This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Cymbalta (Duloxetine) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (2596)
Death (121)
Life Threatening Events (165)
Disability (81)
Reports by Reaction Type
Nausea (263),
Dizziness (233),
Drug Ineffective (224),
Pain (179),
Drug Withdrawal Syndrome (173),
Depression (169),
Insomnia (166),
Headache (163),
Feeling Abnormal (158),
Fatigue (155),
Vomiting (152),
Off Label Use (151)
Below are a few examples of reports where side effects / adverse reactions may be related to Cymbalta (Duloxetine). For a complete list or a specific selection of reports, please use the links above.
Possible Cymbalta side effects in female
Reported by a physician from France on 2012-08-27
Patient: female
Reactions: Confusional State, Acute Pulmonary Oedema, Agitation, Renal Failure Acute
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Acetaminophen
Administration route: Oral
End date: 2012-07-26
Aspirin
Administration route: Oral
Atorvastatin
Administration route: Oral
Bisoprolol Fumarate
Dosage: 2.5 mg in the morning and 1.25 mg in the evening
Administration route: Oral
End date: 2012-07-27
Cymbalta
Administration route: Oral
End date: 2012-07-26
Duragesic-100
End date: 2012-07-26
Lercanidipine
Administration route: Oral
End date: 2012-07-26
Lyrica
Administration route: Oral
End date: 2012-07-26
Nexium
Administration route: Oral
Nitroglycerin
End date: 2012-07-26
Plavix
Administration route: Oral
Ramipril
Administration route: Oral
End date: 2012-07-26
Zometa
Start date: 2012-07-19
End date: 2012-07-19
Possible Cymbalta side effects in female
Reported by a physician from United States on 2012-08-27
Patient: female
Reactions: Malaise, Drug Withdrawal Syndrome, Diabetic Gastroparesis
Drug(s) suspected as cause:
Cymbalta
Possible Cymbalta side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: female
Reactions: Renal Failure Chronic
Drug(s) suspected as cause:
Cymbalta
Other drugs received by patient: Insulin; Crestor; Cozaar
Possible Cymbalta side effects in 61 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-27
Patient: 61 year old female
Reactions: Agitation, Confusional State, Acute Pulmonary Oedema, Metastatic Pain, Hypercalcaemia, Renal Failure Acute
Adverse event resulted in: death, life threatening event, hospitalization
Drug(s) suspected as cause:
Acetaminophen
Dosage: 1 g, 1x/day
Administration route: Oral
End date: 2012-07-26
Aspirin
Dosage: 75 mg, 1x/day
Administration route: Oral
Atorvastatin
Dosage: 10 mg, 1x/day
Administration route: Oral
Bisoprolol Fumarate
Dosage: 3.75 mg, 1x/day
Administration route: Oral
End date: 2012-07-27
Cymbalta
Dosage: 60 mg, 1x/day
Administration route: Oral
End date: 2012-07-26
Duragesic-100
Dosage: 50 mg, 1x/day
End date: 2012-07-26
Lercanidipine
Dosage: 10 mg, 1x/day
Administration route: Oral
End date: 2012-07-26
Lyrica
Dosage: 75 mg, 2x/day
Administration route: Oral
End date: 2012-07-26
Nexium
Dosage: 20 mg, 1x/day
Administration route: Oral
Nitroglycerin
Dosage: 5 mg, 1x/day
End date: 2012-07-26
Plavix
Dosage: 75 mg, 1x/day
Administration route: Oral
Ramipril
Dosage: 10 mg, 1x/day
Administration route: Oral
End date: 2012-07-26
Zometa
Dosage: 4 mg, single
Indication: Hypercalcaemia
Start date: 2012-07-19
End date: 2012-07-19
Possible Cymbalta side effects in 32 year old female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: 32 year old female
Reactions: Blood Calcium Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cymbalta
Dosage: 60mg, unk
Cymbalta
Dosage: unk, unknown
Possible Cymbalta side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: female
Reactions: Suicide Attempt, Drug Withdrawal Syndrome, Suicidal Ideation
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cymbalta
Dosage: unk
Start date: 2012-08-01
Cymbalta
Dosage: 120 mg, qd
