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Cytoxan (Cyclophosphamide) - Pyrexia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Pyrexia (15)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Cytoxan (Cyclophosphamide) where reactions include pyrexia. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Cytoxan side effects in

Reported by a physician from Israel on 2012-07-28

Patient:

Reactions: Febrile Neutropenia, Hyponatraemia, Pyrexia, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Placebo
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Dexamethasone
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Vincristine Sulfate
    Dosage: 0.6 mg, qd
    Start date: 2012-06-24
    End date: 2012-06-24

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Ondansetron HCL
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Cytoxan
    Dosage: 172 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-19
    End date: 2012-06-20

Ondansetron
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2012-06-18
    End date: 2012-06-22

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded PRE Trial Therapy
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Dexamethasone
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Cisplatin
    Dosage: 46.2 mg/kg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Vincristine Sulfate
    Dosage: 0.66 mg, qd
    Start date: 2012-07-01
    End date: 2012-07-01

Etoposide
    Dosage: 33 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-20

Blinded PRE Trial Therapy
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Placebo
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Vincristine Sulfate
    Dosage: 0.66 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Post Trial Therapy
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded Ondansetron HCL
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded Post Trial Therapy
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Other drugs received by patient: Dexacort (Dexamethasone Sodium Phosphate); Mesna; Resprim; Diamox



Possible Cytoxan side effects in

Reported by a physician from Israel on 2012-07-17

Patient:

Reactions: Febrile Neutropenia, Hyponatraemia, Pyrexia, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Blinded Post Trial Therapy
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Ondansetron HCL
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Placebo
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded Post Trial Therapy
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded PRE Trial Therapy
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Cisplatin
    Dosage: 46.2 mg/kg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-18

Cytoxan
    Dosage: 172 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-19
    End date: 2012-06-20

Dexamethasone
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Vincristine Sulfate
    Dosage: 0.66 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-18

Dexamethasone
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Ondansetron HCL
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded PRE Trial Therapy
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Placebo
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Vincristine Sulfate
    Dosage: 0.6 mg, qd
    Start date: 2012-06-24
    End date: 2012-06-24

Etoposide
    Dosage: 33 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-20

Ondansetron
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2012-06-18
    End date: 2012-06-22

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Vincristine Sulfate
    Dosage: 0.66 mg, qd
    Start date: 2012-07-01
    End date: 2012-07-01

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Other drugs received by patient: Dexacort (Dexamethasone Sodium Phosphate); Resprim; Diamox; Mesna



Possible Cytoxan side effects in 12 year old female

Reported by a physician from Argentina on 2012-05-25

Patient: 12 year old female

Reactions: Acute Lymphocytic Leukaemia, Neutropenia, Pyrexia

Adverse event resulted in: death

Drug(s) suspected as cause:
Etoposide
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-07-01

Clolar
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-07-01

Cytoxan
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-07-01



Possible Cytoxan side effects in 10 year old male

Reported by a physician from United States on 2012-05-24

Patient: 10 year old male, weighing 22.3 kg (49.1 pounds)

Reactions: Pyrexia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin HCL
    Dosage: 27 mg, qd on day 1 and 5
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-03-31
    End date: 2012-05-01

Methylprednisolone Acetate
    Dosage: 9.7 mg, q8h on day 4 to day 32
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-03

Etoposide
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-10

Afinitor
    Dosage: 2 mg, qd on day 1 to day 32
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-03-31
    End date: 2012-05-01

Oncaspar
    Dosage: 2275 iu, qd on days 4 to 32
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-03-31
    End date: 2012-05-01

Vincristine
    Dosage: 1.4 mg, qd on day 4, 11, 18 and 25
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-03-31
    End date: 2012-05-01

Cytoxan
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-10

Other drugs received by patient: Leucovorin Calcium; Ondansetron; Senna-Mint WAF; Colace; Sulfamethoxypyrazine / Trimethoprim; Ondansetron; Concerta; Calcium Carbonate; Clonidine



Possible Cytoxan side effects in male

Reported by a physician from United States on 2012-05-18

Patient: male, weighing 169.0 kg (371.8 pounds)

