This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Definity (Perflutren) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (16)
Death (2)
Life Threatening Events (1)
Reports by Reaction Type
Back Pain (6),
Atrial Fibrillation (4),
Anxiety (4),
Pruritus (3),
Unresponsive To Stimuli (3),
Ejection Fraction Decreased (3),
Pain (2),
Headache (2),
Viith Nerve Paralysis (2),
Fatigue (2),
Neck Pain (2),
Chest Pain (2)
Possible Definity side effects in 58 year old female
Reported by a physician from United States on 2012-06-27
Patient: 58 year old female, weighing 127.0 kg (279.4 pounds)
Reactions: Myoclonus, Unresponsive To Stimuli, Temporal Lobe Epilepsy, Tardive Dyskinesia
Drug(s) suspected as cause:
Definity
Possible Definity side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-31
Patient: female, weighing 100.0 kg (220.0 pounds)
Reactions: Back Pain, Injection Related Reaction
Drug(s) suspected as cause:
Definity
Possible Definity side effects in 67 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-16
Patient: 67 year old female, weighing 120.0 kg (264.0 pounds)
Reactions: Back Pain, Anxiety, Acute Myocardial Infarction
Drug(s) suspected as cause:
Definity
Dosage: 2 ml definity diluted with 8 ml normal saline (1 ml), intravenous bolus
Indication: Cardiac Failure Congestive
Start date: 2012-04-28
End date: 2012-04-28
Definity
Dosage: 2 ml definity diluted with 8 ml normal saline (1 ml), intravenous bolus
Indication: Echocardiogram
Start date: 2012-04-28
End date: 2012-04-28
Definity
Dosage: 2 ml definity diluted with 8 ml normal saline (1 ml), intravenous bolus
Indication: Cardiac Failure Congestive
Start date: 2012-04-28
End date: 2012-04-28
Definity
Dosage: 2 ml definity diluted with 8 ml normal saline (1 ml), intravenous bolus
Indication: Echocardiogram
Start date: 2012-04-28
End date: 2012-04-28
Definity
Dosage: 2 ml definity diluted with 8 ml normal saline (1 ml), intravenous bolus
Indication: Cardiac Failure Congestive
Start date: 2012-04-28
End date: 2012-04-28
Definity
Dosage: 2 ml definity diluted with 8 ml normal saline (1 ml), intravenous bolus
Indication: Echocardiogram
Start date: 2012-04-28
End date: 2012-04-28
Other drugs received by patient: Lexapro; Iron; Lasix; Losartan Potassium; Metoprolol; Trazodone HCL; Augmentin '125'; Latanoprost; Methylprednisolone; Prandin (Deflazacort); Zocor; Lovenox; Lidocaine; Albuterol; Insulin; Magnesium Oxide; Aspirin; Ipratropium Bromide
Possible Definity side effects in 63 year old male
Reported by a physician from Germany on 2012-05-14
Patient: 63 year old male, weighing 66.0 kg (145.2 pounds)
Reactions: Syncope, Ejection Fraction Decreased, Congestive Cardiomyopathy, Disease Progression
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Definity
Dosage: 1 vial of definity with 8.7 ml of normal saline, intravenous
Indication: Product Used FOR Unknown Indication
Start date: 2011-10-19
End date: 2011-10-19
Definity
Dosage: 1 vial of definity with 8.7 ml of normal saline, intravenous
Indication: Product Used FOR Unknown Indication
Start date: 2010-10-08
End date: 2010-10-08
Definity
Dosage: 1 vial of definity with 8.7 ml of normal saline, intravenous
Indication: Product Used FOR Unknown Indication
Start date: 2011-06-29
End date: 2011-06-29
Definity
Dosage: 1 vial of definity with 8.7 ml of normal saline, intravenous
Indication: Product Used FOR Unknown Indication
Start date: 2010-09-29
End date: 2010-09-29
