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Clozapine (Clozapine) - Hospitalization - Suspected Cause - Side Effect Reports

 
 



Index of reports > Hospitalization (752)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Clozapine hospitalization. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 752   Next >>

Possible Clozapine side effects in 36 year old female

Reported by a physician from United Kingdom on 2012-08-27

Patient: 36 year old female

Reactions: Body Mass Index Decreased, Diabetes Mellitus, Pyrexia, Mean Cell Volume Decreased, Constipation, Abdominal Tenderness, Malaise, Iron Deficiency Anaemia, White Blood Cell Count Increased, Neutrophil Count Increased, Hiatus Hernia, Cardiac Murmur, Urinary Tract Infection, Physical Assault, Skin Disorder, Monocyte Count Increased, White Blood Cell Disorder, Staphylococcal Infection, Thrombocytosis, Hypertension, Sinus Tachycardia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2005-05-01
    End date: 2005-05-19

Clozapine
    Administration route: Oral
    Start date: 2008-06-05

Clozapine
    Administration route: Oral
    Start date: 2008-05-19

Clozapine
    Administration route: Oral
    Start date: 2006-06-05
    End date: 2006-07-13

Diazepam
    Indication: Product Used FOR Unknown Indication

Ferrous Sulfate TAB
    Indication: Product Used FOR Unknown Indication

Folic Acid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Lactulose
    Indication: Product Used FOR Unknown Indication

Lansoprazole
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Perindopril
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Trimethoprim
    Indication: Urinary Tract Infection

Zopiclone
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Furosemide; Ramipril; Atorvastatin; Bendroflumethiazide; Aripiprazole



Possible Clozapine side effects in male

Reported by a physician from Malta on 2012-08-27

Patient: male

Reactions: Haemoglobin Decreased, Iron Deficiency Anaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Start date: 2012-07-01

Clozapine
    Dosage: 300 mg, bid
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2007-01-01
    End date: 2012-03-01



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-27

Patient: male

Reactions: Colitis Ischaemic, Intestinal Obstruction, Septic Shock

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-01-11

Haloperidol Lactate
    Administration route: Oral
    Indication: Schizophrenia
    End date: 2012-01-01



Possible Clozapine side effects in 41 year old male

Reported by a physician from France on 2012-08-24

Patient: 41 year old male

Reactions: Agranulocytosis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clonazepam
    Administration route: Oral
    Indication: Schizophrenia, Paranoid Type
    Start date: 2011-11-11
    End date: 2012-04-21

Clonazepam
    Administration route: Oral
    Start date: 2012-04-25

Clozapine
    Administration route: Oral
    Indication: Schizophrenia, Paranoid Type
    Start date: 2011-11-11
    End date: 2012-04-21

Havlane
    Administration route: Oral
    Start date: 2012-04-25

Havlane
    Administration route: Oral
    Indication: Schizophrenia, Paranoid Type
    Start date: 2011-11-11
    End date: 2012-04-21

Risperdal Consta
    Start date: 2012-04-25

Risperdal Consta
    Indication: Schizophrenia, Paranoid Type
    Start date: 2011-11-11
    End date: 2012-04-21



Possible Clozapine side effects in 63 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-23

Patient: 63 year old female

Reactions: Cerebrovascular Accident

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: unk
    Administration route: Oral
    Indication: Schizophrenia

Felodipine
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Simvastatin
    Dosage: unk
    Indication: Product Used FOR Unknown Indication



Possible Clozapine side effects in 63 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-23

Patient: 63 year old female

Reactions: Cerebrovascular Accident

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizophrenia

Felodipine

Zocor
    Administration route: Oral



Possible Clozapine side effects in 28 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-23

Patient: 28 year old male

Reactions: Abdominal Pain, Intestinal Ischaemia, Colitis Ischaemic, Peripheral Coldness, Hyperlactacidaemia, Tachycardia, Hypotension, Intestinal Obstruction, Gastrointestinal Necrosis, Pallor, Constipation, Ascites, Dysuria, Abdominal Distension, Septic Shock

