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Cyclophosphamide (Cyclophosphamide) - Renal Impairment - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Renal Impairment ()

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Cyclophosphamide where reactions include renal impairment. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of    Next >>

Possible Cyclophosphamide side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-23

Patient: male

Reactions: Phlebitis, Lymphocyte Percentage Decreased, Hydronephrosis, Arterial Thrombosis Limb, Urinary Tract Infection, Cystitis Noninfective, Human Polyomavirus Infection, Prothrombin Time Prolonged, Urethritis, Blood Fibrinogen Increased, Genitourinary Tract Infection, Renal Impairment, Adenovirus Infection, Prostatomegaly, Leukopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 500 mg/m2, first 3 days of each cycle (6 cycles)
    Administration route: Oral
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2008-07-15
    End date: 2008-12-03

Fludara
    Dosage: 80 mg/m2, first 3 days of each cycle (6 cycles)
    Administration route: Oral
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2008-07-15
    End date: 2008-12-03

Campath
    Dosage: 30 mg/m2, first 3 days of each cycle (6 cycles)
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2008-07-15
    End date: 2008-12-03

Other drugs received by patient: Bactrim; Valganciclovir; Vfend; Folic Acid



Possible Cyclophosphamide side effects in 75 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-21

Patient: 75 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Renal Impairment

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Revlimid
    Dosage: 25 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2012-04-13

Revlimid
    Administration route: Oral
    End date: 2012-06-26

Dexamethasone
    Dosage: 20 milligram
    Administration route: Oral
    End date: 2012-06-26

Cyclophosphamide
    Dosage: 500 milligram
    Administration route: Oral
    End date: 2012-06-26

Dexamethasone
    Dosage: 20 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2012-04-13

Cyclophosphamide
    Dosage: 500 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2012-04-13



Possible Cyclophosphamide side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-17

Patient: male

Reactions: Hydronephrosis, Urinary Tract Infection, Cystitis Noninfective, Urethritis, Human Polyomavirus Infection, Renal Impairment, Adenovirus Infection, Prostatomegaly, Leukopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Campath
    Dosage: 30 mg/m2, unk
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2008-07-15
    End date: 2008-12-03

Cyclophosphamide
    Dosage: 500 mg/m2, unk
    Administration route: Oral
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2008-07-15
    End date: 2008-12-03

Fludara
    Dosage: 80 mg/m2, unk
    Administration route: Oral
    Indication: Chronic Lymphocytic Leukaemia
    Start date: 2008-07-15
    End date: 2008-12-03

Other drugs received by patient: Bactrim; Vfend; Valganciclovir; Folic Acid



Possible Cyclophosphamide side effects in 75 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-31

Patient: 75 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Renal Impairment

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Revlimid
    Administration route: Oral
    End date: 2012-06-26

Cyclophosphamide
    Dosage: 500 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2012-04-13

Dexamethasone
    Dosage: 20 milligram
    Administration route: Oral
    End date: 2012-06-26

Revlimid
    Dosage: 25 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2012-04-13

Cyclophosphamide
    Dosage: 500 milligram
    Administration route: Oral
    End date: 2012-06-26

Dexamethasone
    Dosage: 20 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2012-04-13



Possible Cyclophosphamide side effects in 70 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-30

Patient: 70 year old female

Reactions: Renal Impairment, Hyperkalaemia, Anaemia, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Dexamethasone
    Indication: Multiple Myeloma
    Start date: 2010-09-24
    End date: 2010-11-03

Revlimid
    Dosage: 10 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2010-09-24
    End date: 2010-11-03

Cyclophosphamide
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2010-09-24
    End date: 2010-11-03



Possible Cyclophosphamide side effects in 54 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-23

Patient: 54 year old female

Reactions: Renal Impairment, Respiratory Failure, Interstitial Lung Disease, Immunosuppressant Drug Level Increased, Disease Progression

Adverse event resulted in: death

Drug(s) suspected as cause:
Methylprednisolone
    Indication: Interstitial Lung Disease

Prednisolone
    Dosage: 1 mg/kg, per day
    Indication: Interstitial Lung Disease

