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Cytoxan (Cyclophosphamide) - Pancytopenia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Pancytopenia (11)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Cytoxan (Cyclophosphamide) where reactions include pancytopenia. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Cytoxan side effects in male

Reported by a consumer/non-health professional from United States on 2012-05-25

Patient: male, weighing 21.3 kg (46.9 pounds)

Reactions: B-Cell Lymphoma, Hypotension, Alanine Aminotransferase Increased, Pancytopenia, Roseolovirus Test Positive, Aspartate Aminotransferase Increased, Venoocclusive Liver Disease, Acute Respiratory Distress Syndrome, Renal Failure Acute

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Mesna
    Indication: Product Used FOR Unknown Indication

Fludarabine Phosphate
    Indication: Product Used FOR Unknown Indication

Velcade
    Dosage: 1.3 mg/m2, cyclic
    Indication: B-Cell Lymphoma
    Start date: 2011-12-27
    End date: 2012-01-06

Cytoxan
    Indication: Product Used FOR Unknown Indication



Possible Cytoxan side effects in female

Reported by a physician from United States on 2012-05-23

Patient: female, weighing 85.0 kg (187.0 pounds)

Reactions: Vomiting, Urinary Tract Infection, Pancytopenia, Clostridium Difficile Colitis, Dysfunctional Uterine Bleeding, Pelvic Pain, Fall, Decubitus Ulcer, Metastases To Bone, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Velcade
    Dosage: 2.7 mg, cyclic
    Indication: Multiple Myeloma
    Start date: 2011-11-08
    End date: 2012-02-24

Velcade
    Dosage: 2.7 mg, cyclic
    Start date: 2012-05-01

Decadron
    Dosage: 40 mg, cyclic
    Administration route: Oral
    Start date: 2012-05-01

Cytoxan

Decadron
    Dosage: 40 mg, cyclic
    Administration route: Oral
    Indication: Multiple Myeloma

Cytoxan
    Indication: Multiple Myeloma

Other drugs received by patient: Peridex / 00133002 /; Neurontin; Oxycodone Hydrochloride; Protonix; Antibiotics; Potassium Chloride; Oxycodone and Acetaminophen



Possible Cytoxan side effects in 49 year old female

Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2012-05-18

Patient: 49 year old female

Reactions: Pneumonia, Anaemia, Pancytopenia, Pyrexia, B Precursor Type Acute Leukaemia, Multi-Organ Failure, Death, Lymphocytosis, Dizziness, Asthenia, Septic Shock, Leukocytosis, Decreased Appetite

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cytoxan
    Dosage: 100 mg, unk
    Indication: Breast Cancer Stage II
    Start date: 2008-03-01

Epirubicin
    Indication: Breast Cancer Stage II
    Start date: 2008-03-01

Fluorouracil
    Indication: Breast Cancer Stage II
    Start date: 2008-03-01



Possible Cytoxan side effects in female

Reported by a physician from United States on 2012-05-18

Patient: female, weighing 94.2 kg (207.2 pounds)

Reactions: Confusional State, Hepatic Function Abnormal, Unresponsive To Stimuli, Post Procedural Complication, Tachycardia, Aphasia, Musculoskeletal Stiffness, Pathogen Resistance, Lethargy, Crying, Febrile Neutropenia, Pancytopenia, Meningism, Computerised Tomogram Abnormal, Dysarthria, Activities of Daily Living Impaired, Enterococcus Test Positive, Pancreatitis, Hypertension, Asthenia, Intracranial Hypotension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Dosage: 45 mg

Cytoxan
    Dosage: 2000 mg

Cytarabine
    Dosage: 1200 mg

Mercaptopurine
    Dosage: 1750 mg

Vincristine Sulfate
    Dosage: 2 mg



Possible Cytoxan side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-07

Patient: female, weighing 85.0 kg (187.0 pounds)

Reactions: Vomiting, Urinary Tract Infection, Pancytopenia, Clostridium Difficile Colitis, Dysfunctional Uterine Bleeding, Pelvic Pain, Fall, Decubitus Ulcer, Metastases To Bone, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Decadron
    Dosage: 40 mg, cyclic
    Administration route: Oral
    Indication: Multiple Myeloma

Velcade
    Dosage: 2.7 mg, cyclic
    Indication: Multiple Myeloma
    Start date: 2011-11-08
    End date: 2012-02-24

Cytoxan
    Indication: Multiple Myeloma

Other drugs received by patient: Antibiotics; Protonix; Peridex / 00133002 /; Oxycodone and Acetaminophen; Oxycodone HCL; Neurontin; Potassium Chloride



Possible Cytoxan side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-24

Patient: male, weighing 58.0 kg (127.6 pounds)

Reactions: Vomiting, Nausea, Hypotension, Candida Sepsis, Pancytopenia, Multi-Organ Failure, Small Intestinal Obstruction, Dehydration, Pulmonary Oedema, Pleural Effusion

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cytoxan
    Dosage: 350 milligram
    Administration route: Oral
    Indication: Amyloidosis
    Start date: 2008-08-28
    End date: 2009-08-10

Dexamethasone
    Dosage: 40 milligram

Revlimid
    Dosage: 15 milligram
    Administration route: Oral
    Indication: Amyloidosis
    Start date: 2008-08-28
    End date: 2009-08-10

