DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Cytoxan (Cyclophosphamide) - Side Effect Reports to FDA

 
 



This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Cytoxan (Cyclophosphamide) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.

Reports by Event Outcome

All Cases (180)
Death (30)
Life Threatening Events (9)
Disability (7)

Reports by Reaction Type

Pyrexia (15)Neuropathy Peripheral (11)Pancytopenia (11)Febrile Neutropenia (11)Respiratory Disorder (9)Fall (9)Neutropenia (9)Asthenia (8)Off Label Use (7)Dyspnoea (7)Vomiting (7)Hypotension (7)

Below are a few examples of reports where side effects / adverse reactions may be related to Cytoxan (Cyclophosphamide). For a complete list or a specific selection of reports, please use the links above.

Possible Cytoxan side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: , weighing 1.9 kg (4.3 pounds)

Reactions: Foetal Growth Restriction

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Stage I

Cytoxan
    Indication: Breast Cancer Stage I

Fluorouracil
    Indication: Breast Cancer Stage I

Paclitaxel
    Indication: Breast Cancer Stage I



Possible Cytoxan side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: female

Reactions: Maternal Exposure During Pregnancy, PRE-Eclampsia

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Stage II

Cytoxan
    Indication: Breast Cancer Stage II

Paclitaxel
    Indication: Breast Cancer Stage II



Possible Cytoxan side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: , weighing 2.4 kg (5.3 pounds)

Reactions: Neutropenia Neonatal, Pyloric Stenosis

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Stage III

Cytoxan
    Indication: Breast Cancer Stage III

Docetaxel
    Indication: Breast Cancer Stage III

Paclitaxel
    Indication: Breast Cancer Stage III



Possible Cytoxan side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: , weighing 1.4 kg (3.1 pounds)

Reactions: Selective IGA Immunodeficiency, Neonatal Respiratory Distress Syndrome, Premature Baby, Gastrooesophageal Reflux Disease, Apnoea, Constipation

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Stage II

Cytoxan
    Indication: Breast Cancer Stage II

Paclitaxel
    Indication: Breast Cancer Stage II



Possible Cytoxan side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: female

Reactions: Maternal Exposure During Pregnancy, Uterine Contractions During Pregnancy

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Stage I

Cytoxan
    Indication: Breast Cancer Stage I

Fluorouracil
    Indication: Breast Cancer Stage I

Paclitaxel
    Indication: Breast Cancer Stage I



Possible Cytoxan side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: female

Reactions: Maternal Exposure During Pregnancy, PRE-Eclampsia

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Stage II

Cytoxan
    Indication: Breast Cancer Stage II

Paclitaxel
    Indication: Breast Cancer Stage II



Possible Cytoxan side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: female

Reactions: Pneumocystis Jiroveci Pneumonia, Maternal Exposure During Pregnancy, Neutropenia, Premature Labour

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Stage II

Cytoxan
    Indication: Breast Cancer Stage II

Paclitaxel
    Indication: Breast Cancer Stage II



Possible Cytoxan side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: , weighing 2.5 kg (5.4 pounds)

Reactions: Foetal Growth Restriction, Foetal Exposure During Pregnancy

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Stage III

Cytoxan
    Indication: Breast Cancer Stage III

Paclitaxel
    Indication: Breast Cancer Stage III



Possible Cytoxan side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: , weighing 2.1 kg (4.7 pounds)

Reactions: Hyperbilirubinaemia

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Stage II

Cytoxan
    Indication: Breast Cancer Stage II

Paclitaxel
    Indication: Breast Cancer Stage II



Possible Cytoxan side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: female

Reactions: Premature Rupture of Membranes, Maternal Exposure During Pregnancy, Uterine Contractions During Pregnancy

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Stage I

Cytoxan
    Indication: Breast Cancer Stage I

Paclitaxel
    Indication: Breast Cancer Stage I



Possible Cytoxan side effects in 57 year old female

Reported by a individual with unspecified qualification from United States on 2012-08-22

