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Clozapine (Clozapine) - Overdose - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Overdose ()

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Clozapine where reactions include overdose. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of    Next >>

Possible Clozapine side effects in 22 year old male

Reported by a physician from United Kingdom on 2012-08-17

Patient: 22 year old male, weighing 66.4 kg (146.1 pounds)

Reactions: Vomiting, Antipsychotic Drug Level Increased, Nausea, Electrocardiogram QT Shortened, Constipation, Faecaloma, Asphyxia, Mental Impairment, Overdose, Aspiration, Pulmonary Congestion, Sedation, Choking, Pulmonary Oedema

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine
    Dosage: 250 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2011-11-30

Lorazepam
    Dosage: 1 t0 4 mg, prn
    Indication: Anxiety

Clozapine
    Dosage: 250 mg, unk
    Start date: 2012-01-11
    End date: 2012-01-11

Lorazepam
    Dosage: 11x1 mg dose

Other drugs received by patient: Propranolol; Kwells; Sertraline Hydrochloride



Possible Clozapine side effects in 45 year old male

Reported by a pharmacist from France on 2012-07-31

Patient: 45 year old male

Reactions: Overdose, Ankle Fracture

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in male

Reported by a physician from United Kingdom on 2012-06-29

Patient: male

Reactions: Mental Impairment, Overdose, Full Blood Count Abnormal, Suicide Attempt, Neutropenia, Aggression

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Hydrocortisone Acetate; Levothyroxine; Quetiapine; Risperidone; Zopiclone; Valproate Sodium; Clopixol; Lorazepam



Possible Clozapine side effects in 35 year old male

Reported by a pharmacist from United States on 2012-06-28

Patient: 35 year old male

Reactions: Overdose

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Lamictal; Wellbutrin SR; Lithium Carbonate



Possible Clozapine side effects in 22 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-06-25

Patient: 22 year old male

Reactions: Vomiting, Antipsychotic Drug Level Increased, Nausea, Electrocardiogram QT Shortened, Constipation, Asphyxia, Mental Impairment, Overdose, Sedation

Adverse event resulted in: death

Drug(s) suspected as cause:
Lorazepam
    Dosage: 1 t0 4 mg, prn
    Indication: Anxiety

Lorazepam
    Dosage: 11x1 mg dose

Clozapine
    Dosage: 250 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2011-11-30

Clozapine
    Dosage: 250 mg, unk
    Start date: 2012-01-11
    End date: 2012-01-11

Other drugs received by patient: Sertraline Hydrochloride; Kwells; Propranolol



Possible Clozapine side effects in male

Reported by a physician from United Kingdom on 2012-05-21

Patient: male

Reactions: Mental Impairment, Overdose, Full Blood Count Abnormal, Suicide Attempt, Neutropenia, Aggression

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Risperidone; Quetiapine; Clopixol; Levothyroxine Sodium; Hydrocortisone; Valproate Sodium



Possible Clozapine side effects in 37 year old male

Reported by a consumer/non-health professional from Australia on 2012-04-27

Patient: 37 year old male

Reactions: Vomiting, Haemoptysis, Diabetes Mellitus, Physical Assault, Adverse Drug Reaction, Drug Withdrawal Syndrome, Drug Prescribing Error, Aggression, Delusion, Suicidal Ideation, Hostility, Syncope, Renal Failure, Overdose, Diarrhoea, Dehydration, Neuroleptic Malignant Syndrome, Hallucination

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Seroquel
    Dosage: dose increased
    Administration route: Oral
    Start date: 2012-02-06

Clopixol
    Dosage: depot
    End date: 2012-02-06

Seroquel
    Administration route: Oral
    Start date: 2008-01-01

Clozapine
    Start date: 2009-01-01

Other drugs received by patient: Ativan; Antipsychotics



Possible Clozapine side effects in 32 year old male

Reported by a consumer/non-health professional from United States on 2012-04-25

Patient: 32 year old male, weighing 86.2 kg (189.6 pounds)

