This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Depakote ER (Divalproex) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (137)
Death (1)
Life Threatening Events (4)
Disability (2)
Reports by Reaction Type
Convulsion (19),
Tremor (15),
Alopecia (12),
Drug Ineffective (10),
Dizziness (10),
Nausea (10),
Weight Increased (9),
Vomiting (9),
Weight Decreased (8),
Headache (8),
Fall (6),
Off Label Use (6)
Below are a few examples of reports where side effects / adverse reactions may be related to Depakote ER (Divalproex). For a complete list or a specific selection of reports, please use the links above.
Possible Depakote ER side effects in male
Reported by a physician from United States on 2012-08-23
Patient: male, weighing 72.1 kg (158.7 pounds)
Reactions: Blood Pressure Increased, Rash
Drug(s) suspected as cause:
Depakote ER
Possible Depakote ER side effects in 11 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-22
Patient: 11 year old female, weighing 66.2 kg (145.7 pounds)
Reactions: Product Substitution Issue, Drug Ineffective, Crying
Drug(s) suspected as cause:
Depakote ER
Dosage: 500 mg, 2xday, imd
Indication: Autism
Depakote ER
Dosage: 500 mg, 2xday, imd
Indication: Attention Deficit / Hyperactivity Disorder
Possible Depakote ER side effects in 48 year old male
Reported by a pharmacist from United States on 2012-08-14
Patient: 48 year old male
Reactions: Homicide, Physical Assault
Drug(s) suspected as cause:
Depakote ER
Indication: Mood Swings
Latuda
Administration route: Oral
Indication: Schizophrenia, Paranoid Type
Start date: 2011-12-15
End date: 2012-05-08
Possible Depakote ER side effects in female
Reported by a physician from United States on 2012-08-06
Patient: female, weighing 48.1 kg (105.9 pounds)
Reactions: Wrong Technique in Drug Usage Process, Rhabdomyolysis, Nausea, Rectal Ulcer, Incorrect Dose Administered, Compartment Syndrome, Nerve Compression, Abdominal Pain Upper, Malaise, Peroneal Nerve Palsy, Dehydration, Tendonitis, Mobility Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Depakote ER
Dosage: two 500 mg capsules at bedtime
Indication: Product Used FOR Unknown Indication
Humira
Indication: Crohn's Disease
Start date: 2009-03-01
Humira
Start date: 2010-05-01
Klonopin
Dosage: 2mg at bedtime
Klonopin
Dosage: 2.5mg qpm
Indication: Anxiety
Klonopin
Dosage: prn
Indication: Bipolar Disorder
Seroquel
Dosage: 400mg qpm
Indication: Product Used FOR Unknown Indication
Seroquel
Dosage: 300mg at bedtime
Other drugs received by patient: Canasa; Pentasa; VFL #3; Dexilant; Mirapex; VFL #3; Flexeril; Vyvanse; Stool Softener
Possible Depakote ER side effects in
Reported by a physician from United States on 2012-08-06
Patient:
Reactions: Drug Level Decreased
Drug(s) suspected as cause:
Depakote ER
Indication: Product Used FOR Unknown Indication
Depakote ER
Divalproex Sodium
Indication: Product Used FOR Unknown Indication
Possible Depakote ER side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-06
Patient: female, weighing 59.0 kg (129.8 pounds)
Reactions: Blood Test Abnormal
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Lorazepam
Possible Depakote ER side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: male
Reactions: Medication Residue
Drug(s) suspected as cause:
Depakote ER
Possible Depakote ER side effects in 20 year old female
Reported by a physician from United States on 2012-08-06
Patient: 20 year old female
Reactions: Weight Increased, Blood Prolactin Increased, Blood Testosterone Increased, Blood Thyroid Stimulating Hormone Decreased
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Unknown Concomitant Medications
Possible Depakote ER side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-06
Patient: female, weighing 47.2 kg (103.9 pounds)
Reactions: Hepatic Enzyme Increased
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Tylenol (Caplet); Multi-Vitamin; Naproxen; Olanzapine; Hydroxyzine
Possible Depakote ER side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: female, weighing 57.7 kg (126.8 pounds)
Reactions: Dizziness, Headache
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Unknown Thyroid Medication
Possible Depakote ER side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: female, weighing 77.2 kg (169.8 pounds)
Reactions: Dysmenorrhoea, Gingival Hypertrophy, Rash, Menorrhagia, Lymphoma
Drug(s) suspected as cause:
Depakote ER
Possible Depakote ER side effects in male
Reported by a pharmacist from United States on 2012-08-06
Patient: male
Reactions: Medication Residue
Drug(s) suspected as cause:
Depakote ER
Possible Depakote ER side effects in male
Reported by a pharmacist from United States on 2012-08-06
Patient: male
Reactions: Antipsychotic Drug Level Increased
Drug(s) suspected as cause:
Depakote ER
Possible Depakote ER side effects in 40 year old male
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: 40 year old male, weighing 95.3 kg (209.7 pounds)
Reactions: Impaired Driving Ability
Drug(s) suspected as cause:
Depakote ER
Possible Depakote ER side effects in 48 year old male
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: 48 year old male, weighing 113.5 kg (249.7 pounds)
Reactions: Nausea
Drug(s) suspected as cause:
Depakote ER
Possible Depakote ER side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: female, weighing 74.0 kg (162.8 pounds)
Reactions: Visual Impairment, Alopecia
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Lovastatin; Iron; Clonazepam; Metformin Hydrochloride; Lexapro; Nexium
Possible Depakote ER side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: male
Reactions: Convulsion
Drug(s) suspected as cause:
Depakote ER
Administration route: Oral
Start date: 2012-02-28
Depakote ER
Administration route: Oral
Indication: Convulsion
End date: 2011-11-26
Depakote ER
Administration route: Oral
Start date: 2011-11-26
End date: 2012-02-28
Possible Depakote ER side effects in 56 year old female
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: 56 year old female, weighing 54.5 kg (119.9 pounds)
Reactions: Abdominal Pain, Wrong Technique in Drug Usage Process, Somnolence, Off Label Use, Myalgia, Fatigue, DRY Mouth, Coordination Abnormal, Lethargy, LIP DRY, Stress, Tremor, Anxiety, Diarrhoea, Dermal Cyst, Vision Blurred
Drug(s) suspected as cause:
Depakote ER
Start date: 2012-03-24
End date: 2012-04-01
Depakote ER
Administration route: Oral
Indication: Anxiety
Start date: 2012-04-03
Other drugs received by patient: Klonopin; Zoloft
Possible Depakote ER side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: male
Reactions: Product Counterfeit, Product Packaging Issue, Drug Ineffective, Counterfeit Drug Administered, Product LOT Number Issue, Drug Level Decreased
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Lamictal; Dilantin; Dilantin; Lamictal
Possible Depakote ER side effects in male
Reported by a physician from United States on 2012-08-06
Patient: male
Reactions: White Blood Cell Count Decreased, Platelet Count Decreased
Drug(s) suspected as cause:
Depakote ER
Indication: Product Used FOR Unknown Indication
Seroquel
Indication: Product Used FOR Unknown Indication
Possible Depakote ER side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: female
Reactions: Medication Residue
Drug(s) suspected as cause:
Depakote ER
Indication: Migraine
Start date: 2011-05-01
Depakote ER
Indication: Vertigo CNS Origin
Other drugs received by patient: Effexor XR; Effexor XR
Possible Depakote ER side effects in male
Reported by a pharmacist from United States on 2012-08-06
Patient: male
Reactions: Off Label Use, Fatigue, Wrong Technique in Drug Usage Process, Depressed Level of Consciousness, Somnolence
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Risperidone; Tenex
Possible Depakote ER side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: male, weighing 63.6 kg (139.8 pounds)
Reactions: Paranoia, Parosmia, Delusion, Decreased Appetite
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Enbrel
Possible Depakote ER side effects in
Reported by a physician from United States on 2012-08-06
Patient:
Reactions: Hepatic Enzyme Increased
Drug(s) suspected as cause:
Depakote ER
Possible Depakote ER side effects in female
Reported by a physician from United States on 2012-08-06
Patient: female, weighing 79.9 kg (175.8 pounds)
Reactions: Weight Increased, Amenorrhoea, Polycystic Ovaries
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Singulair; Declined Full List
Possible Depakote ER side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: female, weighing 49.0 kg (107.9 pounds)
Reactions: Alopecia, Feeling Abnormal, Tremor
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Wellbutrin; Zoloft
Possible Depakote ER side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: female, weighing 54.0 kg (118.9 pounds)
Reactions: Rhinorrhoea
Drug(s) suspected as cause:
Depakote ER
Other drugs received by patient: Dilantin
Possible Depakote ER side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: female
Reactions: Anxiety, Drug Dose Omission, Movement Disorder, Malaise, Hyperacusis, Nausea, Photophobia, Asthenia
Drug(s) suspected as cause:
Depakote ER
Dosage: depakote
Start date: 1989-01-01
End date: 2008-01-01
Depakote ER
Indication: Convulsion
Start date: 2008-01-01
Possible Depakote ER side effects in female
Reported by a physician from United States on 2012-08-06
Patient: female, weighing 65.4 kg (143.8 pounds)
Reactions: Weight Increased, Pruritus, Rash
Drug(s) suspected as cause:
Amitriptyline HCL
Dosage: at hour of sleep
Administration route: Oral
Indication: Headache
Start date: 2011-10-05
Depakote ER
Dosage: at hour of sleep
Administration route: Oral
Indication: Headache
Start date: 2011-10-05
End date: 2011-10-30
Other drugs received by patient: Maxalt
Possible Depakote ER side effects in 23 year old female
Reported by a consumer/non-health professional from United States on 2012-08-06
Patient: 23 year old female, weighing 77.2 kg (169.8 pounds)
Reactions: Weight Increased, Alopecia, Tremor
Drug(s) suspected as cause:
Depakote ER
Indication: Bipolar Disorder
Start date: 2003-12-18
End date: 2009-10-03
Depakote ER
Dosage: 1 tablet in am and 2 tablets in pm
Administration route: Oral
Start date: 2011-05-23
Other drugs received by patient: Unknown Birth Control Pill; Wellbutrin; Zoloft; Wellbutrin; Prozac; Inderal
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