Cyclophosphamide
    Indication: Interstitial Lung Disease

Cyclosporine
    Dosage: 0.17 mg/kg, per hour
    Indication: Interstitial Lung Disease

Other drugs received by patient: Immune Globulin NOS



Possible Cyclophosphamide side effects in 54 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-20

Patient: 54 year old female

Reactions: Renal Impairment, Interstitial Lung Disease, Respiratory Failure, Immunosuppressant Drug Level Increased, Disease Progression

Adverse event resulted in: death

Drug(s) suspected as cause:
Prednisolone
    Dosage: 1 mg/kg, per day
    Indication: Interstitial Lung Disease

Cyclosporine
    Dosage: 0.17 mg/kg, per hour
    Indication: Interstitial Lung Disease

Methylprednisolone
    Indication: Interstitial Lung Disease

Cyclophosphamide
    Indication: Interstitial Lung Disease

Other drugs received by patient: Immune Globulin NOS



Possible Cyclophosphamide side effects in 54 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-20

Patient: 54 year old female

Reactions: Renal Impairment, Interstitial Lung Disease, Respiratory Failure, Immunosuppressant Drug Level Increased, Disease Progression

Adverse event resulted in: death

Drug(s) suspected as cause:
Prednisolone
    Dosage: 1 mg/kg, per day
    Indication: Interstitial Lung Disease

Cyclosporine
    Dosage: 0.17 mg/kg, per hour
    Indication: Interstitial Lung Disease

Methylprednisolone
    Indication: Interstitial Lung Disease

Cyclophosphamide
    Indication: Interstitial Lung Disease

Other drugs received by patient: Immune Globulin NOS



Possible Cyclophosphamide side effects in 75 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-12

Patient: 75 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Renal Impairment

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Revlimid
    Dosage: 25 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2012-04-13

Cyclophosphamide
    Dosage: 500 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2012-04-13

Dexamethasone
    Dosage: 20 milligram
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2012-04-13

Revlimid
    Administration route: Oral



Possible Cyclophosphamide side effects in 67 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-02

Patient: 67 year old male

Reactions: Weight Decreased, Anaemia, Acute Phosphate Nephropathy, Mental Status Changes, Hypercalcaemia, Hyperuricaemia, Haemodialysis, Tumour Lysis Syndrome, Renal Impairment, Oliguria, Leukocytosis, Thrombocytopenia, Decreased Appetite, Renal Failure Acute, Hepatosplenomegaly

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin HCL
    Indication: Chemotherapy

Vincristine
    Indication: Chemotherapy

Dexamethasone Sodium Phosphate
    Indication: Chemotherapy

Cyclophosphamide
    Indication: Chemotherapy



Possible Cyclophosphamide side effects in 43 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-06-11

Patient: 43 year old male

Reactions: Liver Injury, Bronchopulmonary Aspergillosis, Dyspnoea, Haemoptysis, Device Related Infection, Death, Renal Failure, Sepsis Syndrome, Renal Impairment, Cardio-Respiratory Arrest, Cardiac Failure, Respiratory Failure, Hallucination, Visual, Neutropenia, Mycobacterium Fortuitum Infection, Influenza

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Ciprofloxacin HCL
    Dosage: 500 mg, 2x/day
    Indication: Mycobacterium Fortuitum Infection

Clarithromycin
    Dosage: 500 mg, 2x/day
    Indication: Mycobacterium Fortuitum Infection

Oseltamivir
    Dosage: 75 mg, 2x/day
    Indication: Product Used FOR Unknown Indication

Cyclophosphamide
    Dosage: 100 mg, 1x/day
    Administration route: Oral
    Indication: Immunosuppression

Amphotericin B
    Indication: Aspergillosis

Prednisolone
    Dosage: 60 mg, unk
    Indication: Immunosuppression

Ciprofloxacin HCL
    Dosage: 60 mg

Voriconazole
    Dosage: unk
    Indication: Aspergillosis

Teicoplanin
    Dosage: 400 mg, 1x/day
    Indication: Product Used FOR Unknown Indication

