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Index of reports
> Cases with Overdose ()
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Clozapine where reactions include overdose. The selected reports were submitted to the FDA during the sample period of about a year. Reports 1 - 30 of Next >>
Possible Clozapine side effects in 22 year old male
Reported by a physician from United Kingdom on 2012-08-17
Patient: 22 year old male, weighing 66.4 kg (146.1 pounds)
Reactions: Vomiting, Antipsychotic Drug Level Increased, Nausea, Electrocardiogram QT Shortened, Constipation, Faecaloma, Asphyxia, Mental Impairment, Overdose, Aspiration, Pulmonary Congestion, Sedation, Choking, Pulmonary Oedema
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozapine
Dosage: 250 mg, qd
Administration route: Oral
Indication: Schizophrenia
Start date: 2011-11-30
Lorazepam
Dosage: 1 t0 4 mg, prn
Indication: Anxiety
Clozapine
Dosage: 250 mg, unk
Start date: 2012-01-11
End date: 2012-01-11
Lorazepam
Dosage: 11x1 mg dose
Other drugs received by patient: Propranolol; Kwells; Sertraline Hydrochloride
Possible Clozapine side effects in 45 year old male
Reported by a pharmacist from France on 2012-07-31
Patient: 45 year old male
Reactions: Overdose, Ankle Fracture
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozapine
Possible Clozapine side effects in male
Reported by a physician from United Kingdom on 2012-06-29
Patient: male
Reactions: Mental Impairment, Overdose, Full Blood Count Abnormal, Suicide Attempt, Neutropenia, Aggression
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Clozapine
Other drugs received by patient: Hydrocortisone Acetate; Levothyroxine; Quetiapine; Risperidone; Zopiclone; Valproate Sodium; Clopixol; Lorazepam
Possible Clozapine side effects in 35 year old male
Reported by a pharmacist from United States on 2012-06-28
Patient: 35 year old male
Reactions: Overdose
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozapine
Other drugs received by patient: Lamictal; Wellbutrin SR; Lithium Carbonate
Possible Clozapine side effects in 22 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-06-25
Patient: 22 year old male
Reactions: Vomiting, Antipsychotic Drug Level Increased, Nausea, Electrocardiogram QT Shortened, Constipation, Asphyxia, Mental Impairment, Overdose, Sedation
Adverse event resulted in: death
Drug(s) suspected as cause:
Lorazepam
Dosage: 1 t0 4 mg, prn
Indication: Anxiety
Lorazepam
Dosage: 11x1 mg dose
Clozapine
Dosage: 250 mg, qd
Administration route: Oral
Indication: Schizophrenia
Start date: 2011-11-30
Clozapine
Dosage: 250 mg, unk
Start date: 2012-01-11
End date: 2012-01-11
Other drugs received by patient: Sertraline Hydrochloride; Kwells; Propranolol
Possible Clozapine side effects in male
Reported by a physician from United Kingdom on 2012-05-21
Patient: male
Reactions: Mental Impairment, Overdose, Full Blood Count Abnormal, Suicide Attempt, Neutropenia, Aggression
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Clozapine
Other drugs received by patient: Risperidone; Quetiapine; Clopixol; Levothyroxine Sodium; Hydrocortisone; Valproate Sodium
Possible Clozapine side effects in 37 year old male
Reported by a consumer/non-health professional from Australia on 2012-04-27
Patient: 37 year old male
Reactions: Vomiting, Haemoptysis, Diabetes Mellitus, Physical Assault, Adverse Drug Reaction, Drug Withdrawal Syndrome, Drug Prescribing Error, Aggression, Delusion, Suicidal Ideation, Hostility, Syncope, Renal Failure, Overdose, Diarrhoea, Dehydration, Neuroleptic Malignant Syndrome, Hallucination
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Seroquel
Dosage: dose increased
Administration route: Oral
Start date: 2012-02-06
Clopixol
Dosage: depot
End date: 2012-02-06
Seroquel
Administration route: Oral
Start date: 2008-01-01
Clozapine
Start date: 2009-01-01