Indication: Depression
End date: 2012-01-01
Other drugs received by patient: Xanax
Possible Cymbalta side effects in 45 year old female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: 45 year old female
Reactions: Jaundice
Drug(s) suspected as cause:
Cymbalta
Other drugs received by patient: Oral Contraceptive NOS; Multivitamin
Possible Cymbalta side effects in 42 year old female
Reported by a physician from United States on 2012-08-27
Patient: 42 year old female
Reactions: Disorientation, Somnolence, Loss of Consciousness, Off Label Use, Vital Functions Abnormal, Speech Disorder, Fatigue, Dizziness, Blood Pressure Increased, Nausea, Drug Withdrawal Syndrome, Heart Rate Decreased, Presyncope, Dissociation, Feeling Abnormal, Asthenia
Drug(s) suspected as cause:
Cymbalta
Dosage: 30 mg, bid
Administration route: Oral
End date: 2012-05-09
Cymbalta
Dosage: 30 mg, qd
Administration route: Oral
Start date: 2012-05-10
End date: 2012-05-10
Cymbalta
Dosage: 30 mg, qd
Administration route: Oral
Indication: Neuralgia
Start date: 2012-05-01
Other drugs received by patient: Lisinopril; Lortab
Possible Cymbalta side effects in 61 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-27
Patient: 61 year old female
Reactions: Confusional State, Agitation, Renal Failure Acute
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Acetaminophen
Administration route: Oral
Indication: Product Used FOR Unknown Indication
End date: 2012-07-26
Aspirin
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Atorvastatin
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Bisoprolol Fumarate
Dosage: 2.5-0-1.25
Administration route: Oral
Indication: Product Used FOR Unknown Indication
End date: 2012-07-27
Cymbalta
Administration route: Oral
Indication: Product Used FOR Unknown Indication
End date: 2012-07-26
Duragesic-100
Indication: Product Used FOR Unknown Indication
End date: 2012-07-26
Lercanidipine
Administration route: Oral
Indication: Product Used FOR Unknown Indication
End date: 2012-07-26
Lyrica
Administration route: Oral
Indication: Product Used FOR Unknown Indication
End date: 2012-07-26
Nexium
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Nitroglycerin
Indication: Product Used FOR Unknown Indication
End date: 2012-07-27
Plavix
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Ramipril
Administration route: Oral
Indication: Product Used FOR Unknown Indication
End date: 2012-07-26
Zometa
Indication: Product Used FOR Unknown Indication
Start date: 2012-07-19
End date: 2012-07-19
Possible Cymbalta side effects in female
Reported by a physician from Germany on 2012-08-27
Patient: female
Reactions: Gamma-Glutamyltransferase Increased, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased
Drug(s) suspected as cause:
Cymbalta
Dosage: 30 mg, unknown
Administration route: Oral
Indication: Depression
Start date: 2012-04-03
End date: 2012-04-13
Cymbalta
Dosage: 60 mg, unknown
Start date: 2012-04-11
End date: 2012-04-16
Other drugs received by patient: Metoprolol Tartrate; Metformin HCL; Fluvastatin Sodium; Diovan; Amlodipine Besylate; Aggrenox; Januvia; Sodium Chloride
Possible Cymbalta side effects in 70 year old male
Reported by a physician from United States on 2012-08-27
Patient: 70 year old male
Reactions: Anaemia, Blood Count Abnormal
Drug(s) suspected as cause:
Cymbalta
Dosage: 30 mg, qd
Cymbalta
Dosage: 30 mg, bid
Indication: Musculoskeletal Pain
Possible Cymbalta side effects in 49 year old female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: 49 year old female
Reactions: Dysphagia, Asthenia, Muscle Disorder
Drug(s) suspected as cause:
Cymbalta
Possible Cymbalta side effects in 47 year old female
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: 47 year old female, weighing 77.1 kg (169.6 pounds)