Patient: 57 year old female

Reactions: Hypogammaglobulinaemia

Drug(s) suspected as cause:
Cytoxan
    Indication: T-Cell Lymphoma

Rituximab
    Indication: T-Cell Lymphoma

Other drugs received by patient: Tacrolimus; Azathioprine Sodium; Bexarotene; Alemtuzumab; Alemtuzumab



Possible Cytoxan side effects in female

Reported by a physician from United States on 2012-08-06

Patient: female

Reactions: Breast Cancer, Asthenia

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Breast Cancer Metastatic

Cytoxan
    Indication: Breast Cancer Metastatic

Herceptin
    Indication: Breast Cancer Metastatic



Possible Cytoxan side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-03

Patient: male

Reactions: Back Pain, Death

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cytoxan
    Dosage: 1620 mg, cyclic
    Indication: Multiple Myeloma
    Start date: 2011-09-08
    End date: 2011-09-08

Dexamethasone
    Dosage: 40 mg, cyclic
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2011-09-08
    End date: 2011-10-13

Velcade
    Dosage: 2 mg, cyclic
    Indication: Multiple Myeloma
    Start date: 2011-09-08
    End date: 2011-10-05



Possible Cytoxan side effects in

Reported by a physician from Israel on 2012-07-28

Patient:

Reactions: Febrile Neutropenia, Hyponatraemia, Pyrexia, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded Ondansetron HCL
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Ondansetron HCL
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded Post Trial Therapy
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Post Trial Therapy
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded PRE Trial Therapy
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded PRE Trial Therapy
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Cisplatin
    Dosage: 46.2 mg/kg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-18

Cytoxan
    Dosage: 172 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-19
    End date: 2012-06-20

Dexamethasone
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Dexamethasone
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Etoposide
    Dosage: 33 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-20

Ondansetron
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2012-06-18
    End date: 2012-06-22

Placebo
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Placebo
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Vincristine Sulfate
    Dosage: 0.6 mg, qd
    Start date: 2012-06-24
    End date: 2012-06-24

Vincristine Sulfate
    Dosage: 0.66 mg, qd
    Start date: 2012-07-01
    End date: 2012-07-01

Vincristine Sulfate
    Dosage: 0.66 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-18

Other drugs received by patient: Dexacort (Dexamethasone Sodium Phosphate); Mesna; Resprim; Diamox



Possible Cytoxan side effects in male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-19

Patient: male, weighing 76.0 kg (167.2 pounds)

Reactions: Hypothyroidism

Drug(s) suspected as cause:
Cytoxan

Other drugs received by patient: Laxoberon; Lendormin; Zithromax; Sennoside A+B Calcium; Loxoprofen; Amaryl; Brocin-Codeine



Possible Cytoxan side effects in

Reported by a physician from Israel on 2012-07-17

Patient:

Reactions: Febrile Neutropenia, Hyponatraemia, Pyrexia, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Aprepitant
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Ondansetron HCL
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded Ondansetron HCL
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Post Trial Therapy
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded Post Trial Therapy
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Blinded PRE Trial Therapy
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Blinded PRE Trial Therapy
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Cisplatin
    Dosage: 46.2 mg/kg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-18

Cytoxan
    Dosage: 172 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-19
    End date: 2012-06-20

Dexamethasone
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Dexamethasone
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Etoposide
    Dosage: 33 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-20

Ondansetron
    Administration route: Oral
    Indication: Prophylaxis of Nausea and Vomiting
    Start date: 2012-06-18
    End date: 2012-06-22

Placebo
    Administration route: Oral
    Start date: 2012-06-19
    End date: 2012-06-20

Placebo
    Administration route: Oral
    Start date: 2012-06-18
    End date: 2012-06-18

Vincristine Sulfate
    Dosage: 0.66 mg, qd
    Indication: Chemotherapy
    Start date: 2012-06-18
    End date: 2012-06-18

Vincristine Sulfate
    Dosage: 0.6 mg, qd
    Start date: 2012-06-24
    End date: 2012-06-24

Vincristine Sulfate
    Dosage: 0.66 mg, qd
    Start date: 2012-07-01
    End date: 2012-07-01

Other drugs received by patient: Dexacort (Dexamethasone Sodium Phosphate); Resprim; Diamox; Mesna