Other drugs received by patient: Ativan; Antipsychotics
Possible Clozapine side effects in 32 year old male
Reported by a consumer/non-health professional from United States on 2012-04-25
Patient: 32 year old male, weighing 86.2 kg (189.6 pounds)
Reactions: Overdose, Convulsion
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozapine
Possible Clozapine side effects in female
Reported by a consumer/non-health professional from United States on 2012-04-03
Patient: female
Reactions: Akathisia, Movement Disorder, Abdominal Pain, Pruritus, Malaise, Palpitations, Mood Altered, Back Pain, Toxicity To Various Agents, Stress, Delirium, Aggression, Sleep Disorder, Ocular Hyperaemia, Vision Blurred, Parosmia, Speech Disorder, Overdose, Abdominal Distension, Depression, Dyspnoea, Vomiting, Self Injurious Behaviour, Discomfort, Heart Rate Increased, Asthenia, Agitation, Dementia, Headache, Pyrexia, Loss of Consciousness, Off Label Use, Yellow Skin, Muscle Spasms, Panic Reaction, Bowel Movement Irregularity, Pain in Extremity, Hypoaesthesia, Convulsion, Decreased Interest, Insomnia, Choking, Ocular Icterus, Disturbance in Attention, Sleep Apnoea Syndrome, Confusional State, Pain, Bone Pain, Constipation, Suicidal Ideation, Weight Increased, Myalgia, Fatigue, Toothache, Hypersomnia, Tooth Decalcification, Mydriasis, Nausea, Dental Caries, Status Epilepticus, Cognitive Disorder, Drug Prescribing Error, Stupor, Anxiety, Mental Impairment, Psychotic Disorder, Feeling Abnormal, Influenza Like Illness
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Olanzapine
Dosage: as needed
Administration route: Oral
Indication: Psychotic Disorder
Start date: 2011-11-01
Lithium Carbonate
Dosage: 900 milligram;
Clozapine
Dosage: 75 mg in am, 50 mg hs
Administration route: Oral
Indication: Psychotic Disorder
Benztropine Mesylate
Other drugs received by patient: Zolpidem Tartrate; Quetiapine
Possible Clozapine side effects in female
Reported by a consumer/non-health professional from United States on 2012-03-27
Patient: female
Reactions: Abdominal Pain, Movement Disorder, Akathisia, Malaise, Mood Altered, Palpitations, Back Pain, Toxicity To Various Agents, Delirium, Aggression, Sleep Disorder, Ocular Hyperaemia, Vision Blurred, Parosmia, Speech Disorder, Overdose, Abdominal Distension, Depression, Dyspnoea, Vomiting, Self Injurious Behaviour, Discomfort, Heart Rate Increased, Asthenia, Agitation, Dementia, Pyrexia, Headache, Loss of Consciousness, Off Label Use, Yellow Skin, Panic Reaction, Muscle Spasms, Bowel Movement Irregularity, Pain in Extremity, Hypoaesthesia, Convulsion, Decreased Interest, Choking, Insomnia, Ocular Icterus, Disturbance in Attention, Confusional State, Pain, Bone Pain, Constipation, Suicidal Ideation, Weight Increased, Myalgia, Toothache, Hypersomnia, Tooth Decalcification, Mydriasis, Nausea, Dental Caries, Status Epilepticus, Cognitive Disorder, Drug Prescribing Error, Stupor, Anxiety, Mental Impairment, Psychotic Disorder, Feeling Abnormal, Influenza Like Illness
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Olanzapine
Dosage: as needed
Administration route: Oral
Indication: Psychotic Disorder
Start date: 2011-11-01
Clozapine
Dosage: 75 mg in am, 50 mg hs
Administration route: Oral
Indication: Psychotic Disorder
Lithium Carbonate
Dosage: 900 milligram;
Benztropine Mesylate
Other drugs received by patient: Quetiapine; Zolpidem Tartrate
Possible Clozapine side effects in female
Reported by a consumer/non-health professional from United States on 2012-03-16
Patient: female