Other drugs received by patient: Theophylline; Aspirin; Metoprolol Tartrate; Spironolactone; Berodual (Fenoterol Hydrobromide, Ipratropium Bromide); Venlafaxine HCL; Albuterol Sulfate; Beclomethasone / Fenoterol (Beclometasone, Fenoterol); Ramipril; Digitoxin TAB; Topasemid (Torasemide)
Possible Definity side effects in 78 year old male
Reported by a physician from United States on 2012-05-09
Patient: 78 year old male, weighing 85.7 kg (188.6 pounds)
Reactions: Acute Pulmonary Oedema, Agitation, Pruritus, Angioedema, Rales, Wheezing, Delirium, Hypokalaemia, Sinus Tachycardia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Definity
Dosage: 1.5 ml definity diluted with 8.5 ml normal saline (0.5 ml), intravenous bolus
Indication: Cerebrovascular Accident
Start date: 2012-02-09
End date: 2012-02-09
Definity
Dosage: 1.5 ml definity diluted with 8.5 ml normal saline (0.5 ml), intravenous bolus
Indication: Echocardiogram
Start date: 2012-02-09
End date: 2012-02-09
Other drugs received by patient: Lopressor; Hyoscymaine (Hyoscyamine); Hydrodiuril; Zestril; Lipitor; Lovenox; Neurontin
Possible Definity side effects in 63 year old male
Reported by a physician from Germany on 2012-04-17
Patient: 63 year old male
Reactions: Syncope, Ejection Fraction Decreased, Bundle Branch Block Left
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Definity
Possible Definity side effects in 68 year old male
Reported by a consumer/non-health professional from United States on 2012-04-10
Patient: 68 year old male, weighing 97.5 kg (214.5 pounds)
Reactions: Back Pain, Pain in Extremity, Pain
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Definity
Possible Definity side effects in 58 year old male
Reported by a physician from United States on 2012-04-04
Patient: 58 year old male, weighing 144.2 kg (317.3 pounds)
Reactions: Dyspnoea, Pruritus, Unresponsive To Stimuli, Erythema, Flushing, Fatigue, Ocular Hyperaemia, Blood Pressure Decreased, NO Reaction ON Previous Exposure To Drug
Drug(s) suspected as cause:
Definity
Dosage: see image
Indication: Cardiomyopathy
Start date: 2012-03-22
End date: 2012-03-22
Definity
Dosage: see image
Indication: Echocardiogram
Start date: 2012-03-22
End date: 2012-03-22
Definity
Dosage: see image
Indication: Cardiomyopathy
Start date: 2012-03-22
End date: 2012-03-22
Definity
Dosage: see image
Indication: Echocardiogram
Start date: 2012-03-22
End date: 2012-03-22
Definity
Dosage: see image
Indication: Cardiomyopathy
Start date: 2012-03-22
End date: 2012-03-22
Definity
Dosage: see image
Indication: Echocardiogram
Start date: 2012-03-22
End date: 2012-03-22
Other drugs received by patient: Aspirin; Lasix; Quinapril HCL; Coreg
Possible Definity side effects in 44 year old male
Reported by a health professional (non-physician/pharmacist) from Germany on 2012-03-06
Patient: 44 year old male, weighing 120.0 kg (264.0 pounds)
Reactions: Nasopharyngitis, Ejection Fraction Decreased, Atrial Fibrillation, Respiratory Tract Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Definity
Other drugs received by patient: Ramipril; Spironolactone; Marcumar; Torsemide; LOC ZOK (Metoprolol Succinate)
Possible Definity side effects in 44 year old male
Reported by a health professional (non-physician/pharmacist) from Germany on 2012-03-06
Patient: 44 year old male, weighing 120.0 kg (264.0 pounds)
Reactions: Chest Pain, Atrial Fibrillation, Respiratory Tract Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Definity
