This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Combigan (Brimonidine / Timolol Ophthalmic) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (147)
Death (3)
Disability (2)
Reports by Reaction Type
Ocular Hyperaemia (27),
Eye Irritation (23),
Eye Pruritus (17),
Eye Pain (15),
Dizziness (11),
Headache (9),
Hypersensitivity (8),
Erythema of Eyelid (8),
Vision Blurred (8),
Dyspnoea (7),
Lacrimation Increased (7),
Erythema (6)
Below are a few examples of reports where side effects / adverse reactions may be related to Combigan (Brimonidine / Timolol Ophthalmic). For a complete list or a specific selection of reports, please use the links above.
Possible Combigan side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: male, weighing 81.6 kg (179.6 pounds)
Reactions: Ventricular Extrasystoles
Drug(s) suspected as cause:
Combigan
Possible Combigan side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-22
Patient: male
Reactions: Dizziness, Disorientation
Drug(s) suspected as cause:
Combigan
Possible Combigan side effects in 60 year old male
Reported by a consumer/non-health professional from Brazil on 2012-08-10
Patient: 60 year old male
Reactions: Hallucination, Visual, Memory Impairment, Loss of Consciousness
Drug(s) suspected as cause:
Combigan
Possible Combigan side effects in 69 year old female
Reported by a consumer/non-health professional from United States on 2012-07-30
Patient: 69 year old female
Reactions: Eye Pruritus
Drug(s) suspected as cause:
Combigan
Indication: Product Used FOR Unknown Indication
Lumigan
Indication: Product Used FOR Unknown Indication
Trusopt
Indication: Product Used FOR Unknown Indication
Possible Combigan side effects in female
Reported by a physician from United States on 2012-07-30
Patient: female
Reactions: Dermatitis Contact, Conjunctivitis Allergic
Drug(s) suspected as cause:
Azopt
Combigan
Indication: Product Used FOR Unknown Indication
Lumigan
Indication: Product Used FOR Unknown Indication
Possible Combigan side effects in 73 year old female
Reported by a consumer/non-health professional from United States on 2012-07-30
Patient: 73 year old female
Reactions: Skin Discolouration, Ocular Hyperaemia
Drug(s) suspected as cause:
Combigan
Dosage: 1 gtt, qam
Indication: Intraocular Pressure Test
Lumigan
Dosage: 1 gtt, qhs
Indication: Intraocular Pressure Test
Possible Combigan side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-30
Patient: female
Reactions: Burning Sensation, Erythema of Eyelid, Ocular Hyperaemia, DRY Skin, Eye Pruritus
Drug(s) suspected as cause:
Combigan
Dosage: unk
Indication: Product Used FOR Unknown Indication
Lumigan
Dosage: unk
Indication: Product Used FOR Unknown Indication
Possible Combigan side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-30
Patient: female
Reactions: Hair Growth Abnormal, Erythema, Pregnancy
Drug(s) suspected as cause:
Combigan
Indication: Product Used FOR Unknown Indication
Lumigan
Indication: Product Used FOR Unknown Indication
Possible Combigan side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-30
Patient: female
Reactions: Ocular Hyperaemia
Drug(s) suspected as cause:
Combigan
Dosage: unk
Indication: Glaucoma
Lumigan
Indication: Glaucoma
Possible Combigan side effects in 87 year old male
Reported by a physician from United States on 2012-07-30
Patient: 87 year old male
Reactions: Erythema of Eyelid, Eyelid Skin Dryness, Eyelid Irritation, Eyelid Exfoliation
Drug(s) suspected as cause:
Combigan
Dosage: 2 gtt, bid
Indication: Glaucoma
Start date: 2010-01-01
Lumigan
Dosage: 2 gtt, qhs
Indication: Glaucoma
Start date: 2010-01-01
Possible Combigan side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-30
Patient: female