Reactions: Pain, Oesophageal Rupture, Eye Pain, Weight Increased, Diplopia, Anxiety, Intervertebral Disc Disorder, Fibromyalgia, Visual Impairment, Depression, Multiple Sclerosis, Neck Surgery
Drug(s) suspected as cause:
Cymbalta
Dosage: 60 mg, 2x/day
Administration route: Oral
Indication: Depression
Start date: 2008-01-01
End date: 2012-01-01
Cymbalta
Dosage: 60 mg, daily
Administration route: Oral
Indication: Fibromyalgia
Start date: 2008-01-01
Halcion
Dosage: 0.25 mg, 1x/day
Administration route: Oral
Indication: Sleep Disorder
Start date: 2006-01-01
Lyrica
Dosage: 75 mg, 2x/day
Indication: Fibromyalgia
Start date: 2008-01-01
End date: 2008-01-01
Lyrica
Dosage: unk
Administration route: Oral
Start date: 2008-01-01
End date: 2008-06-01
Rebif
Dosage: unk, three days in a week
Indication: Multiple Sclerosis
Start date: 2008-07-01
End date: 2009-07-01
Other drugs received by patient: Nuvigil; Copaxane; Furosemide; Hydrocodone; Creon 12000; Methocarbamol; Ventolin; Triazolam; Nexium; Naproxen; Ondansetron; Fluticasone Propionate; Triazolam; Furosemide; Levothyroxine Sodium; Hydrocodone Bitartrate and Ibuprofen; Fentanyl; Morphine; Levothyroxine Sodium; Hydrocodone Bitartrate + Acetaminophen; Lisinopril; Flexeril; Carafate; Nuvigil
Possible Cymbalta side effects in 70 year old male
Reported by a physician from United Kingdom on 2012-08-24
Patient: 70 year old male
Reactions: Syncope
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cymbalta
Zyprexa
Possible Cymbalta side effects in female
Reported by a physician from United States on 2012-08-24
Patient: female
Reactions: Maternal Exposure During Pregnancy, PRE-Eclampsia
Drug(s) suspected as cause:
Cymbalta
Possible Cymbalta side effects in 33 year old male
Reported by a physician on 2012-08-24
Patient: 33 year old male, weighing 81.6 kg (179.6 pounds)
Reactions: Blood Bilirubin Increased
Drug(s) suspected as cause:
Cymbalta
Dosage: daily
Indication: Depression
Cymbalta
Dosage: daily
Indication: Insomnia
Cymbalta
Dosage: daily
Indication: Neuralgia
Possible Cymbalta side effects in female
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-24
Patient: female
Reactions: Agitation, Confusional State, Renal Failure Acute
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Acetaminophen
Administration route: Oral
End date: 2012-07-26
Aspirin
Administration route: Oral
Atorvastatin
Administration route: Oral
Bisoprolol Fumarate
Administration route: Oral
End date: 2012-07-27
Cymbalta
Administration route: Oral
End date: 2012-07-26
Duragesic-100
End date: 2012-07-26
Lercanidipine
Administration route: Oral
End date: 2012-07-26
Lyrica
Administration route: Oral
End date: 2012-07-26
Nexium
Administration route: Oral
Nitroglycerin
End date: 2012-07-27
Plavix
Administration route: Oral
Ramipril
Administration route: Oral
End date: 2012-07-26
Zometa
Start date: 2012-07-19
End date: 2012-07-19
Possible Cymbalta side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: female
Reactions: Muscle Contractions Involuntary, Urinary Incontinence, Loss of Consciousness, Off Label Use, Fatigue, Liver Function Test Abnormal, Urinary Retention, Nervousness, Dysphagia, Dyspnoea, Vomiting, Drug Withdrawal Syndrome, Epilepsy, Convulsion, Dehydration, Feeling Abnormal
Drug(s) suspected as cause:
Cymbalta
Possible Cymbalta side effects in 46 year old female
Reported by a physician from Australia on 2012-08-24
Patient: 46 year old female
Reactions: Off Label Use, Electrocardiogram QT Prolonged, Ventricular Fibrillation
Adverse event resulted in: life threatening event, hospitalization, disablity
Drug(s) suspected as cause:
Cymbalta
Administration route: Oral
Seroquel
Administration route: Oral
Other drugs received by patient: Opiates; Reboxetine
Possible Cymbalta side effects in 56 year old female
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: 56 year old female
