This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Clonazepam and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (1384)
Death (497)
Life Threatening Events (117)
Disability (38)
Reports by Reaction Type
Completed Suicide (261),
Toxicity To Various Agents (160),
Cardiac Arrest (117),
Respiratory Arrest (109),
Cardio-Respiratory Arrest (104),
Death (93),
Drug Ineffective (78),
Anxiety (78),
Somnolence (66),
Convulsion (66),
Suicide Attempt (57),
Drug Interaction (54)
Below are a few examples of reports where side effects / adverse reactions may be related to Clonazepam. For a complete list or a specific selection of reports, please use the links above.
Possible Clonazepam side effects in 40 year old female
Reported by a physician from Italy on 2012-08-27
Patient: 40 year old female, weighing 80.0 kg (176.0 pounds)
Reactions: Self Injurious Behaviour, Sluggishness
Drug(s) suspected as cause:
Adepril
Indication: Product Used FOR Unknown Indication
Start date: 2012-08-19
End date: 2012-08-19
Atorvastatin
Indication: Product Used FOR Unknown Indication
Start date: 2012-08-19
End date: 2012-08-19
Clonazepam
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-08-19
End date: 2012-08-19
Depakin Chrono
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-08-19
End date: 2012-08-19
Flurazepam Hydrochloride
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-08-19
End date: 2012-08-19
Invega
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-08-19
End date: 2012-08-19
Lorazepam
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-08-19
End date: 2012-08-19
Sertraline Hydrochloride
Indication: Product Used FOR Unknown Indication
Start date: 2012-08-19
End date: 2012-08-19
Possible Clonazepam side effects in female
Reported by a health professional (non-physician/pharmacist) from Sweden on 2012-08-27
Patient: female
Reactions: Vomiting, Pain, Skin Disorder, Social Phobia, Drug Withdrawal Syndrome, Tremor, Suicidal Ideation, Anxiety, Post-Traumatic Stress Disorder, Fatigue, Heart Rate Increased, Zinc Deficiency, Disturbance in Attention, Injury, Depression, Asthenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clonazepam
Indication: Product Used FOR Unknown Indication
Concerta
Indication: Product Used FOR Unknown Indication
Possible Clonazepam side effects in 70 year old female
Reported by a physician from Japan on 2012-08-27
Patient: 70 year old female, weighing 53.5 kg (117.7 pounds)
Reactions: Coronary Artery Disease
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Blinded Therapy
Dosage: double blind (5mg or placebo) (1 in 1 d)
Administration route: Oral
Start date: 2011-10-20
Blinded Therapy
Dosage: double blind (3mg or placebo) (1 in 1 d)
Administration route: Oral
Indication: Parkinson's Disease
Start date: 2011-10-12
End date: 2011-10-19
Brotizolam
Dosage: 0.25 mg, 1x/day
Administration route: Oral
Indication: Insomnia
Start date: 2011-04-14
Cabergoline
Dosage: 0.5 mg, 1x/day
Administration route: Oral
Indication: Parkinson's Disease
Carbidopa
Dosage: unk
Administration route: Oral
Indication: Parkinson's Disease
Start date: 2007-07-10
Clonazepam
Dosage: 1 mg, 1x/day
Administration route: Oral
Indication: Insomnia
Start date: 2007-01-01
Comtan
Dosage: 100 mg, 3x/day
Administration route: Oral
Indication: Parkinson's Disease
Start date: 2009-06-15
Famotidine
Dosage: 20 mg, 1x/day
Administration route: Oral
Indication: Prophylaxis
Start date: 2011-05-06
Flurbiprofen
Dosage: unk
Administration route: Oral
Indication: Parkinson's Disease
Start date: 2008-06-19
Gasmotin
Dosage: 5 mg, 2x/day
Administration route: Oral
Indication: Prophylaxis
Magmitt
Dosage: 1650 mg, 3x/day
Administration route: Oral
Indication: Constipation
Start date: 2007-01-01
Symmetrel
Dosage: 50 mg, 2x/day
Administration route: Oral
Indication: Parkinson's Disease
Start date: 2009-12-21
Tizanidine Hydrochloride
Dosage: 1 mg, 3x/day
Administration route: Oral
Indication: Parkinson's Disease
Start date: 2007-12-20
Other drugs received by patient: Digoxin
Possible Clonazepam side effects in male