Meropenem
    Dosage: 1 g, 2x/day
    Indication: Product Used FOR Unknown Indication



Possible Cyclophosphamide side effects in 43 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-05-30

Patient: 43 year old male

Reactions: Liver Injury, Device Related Infection, Death, Cardio-Respiratory Arrest, Mycobacterium Fortuitum Infection, Bronchopulmonary Aspergillosis, Dyspnoea, Haemoptysis, Sepsis Syndrome, Renal Failure, Renal Impairment, Cardiac Failure, Hallucination, Visual, Respiratory Failure, Neutropenia, Influenza

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Ciprofloxacin HCL
    Dosage: 500 mg, 2x/day
    Indication: Mycobacterium Fortuitum Infection

Prednisolone
    Dosage: 60 mg, unk
    Indication: Immunosuppression

Oseltamivir
    Indication: Product Used FOR Unknown Indication

Teicoplanin
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Cyclophosphamide
    Dosage: 100 mg, 1x/day
    Administration route: Oral
    Indication: Immunosuppression

Clarithromycin
    Dosage: 500 mg, 2x/day
    Indication: Mycobacterium Fortuitum Infection

Voriconazole
    Dosage: unk
    Indication: Aspergillosis

Meropenem
    Indication: Product Used FOR Unknown Indication

Amphotericin B
    Indication: Aspergillosis



Possible Cyclophosphamide side effects in male

Reported by a physician from France on 2012-05-23

Patient: male, weighing 68.0 kg (149.6 pounds)

Reactions: Complications of Transplanted Kidney, Wound Dehiscence, Malnutrition, Bronchial Obstruction, Anastomotic Haemorrhage, Renal Impairment, Unevaluable Event, Culture Wound Positive, Thrombocytopenia, Escherichia Sepsis

Adverse event resulted in: death, life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Esomeprazole Magnesium
    Start date: 2011-01-16
    End date: 2011-02-01

Prednisone TAB
    Administration route: Oral
    Indication: Transplant Rejection

Cyclosporine

Everolimus
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-02-02
    End date: 2011-02-09

Cellcept
    Dosage: permanently discontinued. date of last dose prior to sae: 08 march 2011.
    Administration route: Oral
    Start date: 2011-03-01
    End date: 2011-03-08

Cellcept
    Dosage: frequency: everyday. temporarily interrupted
    Administration route: Oral
    Indication: Transplant Rejection
    Start date: 2011-01-15
    End date: 2011-02-09

Prednisone TAB
    Dosage: date of last dose prior to sae: 16 march 2011.
    Administration route: Oral

Cyclophosphamide
    Administration route: Oral
    Indication: Transplant Rejection
    Start date: 2011-01-17
    End date: 2011-02-01

Methylprednisolone and Methylprednisolone
    Indication: Transplant Rejection
    Start date: 2011-01-15
    End date: 2011-01-15

Basiliximab
    Indication: Transplant Rejection
    Start date: 2011-01-15
    End date: 2011-01-15

Valcyte
    Dosage: twice a week
    Start date: 2011-01-29
    End date: 2011-02-01

Cyclosporine

Sulfamethoxazole and Trimethoprim
    Start date: 2011-01-24
    End date: 2011-02-01

Ranitidine HCL
    Start date: 2011-02-02
    End date: 2011-02-09

Other drugs received by patient: Adancor; Amlodipine Besylate; Insulatard NPH Human; Econazole Nitrate; Potassium Chloride; Adancor; Imodium; Alfuzosin HCL; Calcidia; Aspirin; Mirtazapine; Calcidia; Lasix; Eprex; Nitroderm; Potassium Chloride; Amoxicillin; Lasix; Sodium Bicarbonate; Aluminum Hydroxide and Magnesium Trisilicate



Possible Cyclophosphamide side effects in 43 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-05-15

Patient: 43 year old male

Reactions: Right Ventricular Failure, Liver Injury, Dyspnoea, Haemoptysis, Cholestasis, H1n1 Influenza, Acid Fast Bacilli Infection, Sepsis Syndrome, Renal Impairment, Cardio-Respiratory Arrest, Respiratory Failure, Hallucination, Visual, Aspergillosis, Neutropenia, Renal Failure Acute

