This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Cubicin (Daptomycin) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (532)
Death (149)
Life Threatening Events (55)
Disability (8)
Reports by Reaction Type
Death (57),
Eosinophilic Pneumonia (49),
Blood Creatine Phosphokinase Increased (38),
Rhabdomyolysis (29),
Blood Creatinine Increased (21),
Endocarditis (19),
Sepsis (19),
Drug Ineffective (18),
Renal Failure Acute (17),
Drug Interaction (14),
Antimicrobial Susceptibility Test Resistant (13),
Hypotension (13)
Below are a few examples of reports where side effects / adverse reactions may be related to Cubicin (Daptomycin). For a complete list or a specific selection of reports, please use the links above.
Possible Cubicin side effects in 84 year old male
Reported by a pharmacist from Japan on 2012-08-27
Patient: 84 year old male
Reactions: Renal Impairment, Henoch-Schonlein Purpura, Eosinophil Count Increased
Drug(s) suspected as cause:
Cubicin
Other drugs received by patient: Vancomycin
Possible Cubicin side effects in male
Reported by a pharmacist from United States on 2012-08-27
Patient: male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Possible Cubicin side effects in 73 year old female
Reported by a physician from Germany on 2012-08-27
Patient: 73 year old female, weighing 87.0 kg (191.4 pounds)
Reactions: Body Temperature Fluctuation, Respiratory Rate Increased, White Blood Cell Disorder, Urine Output Decreased, Hypotension
Drug(s) suspected as cause:
Cubicin
Other drugs received by patient: Ampicillin; Ceftazidime
Possible Cubicin side effects in 72 year old male
Reported by a physician from Germany on 2012-08-27
Patient: 72 year old male, weighing 90.0 kg (198.0 pounds)
Reactions: Blood Creatinine Increased
Drug(s) suspected as cause:
Cubicin
End date: 2011-08-23
Cubicin
Indication: Bacteraemia
Start date: 2011-08-14
Cubicin
End date: 2011-08-23
Cubicin
Indication: Postoperative Wound Infection
Start date: 2011-08-14
Other drugs received by patient: Antibiotics; Levofloxacin
Possible Cubicin side effects in 77 year old male
Reported by a physician from United States on 2012-08-24
Patient: 77 year old male
Reactions: Cardiac Valve Abscess, Cardiac Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cubicin
Possible Cubicin side effects in 46 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-22
Patient: 46 year old male
Reactions: Depressed Level of Consciousness, Somnolence, Asthenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cubicin
Indication: Product Used FOR Unknown Indication
Cubicin
Other drugs received by patient: Fluconazole; Itraconazole; Tazobactam; Doxycycline HCL; Anidulafungin; Ciprofloxacin; Fluconazole; Cefazolin; Vancomycin; Anidulafungin; Voriconazole; Piperacillin
Possible Cubicin side effects in female
Reported by a pharmacist from United Kingdom on 2012-08-22
Patient: female
Reactions: Creatinine Renal Clearance Decreased, Drug Ineffective, Inflammatory Marker Increased
Drug(s) suspected as cause:
Cubicin
Possible Cubicin side effects in 72 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-20
Patient: 72 year old male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Indication: Treatment Failure
Cubicin
Indication: Staphylococcal Infection
Other drugs received by patient: Flucloxacillin; Rifampicin
Possible Cubicin side effects in 78 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-20
Patient: 78 year old female
Reactions: Device Breakage
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Indication: Staphylococcal Infection
Cubicin
Indication: Treatment Failure
Other drugs received by patient: Rifampicin; Vancomycin; Gentamicin
Possible Cubicin side effects in
Reported by a pharmacist from United States on 2012-08-20
Patient:
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Possible Cubicin side effects in 72 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-20
Patient: 72 year old female
Reactions: Infection