Reported by a consumer/non-health professional from Brazil on 2012-08-27
Patient: male, weighing 64.0 kg (140.8 pounds)
Reactions: Neck Pain, Dizziness, Convulsion
Drug(s) suspected as cause:
Clonazepam
Administration route: Oral
Indication: Insomnia Related To Another Mental Condition
Start date: 1989-01-01
Gemfibrozil
Indication: Blood Triglycerides
Xalcom
Indication: Glaucoma
Possible Clonazepam side effects in 10 year old male
Reported by a physician from India on 2012-08-27
Patient: 10 year old male
Reactions: Off Label Use, Palmar-Plantar Erythrodysaesthesia Syndrome
Drug(s) suspected as cause:
Clonazepam
Possible Clonazepam side effects in female
Reported by a physician from Italy on 2012-08-27
Patient: female
Reactions: Syncope, Tonic Clonic Movements
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clonazepam
Administration route: Oral
Indication: Epilepsy
Start date: 2012-01-01
Levothyroxine Sodium
Administration route: Oral
Indication: Hypothyroidism
Start date: 2011-04-01
Sertraline Hydrochloride
Administration route: Oral
Indication: Depression
Start date: 2012-01-01
Possible Clonazepam side effects in 41 year old male
Reported by a physician from France on 2012-08-24
Patient: 41 year old male
Reactions: Agranulocytosis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clonazepam
Administration route: Oral
Indication: Schizophrenia, Paranoid Type
Start date: 2011-11-11
End date: 2012-04-21
Clonazepam
Administration route: Oral
Start date: 2012-04-25
Clozapine
Administration route: Oral
Indication: Schizophrenia, Paranoid Type
Start date: 2011-11-11
End date: 2012-04-21
Havlane
Administration route: Oral
Start date: 2012-04-25
Havlane
Administration route: Oral
Indication: Schizophrenia, Paranoid Type
Start date: 2011-11-11
End date: 2012-04-21
Risperdal Consta
Start date: 2012-04-25
Risperdal Consta
Indication: Schizophrenia, Paranoid Type
Start date: 2011-11-11
End date: 2012-04-21
Possible Clonazepam side effects in 80 year old male
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: 80 year old male, weighing 73.0 kg (160.6 pounds)
Reactions: Blood Pressure Increased, Weight Decreased, Confusional State, Cognitive Disorder, Amnesia, Tremor, Off Label Use, Thinking Abnormal, Malaise, Dizziness, Lethargy
Drug(s) suspected as cause:
Amlodipine
Indication: Hypertension
End date: 2012-05-01
Clonazepam
Dosage: 1/2 tablet qd
Indication: Rapid Eye Movements Sleep Abnormal
Start date: 2011-08-01
End date: 2012-08-20
Namenda
Dosage: 10 mg bid
Administration route: Oral
Indication: Fahr's Disease
Start date: 2011-08-01
Other drugs received by patient: Galantamine Hydrobromide; Atenolol; Plavix; Aspirin
Possible Clonazepam side effects in male
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-08-24
Patient: male
Reactions: Dysarthria, Tachycardia, Snoring, Drug Abuse, Sopor
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Anafranil
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Clonazepam
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Haldol
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Lantanon
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Olanzapine
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Trazodone HCL
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Valproic Acid
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Possible Clonazepam side effects in female
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-24
Patient: female
Reactions: Pregnancy
Drug(s) suspected as cause:
Clonazepam
Indication: Insomnia Related To Another Mental Condition
Diazepam
Indication: Insomnia Related To Another Mental Condition
Isotretinoin
Indication: Acne
Vesanoid
Indication: Acne
Possible Clonazepam side effects in female
Reported by a consumer/non-health professional from Czech Republic on 2012-08-23
Patient: female
Reactions: Panic Attack, Drug Withdrawal Syndrome, Drug Dependence
Drug(s) suspected as cause:
Clonazepam
Possible Clonazepam side effects in 8 month old female
Reported by a physician from Switzerland on 2012-08-23