Reactions: Abdominal Pain, Akathisia, Movement Disorder, Agitation, Dementia, Pyrexia, Headache, Loss of Consciousness, Off Label Use, Malaise, Yellow Skin, Mood Altered, Palpitations, Panic Reaction, Muscle Spasms, Bowel Movement Irregularity, Back Pain, Pain in Extremity, Toxicity To Various Agents, Hypoaesthesia, Delirium, Aggression, Convulsion, Decreased Interest, Sleep Disorder, Ocular Hyperaemia, Choking, Insomnia, Vision Blurred, Ocular Icterus, Disturbance in Attention, Parosmia, Confusional State, Bone Pain, Pain, Constipation, Suicidal Ideation, Weight Increased, Myalgia, Speech Disorder, Overdose, Abdominal Distension, Depression, Hypersomnia, Vomiting, Dyspnoea, Mydriasis, Nausea, Cognitive Disorder, Status Epilepticus, Self Injurious Behaviour, Drug Prescribing Error, Stupor, Discomfort, Mental Impairment, Anxiety, Psychotic Disorder, Heart Rate Increased, Feeling Abnormal, Asthenia, Influenza Like Illness
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Benztropine Mesylate
Olanzapine
Dosage: as needed
Administration route: Oral
Indication: Psychotic Disorder
Start date: 2011-11-01
Clozapine
Dosage: 75 mg in am, 50 mg hs
Administration route: Oral
Indication: Psychotic Disorder
Lithium Carbonate
Dosage: 900 milligram;
Other drugs received by patient: Quetiapine; Zolpidem Tartrate
Possible Clozapine side effects in 34 year old male
Reported by a individual with unspecified qualification from Australia on 2012-03-15
Patient: 34 year old male
Reactions: Vomiting, Diabetes Mellitus, Haemoptysis, Physical Assault, Drug Withdrawal Syndrome, Drug Prescribing Error, Aggression, Suicidal Ideation, Delusion, Hostility, Overdose, Diarrhoea, Neuroleptic Malignant Syndrome, Hallucination
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozapine
Start date: 2009-01-01
Seroquel
Administration route: Oral
Start date: 2008-01-01
Seroquel
Dosage: dose increased
Administration route: Oral
Start date: 2012-02-06
Clopixol
Dosage: depot
Other drugs received by patient: Ativan; Antipsychotics
Possible Clozapine side effects in male
Reported by a physician from United Kingdom on 2012-03-13
Patient: male
Reactions: Mental Impairment, Overdose, Suicide Attempt, Neutropenia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Clozapine
Other drugs received by patient: Valproate Sodium; Clopixol; Risperidone; Quetiapine; Levothyroxine Sodium; Hydrocortisone
Possible Clozapine side effects in female
Reported by a consumer/non-health professional from United States on 2012-03-12
Patient: female
Reactions: Movement Disorder, Akathisia, Abdominal Pain, Abdominal Discomfort, Palpitations, Mood Altered, Victim of Abuse, Back Pain, Toxicity To Various Agents, Delirium, Aggression, Post-Traumatic Stress Disorder, Thought Blocking, Sleep Disorder, Ocular Hyperaemia, Vision Blurred, Parosmia, Drug Interaction, Speech Disorder, Overdose, Abdominal Distension, Depression, Dyspnoea, Vomiting, Self Injurious Behaviour, Discomfort, Heart Rate Increased, Asthenia, Agitation, Dementia, Headache, Pyrexia, Loss of Consciousness, Off Label Use, Brain Injury, Yellow Skin, Panic Reaction, Muscle Spasms, Bowel Movement Irregularity, Pain in Extremity, Hypoaesthesia, Convulsion, Decreased Interest, Choking, Insomnia, Ocular Icterus, Disturbance in Attention, Confusional State, Pain, Fear, Bone Pain, Constipation, Suicidal Ideation, Weight Increased, Myalgia, Fatigue, Hypersomnia, Refusal of Treatment by Patient, Mydriasis, Nausea, Condition Aggravated, Status Epilepticus, Cognitive Disorder, Stupor, Anxiety, Mental Impairment, Psychotic Disorder, Emotional Poverty, Feeling Abnormal, Influenza Like Illness
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Benztropine Mesylate
Olanzapine
Dosage: as needed
Administration route: Oral
Indication: Psychotic Disorder
Start date: 2011-11-01
Clozapine
Dosage: 75 mg in am, 50 mg hs
Administration route: Oral
Indication: Psychotic Disorder
Lithium Carbonate
Dosage: 900 milligram;
Other drugs received by patient: Zolpidem Tartrate; Quetiapine
Possible Clozapine side effects in female
Reported by a physician from Italy on 2012-03-09
Patient: female
Reactions: Dysarthria, Overdose, Apraxia
Drug(s) suspected as cause:
Clozapine
Possible Clozapine side effects in female
