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Clozapine (Clozapine) - Serious Reactions - Suspected Cause - Side Effect Reports

 
 



Index of reports > Serious Reactions (1274)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Clozapine serious reactions. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 1274   Next >>

Possible Clozapine side effects in 48 year old female

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-08-27

Patient: 48 year old female

Reactions: Catatonia, Neuroleptic Malignant Syndrome

Drug(s) suspected as cause:
Clozapine
    Dosage: 25 mg/day

Haloperidol
    Dosage: 2mg
    Start date: 2008-12-01

Olanzapine
    Dosage: up to 10 mg/day
    Start date: 2008-01-01

Chlorpromazine HCL
    Dosage: 50mg
    Start date: 2008-12-01

Other drugs received by patient: Doxazosin Mesylate



Possible Clozapine side effects in female

Reported by a physician from United States on 2012-08-27

Patient: female

Reactions: Cardiac Arrest, Cardiovascular Disorder

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Cogentin; Ambien; Wellbutrin XL; Risperdal; Colace; Ativan



Possible Clozapine side effects in 48 year old female

Reported by a physician from Italy on 2012-08-27

Patient: 48 year old female

Reactions: Catatonia, Neuroleptic Malignant Syndrome

Drug(s) suspected as cause:
Clozapine
    Dosage: 100 milligram daily;

Haloperidol
    Dosage: 2 milligram daily;
    Start date: 2008-12-01

Olanzapine
    Dosage: up to 10 mg/day
    Start date: 2008-01-01

Clozapine
    Dosage: overdose
    Start date: 2008-11-01

Chlorpromazine HCL
    Dosage: 50 milligram daily;
    Start date: 2008-12-01

Clozapine
    Dosage: 25 milligram daily;
    Indication: Intentional Overdose

Other drugs received by patient: Doxazosin Mesylate



Possible Clozapine side effects in 36 year old female

Reported by a physician from United Kingdom on 2012-08-27

Patient: 36 year old female

Reactions: Body Mass Index Decreased, Diabetes Mellitus, Pyrexia, Mean Cell Volume Decreased, Constipation, Abdominal Tenderness, Malaise, Iron Deficiency Anaemia, White Blood Cell Count Increased, Neutrophil Count Increased, Hiatus Hernia, Cardiac Murmur, Urinary Tract Infection, Physical Assault, Skin Disorder, Monocyte Count Increased, White Blood Cell Disorder, Staphylococcal Infection, Thrombocytosis, Hypertension, Sinus Tachycardia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Folic Acid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Zopiclone
    Indication: Product Used FOR Unknown Indication

Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2005-05-01
    End date: 2005-05-19

Diazepam
    Indication: Product Used FOR Unknown Indication

Perindopril
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Lansoprazole
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Trimethoprim
    Indication: Urinary Tract Infection

Clozapine
    Administration route: Oral
    Start date: 2008-06-05

Lactulose
    Indication: Product Used FOR Unknown Indication

Clozapine
    Administration route: Oral
    Start date: 2008-05-19

Clozapine
    Administration route: Oral
    Start date: 2006-06-05
    End date: 2006-07-13

Ferrous Sulfate TAB
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Furosemide; Ramipril; Atorvastatin; Bendroflumethiazide; Aripiprazole



Possible Clozapine side effects in 48 year old female

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-08-27

Patient: 48 year old female

Reactions: Catatonia, Neuroleptic Malignant Syndrome

Drug(s) suspected as cause:
Clozapine
    Dosage: 25 mg/day

Olanzapine
    Dosage: up to 10 mg/day
    Start date: 2008-01-01

Chlorpromazine HCL
    Dosage: 50mg
    Start date: 2008-12-01

Haloperidol
    Dosage: 2mg
    Start date: 2008-12-01

Other drugs received by patient: Doxazosin Mesylate



Possible Clozapine side effects in male

Reported by a physician from Germany on 2012-08-24

Patient: male

Reactions: C-Reactive Protein Increased, Lipase Increased

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Tiapridex



Possible Clozapine side effects in female

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-08-24

Patient: female

Reactions: Haemorrhagic Anaemia, Gastrooesophageal Reflux Disease

Drug(s) suspected as cause:
Taxilan

Clozapine

Haloperidol Lactate

Levofloxacin



Possible Clozapine side effects in 53 year old male

Reported by a physician from Finland on 2012-08-24

Patient: 53 year old male

Reactions: Psychotic Disorder, Neutrophil Count Decreased

Drug(s) suspected as cause:
Clozapine
    Dosage: unk
    Administration route: Oral

