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Clolar (Clofarabine) - Renal Failure - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Renal Failure (8)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Clolar (Clofarabine) where reactions include renal failure. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Clolar side effects in female

Reported by a physician from United States on 2012-08-21

Patient: female, weighing 25.0 kg (55.0 pounds)

Reactions: Ischaemia, Pulmonary Alveolar Haemorrhage, Pericardial Effusion, Renal Failure, Cardiac Failure, Respiratory Failure, Sepsis, Pleural Effusion, Hypertension, Fusarium Infection

Adverse event resulted in: death, life threatening event, disablity

Drug(s) suspected as cause:
Clolar
    Dosage: 70 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-01-10
    End date: 2012-01-11

Fludara
    Dosage: 140 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-11
    End date: 2012-06-15

Mozobil
    Dosage: 6 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-16
    End date: 2012-06-18

Thymoglobulin
    Dosage: 254 mg, qd
    Start date: 2012-06-16
    End date: 2012-06-19

Thymoglobulin
    Dosage: 229.9 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-01-15
    End date: 2012-01-18

Other drugs received by patient: Meropenem; Fentanyl Citrate; Cytarabine; Thiotepa; Melphalan Hydrochloride; Dilaudid; Busulfan



Possible Clolar side effects in female

Reported by a physician from United States on 2012-08-21

Patient: female, weighing 25.0 kg (55.0 pounds)

Reactions: Ischaemia, Pulmonary Alveolar Haemorrhage, Pericardial Effusion, Renal Failure, Respiratory Failure, Cardiac Failure, Sepsis, Pleural Effusion, Fusarium Infection, Hypertension

Adverse event resulted in: death, life threatening event, disablity

Drug(s) suspected as cause:
Clolar
    Dosage: 70 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-01-10
    End date: 2012-01-11

Fludara
    Dosage: 140 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-11
    End date: 2012-06-15

Mozobil
    Dosage: 6 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-16
    End date: 2012-06-18

Thymoglobulin
    Dosage: 229.9 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-01-15
    End date: 2012-01-18

Thymoglobulin
    Dosage: 254 mg, qd
    Start date: 2012-06-16
    End date: 2012-06-19

Other drugs received by patient: Busulfan; Thiotepa; Dilaudid; Meropenem; Cytarabine; Melphalan Hydrochloride; Fentanyl Citrate



Possible Clolar side effects in female

Reported by a physician from United States on 2012-08-16

Patient: female, weighing 25.2 kg (55.4 pounds)

Reactions: Ischaemia, Pulmonary Alveolar Haemorrhage, Pericardial Effusion, Renal Failure, Cardiac Failure, Respiratory Failure, Sepsis, Pleural Effusion, Fusarium Infection, Hypertension

Adverse event resulted in: death, life threatening event, disablity

Drug(s) suspected as cause:
Clolar
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-01-10
    End date: 2012-01-11

Fludara
    Dosage: 140 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-11
    End date: 2012-06-15

Mozobil
    Dosage: 6 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-16
    End date: 2012-06-18

Thymoglobulin
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-01-15
    End date: 2012-01-18

Thymoglobulin
    Dosage: unk
    Start date: 2012-06-16
    End date: 2012-06-19

Other drugs received by patient: Melphalan Hydrochloride; Busulfan; Fentanyl; Thiotepa; Cytarabine; Dilaudid; Meropenem



Possible Clolar side effects in female

Reported by a physician from United States on 2012-08-13

Patient: female, weighing 25.2 kg (55.4 pounds)

Reactions: Ischaemia, Pulmonary Alveolar Haemorrhage, Pericardial Effusion, Renal Failure, Respiratory Failure, Cardiac Failure, Sepsis, Pleural Effusion, Fusarium Infection, Hypertension

Adverse event resulted in: death, life threatening event, disablity

Drug(s) suspected as cause:
Clolar
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-01-10
    End date: 2012-01-11

Fludara
    Dosage: 140 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-11
    End date: 2012-06-15

Mozobil
    Dosage: 6 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-16
    End date: 2012-06-18

Thymoglobulin
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-01-15
    End date: 2012-01-18

Thymoglobulin
    Dosage: unk
    Start date: 2012-06-16
    End date: 2012-06-19

Other drugs received by patient: Meropenem; Melphalan Hydrochloride; Cytarabine; Busulfan; Dilaudid; Fentanyl; Thiotepa



Possible Clolar side effects in female

Reported by a physician from United States on 2012-04-24

Patient: female, weighing 41.7 kg (91.7 pounds)