Reactions: Staphylococcal Infection, Conjunctivitis, Blood Culture Positive, Ear Pain, Device Related Infection, Oropharyngeal Pain, Pyrexia, Cough, Influenza Like Illness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Rituximab (Moab C2b8 ATI Cd20, Chimeric)

Cytoxan

Vincristine Sulfate

Doxorubicin Hydrochloride

Prednisone TAB



Possible Cytoxan side effects in 49 year old female

Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2012-05-18

Patient: 49 year old female

Reactions: Pneumonia, Anaemia, Pancytopenia, Pyrexia, B Precursor Type Acute Leukaemia, Multi-Organ Failure, Death, Lymphocytosis, Dizziness, Asthenia, Septic Shock, Leukocytosis, Decreased Appetite

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cytoxan
    Dosage: 100 mg, unk
    Indication: Breast Cancer Stage II
    Start date: 2008-03-01

Epirubicin
    Indication: Breast Cancer Stage II
    Start date: 2008-03-01

Fluorouracil
    Indication: Breast Cancer Stage II
    Start date: 2008-03-01



Possible Cytoxan side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-14

Patient: male, weighing 81.8 kg (180.0 pounds)

Reactions: Neuropathy Peripheral, Arthralgia, Joint Swelling, Pyrexia, Herpes Zoster

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytoxan
    Start date: 2008-10-01
    End date: 2009-03-01

Rituxan
    Start date: 2008-10-01
    End date: 2009-03-01

Pentostatin
    Start date: 2008-10-01
    End date: 2008-12-01

Other drugs received by patient: Immune Globulin NOS; Clarinex-D; Valtrex; Gamimune; Steroids; Cyanocobalamin; Nexium; Levoxyl; Amlodipine Besylate; Vitamin B-12; Celebrex



Possible Cytoxan side effects in male

Reported by a consumer/non-health professional from United States on 2012-04-22

Patient: male, weighing 81.8 kg (180.0 pounds)

Reactions: Neuropathy Peripheral, Joint Swelling, Arthralgia, Pyrexia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Rituxan

Pentostatin

Cytoxan
    Start date: 2008-10-01
    End date: 2009-03-01

Other drugs received by patient: Amlodipine Besylate; Nexium; Levoxyl; Cyanocobalamin; Valtrex; Clarinex-D; Vitamin B-12; Celebrex



Possible Cytoxan side effects in female

Reported by a individual with unspecified qualification from United States on 2012-04-18

Patient: female, weighing 96.6 kg (212.5 pounds)

Reactions: Pyrexia, Asthenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Prednisone TAB
    Administration route: Oral
    Indication: Diffuse Large B-Cell Lymphoma
    Start date: 2011-11-14
    End date: 2012-02-19

Doxorubicin HCL
    Indication: Diffuse Large B-Cell Lymphoma
    Start date: 2011-11-14
    End date: 2012-02-15

Vincristine
    Indication: Diffuse Large B-Cell Lymphoma
    Start date: 2011-11-14
    End date: 2012-02-15

Velcade
    Indication: Diffuse Large B-Cell Lymphoma
    Start date: 2011-11-14
    End date: 2011-12-27

Cytoxan
    Indication: Diffuse Large B-Cell Lymphoma
    Start date: 2011-11-14
    End date: 2012-02-15

Rituximab
    Indication: Diffuse Large B-Cell Lymphoma
    Start date: 2011-11-14
    End date: 2012-02-15



Possible Cytoxan side effects in 74 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-26

Patient: 74 year old male, weighing 81.2 kg (178.6 pounds)

Reactions: Excoriation, Anaemia, Hypotension, Neutropenic Sepsis, Tachycardia, Mental Status Changes, Atrial Fibrillation, Pyrexia, Fall, Cardiac Failure, Diarrhoea, Neutropenia, Cardiac Arrest, Lethargy, Cough

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Prednisone
    Administration route: Oral
    Start date: 2012-02-02
    End date: 2012-02-15

