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Clozapine (Clozapine) - Agranulocytosis - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Agranulocytosis (100)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Clozapine where reactions include agranulocytosis. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 100   Next >>

Possible Clozapine side effects in 41 year old male

Reported by a physician from France on 2012-08-24

Patient: 41 year old male

Reactions: Agranulocytosis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clonazepam
    Administration route: Oral
    Indication: Schizophrenia, Paranoid Type
    Start date: 2011-11-11
    End date: 2012-04-21

Clonazepam
    Administration route: Oral
    Start date: 2012-04-25

Clozapine
    Administration route: Oral
    Indication: Schizophrenia, Paranoid Type
    Start date: 2011-11-11
    End date: 2012-04-21

Havlane
    Administration route: Oral
    Start date: 2012-04-25

Havlane
    Administration route: Oral
    Indication: Schizophrenia, Paranoid Type
    Start date: 2011-11-11
    End date: 2012-04-21

Risperdal Consta
    Start date: 2012-04-25

Risperdal Consta
    Indication: Schizophrenia, Paranoid Type
    Start date: 2011-11-11
    End date: 2012-04-21



Possible Clozapine side effects in 38 year old male

Reported by a physician from France on 2012-08-20

Patient: 38 year old male

Reactions: Agranulocytosis, Lung Disorder, Anaemia, Colitis

Drug(s) suspected as cause:
Clozapine
    Dosage: 75 mg /day
    Administration route: Oral
    Indication: Schizophrenia
    Start date: 2012-06-21

Clozapine
    Dosage: 200 mg/day ( increments of 25 mg to reach 200 mg daily)
    Administration route: Oral
    End date: 2012-07-31



Possible Clozapine side effects in female

Reported by a health professional (non-physician/pharmacist) from Netherlands on 2012-08-16

Patient: female, weighing 75.0 kg (165.0 pounds)

Reactions: Renal Disorder, Agranulocytosis, Hypophagia, Somnolence, Leukopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Aspirin; Persantine; Exelon; Nexium; Carbidopa + Levodopa; Movicolon; Triamteren; Amoxicillin and Clavulanate Potassium; Trimethoprim; Arimidex; Acetaminophen; Seroquel; Calcium Carbonate W / Colecalciferol



Possible Clozapine side effects in 44 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-06

Patient: 44 year old female

Reactions: Psychotic Disorder, Agranulocytosis, Dizziness, Rash, Neuroleptic Malignant Syndrome, Neutrophil Count Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Indication: Product Used FOR Unknown Indication

Lamotrigine
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Olanzapine



Possible Clozapine side effects in 44 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-02

Patient: 44 year old female

Reactions: Agranulocytosis, Dizziness, Neuroleptic Malignant Syndrome, Rash

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Indication: Psychotic Disorder

Lamotrigine
    Indication: Psychotic Disorder



Possible Clozapine side effects in 30 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-02

Patient: 30 year old male

Reactions: Haemoglobin Decreased, Agranulocytosis, RED Blood Cell Count Decreased, Platelet Count Decreased, Oropharyngeal Pain

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 300 mg, 1x/day
    Administration route: Oral
    Start date: 2010-04-14
    End date: 2012-06-17

Effexor XR
    Dosage: 75 mg, 1x/day
    Administration route: Oral
    Start date: 2012-01-01

Tercian
    Dosage: 25 mg, 4x/day
    Administration route: Oral
    Start date: 2008-01-01
    End date: 2012-06-17

Other drugs received by patient: Lorazepam



Possible Clozapine side effects in male

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-31

Patient: male

Reactions: Agranulocytosis, Pyrexia, Oropharyngeal Pain, Pharyngeal Erythema

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 300 mg, qd
    Start date: 2010-04-14
    End date: 2012-06-17

Effexor
    Dosage: 75 mg, qd
    Start date: 2012-01-01

Tercian
    Dosage: unk ukn, unk

Tercian
    Dosage: 25 mg, 4 times daily
    Start date: 2008-01-01
    End date: 2012-06-17

Other drugs received by patient: Lorazepam



Possible Clozapine side effects in 44 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-31

Patient: 44 year old female

Reactions: Agranulocytosis, Drug Interaction, Rash, Neuroleptic Malignant Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient possibly interacting with the suspect drug:
Clozapine

Lamotrigine
    Dosage: dose titrated upward due to persistent psychotic symptoms

Other drugs received by patient: Olanzapine



Possible Clozapine side effects in 44 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-30