Reactions: Contusion, Skin Exfoliation, Pyrexia, Haematemesis, Oral Candidiasis, Skin Discolouration, Epistaxis, Blood Pressure Increased, Swelling Face, Stomatitis, Vomiting, Pain in Extremity, Nausea, Acute Lymphocytic Leukaemia, Renal Failure, Diarrhoea

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Clolar

Other drugs received by patient: Promethazine; Vinorelbine; Zosyn; Linezolid; Amphojel; Meropenem; Nystatin; Norvasc; Octreotide Acetate; Dexamethasone; Vinorelbine; Caphosol; Vinorelbine; Pepcid; Zoloft; Bactrim; Caspofungin Acetate; Thiotepa; RED Blood Cells, Concentrated; Platelets; Allopurinol; Acyclovir; Solutions FOR Parenteral Nutrition; Oxycodone HCL; Neupogen; Ondansetron; Lorazepam; Zithromax; Vfend; Vancomycin; Octreotide Acetate; Topotecan; Cefepime; Imodium; Dexamethasone; D5 1 / 2 NS + KCL 20 MEQ / L; Imodium



Possible Clolar side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-17

Patient: male, weighing 116.6 kg (256.5 pounds)

Reactions: Renal Failure, Pneumonia, Neutropenic Colitis, Neutropenic Sepsis, Hypotension, Pleural Effusion, Mental Status Changes, Staphylococcal Bacteraemia, Pulseless Electrical Activity

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Busulfan
    Dosage: 249 mg, once
    Indication: Acute Myeloid Leukaemia
    Start date: 2012-03-30
    End date: 2012-03-31

Busulfan
    Dosage: 390 mg, once
    Indication: Bone Marrow Conditioning Regimen
    Start date: 2012-04-01
    End date: 2012-04-02

Clolar
    Dosage: 94 mg, once
    Indication: Acute Myeloid Leukaemia
    Start date: 2012-03-29
    End date: 2012-04-02

Clolar
    Indication: Bone Marrow Conditioning Regimen



Possible Clolar side effects in female

Reported by a physician from United States on 2012-04-11

Patient: female, weighing 41.7 kg (91.7 pounds)

Reactions: Contusion, Skin Exfoliation, Pyrexia, Haematemesis, Oral Candidiasis, Skin Discolouration, Epistaxis, Blood Pressure Increased, Swelling Face, Vomiting, Nausea, Pain in Extremity, Acute Lymphocytic Leukaemia, Mucosal Inflammation, Renal Failure, Diarrhoea

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Clolar

Other drugs received by patient: D5 1 / 2 NS + KCL 20 MEQ / L; Vfend; Pepcid; Zoloft; Solutions FOR Parenteral Nutrition; Imodium; Thiotepa; Ondansetron; Lorazepam; Vinorelbine; Vinorelbine; Zosyn; Zithromax; Norvasc; Bactrim; Octreotide Acetate; Oxycodone HCL; Acyclovir; Caphosol; Neupogen; Promethazine; Nystatin; Platelets; Cefepime; Imodium; RED Blood Cells, Concentrated; Allopurinol; Vinorelbine; Amphojel; Meropenem; Vancomycin; Dexamethasone; Dexamethasone; Topotecan; Linezolid; Caspofungin Acetate; Octreotide Acetate



Possible Clolar side effects in female

Reported by a physician from United States on 2011-12-02

Patient: female, weighing 53.0 kg (116.6 pounds)

Reactions: Thrombosis, Hepatic Function Abnormal, Citrobacter Infection, Hyperbilirubinaemia, Atrial Flutter, Pulmonary Alveolar Haemorrhage, Cerebral Ischaemia, Mucosal Inflammation, Renal Failure, Neoplasm Malignant, Acute Respiratory Distress Syndrome, Acute Respiratory Failure, Hypertension

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Clolar
    Dosage: 20 mg/m2, qdx5
    Indication: Acute Myeloid Leukaemia
    Start date: 2010-11-15
    End date: 2010-11-19

Melphalan Hydrochloride
    Dosage: 110 mg, unk
    Indication: Acute Myeloid Leukaemia
    Start date: 2010-11-21
    End date: 2010-11-22

Thiotepa
    Dosage: 600 mg, unk
    Indication: Acute Myeloid Leukaemia
    Start date: 2010-11-20
    End date: 2010-11-20

Other drugs received by patient: Tacrolimus; Filgrastim; Mycophenolate Mofetil; Methotrexate; Methotrexate; Mycophenolate Mofetil

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