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Clozapine (Clozapine) - Life Threatening Events - Suspected Cause - Side Effect Reports

 
 



Index of reports > Life Threatening Events (141)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Clozapine life threatening events. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 141   Next >>

Possible Clozapine side effects in male

Reported by a physician from Germany on 2012-08-22

Patient: male

Reactions: Infection

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in female

Reported by a consumer/non-health professional from Germany on 2012-08-22

Patient: female

Reactions: Neutrophil Count Increased, Antipsychotic Drug Level Increased, Fear of Death, Tachycardia, Condition Aggravated, Cerebrovascular Accident, Viith Nerve Paralysis, Dysarthria, Antipsychotic Drug Level Below Therapeutic, Incontinence, Psychotic Disorder, Salivary Hypersecretion, White Blood Cell Count Increased

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Dosage: 100 mg, qid
    Administration route: Oral
    Start date: 2011-02-01
    End date: 2011-08-01

Clozapine
    Dosage: 300 mg, (0-0-50-250-mg qd)
    Administration route: Oral
    Start date: 2011-08-04

Other drugs received by patient: Lorazepam; Valproate Sodium



Possible Clozapine side effects in male

Reported by a physician from France on 2012-08-21

Patient: male, weighing 87.0 kg (191.4 pounds)

Reactions: Intestinal Ischaemia, Dissociative Disorder, Colitis Ischaemic, Anaemia, Intestinal Obstruction, Delirium, Hypokalaemia, Lung Disorder, Hypomagnesaemia, Hypoalbuminaemia, Suicide Attempt, Septic Shock

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Arixtra
    Start date: 2012-01-01
    End date: 2012-03-01

Atarax

Clozapine
    Dosage: 300 mg to 400 mg per day
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-01-12
    End date: 2012-01-19

Codeine Sulfate
    Administration route: Oral
    Start date: 2012-02-01
    End date: 2012-03-01

Imodium
    Administration route: Oral
    Indication: Diarrhoea
    Start date: 2012-02-01
    End date: 2012-03-01

Nexium
    Administration route: Oral

Sandostatin
    Start date: 2012-02-01
    End date: 2012-03-01

Seroquel
    Dosage: dose progressively increased
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-02-06
    End date: 2012-03-05

Tranxene
    Administration route: Oral
    Indication: Agitation
    Start date: 2012-01-27
    End date: 2012-03-05

Tranxene
    Administration route: Oral
    Indication: Anxiety
    Start date: 2012-01-27
    End date: 2012-03-05



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-21

Patient: male

Reactions: Ischaemia, Volvulus

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: long-term
    Administration route: Oral
    Indication: Schizophrenia, Disorganised Type

Haloperidol Lactate
    Dosage: long-term
    Administration route: Oral
    Indication: Schizophrenia, Disorganised Type

Lepticur
    Dosage: long-term
    Administration route: Oral
    Indication: Dyskinesia

Other drugs received by patient: Tranxene



Possible Clozapine side effects in female

Reported by a consumer/non-health professional from Germany on 2012-08-17

Patient: female

Reactions: Neutrophil Count Increased, Fear of Death, Tachycardia, Cerebrovascular Accident, Viith Nerve Paralysis, Dysarthria, Psychotic Disorder, Incontinence, Salivary Hypersecretion, White Blood Cell Count Increased

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Dosage: 100 mg, qid
    Administration route: Oral
    Start date: 2011-02-01
    End date: 2011-08-01

Clozapine
    Dosage: 300 mg, (0-0-50-250-mg qd)
    Administration route: Oral
    Start date: 2011-08-04

Other drugs received by patient: Valproate Sodium



Possible Clozapine side effects in male

Reported by a physician from France on 2012-08-17

Patient: male, weighing 87.0 kg (191.4 pounds)

Reactions: Colitis Ischaemic, Intestinal Ischaemia, Dissociative Disorder, Anaemia, Intestinal Obstruction, Delirium, Hypokalaemia, Lung Disorder, Hypomagnesaemia, Hypoalbuminaemia, Suicide Attempt, Septic Shock

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Arixtra
    Start date: 2012-01-01
    End date: 2012-03-01

Atarax

Clozapine
    Dosage: 300 mg to 400 mg per day
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-01-12
    End date: 2012-01-19

Codeine Sulfate
    Administration route: Oral
    Start date: 2012-02-01
    End date: 2012-03-01

Imodium
    Administration route: Oral
    Indication: Diarrhoea
    Start date: 2012-02-01
    End date: 2012-03-01

