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Depocyt (Cytarabine) - Deafness - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Deafness (5)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Depocyt (Cytarabine) where reactions include deafness. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Depocyt side effects in 14 year old male

Reported by a consumer/non-health professional from Norway on 2012-06-10

Patient: 14 year old male

Reactions: C-Reactive Protein, Listless, Arachnoiditis, Deafness, Pyrexia, Headache, Somnolence, Fall, Neurotoxicity, Fatigue, Chest Pain, Coordination Abnormal, Sinusitis, Decreased Appetite, Ataxia, Cognitive Disorder, Mucosal Inflammation, Medulloblastoma Recurrent, Dysarthria, Metastases To Spine, Visual Impairment, Hypothyroidism, Neutropenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Depocyt
    Dosage: initially given every other week,then monthly,cumulative dose 650mg,resatarted after 18months
    Indication: Medulloblastoma

Etoposide
    Dosage: 25 mg/day on alternate days; max 100mg daily (50 mg/m2 cumu dose:11.5 g/m2 over 31 months
    Administration route: Oral
    Indication: Medulloblastoma

Celecoxib
    Dosage: also taken 400mg bid 430mg/m2
    Administration route: Oral
    Indication: Medulloblastoma

Thalidomide
    Dosage: also taken 50mg 3mg/kg
    Administration route: Oral
    Indication: Medulloblastoma

Other drugs received by patient: Prednisolone Hydrogen Succinate; Dexamethasone



Possible Depocyt side effects in male

Reported by a health professional (non-physician/pharmacist) from Norway on 2012-05-30

Patient: male, weighing 75.0 kg (165.0 pounds)

Reactions: Confusional State, Listless, Arachnoiditis, Deafness, Pyrexia, Headache, Somnolence, Fall, Fatigue, C-Reactive Protein Increased, Chest Pain, Sinusitis, Decreased Appetite, Ataxia, Hypoaesthesia, Paraesthesia, Haematotoxicity, Mucosal Inflammation, Dysarthria, Anxiety, Neutropenia

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Etoposide
    Dosage: 25mg every other day for the last 8 months; cumulative dose of 11.5 g/m2 over 31 months
    Administration route: Oral

Thalidomide
    Dosage: maximal dose 200mg daily (3 mg/kg)
    Administration route: Oral
    Indication: Medulloblastoma Recurrent

Etoposide
    Dosage: maximal dose 100mg daily (50 mg/m2); cumulative dose of 11.5 g/m2 over 31 months
    Administration route: Oral
    Indication: Medulloblastoma Recurrent

Depocyt
    Dosage: 50mg on alternate weeks, gradually increased to every other month; 3-month break after 7th course
    Indication: Medulloblastoma Recurrent

Celecoxib
    Dosage: maximal dose 400mg x 2 daily (430 mg/m2)
    Administration route: Oral
    Indication: Medulloblastoma Recurrent

Other drugs received by patient: Prednisolone Sodium Succinate; Dexamethasone



Possible Depocyt side effects in male

Reported by a health professional (non-physician/pharmacist) from Norway on 2012-04-26

Patient: male

Reactions: Dysarthria, Visual Impairment, Hypothyroidism, Ataxia, Deafness, Coordination Abnormal, Cognitive Disorder

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Temozolomide
    Dosage: not reported

(Therapeutic Radiopharmaceuticals)
    Dosage: 35 gy, unknown, other

Vincristine Sulfate
    Dosage: not reported

Etoposide
    Dosage: not reported

Cyclophosphamide
    Dosage: not reported

Carboplatin
    Dosage: 700 mg/m 2 milligram(s)/sq. meter

Cisplatin
    Dosage: 80 mg/m 2 milligram(s)/sq. meter

Depocyt
    Dosage: 50 mg milligram(s), intrathecal

(Lomustine)
    Dosage: not reported



Possible Depocyt side effects in male

Reported by a physician from Norway on 2011-12-28

Patient: male, weighing 75.0 kg (165.0 pounds)

Reactions: Confusional State, Arachnoiditis, Ataxia, Deafness, Pyrexia, Hypoaesthesia, Headache, Somnolence, Fall, Paraesthesia, Anxiety, Dysarthria, C-Reactive Protein Increased, Chest Pain, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Depocyt

Other drugs received by patient: Dexamethasone; Thalidomide; Celecoxib; Prednisolone; Etoposide



Possible Depocyt side effects in male

Reported by a physician from Poland on 2011-10-07

Patient: male

Reactions: Inner Ear Disorder, Deafness

Drug(s) suspected as cause:
Depocyt

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