Reactions: Hypoaesthesia Oral, Heart Rate Increased
Drug(s) suspected as cause:
Combigan
Indication: Product Used FOR Unknown Indication
Lumigan
Dosage: unk
Indication: Product Used FOR Unknown Indication
Possible Combigan side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-18
Patient: female
Reactions: Ecchymosis
Drug(s) suspected as cause:
Cascara TAB
Combigan
Coumadin
Dosage: blue tab
Possible Combigan side effects in
Reported by a physician from United States on 2012-07-11
Patient:
Reactions: Deafness
Drug(s) suspected as cause:
Combigan
Possible Combigan side effects in 79 year old female
Reported by a pharmacist from Spain on 2012-07-06
Patient: 79 year old female
Reactions: Syncope, Sinus Disorder
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Combigan
Other drugs received by patient: Emeproton 20 MG Capsulas Duras Gastrorresistentes , 14 Capsulas; Indapamida; Xalatan 0,005%, Colirio EN Solucion , 1 Frasco DE 5 ML; Vesicare 5 MG Comprimidos Recubiertos CON Pelicula , 30 Comprimidos; Alphagan 2 MG / ML Colirio EN Solucion , 1 Envase DE 5 ML; Lormetazepam; Duphalac Solucion Oral Sobres , 10 Sobres; Cymbalta 30mg 28 Capsulas Duras
Possible Combigan side effects in 60 year old male
Reported by a consumer/non-health professional from Brazil on 2012-07-03
Patient: 60 year old male
Reactions: Hallucination, Visual, Memory Impairment, Loss of Consciousness
Drug(s) suspected as cause:
Combigan
Possible Combigan side effects in 89 year old female
Reported by a physician from United States on 2012-06-25
Patient: 89 year old female, weighing 65.8 kg (144.7 pounds)
Reactions: Confusional State, Incorrect Dose Administered, Swollen Tongue, Speech Disorder, Overdose, DRY Mouth, Dehydration, Bradycardia, Transient Ischaemic Attack, Asthenia, Lethargy
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Combigan
Other drugs received by patient: Plavix; Levothyroxine; Travatan Z
Possible Combigan side effects in male
Reported by a consumer/non-health professional from Brazil on 2012-06-22
Patient: male
Reactions: Hallucination, Visual, Memory Impairment, Loss of Consciousness
Drug(s) suspected as cause:
Combigan
Possible Combigan side effects in 66 year old female
Reported by a consumer/non-health professional from United States on 2012-06-21
Patient: 66 year old female
Reactions: Eye Irritation, Scleral Hyperaemia, Rash, Eye Disorder, Erythema, Eye Pruritus
Drug(s) suspected as cause:
Combigan
Dosage: 2 gtt, bid
Indication: Intraocular Pressure Increased
Start date: 2012-02-01
Lumigan
Dosage: 2 gtt, qhs
Indication: Intraocular Pressure Increased
Start date: 2012-02-01
Possible Combigan side effects in 44 year old male
Reported by a consumer/non-health professional from United States on 2012-06-21
Patient: 44 year old male
Reactions: Dizziness, Headache, Eye Pain
Drug(s) suspected as cause:
Combigan
Dosage: 1 gtt, bid
Indication: Glaucoma
Start date: 2011-12-01
End date: 2012-01-01
Lumigan
Dosage: 1 gtt, bid
Indication: Glaucoma
Start date: 2011-12-01
Possible Combigan side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-21
Patient: female
Reactions: Burning Sensation, Ocular Hyperaemia
Drug(s) suspected as cause:
Combigan
Dosage: one drop to each eye, twice per day
Indication: Intraocular Pressure Test
Start date: 2012-03-02
Lumigan
Dosage: one drop to each eye, once at night
Indication: Intraocular Pressure Test
Start date: 2012-03-02
Possible Combigan side effects in 68 year old male
Reported by a physician from United States on 2012-06-21
Patient: 68 year old male
Reactions: Eye Irritation, Lacrimation Increased
Drug(s) suspected as cause:
Combigan
Dosage: 1 gtt, qhs
Indication: Intraocular Pressure Increased
Start date: 2007-01-01
Lumigan