Reported by a consumer/non-health professional from United States on 2012-02-24
Patient: female
Reactions: Agitation, Movement Disorder, Akathisia, Dementia, Pyrexia, Headache, Loss of Consciousness, Off Label Use, Abdominal Discomfort, Mood Altered, Yellow Skin, Palpitations, Muscle Spasms, Panic Reaction, Back Pain, Pain in Extremity, Hypoaesthesia, Toxicity To Various Agents, Delirium, Convulsion, Aggression, Insomnia, Choking, Ocular Hyperaemia, Ocular Icterus, Disturbance in Attention, Vision Blurred, Parosmia, Confusional State, Pain, Constipation, Suicidal Ideation, Myalgia, Speech Disorder, Weight Increased, Overdose, Hypersomnia, Dyspnoea, Mydriasis, Vomiting, Nausea, Self Injurious Behaviour, Cognitive Disorder, Status Epilepticus, Stupor, Mental Impairment, Anxiety, Psychotic Disorder, Heart Rate Increased, Asthenia, Feeling Abnormal, Influenza Like Illness
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Benztropine Mesylate
Lithium Carbonate
Dosage: 900 milligram;
Clozapine
Dosage: 75 mg in am, 50 mg hs
Administration route: Oral
Indication: Psychotic Disorder
Olanzapine
Dosage: as needed
Administration route: Oral
Indication: Psychotic Disorder
Start date: 2011-11-01
Other drugs received by patient: Quetiapine; Zolpidem Tartrate
Possible Clozapine side effects in 22 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-02-22
Patient: 22 year old male
Reactions: Overdose, Electrocardiogram QT Shortened, Asphyxia
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozapine
Dosage: 250 mg, qd
Administration route: Oral
Indication: Schizophrenia
Start date: 2011-11-30
Lorazepam
Dosage: 1 t0 4 mg, prn
Indication: Anxiety
Other drugs received by patient: Kwells; Propranolol; Sertraline Hydrochloride
Possible Clozapine side effects in 34 year old male
Reported by a individual with unspecified qualification from Australia on 2012-02-15
Patient: 34 year old male
Reactions: Vomiting, Diabetes Mellitus, Haemoptysis, Physical Assault, Drug Prescribing Error, Suicidal Ideation, Delusion, Aggression, Hostility, Overdose, Diarrhoea, Neuroleptic Malignant Syndrome, Hallucination
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Seroquel
Dosage: dose increased
Administration route: Oral
Start date: 2012-02-06
Seroquel
Administration route: Oral
Start date: 2008-01-01
Clopixol
Dosage: depot
Clozapine
Start date: 2009-01-01
Other drugs received by patient: Antipsychotics
Possible Clozapine side effects in 56 year old male
Reported by a physician from United States on 2012-01-23
Patient: 56 year old male
Reactions: Overdose, Completed Suicide
Adverse event resulted in: death
Drug(s) suspected as cause:
Benztropine Mesylate
Administration route: Oral
Clozapine
Administration route: Oral
Zetia
Administration route: Oral
Bupropion Hydrochloride
Administration route: Oral
Sertraline Hydrochloride
Administration route: Oral
Possible Clozapine side effects in
Reported by a individual with unspecified qualification from United States on 2011-12-14
Patient:
Reactions: Pain, Drug Interaction, Toxicity To Various Agents, Intentional Self-Injury, Delirium, Off Label Use, Overdose, Palpitations, Yellow Skin, Suicide Attempt, Asthenia, Feeling Abnormal, Crying
Drug(s) suspected as cause:
Zyprexa
Clozapine
Possible Clozapine side effects in 32 year old male
Reported by a consumer/non-health professional from Denmark on 2011-12-12
Patient: 32 year old male
Reactions: Electrocardiogram ST Segment Depression, Bedridden, Suicidal Ideation, Overdose, C-Reactive Protein Increased, Decubitus Ulcer, Neuroleptic Malignant Syndrome, Hallucination, Oxygen Saturation Decreased, Pneumonia, Toxicity To Various Agents, Electrocardiogram QRS Complex Shortened, Psychotic Disorder, Hallucinations, Mixed, Hypophagia, Fluid Intake Reduced, Depressed Level of Consciousness
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Abilify
Dosage: interrupted and restarted with 15mg