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Indication: Drug Therapy Changed
Cubicin
Indication: Staphylococcal Infection
Other drugs received by patient: Gentamicin; Vancomycin; Rifampicin
Possible Cubicin side effects in 61 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-20
Patient: 61 year old male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Indication: Staphylococcal Infection
Cubicin
Indication: Treatment Failure
Other drugs received by patient: Linezolid; Flucloxacillin; Gentamicin; Rifampicin
Possible Cubicin side effects in 75 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-20
Patient: 75 year old female
Reactions: Infection
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Indication: Treatment Failure
Cubicin
Indication: Staphylococcal Infection
Other drugs received by patient: Gentamicin; Flucloxacillin; Rifampicin
Possible Cubicin side effects in 76 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-20
Patient: 76 year old female
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Indication: Treatment Failure
Cubicin
Indication: Staphylococcal Infection
Other drugs received by patient: Rifampicin; Vancomycin
Possible Cubicin side effects in 70 year old male
Reported by a physician from United States on 2012-08-17
Patient: 70 year old male
Reactions: Coma
Drug(s) suspected as cause:
Cubicin
Possible Cubicin side effects in 67 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-17
Patient: 67 year old male
Reactions: Vasculitic Rash
Drug(s) suspected as cause:
Cubicin
Indication: Renal Failure Acute
Cubicin
Indication: Staphylococcal Infection
Rifampicin
Indication: Product Used FOR Unknown Indication
Other drugs received by patient: Vancomycin; Gentamicin
Possible Cubicin side effects in 59 year old female
Reported by a physician from United Kingdom on 2012-08-17
Patient: 59 year old female
Reactions: Hyperparathyroidism
Adverse event resulted in: life threatening event, hospitalization, disablity
Drug(s) suspected as cause:
Cubicin
Other drugs received by patient: Vitamin A+D; Clindamycin
Possible Cubicin side effects in 7 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-17
Patient: 7 year old male
Reactions: Convulsion
Drug(s) suspected as cause:
Cubicin
Possible Cubicin side effects in 69 year old female
Reported by a physician from Germany on 2012-08-10
Patient: 69 year old female, weighing 93.0 kg (204.6 pounds)
Reactions: Haemothorax, Haemoglobin Decreased, Disseminated Intravascular Coagulation, Shock Haemorrhagic, Pneumothorax, Subcutaneous Haematoma, Small Intestinal Haemorrhage
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Cubicin
Other drugs received by patient: Ceftazidime; Cancidas; Garamycin
Possible Cubicin side effects in 43 year old male
Reported by a physician on 2012-08-10
Patient: 43 year old male, weighing 98.0 kg (215.6 pounds)
Reactions: Blood Creatine Phosphokinase Increased, Cardiac Failure, Pain, Hypertension
Drug(s) suspected as cause:
Cubicin
Other drugs received by patient: Meropenem
Possible Cubicin side effects in 43 year old
Reported by a health professional (non-physician/pharmacist) from Switzerland on 2012-08-09
Patient: 43 year old
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Indication: Enterococcal Infection
Cubicin
Possible Cubicin side effects in 57 year old
Reported by a health professional (non-physician/pharmacist) from Switzerland on 2012-08-09
Patient: 57 year old , weighing 56.0 kg (123.2 pounds)
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Indication: Staphylococcal Infection
Cubicin
Possible Cubicin side effects in 66 year old
Reported by a health professional (non-physician/pharmacist) from Switzerland on 2012-08-09
Patient: 66 year old , weighing 112.0 kg (246.4 pounds)
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Indication: Enterococcal Infection
Cubicin
Possible Cubicin side effects in 63 year old male
Reported by a physician from United States on 2012-08-06