Dosage: 2 gtt, qam
Indication: Intraocular Pressure Increased
Possible Combigan side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-19
Patient: female
Reactions: Ear Discomfort, Nasal Oedema, Dyspnoea, Swelling, Pain, Ear Pain, Headache
Drug(s) suspected as cause:
Azopt
Dosage: unk, each eye 1x/day
Combigan
Dosage: unk, each eye 2x/day
Latanoprost
Dosage: unk
Lumigan
Dosage: unk, each eye every night at bed time
Pilocarpine HCL
Dosage: unk
Xalatan
Dosage: unk, each eye every night at bed time
Possible Combigan side effects in 77 year old female
Reported by a physician from United States on 2012-06-15
Patient: 77 year old female
Reactions: Coronary Artery Occlusion
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Alphagan P
Dosage: unk
Indication: Glaucoma
Start date: 2011-12-05
End date: 2012-05-01
Combigan
Indication: Glaucoma
Other drugs received by patient: Plavix; Lisinopril; Aspirin
Possible Combigan side effects in 42 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-24
Patient: 42 year old male, weighing 111.0 kg (244.2 pounds)
Reactions: Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Combigan
Dosage: 2 gtt, bid
Indication: Glaucoma
Start date: 2010-04-01
Lumigan
Dosage: 2 gtt, qhs
Indication: Glaucoma
Start date: 2005-07-01
Possible Combigan side effects in 63 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-05-21
Patient: 63 year old male
Reactions: Pain, Localised Oedema, Erythema
Drug(s) suspected as cause:
Azopt
Dosage: (ophthalmic)
Start date: 2012-04-17
End date: 2012-04-23
Combigan
Dosage: (ophthalmic)
Start date: 2012-04-17
End date: 2012-04-23
Possible Combigan side effects in 63 year old male
Reported by a consumer/non-health professional from United Kingdom on 2012-05-16
Patient: 63 year old male
Reactions: Local Reaction, Pain, Localised Oedema, Erythema
Drug(s) suspected as cause:
Azopt
Dosage: unk
Administration route: Topical
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-17
End date: 2012-04-23
Combigan
Dosage: unk
Administration route: Topical
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-17
End date: 2012-04-23
Possible Combigan side effects in 89 year old female
Reported by a physician from United States on 2012-05-11
Patient: 89 year old female, weighing 65.8 kg (144.7 pounds)
Reactions: Confusional State, Incorrect Dose Administered, Swollen Tongue, Asthenia, Lethargy
Drug(s) suspected as cause:
Combigan
Other drugs received by patient: Plavix; Levothyroxine Sodium
Possible Combigan side effects in 42 year old male
Reported by a physician from United States on 2012-05-03
Patient: 42 year old male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Combigan
Dosage: unk
Indication: Product Used FOR Unknown Indication
Start date: 2009-01-01
Lumigan
Dosage: unk
Indication: Product Used FOR Unknown Indication
Start date: 2009-01-01
Possible Combigan side effects in female
Reported by a individual with unspecified qualification from United States on 2012-03-26
Patient: female, weighing 49.4 kg (108.8 pounds)
Reactions: Thinking Abnormal, Dizziness, Vertigo, Blindness Unilateral, Disorientation, Cerebrovascular Accident
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Combigan
Dosage: 2@day
Travatan
Dosage: 1 @day
Possible Combigan side effects in 73 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-03-20
Patient: 73 year old female, weighing 68.0 kg (149.6 pounds)
Reactions: Swelling Face, Diarrhoea, Headache, Throat Tightness
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Combigan
Other drugs received by patient: Timolol Maleate; Zovirax; Azopt; Bendroflumethiazide; Bisoprolol Fumarate; Hypromellose; Amitriptyline HCL; Maxidex
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