Clozapine
    Dosage: unk
    Administration route: Oral

Clozapine
    Dosage: unk
    Administration route: Oral



Possible Clozapine side effects in female

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-08-24

Patient: female

Reactions: Haemorrhagic Anaemia, Gastrooesophageal Reflux Disease

Drug(s) suspected as cause:
Levofloxacin

Taxilan

Clozapine

Haloperidol Lactate



Possible Clozapine side effects in 50 year old female

Reported by a physician from Finland on 2012-08-23

Patient: 50 year old female

Reactions: Antipsychotic Drug Level Increased, Body Mass Index Increased, Blood Triglycerides Increased, Oropharyngeal Pain, Genital Haemorrhage, Constipation, Liver Disorder, Malaise, C-Reactive Protein Increased, Proteinuria, Urosepsis, Metabolic Disorder, Blood Creatinine Increased, Anaemia, Urinary Tract Infection, Hepatic Enzyme Increased, Renal Impairment, Neoplasm Malignant, Insomnia, Enterococcus Test Positive

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 250 mg, qd
    Administration route: Oral
    Start date: 2012-07-19

Clozapine
    Dosage: 500 mg, per day
    Administration route: Oral

Other drugs received by patient: Abilify; Sodium Bicarbonate; Obsidan; Haloperidol; Primolut; Metronidazole HCL; Calcium Carbonate; Gaviscon; Terolut



Possible Clozapine side effects in female

Reported by a physician from Japan on 2012-08-22

Patient: female

Reactions: Pulmonary Embolism, Deep Vein Thrombosis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Olanzapine
    Indication: Product Used FOR Unknown Indication

Haloperidol
    Indication: Product Used FOR Unknown Indication

Clozapine
    Indication: Product Used FOR Unknown Indication

Impromen
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Risperdal
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Zotepine
    Indication: Product Used FOR Unknown Indication

Levomefolate Calcium
    Indication: Product Used FOR Unknown Indication



Possible Clozapine side effects in female

Reported by a consumer/non-health professional from Germany on 2012-08-22

Patient: female

Reactions: Neutrophil Count Increased, Antipsychotic Drug Level Increased, Fear of Death, Tachycardia, Condition Aggravated, Cerebrovascular Accident, Viith Nerve Paralysis, Dysarthria, Antipsychotic Drug Level Below Therapeutic, Incontinence, Psychotic Disorder, Salivary Hypersecretion, White Blood Cell Count Increased

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Dosage: 100 mg, qid
    Administration route: Oral
    Start date: 2011-02-01
    End date: 2011-08-01

Clozapine
    Dosage: 300 mg, (0-0-50-250-mg qd)
    Administration route: Oral
    Start date: 2011-08-04

Other drugs received by patient: Lorazepam; Valproate Sodium



Possible Clozapine side effects in male

Reported by a physician from France on 2012-08-21

Patient: male, weighing 87.0 kg (191.4 pounds)

Reactions: Intestinal Ischaemia, Dissociative Disorder, Colitis Ischaemic, Anaemia, Intestinal Obstruction, Delirium, Hypokalaemia, Lung Disorder, Hypomagnesaemia, Hypoalbuminaemia, Suicide Attempt, Septic Shock

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Seroquel
    Dosage: dose progressively increased
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-02-06
    End date: 2012-03-05

Arixtra
    Start date: 2012-01-01
    End date: 2012-03-01

Atarax

Clozapine
    Dosage: 300 mg to 400 mg per day
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-01-12
    End date: 2012-01-19

Codeine Sulfate
    Administration route: Oral
    Start date: 2012-02-01
    End date: 2012-03-01

Sandostatin
    Start date: 2012-02-01
    End date: 2012-03-01

Nexium
    Administration route: Oral

Tranxene
    Administration route: Oral
    Indication: Agitation
    Start date: 2012-01-27
    End date: 2012-03-05

Imodium
    Administration route: Oral
    Indication: Diarrhoea
    Start date: 2012-02-01
    End date: 2012-03-01

Tranxene
    Administration route: Oral
    Indication: Anxiety
    Start date: 2012-01-27
    End date: 2012-03-05



Possible Clozapine side effects in female

Reported by a physician from United Kingdom on 2012-08-21

Patient: female

Reactions: Body Mass Index Decreased, Diabetes Mellitus, Mean Cell Volume Decreased, Pyrexia, Constipation, Abdominal Tenderness, Malaise, Iron Deficiency Anaemia, White Blood Cell Count Increased, Hiatus Hernia, Cardiac Murmur, Neutrophil Count Increased, Urinary Tract Infection, Skin Disorder, Monocyte Count Increased, Aggression, White Blood Cell Disorder, Staphylococcal Infection, Thrombocytosis, Sinus Tachycardia, Hypertension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Diazepam
    Dosage: unk ukn, prn