Reactions: Scab, Pain, Suicidal Ideation, Burning Sensation, Rash Erythematous, Vasculitis, Blister, Wound Necrosis, Crying
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cymbalta
Dosage: 30 mg, unk
Indication: Musculoskeletal Pain
Start date: 2012-06-01
Cymbalta
Dosage: 60 mg, unk
End date: 2012-07-01
Other drugs received by patient: Dilaudid; Fentanyl; Santyl
Possible Cymbalta side effects in
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient:
Reactions: Pruritus, Nasopharyngitis, Oropharyngeal Pain, Cardiomegaly, Rheumatoid Arthritis, Incontinence, LOW Turnover Osteopathy, Back Disorder, Immunosuppression, Eye Pruritus, Haematuria, Macular Fibrosis, Macular Hole, Tonsillar Disorder, Increased Tendency To Bruise, Uterine Disorder, Rosacea, Muscle Disorder, Osteoporosis, Adverse Drug Reaction, Vitreous Detachment, Somnolence, Fall, Poor Quality Sleep, Tarsal Tunnel Syndrome, Nitrite Urine, Urosepsis, Rotator Cuff Syndrome, Depression, Exostosis, Macrocytosis, Vomiting, Haemorrhoids, Cardiac Infection, Alcohol Poisoning, Syncope, Lung Disorder, Arthralgia, Limb Asymmetry, Hypothyroidism, Gait Disturbance, Thrombosis, Femur Fracture, Wound, Urinary Incontinence, Lumbar Spinal Stenosis, Klebsiella Infection, Arthropathy, Adverse Event, Irritable Bowel Syndrome, Urinary Retention, Carpal Tunnel Syndrome, Radiculopathy, Intervertebral Disc Protrusion, Cellulitis, Breast Calcifications, Ankle Fracture, Insomnia, Stress Fracture, Drug Ineffective, Myalgia, Intervertebral Disc Disorder, Fibromyalgia, Device Component Issue, Nausea, Urinary Tract Infection, Cardiac Valve Vegetation, Synovitis, Adenoidal Disorder, Rash, Appendix Disorder, Intraocular Lens Implant, Osteoarthritis, Anxiety, Dysuria, Oral Disorder, Pollakiuria, Spinal Osteoarthritis, Spinal Claudication, Infection, Infusion Related Reaction
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Cymbalta
Indication: Depression
Fosamax
Dosage: unk
Administration route: Oral
Indication: Osteopenia
Start date: 2003-01-01
Fosamax
Dosage: 35 mg, qw
Administration route: Oral
Start date: 2008-09-08
Fosamax
Dosage: 35 mg, unk
Administration route: Oral
Start date: 2004-01-16
End date: 2009-04-09
Other drugs received by patient: Meticorten; Bextra (Parecoxib Sodium); Hydroxychloroquine Sulfate; Triamcinolone; Atrexel; Leflunomide; Arava; MK-9039
Possible Cymbalta side effects in female
Reported by a physician from France on 2012-08-24
Patient: female
Reactions: Agitation, Confusional State, Acute Pulmonary Oedema, Nephrolithiasis, Dyspnoea, Hypercalcaemia, Renal Failure Acute
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Acetaminophen
Dosage: 1 mg, unk
End date: 2012-07-26
Aspirin
Dosage: 75 mg, unk
Atorvastatin
Dosage: 10 mg, qd
Bisoprolol Fumarate
Dosage: 3.75 mg, daily (2.5 mg in the morning and 1.25 mg in the evening)
End date: 2012-07-27
Cymbalta
Dosage: 60 mg, qd
End date: 2012-07-26
Duragesic-100
Dosage: 50 ug, daily
End date: 2012-07-26
Lercanidipine
Dosage: 10 mg, qd
End date: 2012-07-26
Lyrica
Dosage: 75 mg, bid
End date: 2012-07-26
Nexium
Dosage: 20 mg, qd
End date: 2012-07-26
Nitroglycerin
Dosage: 5 mg, daily
End date: 2012-07-27
Plavix
Dosage: 75 mg, qd
End date: 2012-07-26
Ramipril
Dosage: 10 mg, qd
End date: 2012-07-26
Zometa
Dosage: 4 mg, in 15 min
Indication: Hypercalcaemia
Start date: 2012-07-19
Possible Cymbalta side effects in female
Reported by a physician from France on 2012-08-24
Patient: female
Reactions: Confusional State, Nephrolithiasis, Acute Pulmonary Oedema, Agitation, Dyspnoea, Hypercalcaemia, Renal Failure Acute
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Acetaminophen
Dosage: 1 mg, unk
End date: 2012-07-26
Aspirin
Dosage: 75 mg, unk
Atorvastatin
Dosage: 10 mg, qd
Bisoprolol Fumarate
Dosage: 3.75 mg, daily (2.5 mg in the morning and 1.25 mg in the evening)
End date: 2012-07-27