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 120 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-01-11
    End date: 2012-01-01

Clozapine
    End date: 2012-02-01

Haloperidol Lactate
    End date: 2012-01-01

Other drugs received by patient: Sandostatin; Perikabiven



Possible Clozapine side effects in 50 year old female

Reported by a physician from Finland on 2012-08-23

Patient: 50 year old female

Reactions: Antipsychotic Drug Level Increased, Body Mass Index Increased, Blood Triglycerides Increased, Oropharyngeal Pain, Genital Haemorrhage, Constipation, Liver Disorder, Malaise, C-Reactive Protein Increased, Proteinuria, Urosepsis, Metabolic Disorder, Blood Creatinine Increased, Anaemia, Urinary Tract Infection, Hepatic Enzyme Increased, Renal Impairment, Neoplasm Malignant, Insomnia, Enterococcus Test Positive

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 250 mg, qd
    Administration route: Oral
    Start date: 2012-07-19

Clozapine
    Dosage: 500 mg, per day
    Administration route: Oral

Other drugs received by patient: Abilify; Sodium Bicarbonate; Obsidan; Haloperidol; Primolut; Metronidazole HCL; Calcium Carbonate; Gaviscon; Terolut



Possible Clozapine side effects in female

Reported by a physician from Japan on 2012-08-22

Patient: female

Reactions: Pulmonary Embolism, Deep Vein Thrombosis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Clozapine
    Indication: Product Used FOR Unknown Indication

Haloperidol
    Indication: Product Used FOR Unknown Indication

Impromen
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Levomefolate Calcium
    Indication: Product Used FOR Unknown Indication

Olanzapine
    Indication: Product Used FOR Unknown Indication

Risperdal
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Zotepine
    Indication: Product Used FOR Unknown Indication



Possible Clozapine side effects in 63 year old female

Reported by a pharmacist from United Kingdom on 2012-08-22

Patient: 63 year old female

Reactions: Cerebrovascular Accident

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: unk
    Administration route: Oral
    Indication: Schizophrenia

Felodipine
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Simvastatin
    Dosage: unk
    Indication: Product Used FOR Unknown Indication



Possible Clozapine side effects in 46 year old male

Reported by a pharmacist from United Kingdom on 2012-08-21

Patient: 46 year old male, weighing 66.6 kg (146.5 pounds)

Reactions: Incontinence, Urinary Tract Infection, Abnormal Behaviour, Catatonia, Neuroleptic Malignant Syndrome, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2005-03-16
    End date: 2012-06-26

Clozapine
    Start date: 1997-12-15
    End date: 2005-03-15

Olanzapine
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Lactulose; Omeprazole; Valproic Acid; Diazepam; Hyoscine HBR HYT; Moviprep; Acetaminophen



Possible Clozapine side effects in male

Reported by a physician from France on 2012-08-21

Patient: male, weighing 87.0 kg (191.4 pounds)

Reactions: Intestinal Ischaemia, Dissociative Disorder, Colitis Ischaemic, Anaemia, Intestinal Obstruction, Delirium, Hypokalaemia, Lung Disorder, Hypomagnesaemia, Hypoalbuminaemia, Suicide Attempt, Septic Shock

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Arixtra
    Start date: 2012-01-01
    End date: 2012-03-01

Atarax

Clozapine
    Dosage: 300 mg to 400 mg per day
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-01-12
    End date: 2012-01-19

Codeine Sulfate
    Administration route: Oral
    Start date: 2012-02-01
    End date: 2012-03-01

Imodium
    Administration route: Oral
    Indication: Diarrhoea
    Start date: 2012-02-01
    End date: 2012-03-01