Patient: 44 year old female

Reactions: Agranulocytosis, Dizziness, Neuroleptic Malignant Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Indication: Product Used FOR Unknown Indication

Lamotrigine
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Olanzapine



Possible Clozapine side effects in female

Reported by a health professional (non-physician/pharmacist) from Netherlands on 2012-07-25

Patient: female, weighing 75.0 kg (165.0 pounds)

Reactions: Renal Disorder, Agranulocytosis, Hypophagia, Somnolence, Leukopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Exelon



Possible Clozapine side effects in

Reported by a pharmacist from Spain on 2012-07-23

Patient:

Reactions: White Blood Cell Count Decreased, Agranulocytosis, Cytomegalovirus Infection, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Clonazepam; Quetiapine; Lithium Carbonate; Lactulose; Lormetazepam



Possible Clozapine side effects in 51 year old female

Reported by a health professional (non-physician/pharmacist) from Switzerland on 2012-07-23

Patient: 51 year old female, weighing 56.0 kg (123.2 pounds)

Reactions: Confusional State, Acquired Tracheo-Oesophageal Fistula, Haemorrhage, Pyrexia, Subclavian Vein Thrombosis, Agranulocytosis, Escherichia Test Positive, Aspiration, Oesophagitis, Respiratory Failure, Urosepsis, Leukopenia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Clozapine
    Dosage: 300 mg, qd
    Administration route: Oral
    Indication: Bipolar Disorder
    Start date: 2012-02-01
    End date: 2012-04-29

Seroquel
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2012-02-01
    End date: 2012-04-29

Other drugs received by patient: Calcimagon-D3; Lorazepam; Levothyroxine Sodium; Lithium Carbonate; Ezetimibe



Possible Clozapine side effects in 44 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-06

Patient: 44 year old female

Reactions: Agranulocytosis, Neuroleptic Malignant Syndrome

Drug(s) suspected as cause:
Clozapine
    Indication: Schizophrenia

Lamotrigine (Lanotrigine)
    Indication: Schizophrenia

Other drugs received by patient: Olanzapine



Possible Clozapine side effects in 45 year old female

Reported by a health professional (non-physician/pharmacist) from India on 2012-07-05

Patient: 45 year old female

Reactions: White Blood Cell Count Decreased, Agranulocytosis, Body Temperature Increased, Platelet Count Decreased, Oropharyngeal Pain, Neutrophil Count Decreased

Drug(s) suspected as cause:
Clozapine
    Dosage: 25 mg, daily
    Administration route: Oral
    Indication: Schizophrenia

Clozapine
    Dosage: 400 mg, daily
    Administration route: Oral



Possible Clozapine side effects in 53 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 53 year old female

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Hallucination, Auditory
    End date: 2012-02-17

Clozapine
    Administration route: Oral
    End date: 2011-11-22

Clozapine
    Administration route: Oral
    End date: 2011-11-22

Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    End date: 2012-02-17

Other drugs received by patient: Cyclobenzaprine; Abilify; Spiriva; Invega; Promethazine; Prilosec; Nexium; Topamax; Trazodone HCL; Fluoxetine; Risperidone



Possible Clozapine side effects in 19 year old male

Reported by a physician from United States on 2012-06-28

Patient: 19 year old male

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Lorazepam; Geodon; Gabapentin; Strattera; Risperdal Consta; Saphris



Possible Clozapine side effects in 42 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 42 year old female

Reactions: Agranulocytosis

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in 65 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 65 year old female

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in 72 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 72 year old female, weighing 74.8 kg (164.6 pounds)

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Start date: 2011-12-23

Clozapine
    Administration route: Oral

Clozapine
    Administration route: Oral
    Indication: Tremor
    End date: 2011-12-19

Clozapine
    Administration route: Oral
    Indication: Parkinson's Disease
    End date: 2011-12-19

Clozapine
    Administration route: Oral
    Start date: 2011-12-23

Clozapine
    Administration route: Oral

Other drugs received by patient: Cymbalta; Milk OF Magnesia TAB; Requip; Multi-Vitamin; Acetaminophen; Sinemet; Tricor; Acetaminophen; Gabapentin; Wellbutrin SR; Senna-Mint WAF; Stalevo 100; Potassium Acetate; Spironolactone; Enema Fleet; Claritin / 00413701 /



Possible Clozapine side effects in 53 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 53 year old female

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Lorazepam; Depakote; Insulin; Simvastatin; Seroquel; Aspirin; Lantus; Haldol; Fish OIL; Levocarnitine; Sertraline Hydrochloride; Synthroid



