This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Clozaril (Clozapine) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (4575)
Death (875)
Life Threatening Events (234)
Disability (138)
Reports by Reaction Type
White Blood Cell Count Increased (651),
White Blood Cell Count Decreased (523),
Neutrophil Count Increased (513),
Death (423),
Neutrophil Count Decreased (407),
Platelet Count Decreased (398),
Malaise (352),
Neutropenia (345),
Haemoglobin Decreased (310),
Pyrexia (235),
Urinary Tract Infection (232),
Mental Impairment (230)
Below are a few examples of reports where side effects / adverse reactions may be related to Clozaril (Clozapine). For a complete list or a specific selection of reports, please use the links above.
Possible Clozaril side effects in female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-27
Patient: female
Reactions: Anxiety, Tachycardia, Therapy Responder
Drug(s) suspected as cause:
Clozaril
Dosage: 450 mg, daily
Administration route: Oral
Indication: Schizophrenia
Start date: 2011-11-18
Hyoscine Hydrobromide
Dosage: 600 ug,daily
Administration route: Oral
Risperidone
Dosage: 2 mg, daily
Administration route: Oral
Indication: Schizophrenia
Venlafaxine
Dosage: 150 mg, daily
Administration route: Oral
Indication: Depressed Mood
Other drugs received by patient: Mirtazapine
Possible Clozaril side effects in male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-27
Patient: male, weighing 81.7 kg (179.7 pounds)
Reactions: Confusional State, Blood Creatine Phosphokinase Increased, Anaemia, General Physical Health Deterioration, Pyrexia, Disorientation, Fall, C-Reactive Protein Increased, Sepsis, Gait Disturbance, Neuroleptic Malignant Syndrome, Neutropenia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Clozaril
Other drugs received by patient: Simvastatin; Escitalopram; Tamsulosin Hydrochloride; Dekristol; Omeprazole; Hyoscine Hydrobromide; Ferrous Sulfate TAB
Possible Clozaril side effects in male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-27
Patient: male
Reactions: Cerebrovascular Accident
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-27
Patient: male
Reactions: Peritonitis
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in female
Reported by a physician from Ireland on 2012-08-27
Patient: female
Reactions: Breast Cancer Recurrent
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a physician from United Kingdom on 2012-08-27
Patient: male
Reactions: Neutrophilia, Fall, Constipation, Abdominal Discomfort, Dehydration, Differential White Blood Cell Count Abnormal, Circulatory Collapse, Fluid Intake Reduced, White Blood Cell Count Increased
Drug(s) suspected as cause:
Clozaril
Administration route: Oral
Indication: Schizophrenia
Start date: 2001-07-01
Clozaril
Dosage: 500 mg, daily
Administration route: Oral
Start date: 2004-01-01
Other drugs received by patient: Duloxetine Hydrochloride
Possible Clozaril side effects in female
Reported by a physician from Canada on 2012-08-27
Patient: female
Reactions: Multi-Organ Failure
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Clozaril
Dosage: unk ukn, unk
Clozaril
Dosage: (1 tablet (25 mg) every night at bedtime along with 4 tablets of 100 mg)
Administration route: Oral
Indication: Schizophrenia
Start date: 1995-10-16
Other drugs received by patient: Entrophen; Quetiapine; Bupropion HCL; Isopto Atropin; Soflax; Valproate Sodium; Novo-Peridol; Metformin HCL; Novo-Peridol; APO-Benztropine; Crestor
Possible Clozaril side effects in male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-27
Patient: male
Reactions: Differential White Blood Cell Count Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozaril
Administration route: Oral
Indication: Psychotic Disorder
Start date: 2007-06-27
Clozaril
Dosage: 350 mg,(150 mg mane and 200 mg notche)
Administration route: Oral
Other drugs received by patient: Procyclidine Hydrochloride 2MG TAB; Lithium Carbonate; Valproate Sodium
Possible Clozaril side effects in male
Reported by a physician from United Kingdom on 2012-08-27
Patient: male
Reactions: White Blood Cell Count Decreased, Neutrophil Count Increased, Platelet Count Decreased, Antipsychotic Drug Level Above Therapeutic, Lymphoma, Neutrophil Count Decreased, White Blood Cell Count Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a physician from United States on 2012-08-27
Patient: male
Reactions: Leukaemia, Psychotic Disorder, RED Blood Cell Count Decreased, Concomitant Disease Aggravated, White Blood Cell Count Increased
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in female
Reported by a physician from Australia on 2012-08-27
Patient: female
Reactions: Drug Ineffective, Salivary Hypersecretion, Enuresis
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Clozaril
Other drugs received by patient: Seroquel; Effexor XR
Possible Clozaril side effects in male
Reported by a pharmacist from United States on 2012-08-27
Patient: male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a physician from Canada on 2012-08-27
Patient: male
Reactions: Death, Fatigue
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozaril
Dosage: 200 mg, qhs
Administration route: Oral
End date: 2010-11-10