Nexium
    Administration route: Oral

Sandostatin
    Start date: 2012-02-01
    End date: 2012-03-01

Seroquel
    Dosage: dose progressively increased
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-02-06
    End date: 2012-03-05

Tranxene
    Administration route: Oral
    Indication: Agitation
    Start date: 2012-01-27
    End date: 2012-03-05

Tranxene
    Administration route: Oral
    Indication: Anxiety
    Start date: 2012-01-27
    End date: 2012-03-05



Possible Clozapine side effects in 63 year old female

Reported by a pharmacist from United Kingdom on 2012-08-21

Patient: 63 year old female

Reactions: Cerebrovascular Accident

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-07-31

Felodipine
    Indication: Product Used FOR Unknown Indication

Simvastatin
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication



Possible Clozapine side effects in

Reported by a physician from Germany on 2012-08-21

Patient:

Reactions: Hypothermia, Dementia, Drug Interaction, Catatonia, Miosis, Liver Function Test Abnormal, Pupil Fixed, Leukopenia, Oxygen Saturation Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 100 mg, / day
    Indication: Schizophrenia, Catatonic Type

Haloperidol
    Dosage: 5 mg, / day
    Indication: Schizophrenia, Catatonic Type

Haloperidol
    Dosage: 2 mg, / day

Haloperidol Decanoate
    Dosage: 100 mg, every 4 weeks
    Indication: Schizophrenia, Catatonic Type

Other drugs received by patient possibly interacting with the suspect drug:
Lorazepam
    Dosage: 3 to 4.5 mg per day,divided into three single doses
    Administration route: Oral
    Indication: Schizophrenia, Catatonic Type

Lorazepam
    Dosage: 1-1-1 mg
    Administration route: Oral

Olanzapine
    Dosage: 10 mg, / day
    Indication: Schizophrenia, Catatonic Type

Olanzapine
    Dosage: 10 mg, single
    Administration route: Oral



Possible Clozapine side effects in 63 year old female

Reported by a pharmacist from United Kingdom on 2012-08-21

Patient: 63 year old female

Reactions: Cerebrovascular Accident

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-07-31

Felodipine
    Indication: Product Used FOR Unknown Indication

Simvastatin
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-21

Patient: male

Reactions: Colitis Ischaemic, Intestinal Obstruction, Septic Shock

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-01-11

Haldol
    Administration route: Oral
    Indication: Schizophrenia
    End date: 2012-01-01



Possible Clozapine side effects in female

Reported by a physician from United Kingdom on 2012-08-21

Patient: female

Reactions: Body Mass Index Decreased, Diabetes Mellitus, Mean Cell Volume Decreased, Pyrexia, Constipation, Abdominal Tenderness, Malaise, Iron Deficiency Anaemia, White Blood Cell Count Increased, Hiatus Hernia, Cardiac Murmur, Neutrophil Count Increased, Urinary Tract Infection, Skin Disorder, Monocyte Count Increased, Aggression, White Blood Cell Disorder, Staphylococcal Infection, Thrombocytosis, Sinus Tachycardia, Hypertension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: unk ukn, qd

Clozapine
    Dosage: unk ukn, unk
    Start date: 2008-05-19

Clozaril
    Administration route: Oral
    Start date: 2008-06-05

Clozaril
    Dosage: unk ukn, unk
    Administration route: Oral
    Start date: 2006-06-05
    End date: 2006-07-13

Clozaril
    Dosage: 250 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2005-05-01
    End date: 2005-05-19

Clozaril
    Dosage: 250 mg, daily
    Administration route: Oral
    Start date: 2008-05-19

Diazepam
    Dosage: unk ukn, prn

Ferrous Sulfate TAB
    Dosage: 200 mg, bid
    Administration route: Oral

Folic Acid
    Dosage: 5 mg, qd
    Administration route: Oral

Lactulose
    Dosage: 10 ml, prn

Lansoprazole
    Dosage: 30 mg, qd
    Administration route: Oral

Perindopril Erbumine
    Dosage: 2 mg, qd
    Administration route: Oral

Trimethoprim
    Dosage: unk ukn, unk
    Indication: Urinary Tract Infection

Zopiclone
    Dosage: 3.75 mg, qhs

Other drugs received by patient: Furosemide; Atorvastatin; Abilify; Ramipril; Bendrofluazide