Cymbalta
Dosage: 60 mg, qd
End date: 2012-07-26
Duragesic-100
Dosage: 50 ug, daily
End date: 2012-07-26
Lercanidipine
Dosage: 10 mg, qd
End date: 2012-07-26
Lyrica
Dosage: 75 mg, bid
End date: 2012-07-26
Nexium
Dosage: 20 mg, qd
End date: 2012-07-26
Nitroglycerin
Dosage: 5 mg, daily
End date: 2012-07-27
Plavix
Dosage: 75 mg, qd
End date: 2012-07-26
Ramipril
Dosage: 10 mg, qd
End date: 2012-07-26
Zometa
Dosage: 4 mg, in 15 min
Indication: Hypercalcaemia
Start date: 2012-07-19
Possible Cymbalta side effects in 50 year old female
Reported by a physician from United States on 2012-08-24
Patient: 50 year old female
Reactions: Malabsorption, Anxiety, Depression, Mesothelioma Malignant
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cymbalta
Other drugs received by patient: Clonazepam; Neurontin; Multivitamin; Synthroid; Lonox; Lexapro; Vitamin D; Lortab
Possible Cymbalta side effects in 31 year old female
Reported by a physician from United States on 2012-08-24
Patient: 31 year old female, weighing 68.0 kg (149.7 pounds)
Reactions: Hypertensive Crisis
Drug(s) suspected as cause:
Cymbalta
Possible Cymbalta side effects in female
Reported by a physician from France on 2012-08-24
Patient: female
Reactions: Nephrolithiasis, Agitation, Confusional State, Acute Pulmonary Oedema, Dyspnoea, Hypercalcaemia, Renal Failure Acute
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Acetaminophen
Dosage: 1 mg, unk
End date: 2012-07-26
Aspirin
Dosage: 75 mg, unk
Atorvastatin
Dosage: 10 mg, qd
Bisoprolol Fumarate
Dosage: 3.75 mg, daily (2.5 mg in the morning and 1.25 mg in the evening)
End date: 2012-07-27
Cymbalta
Dosage: 60 mg, qd
End date: 2012-07-26
Duragesic-100
Dosage: 50 ug, daily
End date: 2012-07-26
Lercanidipine
Dosage: 10 mg, qd
End date: 2012-07-26
Lyrica
Dosage: 75 mg, bid
End date: 2012-07-26
Nexium
Dosage: 20 mg, qd
End date: 2012-07-26
Nitroglycerin
Dosage: 5 mg, daily
End date: 2012-07-27
Plavix
Dosage: 75 mg, qd
End date: 2012-07-26
Ramipril
Dosage: 10 mg, qd
End date: 2012-07-26
Zometa
Dosage: 4 mg, in 15 min
Indication: Hypercalcaemia
Start date: 2012-07-19
Possible Cymbalta side effects in 36 year old male
Reported by a consumer/non-health professional from Germany on 2012-08-24
Patient: 36 year old male
Reactions: Accident, Surgery, Depressed Level of Consciousness, Drug Withdrawal Syndrome, Headache, Intentional Drug Misuse, Vertigo Positional
Drug(s) suspected as cause:
Cymbalta
Other drugs received by patient: Anaesthetics
Possible Cymbalta side effects in 26 year old female
Reported by a consumer/non-health professional from United Kingdom on 2012-08-23
Patient: 26 year old female
Reactions: Complication of Delivery, Maternal Exposure During Pregnancy, Haemorrhage in Pregnancy
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Cymbalta
Dosage: 120 mg, qd
Cymbalta
Dosage: 90 mg, unk
Cymbalta
Dosage: 60 mg, unk
Indication: Depression
Possible Cymbalta side effects in 25 year old female
Reported by a consumer/non-health professional from United States on 2012-08-23
Patient: 25 year old female, weighing 52.2 kg (114.8 pounds)
Reactions: Serotonin Syndrome
Drug(s) suspected as cause:
Cymbalta
Dosage: 40mg qd po
Administration route: Oral
Indication: Depression
Start date: 2012-04-01
End date: 2012-08-18
Zomig
Dosage: 5mg prn po
Administration route: Oral
Indication: Migraine
Start date: 2012-08-14
End date: 2012-08-15
Possible Cymbalta side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-23
Patient: female
Reactions: Stomatitis, Pruritus, Hyperhidrosis, Device Breakage, Oral Fungal Infection, Papule
Drug(s) suspected as cause:
Cymbalta
Dosage: 30 mg, tid
Indication: Back Pain
Cymbalta
Dosage: 30 mg, bid
Other drugs received by patient: Percogesic; Fentanyl; Laxative; Oxycodone HCL; Oxycontin
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