Patient: 8 month old female, weighing 5.0 kg (11.0 pounds)
Reactions: Neutropenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Augmentin '500'
Start date: 2012-06-08
End date: 2012-06-11
Clonazepam
Administration route: Oral
Start date: 2012-05-01
Enoxaparin Sodium
Start date: 2012-06-01
Floxacillin Sodium
Start date: 2012-06-11
End date: 2012-06-26
Garamycin
Dosage: 1 per 30 hours
Start date: 2012-06-11
End date: 2012-06-15
Motilium
Administration route: Oral
Valproate Sodium
Administration route: Oral
Start date: 2012-01-01
Possible Clonazepam side effects in 43 year old female
Reported by a physician from Italy on 2012-08-23
Patient: 43 year old female
Reactions: Multiple Drug Overdose Intentional, Self Injurious Behaviour
Drug(s) suspected as cause:
Clonazepam
Administration route: Oral
Indication: Self Injurious Behaviour
Start date: 2012-08-14
End date: 2012-08-14
Risperdal
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-08-14
End date: 2012-08-14
Possible Clonazepam side effects in 70 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-22
Patient: 70 year old female
Reactions: Off Label Use, Pyoderma Gangrenosum, Cytolytic Hepatitis, Wrong Drug Administered, Cholestasis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acetaminophen and Codeine Phosphate
Administration route: Oral
Start date: 2012-04-20
End date: 2012-04-26
Acetaminophen and Codeine Phosphate
Administration route: Oral
Indication: Pain
Start date: 2012-04-27
End date: 2012-05-19
Acetaminophen W / Codeine
Administration route: Oral
Indication: Pain
End date: 2012-04-20
Cetirizine HCL
Administration route: Oral
Indication: Pain
Cetirizine HCL
Administration route: Oral
Clonazepam
Administration route: Oral
Indication: Pain
Start date: 2012-04-20
Other drugs received by patient: Humalog; Furosemide; Lyrica; Tramadol HCL; Lantus; Flecainide Acetate; Levothyroxine Sodium; Remicade; Prednisolone
Possible Clonazepam side effects in male
Reported by a physician from Italy on 2012-08-22
Patient: male, weighing 80.0 kg (176.0 pounds)
Reactions: Hypotension, Multiple Drug Overdose, Self Injurious Behaviour, Sopor
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Anafranil
Administration route: Oral
Indication: Self Injurious Behaviour
Start date: 2012-07-13
End date: 2012-07-13
Clonazepam
Administration route: Oral
Indication: Self Injurious Behaviour
Start date: 2012-07-13
End date: 2012-07-13
Haloperidol Lactate
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-07-13
End date: 2012-07-13
Lantanon
Administration route: Oral
Indication: Self Injurious Behaviour
Start date: 2012-07-13
End date: 2012-07-13
Olanzapine
Administration route: Oral
Indication: Self Injurious Behaviour
Start date: 2012-07-13
End date: 2012-07-13
Trazodone HCL
Administration route: Oral
Indication: Self Injurious Behaviour
Start date: 2012-07-13
End date: 2012-07-13
Valproate Sodium
Administration route: Oral
Indication: Self Injurious Behaviour
Start date: 2012-07-13
End date: 2012-07-13
Possible Clonazepam side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: male
Reactions: Irritability, Anger, Abnormal Behaviour, Homicidal Ideation, Withdrawal Syndrome, Frustration, Suicidal Ideation
Drug(s) suspected as cause:
Clonazepam
Possible Clonazepam side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: male
Reactions: Anxiety, Mental Impairment, Thinking Abnormal, Paranoia, Hallucination, Auditory, Extrasystoles, Formication, Memory Impairment
Drug(s) suspected as cause:
Clonazepam
Indication: Anxiety
Clonazepam
Indication: Depression
Escitalopram
Indication: Anxiety
Escitalopram
Indication: Depression
Seroquel XR
Administration route: Oral
Indication: Anxiety
Seroquel XR
Administration route: Oral
Indication: Depression
Trazodone Hydrochloride
Indication: Depression
Trazodone Hydrochloride
Indication: Anxiety
Possible Clonazepam side effects in 36 year old female
Reported by a physician from Spain on 2012-08-21
Patient: 36 year old female
Reactions: Abdominal Pain, Hypertensive Encephalopathy, Left Ventricular Hypertrophy
Drug(s) suspected as cause:
Abacavir
Indication: HIV Infection
Start date: 2010-08-01
Clonazepam
Indication: Product Used FOR Unknown Indication
Start date: 2010-08-01
Intelence
Indication: HIV Infection
Start date: 2010-08-01
Pentamidine
Indication: Product Used FOR Unknown Indication
Start date: 2010-08-01
Prezista
Indication: HIV Infection
Start date: 2010-08-01
Raltegravir
Indication: HIV Infection
Start date: 2010-08-01
Ritonavir
Indication: HIV Infection
Start date: 2010-08-01
Possible Clonazepam side effects in 43 year old female
Reported by a physician from United States on 2012-08-20
Patient: 43 year old female
Reactions: Ecchymosis
Drug(s) suspected as cause:
Clonazepam
Dosage: 25 mg, 2x/day
Zoloft
Dosage: 100 mg, per day
Possible Clonazepam side effects in 70 year old female
Reported by a physician from France on 2012-08-20
Patient: 70 year old female
Reactions: Cytolytic Hepatitis, Cholestasis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acetaminophen and Codeine Phosphate
Administration route: Oral
Indication: Pain
Start date: 2012-04-20
End date: 2012-05-19
Acetaminophen W / Codeine
Administration route: Oral
Indication: Pain
End date: 2012-04-20
Cetirizine HCL
Administration route: Oral
Indication: Pain
Clonazepam
Administration route: Oral
Indication: Pain
Start date: 2012-04-20
Other drugs received by patient: Humalog; Furosemide; Prednisolone; Flecainide Acetate; Levothyroxine Sodium; Lantus
Possible Clonazepam side effects in 8 month old female
Reported by a physician from Switzerland on 2012-08-20
Patient: 8 month old female, weighing 5.0 kg (11.0 pounds)
Reactions: Neutropenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Amoxicillin and Clavulanate Potassium
Indication: Staphylococcal Infection
Start date: 2012-06-08
End date: 2012-06-11
Clonazepam
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Enoxaparin Sodium
Indication: Product Used FOR Unknown Indication
Start date: 2012-06-01
Floxacillin Sodium
Indication: Staphylococcal Infection
Start date: 2012-06-11
End date: 2012-06-26
Gentamicin Sulfate
Indication: Staphylococcal Infection
Start date: 2012-06-11
End date: 2012-06-15
Motilium
Indication: Product Used FOR Unknown Indication
Valproate Sodium
Administration route: Oral
Indication: Epilepsy
Start date: 2012-01-01
Possible Clonazepam side effects in 52 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-20
Patient: 52 year old female
Reactions: Nausea, Dizziness, Feeling Abnormal
Drug(s) suspected as cause:
Clonazepam
Dosage: 1mg tid
Indication: Panic Disorder
Start date: 1996-01-01
Clonazepam
Dosage: 1mg tid
Indication: Major Depression
Start date: 1996-01-01
Possible Clonazepam side effects in 43 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-17
Patient: 43 year old female, weighing 78.0 kg (171.6 pounds)
Reactions: Vomiting, Pain in Extremity, Pain, Headache, Anxiety, Malaise, Diarrhoea, Withdrawal Syndrome, Feeling Abnormal, Cold Sweat, Nervousness
Drug(s) suspected as cause:
Clonazepam
Dosage: 1 mg, 3x/day (1/2-1 prn)
Administration route: Oral
Indication: Anxiety
Start date: 2011-11-11
Klonopin
Dosage: 1mg, 1/2 to 1 tablet, 3 times a day
Administration route: Oral
Indication: Stress
Klonopin
Indication: Anxiety
Lortab
Indication: Arthritis
Lortab
Indication: Pain
Lortab
Indication: Spondylitis
Lortab
Dosage: 10-500 mg, take 1-2 tablets every 6-8 hours as needed
Administration route: Oral
Indication: Fibromyalgia
Start date: 2012-06-08
Lyrica
Dosage: 150 mg, 3x/day
Administration route: Oral
Indication: Fibromyalgia
Start date: 2011-03-04
End date: 2012-05-01
Other drugs received by patient: Ranitidine; Tizanidine; Tizanidine; Citalopram; Zantac; Loratadine; Hydrochlorothiazide; Tizanidine; Citalopram; Tizanidine; Ranitidine; Claritin
Possible Clonazepam side effects in 5 year old male
Reported by a physician from Japan on 2012-08-16
Patient: 5 year old male
Reactions: Drug Ineffective, Atonic Seizures
Drug(s) suspected as cause:
Clobazam
Indication: Infantile Spasms
Clonazepam
Indication: Infantile Spasms
Gabapentin
Indication: Infantile Spasms