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-21

Patient: male

Reactions: Ischaemia, Volvulus

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: long-term
    Administration route: Oral
    Indication: Schizophrenia, Disorganised Type

Haloperidol Lactate
    Dosage: long-term
    Administration route: Oral
    Indication: Schizophrenia, Disorganised Type

Lepticur
    Dosage: long-term
    Administration route: Oral
    Indication: Dyskinesia

Other drugs received by patient: Tranxene



Possible Clozapine side effects in female

Reported by a physician from Norway on 2012-08-20

Patient: female

Reactions: C-Reactive Protein Increased, Chills, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Pyrexia, Influenza Like Illness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Vallergan; AFI-D2-Forte; Seroquel



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from Denmark on 2012-08-20

Patient: male

Reactions: Ischaemic Stroke

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 25 mg
    Administration route: Oral
    Start date: 2007-01-01

Escitalopram
    Dosage: 10 mg
    Administration route: Oral
    Start date: 2007-01-01

Exelon
    Dosage: 1 df
    Start date: 2007-01-01

Modopar
    Dosage: 100mg / 25mg
    Administration route: Oral
    Start date: 2007-01-01

Modopar
    Dosage: 4 df
    Administration route: Oral
    Start date: 2007-01-01

Oxybutynine
    Dosage: 2 df
    Administration route: Oral
    Start date: 2007-01-01

Other drugs received by patient: Aspirin



Possible Clozapine side effects in 39 year old female

Reported by a physician from Spain on 2012-08-20

Patient: 39 year old female

Reactions: Pleuropericarditis, Pleural Effusion, Toxicity To Various Agents, Pyrexia, Leukocytosis, Blood Creatinine Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Lithium



Possible Clozapine side effects in 50 year old female

Reported by a physician from Finland on 2012-08-20

Patient: 50 year old female

Reactions: Body Mass Index Increased, Antipsychotic Drug Level Increased, Blood Triglycerides Increased, Oropharyngeal Pain, Constipation, Liver Disorder, Malaise, C-Reactive Protein Increased, Proteinuria, Urosepsis, Metabolic Disorder, Blood Creatinine Increased, Urinary Tract Infection, Anaemia, Hepatic Enzyme Increased, Renal Impairment, Insomnia, Enterococcus Test Positive

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 250 mg, qd
    Administration route: Oral
    Start date: 2012-07-19

Clozapine
    Dosage: 500 mg, per day
    Administration route: Oral

Other drugs received by patient: Haloperidol; Abilify; Metronidazole HCL; Obsidan; Primolut; Gaviscon



Possible Clozapine side effects in 24 year old male

Reported by a physician from Australia on 2012-08-20

Patient: 24 year old male, weighing 120.0 kg (264.0 pounds)

Reactions: Pancreatitis, Hypertriglyceridaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine

Clozapine
    Dosage: reduced dose

Rabeprazole Sodium
    Administration route: Oral



Possible Clozapine side effects in male

Reported by a physician from France on 2012-08-17

Patient: male, weighing 87.0 kg (191.4 pounds)

Reactions: Colitis Ischaemic, Intestinal Ischaemia, Dissociative Disorder, Anaemia, Intestinal Obstruction, Delirium, Hypokalaemia, Lung Disorder, Hypomagnesaemia, Hypoalbuminaemia, Suicide Attempt, Septic Shock

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Arixtra
    Start date: 2012-01-01
    End date: 2012-03-01

Atarax

Clozapine
    Dosage: 300 mg to 400 mg per day
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-01-12
    End date: 2012-01-19