Nexium
    Administration route: Oral

Sandostatin
    Start date: 2012-02-01
    End date: 2012-03-01

Seroquel
    Dosage: dose progressively increased
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-02-06
    End date: 2012-03-05

Tranxene
    Administration route: Oral
    Indication: Agitation
    Start date: 2012-01-27
    End date: 2012-03-05

Tranxene
    Administration route: Oral
    Indication: Anxiety
    Start date: 2012-01-27
    End date: 2012-03-05



Possible Clozapine side effects in female

Reported by a physician from Germany on 2012-08-17

Patient: female

Reactions: Breast Cancer

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Dosage: 200 mg, unk
    Administration route: Oral
    Start date: 2007-01-01

Clozapine
    Dosage: 100 mg, unk
    Administration route: Oral
    Indication: Schizophrenia

Clozapine
    Dosage: 300 mg, qd
    Administration route: Oral

Other drugs received by patient: Tamoxifen Citrate



Possible Clozapine side effects in male

Reported by a physician from United States on 2012-08-15

Patient: male

Reactions: Product Substitution Issue, Drooling, Hyperphagia, Decreased Activity, Dizziness, Vertigo

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-13

Patient: male

Reactions: Ischaemia, Volvulus

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: long-term
    Administration route: Oral
    Indication: Schizophrenia, Disorganised Type

Haldol
    Dosage: long-term
    Administration route: Oral
    Indication: Schizophrenia, Disorganised Type

Lepticur
    Dosage: long-term
    Administration route: Oral
    Indication: Dyskinesia

Other drugs received by patient: Tranxene



Possible Clozapine side effects in female

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-09

Patient: female

Reactions: Vomiting, Rhabdomyolysis, Cytolytic Hepatitis, Coma, Somnolence, Hepatic Steatosis, Electroencephalogram Abnormal, Psychotic Disorder, Fatigue, Hepatic Encephalopathy, Renal Failure, Drug-Induced Liver Injury, Hepatic Ischaemia, Blood Pressure Decreased, Hepatitis Fulminant

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Metformin Hydrochloride; Haldol; Irbesartan and Hydrochlorothiazide; Tenormin; Ferrous Sulfate TAB; Nicardipine HCL; Ditropan; Tenormin; Amaryl; Amlodipine Besylate



Possible Clozapine side effects in female

Reported by a consumer/non-health professional from Germany on 2012-08-08

Patient: female

Reactions: Dysarthria, Fear of Death, Incontinence, Tachycardia, Salivary Hypersecretion, Cerebrovascular Accident, Viith Nerve Paralysis

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Dosage: 300 mg, (0-0-50-250-mg qd)
    Administration route: Oral
    Start date: 2011-08-01

Clozapine
    Dosage: 100 mg, qid
    Administration route: Oral
    Start date: 2011-02-01
    End date: 2011-08-01



Possible Clozapine side effects in 49 year old female

Reported by a physician from United Kingdom on 2012-08-04

Patient: 49 year old female

Reactions: Neutropenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Dosage: 650 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2006-01-01
    End date: 2012-01-09

Mirtazapine
    Dosage: 45 mg, qd
    Administration route: Oral
    Indication: Depression
    End date: 2012-01-21

Topiramate
    Dosage: 300 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2007-01-01
    End date: 2012-01-21

Other drugs received by patient: Zopiclone; Amoxicillin



Possible Clozapine side effects in male

Reported by a pharmacist from United States on 2012-07-27

Patient: male

Reactions: Choking

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in 49 year old female

Reported by a physician from United Kingdom on 2012-07-26

Patient: 49 year old female

Reactions: Neutropenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Dosage: 650 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2006-01-01
    End date: 2012-01-09

Mirtazapine
    Dosage: 45 mg, qd
    Administration route: Oral
    Indication: Depression
    End date: 2012-01-21

Topiramate
    Dosage: 300 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2007-01-01
    End date: 2012-01-21

Other drugs received by patient: Amoxicillin; Zopiclone



Possible Clozapine side effects in male

Reported by a physician from Brazil on 2012-07-26

Patient: male

Reactions: Apparent Death, Fatigue, Myocarditis

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in 35 year old male

Reported by a physician from Australia on 2012-07-20

Patient: 35 year old male

Reactions: Akathisia, Therapeutic Response Decreased, Incorrect Dose Administered, Cardiomyopathy, Delirium

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Indication: Product Used FOR Unknown Indication

Risperdal Consta
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-01-01



Possible Clozapine side effects in 49 year old female

Reported by a physician from United Kingdom on 2012-07-13

Patient: 49 year old female

Reactions: Neutropenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2006-01-01
    End date: 2012-01-09