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Prednisolone
    Dosage: 60 mg, qd
    Administration route: Oral
    Indication: Vasculitis

Cyclophosphamide
    Dosage: 100 mg, qd
    Administration route: Oral
    Indication: Vasculitis

Other drugs received by patient: Ciprofloxacin; Ciprofloxacin; Clarithromycin; Clarithromycin



Possible Cyclophosphamide side effects in 70 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-05-10

Patient: 70 year old female

Reactions: Renal Impairment, Hyperkalaemia, Anaemia, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Revlimid
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2010-09-24
    End date: 2010-11-03

Cyclophosphamide
    Indication: Multiple Myeloma
    Start date: 2010-09-24
    End date: 2010-11-03

Dexamethasone
    Indication: Multiple Myeloma
    Start date: 2010-09-24
    End date: 2010-11-03



Possible Cyclophosphamide side effects in

Reported by a physician from Greece on 2012-05-08

Patient:

Reactions: Sudden Death, Orthostatic Hypotension, Constipation, Myalgia, Neuropathy Peripheral, Fatigue, Oedema Peripheral, Hypocalcaemia, Acute Myocardial Infarction, Blood Creatinine Increased, Thrombocytopenia, Hypotension, Hyponatraemia, Rash, Cerebrovascular Accident, Renal Impairment, Diarrhoea, Amyloidosis, Neutropenia, Deep Vein Thrombosis, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Revlimid
    Dosage: 15 milligram
    Administration route: Oral

Dexamethasone
    Dosage: 20 milligram
    Indication: Amyloidosis

Cyclophosphamide
    Dosage: level 0: 50mg, level 1-4: 100mg
    Indication: Amyloidosis

Revlimid
    Dosage: level 0-1: 10mg, level 2: 15mg, level 3: 20mg, level 4: 25mg
    Administration route: Oral
    Indication: Amyloidosis

Revlimid
    Dosage: 15 milligram
    Administration route: Oral

Other drugs received by patient: Aspirin



Possible Cyclophosphamide side effects in 41 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-05-04

Patient: 41 year old male, weighing 77.0 kg (169.4 pounds)

Reactions: Jaundice, Confusional State, Somnolence, Treatment Noncompliance, Overdose, Left Ventricular Dysfunction, Cholangitis, Acute Respiratory Distress Syndrome, Bone Marrow Failure, Thrombocytopenia, Engraftment Syndrome, Neurological Decompensation, Pseudomonas Infection, Haemoglobin Decreased, Mucosal Inflammation, Cholelithiasis, Renal Failure, Renal Impairment, Ventricular Dysfunction, Miosis, Enterococcus Test Positive, Multi-Organ Disorder, Septic Shock, Staphylococcus Test Positive

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Busulfex
    Dosage: 3.2 mg/kg, qd, intravenous, 232.9 mg milligram(s), intravenous
    Indication: Myeloid Leukaemia
    Start date: 2011-08-19

Busulfex
    Dosage: 3.2 mg/kg, qd, intravenous, 232.9 mg milligram(s), intravenous
    Indication: Myeloid Leukaemia
    Start date: 2011-08-16

Cyclophosphamide
    Dosage: 60 mg/kg, qd, intravenous
    Indication: Acute Myeloid Leukaemia
    Start date: 2011-08-21
    End date: 2011-08-22



Possible Cyclophosphamide side effects in

Reported by a health professional (non-physician/pharmacist) from China on 2012-03-26

Patient:

Reactions: Pancreatitis Acute, Gastrointestinal Haemorrhage, Tuberculosis, Lung Infection, Fungal Sepsis, Renal Impairment, Fungal Infection, Central Nervous System Infection, Meningitis Cryptococcal, Bone Marrow Failure, Skin Infection, Candidiasis, Pneumococcal Sepsis