Possible Clozapine side effects in 66 year old male

Reported by a pharmacist from United States on 2012-06-28

Patient: 66 year old male

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Chemotherapeutics

Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    End date: 2011-04-22



Possible Clozapine side effects in 33 year old male

Reported by a pharmacist from United States on 2012-06-28

Patient: 33 year old male, weighing 67.7 kg (148.9 pounds)

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Lorazepam; Lithium Carbonate; Propranolol



Possible Clozapine side effects in 36 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 36 year old female

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Drug(s) suspected as cause:
Clozapine

Other drugs received by patient: Lorazepam; Bactrim; Benzac / 00088302 /; Lipitor; Detrol LA; Glycopyrrolate; Levothyroxine; Triamterene and Hydrochlorothiazide; Valtrex; Voltaren; Cytomel; Estradiol; Metformin HCL; Nasonex; Polyethylene Glycol; Dicyclomine; Nystatin; Pantoprazole; Tizanidine Hydrochloride; Albuterol Sulfate



Possible Clozapine side effects in 47 year old male

Reported by a pharmacist from United States on 2012-06-28

Patient: 47 year old male

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    End date: 2011-09-06

Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    End date: 2011-09-06

Clozapine
    Administration route: Oral
    Indication: Schizoaffective Disorder
    End date: 2011-09-06

Clozapine
    Administration route: Oral
    End date: 2011-09-06

Other drugs received by patient: Lithium Carbonate; Clonazepam; Ambien



Possible Clozapine side effects in 49 year old male

Reported by a pharmacist from United States on 2012-06-28

Patient: 49 year old male

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Chemotherapeutics

Clozapine
    Administration route: Oral
    Indication: Psychotic Disorder
    End date: 2011-04-27

Clozapine
    Administration route: Oral
    Start date: 2011-05-01

Clozapine
    Administration route: Oral
    Start date: 2011-04-28
    End date: 2011-05-01

Clozapine
    Administration route: Oral
    Indication: Schizophrenia
    End date: 2011-04-27

Clozapine
    Administration route: Oral
    Start date: 2011-04-28
    End date: 2011-05-01

Clozapine
    Administration route: Oral
    Start date: 2011-05-01

Other drugs received by patient: Cogentin; Haldol



Possible Clozapine side effects in 18 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 18 year old female

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Clozapine



Possible Clozapine side effects in 65 year old female

Reported by a pharmacist from United States on 2012-06-28

Patient: 65 year old female, weighing 65.1 kg (143.2 pounds)

Reactions: Agranulocytosis, Heart Rate Increased, Chest Pain, Leukopenia

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2011-10-03
    End date: 2011-10-06

Clozapine
    Administration route: Oral
    Start date: 2011-10-07
    End date: 2011-10-20

Other drugs received by patient: Celexa; Risperidone; Cogentin; Minocycline HCL; Vitamin D; Omeprazole; Risperidone; Levothyroxine; Ativan



Possible Clozapine side effects in 48 year old male

Reported by a physician from United States on 2012-06-28

Patient: 48 year old male

Reactions: Agranulocytosis, Leukopenia

Drug(s) suspected as cause:
Chemotherapeutics
    Indication: Lung Neoplasm Malignant

Clozapine



Possible Clozapine side effects in 56 year old female

Reported by a physician from United States on 2012-06-28

Patient: 56 year old female

Reactions: Agranulocytosis, Granulocytopenia, Leukopenia

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizoaffective Disorder
    End date: 2011-09-23

Clozapine
    Administration route: Oral
    End date: 2011-09-23

Other drugs received by patient: Zoloft; Benadryl; Benztropine Mesylate



Possible Clozapine side effects in 69 year old male

Reported by a physician from United States on 2012-06-28

Patient: 69 year old male, weighing 87.1 kg (191.6 pounds)

Reactions: Agranulocytosis, Pneumonia, Granulocytopenia, Leukopenia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Parkinson's Disease
    Start date: 2012-02-22
    End date: 2012-03-07

Clozapine
    Administration route: Oral
    Indication: Psychotic Disorder
    Start date: 2012-02-22
    End date: 2012-03-07

Clozapine
    Administration route: Oral
    Indication: Hallucination
    Start date: 2012-02-22
    End date: 2012-03-07

Other drugs received by patient: Midodrine Hydrochloride; Carbidopa and Levodopa; Hydrocortisone Acetate; Venlafaxine; Midodrine Hydrochloride; Rivastigmine



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