Cytoxan
    Dosage: 300 milligram/sq. meter
    Administration route: Oral

Avastin
    Indication: Pleural Effusion

Dexamethasone
    Dosage: 20 milligram
    Indication: Amyloidosis
    Start date: 2008-08-28
    End date: 2009-08-10

Other drugs received by patient: Aldactone; Lasix; Nitroglycerin; Dobutamine HCL; RED Blood Cells; Crestor; Neupogen; Colace; Zetia; Acyclovir; Aspirin; Multi-Vitamin; Platelets; Ambien; Neupogen; Bactrim; Xopenex HFA; Zosyn; Phenylephrine HCL



Possible Cytoxan side effects in 81 year old female

Reported by a consumer/non-health professional from United States on 2012-04-10

Patient: 81 year old female

Reactions: Small Intestinal Obstruction, Herpes Simplex, Urinary Tract Infection Fungal, Febrile Neutropenia, Pancytopenia, Electrolyte Imbalance, Enteritis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytoxan
    Indication: B-Cell Small Lymphocytic Lymphoma
    Start date: 2011-11-18
    End date: 2012-01-16

Rituximab
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-11-18
    End date: 2012-01-16

Dexamethasone
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-11-18
    End date: 2012-01-16

Vincristine
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-11-18
    End date: 2012-01-16

Rituximab
    Indication: B-Cell Small Lymphocytic Lymphoma
    Start date: 2011-11-18
    End date: 2012-01-16

Dexamethasone
    Indication: B-Cell Small Lymphocytic Lymphoma
    Start date: 2011-11-18
    End date: 2012-01-16

Cytoxan
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-11-18
    End date: 2012-01-16

Vincristine
    Indication: B-Cell Small Lymphocytic Lymphoma
    Start date: 2011-11-18
    End date: 2012-01-16



Possible Cytoxan side effects in 75 year old female

Reported by a physician from United States on 2012-03-23

Patient: 75 year old female

Reactions: Pancytopenia, Light Chain Analysis Increased

Drug(s) suspected as cause:
Revlimid
    Dosage: 10 mg, 1 ub 1 d, po; 5-10mg, daily, po, 10 mg, 1 in 1 d, po
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2010-05-01
    End date: 2011-02-10

Revlimid
    Dosage: 10 mg, 1 ub 1 d, po; 5-10mg, daily, po, 10 mg, 1 in 1 d, po
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2009-06-01
    End date: 2009-01-01

Revlimid
    Dosage: 10 mg, 1 ub 1 d, po; 5-10mg, daily, po, 10 mg, 1 in 1 d, po
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2009-09-01
    End date: 2010-01-01

Cytoxan
    Indication: Multiple Myeloma
    Start date: 2011-01-01
    End date: 2011-01-01

Other drugs received by patient: Velcade; Prednisone TAB



Possible Cytoxan side effects in 58 year old female

Reported by a consumer/non-health professional from United States on 2011-11-23

Patient: 58 year old female

Reactions: Tumour Lysis Syndrome, Urinary Tract Infection, Pancytopenia, Febrile Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytoxan
    Dosage: d1-3. q28d
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-07-26
    End date: 2011-07-26

Fludarabine Phosphate
    Dosage: d1-3.q28d
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-07-26
    End date: 2011-07-26

Rituxan
    Dosage: d1 q28d
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-07-26
    End date: 2011-07-26



Possible Cytoxan side effects in 46 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-17

Patient: 46 year old female

Reactions: Plasmacytoma, Pancytopenia, Cardiomyopathy

Drug(s) suspected as cause:
Revlimid
    Dosage: caps; 17aug09 to 29dec09(134d) 21sep2010 to unk(15mg);last dose:02dec2010
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2009-08-17

Etoposide
    Start date: 2010-01-08

Platinol
    Start date: 2010-01-08

Cytoxan
    Indication: Multiple Myeloma
    Start date: 2010-09-21

Velcade
    Indication: Multiple Myeloma
    Start date: 2009-08-17
    End date: 2009-12-29

Adriamycin PFS
    Start date: 2010-01-08

Dexamethasone
    Dosage: 17aug09 to 29dec09(134d) 21sep2010 to unk
    Indication: Multiple Myeloma
    Start date: 2009-08-17



Possible Cytoxan side effects in 76 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-28

Patient: 76 year old female, weighing 66.0 kg (145.2 pounds)

Reactions: Pancytopenia, Pyrexia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytoxan
    Dosage: 1 2 3 qcycle
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-06-22

Cytoxan
    Dosage: 1 2 3 qcycle
    Indication: B-Cell Small Lymphocytic Lymphoma
    Start date: 2011-04-19
    End date: 2011-06-22

Rituxan
    Dosage: 1 2 3 qcycle
    Indication: B-Cell Small Lymphocytic Lymphoma
    Start date: 2011-04-19
    End date: 2011-06-21

Fludarabine Phosphate
    Dosage: 1 2 3 qcycle
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-06-22

Fludarabine Phosphate
    Dosage: 1 2 3 qcycle
    Indication: B-Cell Small Lymphocytic Lymphoma
    Start date: 2011-04-19
    End date: 2011-06-22

Rituxan
    Dosage: 1 2 3 qcycle
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2011-04-19
    End date: 2011-06-21

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