Lasix
    Indication: Cardiac Disorder
    End date: 2012-02-22

Matulane
    Administration route: Oral
    Start date: 2012-02-02
    End date: 2012-02-15

Spironolactone
    Indication: Cardiac Disorder
    End date: 2012-02-22

Coreg
    Indication: Cardiac Disorder
    End date: 2012-02-22

Cytoxan
    Start date: 2012-02-09
    End date: 2012-02-16

Lisinopril
    Indication: Cardiac Disorder
    End date: 2012-02-22

Vinblastine Sulfate
    Start date: 2012-02-09
    End date: 2012-02-16

Other drugs received by patient: Levofloxacin; Prevacid; Tamsulosin HCL; Klor-CON; Folic Acid; Multi-Vitamins; Bleomycin Sulfate; Dacarbazine; Lidocaine; Zofran; Doxorubicin HCL



Possible Cytoxan side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-05

Patient: 54 year old male, weighing 119.0 kg (261.8 pounds)

Reactions: Nasopharyngitis, Dyspnoea, Oropharyngeal Pain, Pyrexia, Cough

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Acyclovir Sodium
    Dosage: 100 mg mwf cycle 1, then 878 d1 cycle 2-6
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-03-14
    End date: 2011-08-02

Cytoxan
    Dosage: 1404 mg on d1 c1-6, wks 1, 5, 9, 13, 17 and 21, intravenous (not otherwise specified)
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-03-14
    End date: 2011-08-02

Campath
    Dosage: 30 mg, tiw x 4 weeks, subcutaneous
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-10-31
    End date: 2011-11-25

Nipent
    Dosage: 9.36 mg on day 1 c1-6, intravenous (not otherwise specified)
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-03-14
    End date: 2011-08-02

Other drugs received by patient: Bactrim DS; Acyclovir



Possible Cytoxan side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-23

Patient: female

Reactions: Vomiting, Posture Abnormal, Pyrexia, Muscle Spasms

Drug(s) suspected as cause:
Cytoxan



Possible Cytoxan side effects in 49 year old male

Reported by a health professional (non-physician/pharmacist) from China on 2011-11-08

Patient: 49 year old male

Reactions: Dyspnoea, Diabetes Mellitus, Folliculitis, Pseudomonas Infection, Purpura, Pyrexia, Herpes Zoster, Tremor, Pneumocystis Jiroveci Pneumonia, Fatigue, Vision Blurred, Escherichia Infection, Candidiasis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Prednisone
    Dosage: 70 mg, daily
    Indication: Pemphigus

Cytoxan
    Dosage: unk
    Indication: Pemphigus



Possible Cytoxan side effects in 76 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-28

Patient: 76 year old female, weighing 66.0 kg (145.2 pounds)

Reactions: Pancytopenia, Pyrexia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytoxan
    Dosage: 1 2 3 qcycle
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-06-22

Cytoxan
    Dosage: 1 2 3 qcycle
    Indication: B-Cell Small Lymphocytic Lymphoma
    Start date: 2011-04-19
    End date: 2011-06-22

Rituxan
    Dosage: 1 2 3 qcycle
    Indication: B-Cell Small Lymphocytic Lymphoma
    Start date: 2011-04-19
    End date: 2011-06-21

Fludarabine Phosphate
    Dosage: 1 2 3 qcycle
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-06-22

Fludarabine Phosphate
    Dosage: 1 2 3 qcycle
    Indication: B-Cell Small Lymphocytic Lymphoma
    Start date: 2011-04-19
    End date: 2011-06-22

Rituxan
    Dosage: 1 2 3 qcycle
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-06-21



Possible Cytoxan side effects in 70 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-12

Patient: 70 year old female, weighing 60.0 kg (132.0 pounds)

Reactions: Arthralgia, Diarrhoea, Pyrexia, Headache

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Rituximab
    Dosage: day 4 every 28 days x 6 cycles
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-05-02

Fludarabine Phosphate
    Dosage: day 1-3 every days x 6 cycles
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-05-02

Cytoxan
    Dosage: day1-3 every 28 days x cycle
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-05-02

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