Drug(s) suspected as cause:
Cytarabine
    Indication: Lymphoma

Ifosfamide
    Indication: Lymphoma

Methotrexate
    Indication: Lymphoma

Leucovorin Calcium
    Indication: Lymphoma

Etoposide
    Indication: Lymphoma

Pirarubicin
    Indication: Lymphoma

Prednisone
    Indication: Lymphoma

Dexamethasone
    Indication: Lymphoma

Rituximab
    Indication: Lymphoma

Vincristine
    Indication: Lymphoma

Cyclophosphamide

Mesna
    Indication: Lymphoma

Doxorubicin HCL
    Indication: Lymphoma

Mitoxantrone
    Indication: Lymphoma

Other drugs received by patient: Stavudine; Zidovudine; Lamivudine (Epivir Hbv); Nevirapine



Possible Cyclophosphamide side effects in female

Reported by a individual with unspecified qualification from United States on 2012-03-01

Patient: female, weighing 19.7 kg (43.3 pounds)

Reactions: Blood Pressure Increased, Pancreatitis Acute, Renal Impairment, Continuous Haemodiafiltration

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 1690 mg
    End date: 2011-12-30

Mercaptopurine
    Dosage: 1500 mg
    End date: 2012-01-11

Methotrexate
    Dosage: 48 mg
    End date: 2011-12-22

PEG-L-Asparaginase (K-H)
    Dosage: 4075 unit
    End date: 2012-01-12

Vincristine Sulfate
    Dosage: 5.1 mg
    End date: 2012-01-19

Cytarabine
    Dosage: 1040 mg
    End date: 2012-01-08



Possible Cyclophosphamide side effects in 8 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-01-26

Patient: 8 year old female

Reactions: Pulmonary Hypertension, Hepatic Function Abnormal, Pulmonary Veno-Occlusive Disease, Toxicity To Various Agents, Idiopathic Pneumonia Syndrome, Haemodialysis, Pulmonary Haemorrhage, Mucosal Inflammation, Renal Impairment, Malaise, Respiratory Failure, Adenovirus Infection, Cytomegalovirus Infection, Bacterial Sepsis, Methylobacterium Infection, Pneumonitis

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Methotrexate
    Indication: Prophylaxis Against Graft Versus Host Disease

Cyclosporine
    Indication: Prophylaxis Against Graft Versus Host Disease

Busulfan
    Dosage: tablet 14 mg/kg
    Indication: Bone Marrow Conditioning Regimen

Cyclophosphamide
    Dosage: 200 mg/kg
    Indication: Bone Marrow Conditioning Regimen

Alemtuzumab
    Dosage: 0.3 mg/kg
    Indication: Bone Marrow Conditioning Regimen



Possible Cyclophosphamide side effects in 46 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-03

Patient: 46 year old male, weighing 106.0 kg (233.2 pounds)

Reactions: Metastatic Malignant Melanoma, Alanine Aminotransferase Increased, Chromaturia, Pyrexia, Renal Impairment, Neoplasm Malignant, Aspartate Aminotransferase Increased, Liver Function Test Abnormal, Dizziness, Rash Maculo-Papular

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vemurafenib
    Start date: 2011-12-06
    End date: 2011-12-13

Cyclophosphamide
    Indication: Metastatic Malignant Melanoma
    Start date: 2011-10-31

Proleukin
    Indication: Metastatic Malignant Melanoma
    Start date: 2011-11-02
    End date: 2011-11-16

Ipilimumab
    Dosage: also on 11mar2011 and 22nov2011.
    Indication: Metastatic Malignant Melanoma
    Start date: 2011-10-04



Possible Cyclophosphamide side effects in 8 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-12-29

Patient: 8 year old female, weighing 22.0 kg (48.4 pounds)

Reactions: Pulmonary Hypertension, Idiopathic Pneumonia Syndrome, Liver Disorder, Mucosal Inflammation, Pulmonary Haemorrhage, Renal Impairment, Venoocclusive Disease, Respiratory Failure, Cytomegalovirus Infection, Bacterial Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Busulfan
    Administration route: Oral
    Indication: Bone Marrow Failure
    Start date: 2011-04-25
    End date: 2011-04-28

Mabcampath
    Indication: Bone Marrow Transplant
    Start date: 2011-04-26
    End date: 2011-04-28