Reactions: Overdose, Convulsion

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in female

Reported by a consumer/non-health professional from United States on 2012-04-03

Patient: female

Reactions: Akathisia, Movement Disorder, Abdominal Pain, Pruritus, Malaise, Palpitations, Mood Altered, Back Pain, Toxicity To Various Agents, Stress, Delirium, Aggression, Sleep Disorder, Ocular Hyperaemia, Vision Blurred, Parosmia, Speech Disorder, Overdose, Abdominal Distension, Depression, Dyspnoea, Vomiting, Self Injurious Behaviour, Discomfort, Heart Rate Increased, Asthenia, Agitation, Dementia, Headache, Pyrexia, Loss of Consciousness, Off Label Use, Yellow Skin, Muscle Spasms, Panic Reaction, Bowel Movement Irregularity, Pain in Extremity, Hypoaesthesia, Convulsion, Decreased Interest, Insomnia, Choking, Ocular Icterus, Disturbance in Attention, Sleep Apnoea Syndrome, Confusional State, Pain, Bone Pain, Constipation, Suicidal Ideation, Weight Increased, Myalgia, Fatigue, Toothache, Hypersomnia, Tooth Decalcification, Mydriasis, Nausea, Dental Caries, Status Epilepticus, Cognitive Disorder, Drug Prescribing Error, Stupor, Anxiety, Mental Impairment, Psychotic Disorder, Feeling Abnormal, Influenza Like Illness

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Olanzapine
    Dosage: as needed
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-11-01

Lithium Carbonate
    Dosage: 900 milligram;

Clozapine
    Dosage: 75 mg in am, 50 mg hs
    Administration route: Oral
    Indication: Psychotic Disorder

Benztropine Mesylate

Other drugs received by patient: Zolpidem Tartrate; Quetiapine



Possible Clozapine side effects in female

Reported by a consumer/non-health professional from United States on 2012-03-27

Patient: female

Reactions: Abdominal Pain, Movement Disorder, Akathisia, Malaise, Mood Altered, Palpitations, Back Pain, Toxicity To Various Agents, Delirium, Aggression, Sleep Disorder, Ocular Hyperaemia, Vision Blurred, Parosmia, Speech Disorder, Overdose, Abdominal Distension, Depression, Dyspnoea, Vomiting, Self Injurious Behaviour, Discomfort, Heart Rate Increased, Asthenia, Agitation, Dementia, Pyrexia, Headache, Loss of Consciousness, Off Label Use, Yellow Skin, Panic Reaction, Muscle Spasms, Bowel Movement Irregularity, Pain in Extremity, Hypoaesthesia, Convulsion, Decreased Interest, Choking, Insomnia, Ocular Icterus, Disturbance in Attention, Confusional State, Pain, Bone Pain, Constipation, Suicidal Ideation, Weight Increased, Myalgia, Toothache, Hypersomnia, Tooth Decalcification, Mydriasis, Nausea, Dental Caries, Status Epilepticus, Cognitive Disorder, Drug Prescribing Error, Stupor, Anxiety, Mental Impairment, Psychotic Disorder, Feeling Abnormal, Influenza Like Illness

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Olanzapine
    Dosage: as needed
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-11-01

Clozapine
    Dosage: 75 mg in am, 50 mg hs
    Administration route: Oral
    Indication: Psychotic Disorder

Lithium Carbonate
    Dosage: 900 milligram;