Possible Cytoxan side effects in

Reported by a individual with unspecified qualification from United States on 2012-07-16

Patient:

Reactions: Multi-Organ Failure, Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytoxan
    Administration route: Oral
    Indication: Amyloidosis

Dexamethasone
    Administration route: Oral
    Indication: Amyloidosis

Lenalidomide
    Administration route: Oral
    Indication: Amyloidosis



Possible Cytoxan side effects in

Reported by a physician from United States on 2012-07-16

Patient:

Reactions: Small Intestinal Obstruction

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytoxan
    Administration route: Oral
    Indication: Amyloidosis

Dexamethasone
    Administration route: Oral
    Indication: Amyloidosis

Lenalidomide
    Administration route: Oral
    Indication: Amyloidosis



Possible Cytoxan side effects in

Reported by a individual with unspecified qualification from United States on 2012-07-06

Patient:

Reactions: Renal Failure

Adverse event resulted in: death

Drug(s) suspected as cause:
Bortezomib
    Indication: Multiple Myeloma

Bortezomib

Cytoxan
    Administration route: Oral
    Indication: Multiple Myeloma

Dexamethasone
    Indication: Multiple Myeloma

Lenalidomide
    Indication: Multiple Myeloma



Possible Cytoxan side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-29

Patient: male, weighing 128.1 kg (281.8 pounds)

Reactions: Musculoskeletal Pain, Anaemia, Mental Status Changes, Multiple Myeloma, Hypercalcaemia, Osteonecrosis, Fatigue, Gait Disturbance, Thrombocytopenia, Pathological Fracture

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Cytoxan

Dexamethasone
    Indication: Product Used FOR Unknown Indication

Etoposide
    Indication: Product Used FOR Unknown Indication

Revlimid
    Indication: Product Used FOR Unknown Indication

Velcade
    Dosage: unk
    Start date: 2012-05-03

Velcade
    Dosage: 1.3 mg, cyclic
    Indication: Multiple Myeloma
    Start date: 2012-03-07
    End date: 2012-04-23

Other drugs received by patient: Metoprolol Succinate; Ramipril; Duloxetime Hydrochloride; Glucophage; Catapres / 00171101 /; Allopurinol; Cymbalta; Percocet; Zometa; Ativan; Ascriptin A / D



Possible Cytoxan side effects in

Reported by a individual with unspecified qualification from United States on 2012-06-28

Patient:

Reactions: Vasculitis Cerebral

Drug(s) suspected as cause:
Bortezomib
    Indication: non-Hodgkin's Lymphoma

Cytoxan
    Administration route: Oral
    Indication: non-Hodgkin's Lymphoma

Rituximab
    Indication: non-Hodgkin's Lymphoma

[pss Gpn] Dexamethasone Solution FOR Infusion Dosette Vial 4 MG
    Administration route: Oral
    Indication: non-Hodgkin's Lymphoma



Possible Cytoxan side effects in 63 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-06-28

Patient: 63 year old male

Reactions: Fungal Infection, Bone Marrow Failure

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytoxan
    Start date: 2011-06-07
    End date: 2011-06-07

Solu-Medrol
    Start date: 2011-06-03
    End date: 2011-06-06

Solu-Medrol
    Start date: 2011-06-07



Possible Cytoxan side effects in male

Reported by a consumer/non-health professional from United States on 2012-06-26

Patient: male, weighing 227.0 kg (499.4 pounds)

Reactions: Osteoarthritis, Neuropathy Peripheral, Peroneal Nerve Palsy, Obesity, Fall

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytoxan
    Indication: Multiple Myeloma
    Start date: 2011-03-29
    End date: 2012-03-06

Decadron
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2011-03-29
    End date: 2012-03-06

Velcade
    Indication: Multiple Myeloma
    Start date: 2011-03-29
    End date: 2012-03-06

Other drugs received by patient: Zovirax; Zometa; Palonosetron



Possible Cytoxan side effects in male

Reported by a physician from Ireland on 2012-06-25

Patient: male, weighing 70.0 kg (154.0 pounds)