Other drugs received by patient: Spironolactone; Marcumar; Metoprolol Succinate; Ramipril; Torsemide
Possible Definity side effects in female
Reported by a pharmacist from United States on 2012-03-02
Patient: female, weighing 103.1 kg (226.8 pounds)
Reactions: Back Pain, Anxiety, Dyspnoea, Fatigue, Pain, Chest Pain, Screaming, Tremor
Drug(s) suspected as cause:
Definity
Dosage: 3ml -1.5ml vial in 8.5ml ns-
Indication: Laboratory Test Interference
Definity
Dosage: 3ml -1.5ml vial in 8.5ml ns-
Indication: Echocardiogram
Possible Definity side effects in 78 year old male
Reported by a physician from United States on 2012-02-27
Patient: 78 year old male, weighing 85.7 kg (188.6 pounds)
Reactions: Acute Pulmonary Oedema, Pruritus
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Definity
Dosage: 1.5 ml definity diluted with 8.5 ml normal saline (0.5 ml) intravenous bolus
Indication: Echocardiogram
Start date: 2012-02-09
End date: 2012-02-09
Definity
Dosage: 1.5 ml definity diluted with 8.5 ml normal saline (0.5 ml) intravenous bolus
Indication: Cerebrovascular Accident
Start date: 2012-02-09
End date: 2012-02-09
Other drugs received by patient: Zestril; Lipitor; Hydrodiuril; Lovenox (Enoxaparin Sodiuim); Loppressor (Metoprolol Tartrate); Hyoscyamine (Hyoscyamine); Neurontin
Possible Definity side effects in 50 year old female
Reported by a physician from United States on 2011-12-15
Patient: 50 year old female, weighing 88.9 kg (195.6 pounds)
Reactions: Back Pain, Headache, Viith Nerve Paralysis, Anxiety, Dysarthria, Heart Rate Decreased, Neck Pain, Transient Ischaemic Attack, Blood Pressure Diastolic Decreased
Drug(s) suspected as cause:
Definity
Other drugs received by patient: Tylenol with Codeine (Codeine Phosphate, Paracetamol) (Tablet); Zoloft; Xanax; Aspirin; Potassium Supplement (Potassium); Lasix; Protonix (Pantoprazole Sodium Sesquihydrate)
Possible Definity side effects in 50 year old female
Reported by a physician from United States on 2011-12-06
Patient: 50 year old female, weighing 88.9 kg (195.6 pounds)
Reactions: Dysarthria, Back Pain, Anxiety, Neck Pain, Headache, Transient Ischaemic Attack, Viith Nerve Paralysis
Drug(s) suspected as cause:
Dobutamine (Dobutamine)
Dosage: 22.9 mg
Indication: Stress Echocardiogram
Start date: 2011-11-08
End date: 2011-11-08
Definity
Dosage: 1.5 ml definity diluted with 1.5 ml normal saline (0.5 ml, 5 in 1 d), intravenous bolus
Indication: Chest Pain
Start date: 2011-11-08
End date: 2011-11-08
Definity
Dosage: 1.5 ml definity diluted with 1.5 ml normal saline (0.5 ml, 5 in 1 d), intravenous bolus
Indication: Stress Echocardiogram
Start date: 2011-11-08
End date: 2011-11-08
Other drugs received by patient: Protonix (Pantoprazole Sodium Sesquihydrate); Xanax; Aspirin; Potassium Supplement (Potassium); Zoloft; Tylenol W / Codeine; Lasix
Possible Definity side effects in 69 year old male
Reported by a pharmacist from United States on 2011-10-12
Patient: 69 year old male, weighing 124.5 kg (273.9 pounds)
Reactions: Tachycardia, Unresponsive To Stimuli, Pulse Absent, Atrial Fibrillation, Oxygen Saturation Decreased
Adverse event resulted in: death
Drug(s) suspected as cause:
Definity
Possible Definity side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-07
Patient: male
Reactions: Cardio-Respiratory Arrest, Atrial Fibrillation, Loss of Consciousness, Pulseless Electrical Activity
Adverse event resulted in: death
Drug(s) suspected as cause:
Definity
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