Benztropine Mesylate

Other drugs received by patient: Quetiapine; Zolpidem Tartrate



Possible Clozapine side effects in female

Reported by a consumer/non-health professional from United States on 2012-03-16

Patient: female

Reactions: Abdominal Pain, Akathisia, Movement Disorder, Agitation, Dementia, Pyrexia, Headache, Loss of Consciousness, Off Label Use, Malaise, Yellow Skin, Mood Altered, Palpitations, Panic Reaction, Muscle Spasms, Bowel Movement Irregularity, Back Pain, Pain in Extremity, Toxicity To Various Agents, Hypoaesthesia, Delirium, Aggression, Convulsion, Decreased Interest, Sleep Disorder, Ocular Hyperaemia, Choking, Insomnia, Vision Blurred, Ocular Icterus, Disturbance in Attention, Parosmia, Confusional State, Bone Pain, Pain, Constipation, Suicidal Ideation, Weight Increased, Myalgia, Speech Disorder, Overdose, Abdominal Distension, Depression, Hypersomnia, Vomiting, Dyspnoea, Mydriasis, Nausea, Cognitive Disorder, Status Epilepticus, Self Injurious Behaviour, Drug Prescribing Error, Stupor, Discomfort, Mental Impairment, Anxiety, Psychotic Disorder, Heart Rate Increased, Feeling Abnormal, Asthenia, Influenza Like Illness

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Benztropine Mesylate

Olanzapine
    Dosage: as needed
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-11-01

Clozapine
    Dosage: 75 mg in am, 50 mg hs
    Administration route: Oral
    Indication: Psychotic Disorder

Lithium Carbonate
    Dosage: 900 milligram;

Other drugs received by patient: Quetiapine; Zolpidem Tartrate



Possible Clozapine side effects in 34 year old male

Reported by a individual with unspecified qualification from Australia on 2012-03-15

Patient: 34 year old male

Reactions: Vomiting, Diabetes Mellitus, Haemoptysis, Physical Assault, Drug Withdrawal Syndrome, Drug Prescribing Error, Aggression, Suicidal Ideation, Delusion, Hostility, Overdose, Diarrhoea, Neuroleptic Malignant Syndrome, Hallucination

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Start date: 2009-01-01

Seroquel
    Administration route: Oral
    Start date: 2008-01-01

Seroquel
    Dosage: dose increased
    Administration route: Oral
    Start date: 2012-02-06

Clopixol
    Dosage: depot

Other drugs received by patient: Ativan; Antipsychotics



Possible Clozapine side effects in male

Reported by a physician from United Kingdom on 2012-03-13

Patient: male

Reactions: Mental Impairment, Overdose, Suicide Attempt, Neutropenia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Valproate Sodium; Clopixol; Risperidone; Quetiapine; Levothyroxine Sodium; Hydrocortisone



Possible Clozapine side effects in female

Reported by a consumer/non-health professional from United States on 2012-03-12

Patient: female

Reactions: Movement Disorder, Akathisia, Abdominal Pain, Abdominal Discomfort, Palpitations, Mood Altered, Victim of Abuse, Back Pain, Toxicity To Various Agents, Delirium, Aggression, Post-Traumatic Stress Disorder, Thought Blocking, Sleep Disorder, Ocular Hyperaemia, Vision Blurred, Parosmia, Drug Interaction, Speech Disorder, Overdose, Abdominal Distension, Depression, Dyspnoea, Vomiting, Self Injurious Behaviour, Discomfort, Heart Rate Increased, Asthenia, Agitation, Dementia, Headache, Pyrexia, Loss of Consciousness, Off Label Use, Brain Injury, Yellow Skin, Panic Reaction, Muscle Spasms, Bowel Movement Irregularity, Pain in Extremity, Hypoaesthesia, Convulsion, Decreased Interest, Choking, Insomnia, Ocular Icterus, Disturbance in Attention, Confusional State, Pain, Fear, Bone Pain, Constipation, Suicidal Ideation, Weight Increased, Myalgia, Fatigue, Hypersomnia, Refusal of Treatment by Patient, Mydriasis, Nausea, Condition Aggravated, Status Epilepticus, Cognitive Disorder, Stupor, Anxiety, Mental Impairment, Psychotic Disorder, Emotional Poverty, Feeling Abnormal, Influenza Like Illness

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Benztropine Mesylate

Olanzapine
    Dosage: as needed
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-11-01

