Spasms, Feeling of Despair, Dystonia, Hypoaesthesia, Drug Withdrawal Syndrome, Paraesthesia, Tremor, Convulsion, Cogwheel Rigidity, NO Therapeutic Response, Insomnia, Feeling Jittery, Disturbance in Attention, Nervous System Disorder, Neuralgia, Confusional State, Restless Legs Syndrome, Dyskinesia, Aphasia, Pain, Disorientation, Pallor, Viith Nerve Paralysis, Suicidal Ideation, Mania, Myalgia, Menstruation Irregular, Fatigue, Road Traffic Accident, Skin Discolouration, Neck Pain, Dizziness, Neuroleptic Malignant Syndrome, Hallucination, Blood Sodium Decreased, Hypersomnia, Swelling Face, Nightmare, Condition Aggravated, Swollen Tongue, Drug Prescribing Error, Eye Pain, Anxiety, Psychotic Disorder, Feeling Abnormal

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Amitriptyline HCL
    Dosage: 25 mg;qd
    Indication: Muscle Spasms
    Start date: 2011-08-10

Amitriptyline HCL
    Dosage: 25 mg;qd
    Indication: Neuralgia
    Start date: 2011-08-10

Clonazepam
    Dosage: po
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Codeine Sulfate
    Dosage: po
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2011-06-15
    End date: 2011-07-23

Lorazepam
    Dosage: 1 mg;po 1 mg;qid;po
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Lorazepam
    Dosage: 1 mg;po 1 mg;qid;po
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-05-23
    End date: 2011-06-27

Mirtazapine
    Dosage: po
    Administration route: Oral
    Indication: Depression
    Start date: 2010-09-23
    End date: 2010-11-08

Omeprazole
    Dosage: 20 mg;qd
    Indication: Dyspepsia
    Start date: 2011-05-25

Paroxetine HCL
    Dosage: 20 mg;tid;po
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 1999-08-01
    End date: 2011-05-01

Paroxetine HCL
    Dosage: 40 mg;po
    Administration route: Oral
    Indication: Depression
    Start date: 1999-08-01
    End date: 2011-07-06

Paroxetine HCL
    Dosage: 40 mg;po
    Administration route: Oral
    Indication: Post-Traumatic Stress Disorder
    Start date: 1999-08-01
    End date: 2011-07-06

Procyclidine Hydrochloride 2MG TAB
    Dosage: 5 mg;tid;po
    Administration route: Oral
    Indication: Extrapyramidal Disorder
    Start date: 2011-05-03
    End date: 2011-05-10

Quetiapine Fumarate
    Dosage: 300 mg;po
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-02-24
    End date: 2011-05-06

Tramadol HCL
    Dosage: qid; po
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2008-07-22

Tramadol HCL
    Dosage: qid; po
    Administration route: Oral
    Indication: Neck Pain
    Start date: 2008-07-22

Tramadol HCL
    Dosage: qid; po
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2008-12-01
    End date: 2010-12-10

Tramadol HCL
    Dosage: qid; po
    Administration route: Oral
    Indication: Neck Pain
    Start date: 2008-12-01
    End date: 2010-12-10

Possible Diazepam side effects in 31 year old female

Reactions: Tinnitus, Pruritus, Contusion, Tachycardia, Paralysis, Schizophrenia, Sensory Loss, Serotonin Syndrome, Hyperhidrosis, Malaise, Incontinence, Balance Disorder, Feeling of Body Temperature Change, Emotional Disorder, Mood Swings, Drooling, Restlessness, Maternal Exposure During Pregnancy, Toxicity To Various Agents, Premature Labour, Delirium, H1n1 Influenza, Sleep Disorder, Limb Injury, Dissociation, Vision Blurred, Parosmia, Muscle Disorder, Drug Interaction, Speech Disorder, Musculoskeletal Stiffness, Depression, Decreased Appetite, Vomiting, Dyspnoea, Gastric PH Decreased, Derealisation, Hallucinations, Mixed, Arthralgia, Visual Impairment, Heart Rate Increased, Gait Disturbance, Asthenia, Agitation, Headache, Pyrexia, Menstrual Disorder, Hypoaesthesia Oral, Cyanosis, Urinary Retention, Muscle Spasms, Feeling of Despair, Dystonia, Drug Withdrawal Syndrome, Hypoaesthesia, Tremor, Convulsion, Paraesthesia, Cogwheel Rigidity, Feeling Jittery, Disturbance in Attention, Dyskinesia, Aphasia, Disorientation, Pallor, Suicidal Ideation, Mania, Fatigue, Skin Discolouration, Dizziness, Neuroleptic Malignant Syndrome, Blood Sodium Decreased, Mydriasis, Nightmare, Swelling Face, Swollen Tongue, Eye Pain, Anxiety, Psychotic Disorder, Diarrhoea