Reactions: Confusional State, Aphasia, Urinary Incontinence, Hemiparesis, Cerebrovascular Accident, Multi-Organ Failure, Dysarthria, Respiratory Failure, Nervous System Disorder, Asthenia, Progressive Multifocal Leukoencephalopathy, Decreased Appetite

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Colchicine
    Indication: Product Used FOR Unknown Indication

Cytoxan
    Administration route: Oral
    Indication: Rheumatoid Vasculitis

Cytoxan
    Administration route: Oral
    End date: 2007-08-01

Plaquenil
    Indication: Product Used FOR Unknown Indication

Plaquenil

Prednisone
    Indication: Vasculitis

Prednisone

Remicade
    Indication: Rheumatoid Arthritis
    End date: 2007-08-01

Remicade
    Indication: Vasculitis
    End date: 2007-08-01

Other drugs received by patient: Flecainide Acetate; Atenolol; Lasix; Theo-DUR; Aspirin; Hytrin; Restoril; Potassium Acetate



Possible Cytoxan side effects in 51 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-25

Patient: 51 year old male

Reactions: Osteoarthritis, Neuropathy Peripheral, Peroneal Nerve Palsy, Musculoskeletal Pain, Obesity, Fall, Paraesthesia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytoxan
    Dosage: 900 mg, 1/week
    Indication: Multiple Myeloma
    Start date: 2011-03-29
    End date: 2011-12-13

Decadron
    Dosage: 40 mg, 1/week
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2011-03-29
    End date: 2011-12-13

Velcade
    Dosage: 3.5 mg, 1/week
    Indication: Multiple Myeloma
    Start date: 2011-03-29
    End date: 2011-12-13



Possible Cytoxan side effects in 77 year old male

Reported by a physician from United States on 2012-06-21

Patient: 77 year old male

Reactions: Mycobacterium Kansasii Infection, Pulmonary Mass

Drug(s) suspected as cause:
Cytoxan
    Indication: Wegener's Granulomatosis

Remicade
    Indication: Wegener's Granulomatosis

Other drugs received by patient: Rituxan; Prednisone TAB; Methotrexate



Possible Cytoxan side effects in 24 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-15

Patient: 24 year old female

Reactions: Cognitive Disorder

Drug(s) suspected as cause:
Adriamycin PFS
    Dosage: no of cycles 4
    Indication: Breast Cancer

Cytoxan
    Dosage: no of cycles 4
    Indication: Breast Cancer

Taxol
    Dosage: no of cycles 4
    Indication: Breast Cancer



Possible Cytoxan side effects in 63 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-06-15

Patient: 63 year old male

Reactions: Fungal Infection, Bone Marrow Failure

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytoxan
    Start date: 2011-06-07
    End date: 2011-06-07

Solu-Medrol
    Start date: 2011-06-07

Solu-Medrol
    Start date: 2011-06-03
    End date: 2011-06-06



Possible Cytoxan side effects in 70 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-13

Patient: 70 year old male

Reactions: Renal Failure, Tumour Lysis Syndrome

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cytoxan
    Indication: Lymphoma

Matulane
    Dosage: 50 mg; bid; po
    Administration route: Oral
    Indication: Lymphoma
    Start date: 2012-05-04

Rituxan
    Indication: Lymphoma

Vincristine
    Indication: Lymphoma



Possible Cytoxan side effects in 74 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-08

Patient: 74 year old male, weighing 90.3 kg (198.7 pounds)

Reactions: Cystitis Noninfective

Drug(s) suspected as cause:
Cytoxan
    Dosage: 600 mg/m2, on day 1 of each cycle
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2012-01-23
    End date: 2012-04-17

Pentostatin
    Dosage: 4 mg/m2, on day 1 of each cycle
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2012-01-23
    End date: 2012-04-17

Rituximab
    Dosage: 100 mg, day 1, 375 mg/m2 day 3 and 5, and days 1 of week 5,9,13,17 and 21
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2012-01-23
    End date: 2012-04-17

Other drugs received by patient: Acyclovir; Digoxin; Actos; Spiriva; Amiloride HCL and Hydrochlorothiazide; Lipitor; Multiple Vitamins

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017