Clozapine
    Dosage: 75 mg in am, 50 mg hs
    Administration route: Oral
    Indication: Psychotic Disorder

Lithium Carbonate
    Dosage: 900 milligram;

Other drugs received by patient: Zolpidem Tartrate; Quetiapine



Possible Clozapine side effects in female

Reported by a physician from Italy on 2012-03-09

Patient: female

Reactions: Dysarthria, Overdose, Apraxia

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in female

Reported by a consumer/non-health professional from United States on 2012-02-24

Patient: female

Reactions: Agitation, Movement Disorder, Akathisia, Dementia, Pyrexia, Headache, Loss of Consciousness, Off Label Use, Abdominal Discomfort, Mood Altered, Yellow Skin, Palpitations, Muscle Spasms, Panic Reaction, Back Pain, Pain in Extremity, Hypoaesthesia, Toxicity To Various Agents, Delirium, Convulsion, Aggression, Insomnia, Choking, Ocular Hyperaemia, Ocular Icterus, Disturbance in Attention, Vision Blurred, Parosmia, Confusional State, Pain, Constipation, Suicidal Ideation, Myalgia, Speech Disorder, Weight Increased, Overdose, Hypersomnia, Dyspnoea, Mydriasis, Vomiting, Nausea, Self Injurious Behaviour, Cognitive Disorder, Status Epilepticus, Stupor, Mental Impairment, Anxiety, Psychotic Disorder, Heart Rate Increased, Asthenia, Feeling Abnormal, Influenza Like Illness

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Benztropine Mesylate

Lithium Carbonate
    Dosage: 900 milligram;

Clozapine
    Dosage: 75 mg in am, 50 mg hs
    Administration route: Oral
    Indication: Psychotic Disorder

Olanzapine
    Dosage: as needed
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-11-01

Other drugs received by patient: Quetiapine; Zolpidem Tartrate



Possible Clozapine side effects in 22 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-02-22

Patient: 22 year old male

Reactions: Overdose, Electrocardiogram QT Shortened, Asphyxia

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine
    Dosage: 250 mg, qd
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2011-11-30

Lorazepam
    Dosage: 1 t0 4 mg, prn
    Indication: Anxiety

Other drugs received by patient: Kwells; Propranolol; Sertraline Hydrochloride



Possible Clozapine side effects in 34 year old male

Reported by a individual with unspecified qualification from Australia on 2012-02-15

Patient: 34 year old male

Reactions: Vomiting, Diabetes Mellitus, Haemoptysis, Physical Assault, Drug Prescribing Error, Suicidal Ideation, Delusion, Aggression, Hostility, Overdose, Diarrhoea, Neuroleptic Malignant Syndrome, Hallucination

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Seroquel
    Dosage: dose increased
    Administration route: Oral
    Start date: 2012-02-06

Seroquel
    Administration route: Oral
    Start date: 2008-01-01

Clopixol
    Dosage: depot

Clozapine
    Start date: 2009-01-01

Other drugs received by patient: Antipsychotics



Possible Clozapine side effects in 56 year old male

Reported by a physician from United States on 2012-01-23

Patient: 56 year old male

Reactions: Overdose, Completed Suicide

Adverse event resulted in: death

Drug(s) suspected as cause:
Benztropine Mesylate
    Administration route: Oral

Clozapine
    Administration route: Oral

Zetia
    Administration route: Oral

Bupropion Hydrochloride
    Administration route: Oral

Sertraline Hydrochloride
    Administration route: Oral



Possible Clozapine side effects in

Reported by a individual with unspecified qualification from United States on 2011-12-14

Patient:

Reactions: Pain, Drug Interaction, Toxicity To Various Agents, Intentional Self-Injury, Delirium, Off Label Use, Overdose, Palpitations, Yellow Skin, Suicide Attempt, Asthenia, Feeling Abnormal, Crying