Adverse event resulted in: life threatening event, hospitalization, disablity

Omeprazole
    Administration route: Oral
    Indication: Dyspepsia
    Start date: 2011-03-01

Omeprazole
    Administration route: Oral
    Indication: Gastric PH Decreased
    Start date: 2011-03-01

Paroxetine HCL
    Administration route: Oral
    Start date: 1999-08-01
    End date: 2011-05-01

Paroxetine HCL
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 1999-01-01
    End date: 2011-05-01

Paroxetine HCL
    Administration route: Oral
    Indication: Depression
    Start date: 1999-08-01
    End date: 2011-07-06

Paroxetine HCL
    Administration route: Oral
    Indication: Post-Traumatic Stress Disorder
    Start date: 1999-08-01
    End date: 2011-07-06

Other drugs received by patient possibly interacting with the suspect drug:
Amitriptyline HCL
Indication: Muscle Spasms
Start date: 2011-08-10

Clonazepam
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Codeine Sulfate
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2011-06-15
    End date: 2011-07-23

Lorazepam
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Lorazepam
    Administration route: Oral
    Start date: 2011-05-23
    End date: 2011-06-27

Mirtazapine
    Administration route: Oral
    Start date: 2010-09-23
    End date: 2010-11-08

Mirtazapine
    Administration route: Oral
    Indication: Depression
    Start date: 2010-10-07
    End date: 2010-10-12

Procyclidine Hydrochloride 2MG TAB
    Administration route: Oral
    Indication: Extrapyramidal Disorder
    Start date: 2011-02-24
    End date: 2011-05-06

Procyclidine Hydrochloride 2MG TAB
    Administration route: Oral
    Start date: 2011-05-03
    End date: 2011-05-10

Quetiapine
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-02-24
    End date: 2011-05-06

Tramadol HCL
    Administration route: Oral
    Indication: Neck Pain
    Start date: 2008-12-01
    End date: 2010-12-10

Tramadol HCL
    Administration route: Oral
    Indication: Back Pain
    Start date: 2008-12-01
    End date: 2010-12-10

Tramadol HCL
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2008-12-01
    End date: 2010-12-10

Possible Diazepam side effects in 46 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-17

Blonanserin
    Dosage: 16 mg, unk
    Administration route: Oral
    Indication: Schizophrenia

Possible Diazepam side effects in 31 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-11

Reactions: Contusion, Pruritus, Tinnitus, Schizophrenia, Serotonin Syndrome, Hyperhidrosis, Malaise, Incontinence, Balance Disorder, Emotional Disorder, Mood Swings, Back Pain, Drooling, Restlessness, Maternal Exposure During Pregnancy, Toxicity To Various Agents, Premature Labour, Delirium, H1n1 Influenza, Incoherent, Irritability, Sleep Disorder, Dissociation, Hypotonia, Vision Blurred, Parosmia, Pregnancy, Muscle Disorder, LIP Swelling, Drug Interaction, Speech Disorder, Musculoskeletal Stiffness, Depression, Decreased Appetite, Vomiting, Dyspnoea, Gastric PH Decreased, Dysstasia, Arthralgia, Heart Rate Increased, Visual Impairment, Gait Disturbance, Asthenia, Agitation, Hallucination, Auditory, Depersonalisation, Pyrexia, Headache, Hypoaesthesia Oral, Cyanosis, Oedema Mouth, Urinary Retention, Muscle Spasms, Feeling of Despair, Dystonia, Drug Withdrawal Syndrome, Hypoaesthesia, Pupillary Disorder, Paraesthesia, Convulsion, Tremor, Cogwheel Rigidity, Insomnia, Feeling Jittery, Disturbance in Attention, Confusional State, Restless Legs Syndrome, Pain, Aphasia, Disorientation, Pallor, Viith Nerve Paralysis, Suicidal Ideation, Myalgia, Mania, Menstruation Irregular, Road Traffic Accident, Fatigue, Neck Pain, Dizziness, Neuroleptic Malignant Syndrome, Blood Sodium Decreased, Hallucination, Hypersomnia, Swelling Face, Nightmare, Swollen Tongue, Eye Pain, Anxiety, Psychotic Disorder, Feeling Abnormal