Administration route: Oral
Indication: Depression
Clozapine
Dosage: interrrupted and restarted with 200 mg
Administration route: Oral
Indication: Mental Disorder
Duloxetine Hydrochloride
Dosage: gastro resistant capsule hard
Administration route: Oral
Indication: Depression
Cymbalta
Dosage: gastro resistant capsule, hard interrupted and restarted with 60mg
Administration route: Oral
Indication: Depression
Other drugs received by patient: Pantoprazole Sodium; Buprenex; Metoprolol Succinate; Simvastatin
Possible Clozapine side effects in 41 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-11-15
Patient: 41 year old male
Reactions: Grand MAL Convulsion, Overdose, Aspiration, Hypotension, Circulatory Collapse, Coma Scale Abnormal, Cardiac Arrest
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Clozapine
Administration route: Oral
Citalopram Hydrobromide
Procyclidine Hydrochloride 2MG TAB
Diazepam
Possible Clozapine side effects in 41 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-11-15
Patient: 41 year old male
Reactions: Grand MAL Convulsion, Overdose, Aspiration, Hypotension, Circulatory Collapse, Coma Scale Abnormal, Cardiac Arrest
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Procyclidine Hydrochloride 2MG TAB
Clozapine
Administration route: Oral
Diazepam
Citalopram Hydrobromide
Possible Clozapine side effects in 24 year old male
Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-24
Patient: 24 year old male
Reactions: Abdominal Pain, Overdose, Suicide Attempt, Pyrexia, Foreign Body, Intentional Self-Injury, Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozapine
Possible Clozapine side effects in 24 year old male
Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-24
Patient: 24 year old male
Reactions: Abdominal Pain, Overdose, Suicide Attempt, Pyrexia, Foreign Body, Intentional Self-Injury, Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozapine
Possible Clozapine side effects in female
Reported by a health professional (non-physician/pharmacist) from Switzerland on 2011-10-17
Patient: female
Reactions: Overdose, Fear, Akinesia, Antipsychotic Drug Level Above Therapeutic, Somnolence, Fall, Tension
Drug(s) suspected as cause:
Clozapine
Clozapine
Clozapine
Dosage: 550 mg, daily
Other drugs received by patient: Lorazepam; Benzodiazepines
Possible Clozapine side effects in male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-10
Patient: male
Reactions: Overdose, Pneumonia Aspiration, Circulatory Collapse
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozapine
Administration route: Oral
Indication: Schizophrenia
Start date: 2006-09-27
End date: 2011-06-01
Heroin
Possible Clozapine side effects in male
Reported by a physician from United Kingdom on 2011-10-07
Patient: male
Reactions: General Physical Condition Abnormal, Intentional Overdose, Sudden Death, Treatment Noncompliance, Accidental Overdose, Chronic Obstructive Pulmonary Disease, Overdose, Circulatory Collapse
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozapine
Administration route: Oral
Indication: Schizophrenia
Start date: 2008-02-04
Diazepam
Dosage: 10 mg/day
Administration route: Oral
Methadone HCL
Possible Clozapine side effects in female
Reported by a physician from United Kingdom on 2011-10-07
Patient: female
Reactions: Overdose
Adverse event resulted in: death
Drug(s) suspected as cause:
Clozapine
Possible Clozapine side effects in male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-07
Patient: male
Reactions: General Physical Condition Abnormal, Overdose, Circulatory Collapse, Chronic Obstructive Pulmonary Disease
Adverse event resulted in: death
Drug(s) suspected as cause:
Methadone HCL
Diazepam
Dosage: 10 mg/day
Administration route: Oral
Clozapine
Administration route: Oral
Indication: Schizophrenia
Start date: 2008-02-04
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