Codeine Sulfate
    Administration route: Oral
    Start date: 2012-02-01
    End date: 2012-03-01

Imodium
    Administration route: Oral
    Indication: Diarrhoea
    Start date: 2012-02-01
    End date: 2012-03-01

Nexium
    Administration route: Oral

Sandostatin
    Start date: 2012-02-01
    End date: 2012-03-01

Seroquel
    Dosage: dose progressively increased
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-02-06
    End date: 2012-03-05

Tranxene
    Administration route: Oral
    Indication: Agitation
    Start date: 2012-01-27
    End date: 2012-03-05

Tranxene
    Administration route: Oral
    Indication: Anxiety
    Start date: 2012-01-27
    End date: 2012-03-05



Possible Clozapine side effects in male

Reported by a consumer/non-health professional from United States on 2012-08-16

Patient: male

Reactions: Drug Level Increased, Heart Rate Increased, Dehydration, Blood Pressure Diastolic Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 350 mg, unk

Clozapine
    Dosage: 400 mg, unk
    Start date: 2012-02-01

Clozaril
    Dosage: 400 mg, unk
    End date: 2012-02-01

Other drugs received by patient: Zyprexa



Possible Clozapine side effects in 26 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-16

Patient: 26 year old female, weighing 98.0 kg (215.6 pounds)

Reactions: Vomiting, Diarrhoea, Tachycardia, Diabetic Coma, Diabetic Ketoacidosis, Type 1 Diabetes Mellitus, Blood Glucose Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Hyoscine Hydrobromide; Propranolol; Sertraline Hydrochloride



Possible Clozapine side effects in 63 year old female

Reported by a pharmacist from United Kingdom on 2012-08-16

Patient: 63 year old female

Reactions: Cerebrovascular Accident

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizophrenia

Felodipine
    Indication: Product Used FOR Unknown Indication

Simvastatin
    Indication: Product Used FOR Unknown Indication



Possible Clozapine side effects in 63 year old female

Reported by a pharmacist from United Kingdom on 2012-08-16

Patient: 63 year old female

Reactions: Cerebrovascular Accident

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Start date: 2012-07-31

Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    End date: 2012-07-30

Felodipine
    Administration route: Oral

Simvastatin

Other drugs received by patient: Diuretic



Possible Clozapine side effects in 36 year old female

Reported by a physician from United Kingdom on 2012-08-16

Patient: 36 year old female

Reactions: Body Mass Index Decreased, Diabetes Mellitus, Pyrexia, Mean Cell Volume Decreased, Constipation, Abdominal Tenderness, Malaise, Iron Deficiency Anaemia, White Blood Cell Count Increased, Hiatus Hernia, Cardiac Murmur, Neutrophil Count Increased, Urinary Tract Infection, Physical Assault, Skin Disorder, Monocyte Count Increased, White Blood Cell Disorder, Staphylococcal Infection, Thrombocytosis, Hypertension, Sinus Tachycardia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Start date: 2006-06-05
    End date: 2006-07-13

Clozapine
    Administration route: Oral
    Start date: 2008-05-19

Clozapine
    Administration route: Oral
    Start date: 2008-06-05

Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2005-05-01
    End date: 2005-05-19

Diazepam
    Indication: Product Used FOR Unknown Indication

Ferrous Sulfate TAB
    Indication: Product Used FOR Unknown Indication

Folic Acid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Lactulose
    Indication: Product Used FOR Unknown Indication

Lansoprazole
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Perindopril Erbumine
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Trimethoprim
    Indication: Urinary Tract Infection

Zopiclone
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Atorvastatin; Bendroflumethiazide; Furosemide; Aripiprazole; Ramipril



Possible Clozapine side effects in male

Reported by a physician from United States on 2012-08-15

Patient: male

Reactions: Product Substitution Issue, Drooling, Hyperphagia, Decreased Activity, Dizziness, Vertigo

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Clozapine



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