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Amitriptyline HCL
Indication: Product Used FOR Unknown Indication

Clonazepam
    Dosage: oral
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Codeine Sulfate
    Dosage: oral
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2011-06-15
    End date: 2011-07-23

Lorazepam
    Dosage: 1.00-mg/oral
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Mirtazapine
    Dosage: oral
    Administration route: Oral
    Indication: Depression
    Start date: 2010-10-07
    End date: 2010-10-12

Paroxetine HCL
    Dosage: 20.00-mg-3.00 times per-1.0days / oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 1999-01-01
    End date: 2011-05-01

Paroxetine HCL
    Dosage: 40.00-mg
    Indication: Post-Traumatic Stress Disorder
    Start date: 1999-08-01
    End date: 2011-07-06

Procyclidine Hydrochloride 2MG TAB
    Dosage: 20.00-mg / oral
    Administration route: Oral
    Indication: Extrapyramidal Disorder
    Start date: 2011-03-24
    End date: 2011-05-06

Quetiapine Fumarate
    Dosage: 300.00-mg/ oral
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-02-24
    End date: 2011-05-06

Tramadol HCL
    Dosage: oral
    Administration route: Oral
    Indication: Neck Pain
    Start date: 2008-12-01
    End date: 2010-12-10

Possible Diazepam side effects in female

Reactions: Tinnitus, Pruritus, Contusion, Tachycardia, Paralysis, Sensory Loss, Schizophrenia, Serotonin Syndrome, Hyperhidrosis, Incontinence, Malaise, Balance Disorder, Emotional Disorder, Mood Swings, Drooling, Restlessness, Maternal Exposure During Pregnancy, Toxicity To Various Agents, Delirium, H1n1 Influenza, Premature Labour, Sleep Disorder, Dissociation, Parosmia, Muscle Disorder, Drug Interaction, Depression, Decreased Appetite, Dyspnoea, Vomiting, Gastric PH Decreased, Derealisation, Hallucinations, Mixed, Arthralgia, Visual Impairment, Gait Disturbance, Asthenia, Agitation, Headache, Pyrexia, Menstrual Disorder, Cyanosis, Urinary Retention, Feeling of Despair, Hypoaesthesia, Drug Withdrawal Syndrome, Tremor, Convulsion, Paraesthesia, Cogwheel Rigidity, Feeling Jittery, Disturbance in Attention, Aphasia, Dyskinesia, Disorientation, Suicidal Ideation, Mania, Skin Discolouration, Dizziness, Neuroleptic Malignant Syndrome, Blood Sodium Decreased, Nightmare, Swelling Face, Mydriasis, Eye Pain, Anxiety, Psychotic Disorder, Diarrhoea

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Amitriptyline HCL
    Dosage: 25mg at night
    Indication: Muscle Spasms
    Start date: 2011-08-10

Clonazepam
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Lorazepam
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-05-23
    End date: 2011-06-27

Mirtazapine
    Administration route: Oral
    Indication: Depression
    Start date: 2010-09-23
    End date: 2010-11-08

Omeprazole
    Dosage: 20mg per day
    Indication: Dyspepsia
    Start date: 2011-05-25

Paroxetine HCL
    Dosage: 20mg three times per day
    Administration route: Oral
    Indication: Depression
    Start date: 1999-08-01
    End date: 2011-05-01