Methotrexate
    Indication: Graft Versus Host Disease
    Start date: 2011-05-08
    End date: 2011-05-11

Cyclophosphamide
    Indication: Bone Marrow Failure
    Start date: 2011-04-29
    End date: 2011-05-02

Other drugs received by patient: Immune Globulin NOS; Thiotepa; Allopurinol; Dapsone; Linezolid; Amphotericin B; Defibrotide; Leucovorin Calcium; Acetaminophen; Caspofungin Acetate; Hydrocortisone; Phenytoin; Mesna; Cyclosporine; Isoniazid; Octreotide Acetate; Metronidazole; Meperidine HCL



Possible Cyclophosphamide side effects in female

Reported by a individual with unspecified qualification from Japan on 2011-12-13

Patient: female, weighing 56.0 kg (123.2 pounds)

Reactions: Hepatic Function Abnormal, Disseminated Intravascular Coagulation, Norovirus Test Positive, Renal Impairment, Lung Disorder, Diarrhoea, Platelet Count Decreased, Circulatory Collapse, Infusion Related Reaction

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Taxotere
    Indication: Breast Cancer Metastatic
    Start date: 2009-04-27
    End date: 2009-07-10

Cyclophosphamide
    Indication: Breast Cancer Metastatic
    Start date: 2009-04-27
    End date: 2009-07-10

Herceptin
    Indication: Breast Cancer Metastatic
    Start date: 2009-07-31
    End date: 2009-07-31

Herceptin
    Start date: 2009-08-21
    End date: 2009-08-21



Possible Cyclophosphamide side effects in 50 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-12-01

Patient: 50 year old female

Reactions: Metastases To Liver, Bile Duct Cancer, Metastases To Stomach, Colonic Polyp, Neuropathy Peripheral, Pleural Effusion, Cardiotoxicity, Thrombocytopenia, Blood Creatinine Increased, Metastases To Lung, Hepatic Cirrhosis, Cardiac Failure Congestive, Bone Marrow Transplant, Blood Urea Increased, Acute Lymphocytic Leukaemia Recurrent, Congestive Cardiomyopathy, Renal Cyst, Toxicity To Various Agents, Rash, Osteosclerosis, Renal Impairment, Diarrhoea, Renal Mass

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vincristine Sulfate
    Dosage: not reported
    Indication: Acute Lymphocytic Leukaemia

Elspar
    Dosage: not reported
    Indication: Acute Lymphocytic Leukaemia

Etoposide
    Dosage: not reported
    Indication: Acute Lymphocytic Leukaemia

Prednisone TAB
    Dosage: not reported
    Indication: Acute Lymphocytic Leukaemia

Cyclophosphamide
    Dosage: not reported
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: not reported
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: not reported, intrathecal
    Indication: Acute Lymphocytic Leukaemia

Mitoxantrone Hydrochloride
    Dosage: not reported
    Indication: Acute Lymphocytic Leukaemia

(Therapeutic Radiopharmaceuticals)
    Dosage: not reported
    Indication: Acute Lymphocytic Leukaemia



Possible Cyclophosphamide side effects in 16 year old female

Reported by a physician from Algeria on 2011-11-11

Patient: 16 year old female, weighing 34.0 kg (74.8 pounds)

Reactions: Off Label Use, Renal Impairment, Drug Ineffective, Systemic Lupus Erythematosus, NO Therapeutic Response

Drug(s) suspected as cause:
Neoral
    Indication: Systemic Lupus Erythematosus

Mabthera
    Indication: Systemic Lupus Erythematosus

Mycophenolate Mofetil (Cellcept)
    Indication: Systemic Lupus Erythematosus

Cyclophosphamide
    Indication: Systemic Lupus Erythematosus



Possible Cyclophosphamide side effects in male

Reported by a health professional (non-physician/pharmacist) from Canada on 2011-11-02

Patient: male

Reactions: Thyroid Cancer, Neuroblastoma, Maternal Exposure During Pregnancy, Respiratory Depression, Renal Impairment, Developmental Delay, Vena Cava Injury, Iron Deficiency Anaemia, Cryptorchism, Nervous System Disorder, Oesophageal Atresia, Carpus Curvus