Clozaril
Dosage: 125 mg, qhs
Administration route: Oral
Indication: Schizophrenia, Disorganised Type
Start date: 2010-11-09
Possible Clozaril side effects in male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-27
Patient: male
Reactions: Neutrophil Count Increased, Vomiting, Platelet Count Decreased, White Blood Cell Count Increased
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a pharmacist from United Kingdom on 2012-08-27
Patient: male
Reactions: Back Pain, Sciatica
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in female
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-27
Patient: female
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a pharmacist from United Kingdom on 2012-08-27
Patient: male
Reactions: Rheumatoid Arthritis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a physician from Australia on 2012-08-27
Patient: male
Reactions: Mental Impairment
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a physician from United Kingdom on 2012-08-27
Patient: male
Reactions: Dysstasia, Hypotension, Dizziness, Salivary Hypersecretion
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a physician from United Kingdom on 2012-08-27
Patient: male, weighing 62.0 kg (136.4 pounds)
Reactions: Overdose, Depression, Schizophrenia, Paranoid Type, Loss of Consciousness
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozaril
Dosage: 375 mg, qd
Start date: 2012-07-03
Clozaril
Dosage: 4 to 6 tablets
Start date: 2012-06-29
Clozaril
Dosage: 375 mg, daily
Administration route: Oral
Indication: Psychotic Disorder
Start date: 2011-08-20
Other drugs received by patient: Paroxetine HCL; Simvastatin; Atenolol; Doxazosin Mesylate; Amisulpride; Aripiprazole
Possible Clozaril side effects in female
Reported by a physician from United Kingdom on 2012-08-27
Patient: female
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a physician from United Kingdom on 2012-08-27
Patient: male
Reactions: Mental Impairment, Colon Cancer, Neuroleptic Malignant Syndrome
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozaril
Administration route: Oral
Indication: Schizophrenia
Start date: 2010-11-01
End date: 2011-09-29
Clozaril
Dosage: unk ukn, unk
Other drugs received by patient: Paliperidone; Olanzapine
Possible Clozaril side effects in male
Reported by a physician from United Kingdom on 2012-08-27
Patient: male
Reactions: Sudden Cardiac Death, Circulatory Collapse
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-27
Patient: male
Reactions: Neutrophil Count Increased, Lymphoma, White Blood Cell Count Increased
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a physician from United Kingdom on 2012-08-27
Patient: male
Reactions: Skin Cancer, Platelet Count Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozaril
Other drugs received by patient: Lithium Carbonate
Possible Clozaril side effects in female
Reported by a physician from United Kingdom on 2012-08-27
Patient: female, weighing 81.0 kg (178.2 pounds)
Reactions: Pneumonia, Respiratory Failure, Malignant Glioma, Chronic Obstructive Pulmonary Disease
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozaril
Dosage: 360 mg, (160 mg mane and 200 mg nocte)
Clozaril
Dosage: unk ukn, unk
Administration route: Oral
Indication: Schizophrenia, Paranoid Type
Start date: 1993-11-30
Other drugs received by patient: Acetaminophen / Hydrocodone Bitartrate; Fluticasone Propionate / Salmeterol; Albuterol Sulate; Lansoprazole; Escitalopram; Procyclidine Hydrochloride 2MG TAB
Possible Clozaril side effects in female
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-27
Patient: female
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozaril
Possible Clozaril side effects in male
Reported by a physician from Australia on 2012-08-27
Patient: male
Reactions: Ventricular Extrasystoles, Atrial Septal Defect, Neutrophil Count Increased, Dilatation Ventricular, Ejection Fraction Decreased, Left Atrial Dilatation, Sinus Tachycardia, Blood Glucose Increased
Drug(s) suspected as cause:
Clozaril
Other drugs received by patient: Benztropine Mesylate; Haloperidol; Citalopram Hydrobromide; Valium; Crestor
Possible Clozaril side effects in female
Reported by a physician from Ireland on 2012-08-27
Patient: female
Reactions: Haemoglobin Decreased, White Blood Cell Count Decreased, Dyspnoea, Lung Neoplasm, non-Small Cell Lung Cancer, Lower Respiratory Tract Infection, Cough
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozaril
Other drugs received by patient: Diazepam; Aripiprazole; Valproic Acid; Fluoxetine HCL; Spiriva
Possible Clozaril side effects in female
Reported by a physician from United Kingdom on 2012-08-27
Patient: female
Reactions: Anxiety, Tachycardia, Therapy Responder
Drug(s) suspected as cause:
Clozaril
Dosage: 450 mg, daily
Administration route: Oral
Indication: Schizophrenia
Start date: 2011-11-18
Hyoscine Hydrobromide
Dosage: 600 ug,daily
Administration route: Oral
Risperidone
Dosage: 2 mg, daily
Administration route: Oral
Indication: Schizophrenia
Venlafaxine
Dosage: 150 mg, daily
Administration route: Oral
Indication: Depressed Mood
Other drugs received by patient: Mirtazapine
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