Procyclidine Hydrochloride 2MG TAB
    Dosage: 5mg three times per day
    Administration route: Oral
    Indication: Extrapyramidal Disorder
    Start date: 2011-05-03
    End date: 2011-05-10

Quetiapine
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-02-24
    End date: 2011-05-06

Possible Diazepam side effects in female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-05

Reactions: Tinnitus, Pruritus, Contusion, Tachycardia, Paralysis, Sensory Loss, Schizophrenia, Serotonin Syndrome, Hyperhidrosis, Malaise, Incontinence, Balance Disorder, Mood Swings, Emotional Disorder, Drooling, Restlessness, Maternal Exposure During Pregnancy, Toxicity To Various Agents, Delirium, Premature Labour, H1n1 Influenza, Sleep Disorder, Dissociation, Parosmia, Muscle Disorder, Drug Interaction, Depression, Decreased Appetite, Vomiting, Dyspnoea, Gastric PH Decreased, Derealisation, Hallucinations, Mixed, Arthralgia, Visual Impairment, Gait Disturbance, Asthenia, Agitation, Pyrexia, Headache, Menstrual Disorder, Cyanosis, Urinary Retention, Feeling of Despair, Drug Withdrawal Syndrome, Hypoaesthesia, Paraesthesia, Tremor, Convulsion, Cogwheel Rigidity, Feeling Jittery, Disturbance in Attention, Aphasia, Dyskinesia, Disorientation, Suicidal Ideation, Mania, Skin Discolouration, Dizziness, Neuroleptic Malignant Syndrome, Blood Sodium Decreased, Swelling Face, Nightmare, Mydriasis, Eye Pain, Anxiety, Psychotic Disorder, Diarrhoea

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Amitriptyline HCL
Indication: Product Used FOR Unknown Indication

Clonazepam
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Codeine Sulfate
    Administration route: Oral
    Indication: Analgesic Therapy
    Start date: 2011-06-15
    End date: 2011-07-23

Lorazepam
    Administration route: Oral
    Indication: Sedation
    Start date: 2011-02-24
    End date: 2011-04-10

Mirtazapine
    Administration route: Oral
    Indication: Depression
    Start date: 2010-10-07
    End date: 2010-10-12

Paroxetine HCL
    Dosage: 20mg three times per day
    Administration route: Oral
    Indication: Depression
    Start date: 1999-08-01
    End date: 2011-07-06

Procyclidine Hydrochloride 2MG TAB
    Administration route: Oral
    Indication: Extrapyramidal Disorder
    Start date: 2011-03-24
    End date: 2011-05-06

Quetiapine
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-02-24
    End date: 2011-05-06

Tramadol HCL
    Indication: Neck Pain
    Start date: 2008-12-01
    End date: 2010-12-10

Diazepam (Diazepam) - Neuroleptic Malignant Syndrome - Suspected Cause - Side Effect Reports

Diazepam Rx

Diazepam News

Diazepam Q&A

Possible Diazepam side effects in 82 year old male

Possible Diazepam side effects in male

Possible Diazepam side effects in male

Possible Diazepam side effects in male

Possible Diazepam side effects in male

Possible Diazepam side effects in male

Possible Diazepam side effects in male

Possible Diazepam side effects in 71 year old female

Possible Diazepam side effects in 42 year old male

Possible Diazepam side effects in 36 year old male

Possible Diazepam side effects in 34 year old male

Possible Diazepam side effects in 51 year old female

Possible Diazepam side effects in 51 year old female

Possible Diazepam side effects in 51 year old female

Possible Diazepam side effects in 34 year old male

Possible Diazepam side effects in

Possible Diazepam side effects in 34 year old male

Possible Diazepam side effects in 34 year old male

Possible Diazepam side effects in 51 year old female

Possible Diazepam side effects in 51 year old female

Possible Diazepam side effects in 31 year old female

Possible Diazepam side effects in 31 year old female

Possible Diazepam side effects in 31 year old

Possible Diazepam side effects in 31 year old female

Possible Diazepam side effects in 31 year old female

Possible Diazepam side effects in 31 year old female

Possible Diazepam side effects in 46 year old male

Possible Diazepam side effects in 31 year old female

Possible Diazepam side effects in female

Possible Diazepam side effects in female