Patient: 63 year old male
Reactions: Rhabdomyolysis, Blood Creatine Phosphokinase Increased, Aspartate Aminotransferase Increased, Drug Interaction
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Crestor
Administration route: Oral
Indication: Acute Respiratory Distress Syndrome
Start date: 2012-04-19
End date: 2012-04-19
Crestor
Administration route: Oral
Indication: Sepsis
Start date: 2012-04-19
End date: 2012-04-19
Crestor
Administration route: Oral
Start date: 2012-04-20
End date: 2012-05-01
Crestor
Administration route: Oral
Start date: 2012-04-20
End date: 2012-05-01
Cubicin
Dosage: 200ml/hour, 580mg
Start date: 2012-05-02
End date: 2012-05-02
Cubicin
Dosage: 200ml/hour, 580mg
Start date: 2012-04-30
End date: 2012-04-30
Other drugs received by patient: Lactulose; Albumin (Human); Diuril; Flagyl; Vancomycin; Meropenem; Ferrous Sulfate and Folic Acid; Casofungin; Atrovent; Levlbuterol; Levofloxacin
Possible Cubicin side effects in 63 year old male
Reported by a physician on 2012-08-06
Patient: 63 year old male
Reactions: Rhabdomyolysis, Blood Creatine Phosphokinase Increased, Refractory Anaemia, Haemorrhage, Hypotension, Aspartate Aminotransferase Increased, Drug Interaction
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Cubicin
Start date: 2012-05-02
End date: 2012-05-02
Cubicin
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-30
End date: 2012-04-30
Rosuvastatin
Administration route: Oral
Start date: 2012-04-19
End date: 2012-04-19
Rosuvastatin
Administration route: Oral
Start date: 2012-04-20
End date: 2012-05-30
Other drugs received by patient: Levalbuterol Hydrochloride; Vancomycin; Meropenem; Chlorothiazide; Lactulose; Ferrous Sulfate TAB; Caspofungin Acetate; Flagyl; Albumin (Human); Atrovent; Levofloxacin
Possible Cubicin side effects in 59 year old female
Reported by a physician from United Kingdom on 2012-08-03
Patient: 59 year old female
Reactions: Hyperparathyroidism
Adverse event resulted in: life threatening event, hospitalization, disablity
Drug(s) suspected as cause:
Cubicin
Other drugs received by patient: Clindamycin HCL
Possible Cubicin side effects in 61 year old male
Reported by a physician from Switzerland on 2012-08-03
Patient: 61 year old male
Reactions: Multi-Organ Failure, Infection
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Indication: Bacteraemia
Cubicin
Indication: Haemodialysis
Cubicin
Indication: Renal Failure
Cubicin
Indication: Hepatic Failure
Other drugs received by patient: Meropenem
Possible Cubicin side effects in 75 year old male
Reported by a physician from United States on 2012-08-03
Patient: 75 year old male
Reactions: Bronchopneumonia, Septic Shock
Adverse event resulted in: death
Drug(s) suspected as cause:
Caspofungin Acetate
Indication: Candidiasis
Cubicin
Indication: Product Used FOR Unknown Indication
Meropenem
Indication: Product Used FOR Unknown Indication
Posaconazole
Indication: Candidiasis
Other drugs received by patient: Cytarabine; Valtrex; Fluconazole; Fludarabine Phosphate; Levofloxacin; Voriconazole
Possible Cubicin side effects in 75 year old male
Reported by a physician from United States on 2012-08-03
Patient: 75 year old male
Reactions: Bronchopneumonia, Septic Shock
Adverse event resulted in: death
Drug(s) suspected as cause:
Caspofungin Acetate
Indication: Candidiasis
Cubicin
Indication: Product Used FOR Unknown Indication
Meropenem
Indication: Product Used FOR Unknown Indication
Posaconazole
Indication: Candidiasis
Other drugs received by patient: Valtrex; Voriconazole; Cytarabine; Fludarabine Phosphate; Fluconazole; Levofloxacin
Possible Cubicin side effects in 48 year old male
Reported by a physician from Switzerland on 2012-08-03
Patient: 48 year old male
Reactions: Post Procedural Haemorrhage, Disease Progression
Adverse event resulted in: death
Drug(s) suspected as cause:
Cubicin
Other drugs received by patient: Vancomycin
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