Drug(s) suspected as cause:
Mercaptopurine
    Indication: Maternal Exposure During Pregnancy

Prednisone
    Indication: Maternal Exposure During Pregnancy

Vincristine
    Indication: Maternal Exposure During Pregnancy

Aminopterin
    Indication: Maternal Exposure During Pregnancy

Cyclophosphamide
    Indication: Maternal Exposure During Pregnancy



Possible Cyclophosphamide side effects in 67 year old female

Reported by a physician from United States on 2011-10-31

Patient: 67 year old female

Reactions: Renal Impairment, Drug Ineffective, Hyperglycaemia, Alveolar Proteinosis, Myopathy

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Wegener's Granulomatosis

Prednisone
    Indication: Wegener's Granulomatosis

Mycophenolate Mofetil
    Dosage: 1.5 g

Cyclophosphamide
    Indication: Interstitial Lung Disease

Sildenafil
    Indication: Pulmonary Hypertension

Mycophenolate Mofetil
    Dosage: 500 mg
    Indication: Wegener's Granulomatosis

Mycophenolate Mofetil
    Dosage: 2000 mg
    Indication: Interstitial Lung Disease

Prednisone
    Indication: Interstitial Lung Disease



Possible Cyclophosphamide side effects in 16 year old female

Reported by a physician from Algeria on 2011-10-31

Patient: 16 year old female, weighing 34.0 kg (74.8 pounds)

Reactions: Off Label Use, Renal Impairment, Drug Ineffective, Systemic Lupus Erythematosus

Drug(s) suspected as cause:
Mycophenolate Mofetil (Cellcept)
    Indication: Systemic Lupus Erythematosus

Neoral
    Indication: Systemic Lupus Erythematosus

Cyclophosphamide
    Indication: Systemic Lupus Erythematosus

Mabthera
    Indication: Systemic Lupus Erythematosus



Possible Cyclophosphamide side effects in 67 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-24

Patient: 67 year old female

Reactions: Clubbing, Superinfection, Blood Lactate Dehydrogenase Increased, Hyperglycaemia, Pyrexia, Alveolar Proteinosis, Myopathy, Renal Impairment, Dyspnoea Exertional, Oedema Peripheral, Hypoxia, Cough

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mycophenolate Mofetil
    Dosage: 500 mg; qd; 2000 mg;qd; 1500 mg; qd
    Indication: Wegener's Granulomatosis

Prednisone
    Indication: Wegener's Granulomatosis

Cyclophosphamide
    Indication: Wegener's Granulomatosis

Other drugs received by patient: Sildenafil



Possible Cyclophosphamide side effects in 8 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-21

Patient: 8 year old female, weighing 22.0 kg (48.4 pounds)

Reactions: Pulmonary Hypertension, Idiopathic Pneumonia Syndrome, Liver Disorder, Mucosal Inflammation, Pulmonary Haemorrhage, Renal Impairment, Venoocclusive Disease, Respiratory Failure, Bacterial Sepsis, Cytomegalovirus Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Busulfan
    Administration route: Oral
    Indication: Bone Marrow Failure
    Start date: 2011-04-25
    End date: 2011-04-28

Cyclophosphamide
    Indication: Bone Marrow Failure
    Start date: 2011-04-29
    End date: 2011-05-02

Methotrexate
    Indication: Graft Versus Host Disease
    Start date: 2011-05-08
    End date: 2011-05-11

Mabcampath
    Indication: Bone Marrow Transplant
    Start date: 2011-04-26
    End date: 2011-04-28

Other drugs received by patient: Metronidazole; Acetaminophen; Thiotepa; Mesna; Allopurinol; Cyclosporine; Dapsone; Ganciclovir; Immune Globulin NOS; Meperidine HCL; Caspofungin Acetate; Defibrotide; Hydrocortisone; Octreotide Acetate; Phenytoin; Leucovorin Calcium; Isoniazid; Amphotericin B; Linezolid



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