Drug(s) suspected as cause:
Zyprexa

Clozapine



Possible Clozapine side effects in 32 year old male

Reported by a consumer/non-health professional from Denmark on 2011-12-12

Patient: 32 year old male

Reactions: Electrocardiogram ST Segment Depression, Bedridden, Suicidal Ideation, Overdose, C-Reactive Protein Increased, Decubitus Ulcer, Neuroleptic Malignant Syndrome, Hallucination, Oxygen Saturation Decreased, Pneumonia, Toxicity To Various Agents, Electrocardiogram QRS Complex Shortened, Psychotic Disorder, Hallucinations, Mixed, Hypophagia, Fluid Intake Reduced, Depressed Level of Consciousness

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Abilify
    Dosage: interrupted and restarted with 15mg
    Administration route: Oral
    Indication: Depression

Clozapine
    Dosage: interrrupted and restarted with 200 mg
    Administration route: Oral
    Indication: Mental Disorder

Duloxetine Hydrochloride
    Dosage: gastro resistant capsule hard
    Administration route: Oral
    Indication: Depression

Cymbalta
    Dosage: gastro resistant capsule, hard interrupted and restarted with 60mg
    Administration route: Oral
    Indication: Depression

Other drugs received by patient: Pantoprazole Sodium; Buprenex; Metoprolol Succinate; Simvastatin



Possible Clozapine side effects in 41 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-11-15

Patient: 41 year old male

Reactions: Grand MAL Convulsion, Overdose, Aspiration, Hypotension, Circulatory Collapse, Coma Scale Abnormal, Cardiac Arrest

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral

Citalopram Hydrobromide

Procyclidine Hydrochloride 2MG TAB

Diazepam



Possible Clozapine side effects in 41 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-11-15

Patient: 41 year old male

Reactions: Grand MAL Convulsion, Overdose, Aspiration, Hypotension, Circulatory Collapse, Coma Scale Abnormal, Cardiac Arrest

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Procyclidine Hydrochloride 2MG TAB

Clozapine
    Administration route: Oral

Diazepam

Citalopram Hydrobromide



Possible Clozapine side effects in 24 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-24

Patient: 24 year old male

Reactions: Abdominal Pain, Overdose, Suicide Attempt, Pyrexia, Foreign Body, Intentional Self-Injury, Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in 24 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-24

Patient: 24 year old male

Reactions: Abdominal Pain, Overdose, Suicide Attempt, Pyrexia, Foreign Body, Intentional Self-Injury, Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in female

Reported by a health professional (non-physician/pharmacist) from Switzerland on 2011-10-17

Patient: female

Reactions: Overdose, Fear, Akinesia, Antipsychotic Drug Level Above Therapeutic, Somnolence, Fall, Tension

Drug(s) suspected as cause:
Clozapine

Clozapine

Clozapine
    Dosage: 550 mg, daily

Other drugs received by patient: Lorazepam; Benzodiazepines



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-10

Patient: male

Reactions: Overdose, Pneumonia Aspiration, Circulatory Collapse

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2006-09-27
    End date: 2011-06-01

Heroin



Possible Clozapine side effects in female

Reported by a physician from United Kingdom on 2011-10-07

Patient: female

Reactions: Overdose

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-07

Patient: male

Reactions: General Physical Condition Abnormal, Overdose, Circulatory Collapse, Chronic Obstructive Pulmonary Disease

Adverse event resulted in: death

Drug(s) suspected as cause:
Methadone HCL

Diazepam
    Dosage: 10 mg/day
    Administration route: Oral

Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2008-02-04



Possible Clozapine side effects in male

Reported by a physician from United Kingdom on 2011-10-07

Patient: male

Reactions: General Physical Condition Abnormal, Intentional Overdose, Sudden Death, Treatment Noncompliance, Accidental Overdose, Chronic Obstructive Pulmonary Disease, Overdose, Circulatory Collapse

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2008-02-04

Diazepam
    Dosage: 10 mg/day
    Administration route: Oral

Methadone HCL



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