Mirtazapine
    Administration route: Oral
    Indication: Depression
    End date: 2012-01-21

Topiramate
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2007-01-01
    End date: 2012-01-21

Other drugs received by patient: Zopiclone; Amoxicillin



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from Norway on 2012-07-04

Patient: male

Reactions: Pneumonia, Brain Natriuretic Peptide Increased, Tachycardia, Chest Pain, Troponin T Increased

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in

Reported by a physician from Germany on 2012-07-02

Patient:

Reactions: Asthma, Dyspnoea, Stridor, Cyanosis

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 12.5 mg, unk
    Start date: 1988-01-01

Clozapine
    Dosage: 25 mg, qd
    Start date: 1988-01-01

Clozapine
    Dosage: 75 mg, qd
    Start date: 1988-01-01

Other drugs received by patient: Theophylline



Possible Clozapine side effects in 82 year old female

Reported by a pharmacist from United States on 2012-07-02

Patient: 82 year old female, weighing 81.2 kg (178.6 pounds)

Reactions: Hypothermia, Hyperkalaemia, Bradycardia, Blood Creatinine Increased

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in male

Reported by a physician from United Kingdom on 2012-06-29

Patient: male

Reactions: Mental Impairment, Overdose, Full Blood Count Abnormal, Suicide Attempt, Neutropenia, Aggression

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Hydrocortisone Acetate; Levothyroxine; Quetiapine; Risperidone; Zopiclone; Valproate Sodium; Clopixol; Lorazepam



Possible Clozapine side effects in 53 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 53 year old female

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Lorazepam; Depakote; Insulin; Simvastatin; Seroquel; Aspirin; Lantus; Haldol; Fish OIL; Levocarnitine; Sertraline Hydrochloride; Synthroid



Possible Clozapine side effects in 83 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 83 year old female

Reactions: Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Chemotherapeutics
    Indication: Lung Neoplasm Malignant

Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    End date: 2012-01-18

Clozapine
    Administration route: Oral
    End date: 2012-01-18

Other drugs received by patient: Aricept; Effexor XR



Possible Clozapine side effects in 69 year old male

Reported by a physician from United States on 2012-06-28

Patient: 69 year old male, weighing 87.1 kg (191.6 pounds)

Reactions: Agranulocytosis, Pneumonia, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Parkinson's Disease
    Start date: 2012-02-22
    End date: 2012-03-07

Clozapine
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2012-02-22
    End date: 2012-03-07

Clozapine
    Administration route: Oral
    Indication: Hallucination
    Start date: 2012-02-22
    End date: 2012-03-07

Other drugs received by patient: Midodrine Hydrochloride; Carbidopa and Levodopa; Hydrocortisone Acetate; Venlafaxine; Midodrine Hydrochloride; Rivastigmine



Possible Clozapine side effects in 54 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 54 year old female, weighing 56.5 kg (124.2 pounds)

Reactions: Granulocytopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Chlorpromazine HCL; Invega; Zyprexa



Possible Clozapine side effects in 12 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 12 year old female, weighing 45.4 kg (99.8 pounds)

Reactions: Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Oxcarbazepine



Possible Clozapine side effects in 53 year old male

Reported by a physician from United States on 2012-06-28

Patient: 53 year old male

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Lithium Carbonate; Risperdal; Clonazepam; Dilantin; Lopressor



Possible Clozapine side effects in 58 year old male

Reported by a individual with unspecified qualification from United States on 2012-06-28

Patient: 58 year old male, weighing 87.1 kg (191.6 pounds)

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizoaffective Disorder
    Start date: 2008-06-01
    End date: 2012-01-20

Clozapine
    Administration route: Oral
    Indication: Schizophrenia, Paranoid Type
    Start date: 2008-06-01
    End date: 2012-01-20

Other drugs received by patient: Neurontin; Senokot; Pepcid; Cogentin; Ddavp; Lexapro; Lexapro; Trazodone HCL; Pravachol; Colace



Possible Clozapine side effects in 51 year old male

Reported by a pharmacist from United States on 2012-06-28

Patient: 51 year old male

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Trazodone HCL; Pepcid; Metformin HCL; Reglan; Acetaminophen; Haldol; Multi-Vitamin; Depakote ER



Possible Clozapine side effects in 60 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 60 year old female

Reactions: Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Lutein / 01638501 /; Vitamin D; Depakote ER; Dextroamphetamine; Multi-Vitamin; Apap TAB; Synthroid; Evista; Trileptal; Restasis; Omega 3 / 01334101 /; Acetylcysteine; Dextroamphetamine; Dextroamphetamine; Vitamin E; Preservision EYE Vitamin and Mineral Suppl.



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