Ferrous Sulfate TAB
    Dosage: 200 mg, bid
    Administration route: Oral

Clozaril
    Administration route: Oral
    Start date: 2008-06-05

Lactulose
    Dosage: 10 ml, prn

Clozaril
    Dosage: unk ukn, unk
    Administration route: Oral
    Start date: 2006-06-05
    End date: 2006-07-13

Lansoprazole
    Dosage: 30 mg, qd
    Administration route: Oral

Perindopril Erbumine
    Dosage: 2 mg, qd
    Administration route: Oral

Folic Acid
    Dosage: 5 mg, qd
    Administration route: Oral

Clozaril
    Dosage: 250 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2005-05-01
    End date: 2005-05-19

Trimethoprim
    Dosage: unk ukn, unk
    Indication: Urinary Tract Infection

Clozapine
    Dosage: unk ukn, qd

Clozaril
    Dosage: 250 mg, daily
    Administration route: Oral
    Start date: 2008-05-19

Zopiclone
    Dosage: 3.75 mg, qhs

Clozapine
    Dosage: unk ukn, unk
    Start date: 2008-05-19

Other drugs received by patient: Furosemide; Atorvastatin; Abilify; Ramipril; Bendrofluazide



Possible Clozapine side effects in 47 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-21

Patient: 47 year old male, weighing 126.6 kg (278.4 pounds)

Reactions: Product Substitution Issue, Mental Impairment

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in

Reported by a physician from Australia on 2012-08-21

Patient:

Reactions: Neuroleptic Malignant Syndrome

Drug(s) suspected as cause:
Vimpat
    Indication: Partial Seizures
    Start date: 2012-07-01

Clozapine
    Indication: Psychotic Disorder
    Start date: 2012-08-01

Other drugs received by patient: Zyprexa



Possible Clozapine side effects in male

Reported by a consumer/non-health professional from Argentina on 2012-08-20

Patient: male

Reactions: Mumps, White Blood Cell Count Increased

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Olanzapine; Benzodiazepines



Possible Clozapine side effects in 38 year old male

Reported by a physician from France on 2012-08-20

Patient: 38 year old male

Reactions: Agranulocytosis, Lung Disorder, Anaemia, Colitis

Drug(s) suspected as cause:
Clozapine
    Dosage: 75 mg /day
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-06-21

Clozapine
    Dosage: 200 mg/day ( increments of 25 mg to reach 200 mg daily)
    Administration route: Oral
    End date: 2012-07-31



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-20

Patient: male

Reactions: Metastatic Neoplasm

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in female

Reported by a physician from Norway on 2012-08-20

Patient: female

Reactions: C-Reactive Protein Increased, Chills, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Pyrexia, Influenza Like Illness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Vallergan; AFI-D2-Forte; Seroquel



Possible Clozapine side effects in

Reported by a individual with unspecified qualification from United States on 2012-08-20

Patient:

Reactions: Lupus-Like Syndrome

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in 50 year old female

Reported by a physician from Finland on 2012-08-20

Patient: 50 year old female

Reactions: Body Mass Index Increased, Antipsychotic Drug Level Increased, Blood Triglycerides Increased, Oropharyngeal Pain, Constipation, Liver Disorder, Malaise, C-Reactive Protein Increased, Proteinuria, Urosepsis, Metabolic Disorder, Blood Creatinine Increased, Urinary Tract Infection, Anaemia, Hepatic Enzyme Increased, Renal Impairment, Insomnia, Enterococcus Test Positive

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 250 mg, qd
    Administration route: Oral
    Start date: 2012-07-19

Clozapine
    Dosage: 500 mg, per day
    Administration route: Oral

Other drugs received by patient: Haloperidol; Abilify; Metronidazole HCL; Obsidan; Primolut; Gaviscon



Possible Clozapine side effects in female

Reported by a consumer/non-health professional from Germany on 2012-08-17

Patient: female

Reactions: Neutrophil Count Increased, Fear of Death, Tachycardia, Cerebrovascular Accident, Viith Nerve Paralysis, Dysarthria, Psychotic Disorder, Incontinence, Salivary Hypersecretion, White Blood Cell Count Increased

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Dosage: 100 mg, qid
    Administration route: Oral
    Start date: 2011-02-01
    End date: 2011-08-01

Clozapine
    Dosage: 300 mg, (0-0-50-250-mg qd)
    Administration route: Oral
    Start date: 2011-08-04

Other drugs received by patient: Valproate Sodium



Possible Clozapine side effects in 22 year old male

Reported by a physician from United Kingdom on 2012-08-17

Patient: 22 year old male, weighing 66.4 kg (146.1 pounds)