Lamotrigine
Indication: Infantile Spasms
Phenytoin
Indication: Infantile Spasms
Topiramate
Indication: Infantile Spasms
Valproic Acid
Indication: Infantile Spasms
Other drugs received by patient: Acetazolamide; Nitrazepam; Corticotropin; Vitamin B6; Zonisamide
Possible Clonazepam side effects in 3 year old female
Reported by a physician from Japan on 2012-08-16
Patient: 3 year old female
Reactions: Drug Ineffective, Atonic Seizures
Drug(s) suspected as cause:
Clonazepam
Dosage: daily
Indication: Infantile Spasms
Lamotrigine
Indication: Infantile Spasms
Topiramate
Dosage: daily
Indication: Infantile Spasms
Valproic Acid
Dosage: daily
Indication: Infantile Spasms
Other drugs received by patient: Corticotropin; Vitamin B6; Zonisamide
Possible Clonazepam side effects in male
Reported by a physician from Italy on 2012-08-16
Patient: male
Reactions: Drug Abuse, Sopor
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Anafranil
Administration route: Oral
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Clonazepam
Administration route: Oral
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Haldol
Administration route: Oral
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Lantanon
Administration route: Oral
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Olanzapine
Administration route: Oral
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Trazodone HCL
Administration route: Oral
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Valproate Sodium
Administration route: Oral
Indication: Drug Abuse
Start date: 2012-07-13
End date: 2012-07-13
Possible Clonazepam side effects in 17 year old female
Reported by a physician from Japan on 2012-08-16
Patient: 17 year old female
Reactions: Drug Ineffective, Atonic Seizures
Drug(s) suspected as cause:
Carbamazepine
Indication: Infantile Spasms
Clobazam
Indication: Infantile Spasms
Clonazepam
Indication: Infantile Spasms
Gabapentin
Indication: Infantile Spasms
Lamotrigine
Indication: Infantile Spasms
Levetiracetam
Indication: Infantile Spasms
Phenobarbital TAB
Indication: Infantile Spasms
Phenytoin
Indication: Infantile Spasms
Valproic Acid
Indication: Infantile Spasms
Other drugs received by patient: Vitamin B6; Corticotropin; Zonisamide; Nitrazepam; Potassium Bromide; Benzodiazepine Derivatives
Possible Clonazepam side effects in 46 year old female
Reported by a consumer/non-health professional from Swaziland on 2012-08-16
Patient: 46 year old female, weighing 68.9 kg (151.7 pounds)
Reactions: Treatment Noncompliance, Fall, High Density Lipoprotein Decreased, Intestinal Haemorrhage, Anxiety, Hysterectomy, Dizziness, Depression, LOW Density Lipoprotein Increased, Feeling Abnormal, Panic Reaction, Epistaxis
Drug(s) suspected as cause:
Clonazepam
Dosage: daily dose 3mg
Effexor XR
Dosage: unk
Indication: Depression
Naproxen Sodium
Indication: Arthritis
Other drugs received by patient: Chlorthalidone; Flexeril; Gemfibrozil; Norco; Neurontin; Diltiazem
Possible Clonazepam side effects in 8 year old female
Reported by a physician from Japan on 2012-08-16
Patient: 8 year old female
Reactions: Drug Ineffective, Atonic Seizures
Drug(s) suspected as cause:
Carbamazepine
Indication: Infantile Spasms
Clonazepam
Indication: Infantile Spasms
Diazepam
Indication: Infantile Spasms
Lamotrigine
Indication: Infantile Spasms
Phenobarbital TAB
Indication: Infantile Spasms
Phenytoin
Indication: Infantile Spasms
Topiramate
Indication: Infantile Spasms
Valproic Acid
Indication: Infantile Spasms
Other drugs received by patient: Benzodiazepine Derivatives; Corticotropin; Potassium Bromide
Possible Clonazepam side effects in 1 year old female
Reported by a physician from Japan on 2012-08-16
Patient: 1 year old female
Reactions: Drug Ineffective, Atonic Seizures
Drug(s) suspected as cause:
Clonazepam
Indication: Infantile Spasms
Phenobarbital TAB
Indication: Infantile Spasms
Topiramate
Indication: Infantile Spasms
Valproic Acid
Indication: Infantile Spasms
Other drugs received by patient: Zonisamide; Corticotropin
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