Reactions: Vomiting, Antipsychotic Drug Level Increased, Nausea, Electrocardiogram QT Shortened, Constipation, Faecaloma, Asphyxia, Mental Impairment, Overdose, Aspiration, Pulmonary Congestion, Sedation, Choking, Pulmonary Oedema

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine
    Dosage: 250 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2011-11-30

Lorazepam
    Dosage: 1 t0 4 mg, prn
    Indication: Anxiety

Clozapine
    Dosage: 250 mg, unk
    Start date: 2012-01-11
    End date: 2012-01-11

Lorazepam
    Dosage: 11x1 mg dose

Other drugs received by patient: Propranolol; Kwells; Sertraline Hydrochloride



Possible Clozapine side effects in female

Reported by a physician from Germany on 2012-08-17

Patient: female

Reactions: Breast Cancer

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Dosage: 200 mg, unk
    Administration route: Oral
    Start date: 2007-01-01

Clozapine
    Dosage: 100 mg, unk
    Administration route: Oral
    Indication: Schizophrenia

Clozapine
    Dosage: 300 mg, qd
    Administration route: Oral

Other drugs received by patient: Tamoxifen Citrate



Possible Clozapine side effects in male

Reported by a physician from France on 2012-08-17

Patient: male, weighing 87.0 kg (191.4 pounds)

Reactions: Colitis Ischaemic, Intestinal Ischaemia, Dissociative Disorder, Anaemia, Intestinal Obstruction, Delirium, Hypokalaemia, Lung Disorder, Hypomagnesaemia, Hypoalbuminaemia, Suicide Attempt, Septic Shock

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Nexium
    Administration route: Oral

Imodium
    Administration route: Oral
    Indication: Diarrhoea
    Start date: 2012-02-01
    End date: 2012-03-01

Tranxene
    Administration route: Oral
    Indication: Agitation
    Start date: 2012-01-27
    End date: 2012-03-05

Seroquel
    Dosage: dose progressively increased
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-02-06
    End date: 2012-03-05

Tranxene
    Administration route: Oral
    Indication: Anxiety
    Start date: 2012-01-27
    End date: 2012-03-05

Codeine Sulfate
    Administration route: Oral
    Start date: 2012-02-01
    End date: 2012-03-01

Clozapine
    Dosage: 300 mg to 400 mg per day
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-01-12
    End date: 2012-01-19

Atarax

Arixtra
    Start date: 2012-01-01
    End date: 2012-03-01

Sandostatin
    Start date: 2012-02-01
    End date: 2012-03-01



Possible Clozapine side effects in male

Reported by a physician from Switzerland on 2012-08-17

Patient: male

Reactions: Retrograde Ejaculation, Infertility Male

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in 36 year old female

Reported by a physician from United Kingdom on 2012-08-16

Patient: 36 year old female

Reactions: Body Mass Index Decreased, Diabetes Mellitus, Pyrexia, Mean Cell Volume Decreased, Constipation, Abdominal Tenderness, Malaise, Iron Deficiency Anaemia, White Blood Cell Count Increased, Hiatus Hernia, Cardiac Murmur, Neutrophil Count Increased, Urinary Tract Infection, Physical Assault, Skin Disorder, Monocyte Count Increased, White Blood Cell Disorder, Staphylococcal Infection, Thrombocytosis, Hypertension, Sinus Tachycardia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Start date: 2006-06-05
    End date: 2006-07-13

Clozapine
    Administration route: Oral
    Start date: 2008-05-19

Perindopril Erbumine
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Lactulose
    Indication: Product Used FOR Unknown Indication

Trimethoprim
    Indication: Urinary Tract Infection

Lansoprazole
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Ferrous Sulfate TAB
    Indication: Product Used FOR Unknown Indication

Zopiclone
    Indication: Product Used FOR Unknown Indication

Folic Acid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Clozapine
    Administration route: Oral
    Start date: 2008-06-05

Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2005-05-01
    End date: 2005-05-19

Diazepam
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Atorvastatin; Bendroflumethiazide; Furosemide; Aripiprazole; Ramipril



Possible Clozapine side effects in 45 year old female

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-08-16

Patient: 45 year old female

Reactions: Oculogyric Crisis

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in female

Reported by a health professional (non-physician/pharmacist) from Netherlands on 2012-08-16

Patient: female, weighing 75.0 kg (165.0 pounds)

Reactions: Renal Disorder, Agranulocytosis, Hypophagia, Somnolence, Leukopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Aspirin; Persantine; Exelon; Nexium; Carbidopa + Levodopa; Movicolon; Triamteren; Amoxicillin and Clavulanate Potassium; Trimethoprim; Arimidex; Acetaminophen; Seroquel; Calcium Carbonate W / Colecalciferol



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