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Chlorthalidone (Chlorthalidone) - Side Effect Reports to FDA

 
 



This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Chlorthalidone and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.

Reports by Event Outcome

All Cases (32)
Life Threatening Events (2)
Disability (1)

Reports by Reaction Type

Hypokalaemia (7)Rhabdomyolysis (4)Blood Creatinine Increased (4)Blood Pressure Increased (4)Hyponatraemia (4)Dizziness (3)Nausea (3)Muscular Weakness (3)Confusional State (2)Drug Interaction (2)Fatigue (2)Blood Sodium Decreased (2)

Below are a few examples of reports where side effects / adverse reactions may be related to Chlorthalidone. For a complete list or a specific selection of reports, please use the links above.

Possible Chlorthalidone side effects in 64 year old male

Reported by a pharmacist from United States on 2012-08-09

Patient: 64 year old male, weighing 75.2 kg (165.4 pounds)

Reactions: Hyponatraemia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Chlorthalidone



Possible Chlorthalidone side effects in 64 year old male

Reported by a pharmacist from United States on 2012-08-09

Patient: 64 year old male, weighing 72.3 kg (159.1 pounds)

Reactions: Hyponatraemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Chlorthalidone



Possible Chlorthalidone side effects in female

Reported by a consumer/non-health professional from United States on 2012-07-19

Patient: female

Reactions: Hypotension

Drug(s) suspected as cause:
Chlorthalidone



Possible Chlorthalidone side effects in male

Reported by a consumer/non-health professional from United States on 2012-06-28

Patient: male

Reactions: Type 2 Diabetes Mellitus, Blood Creatinine Increased

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Simvastatin
    Dosage: 10mg once a day po
    Administration route: Oral
    Indication: Hypertension

Chlorthalidone
    Dosage: 12.5mg once a day po
    Administration route: Oral
    Indication: Hypertension

Other drugs received by patient: Metformin HCL; Glypocide



Possible Chlorthalidone side effects in 78 year old male

Reported by a pharmacist from United States on 2012-05-25

Patient: 78 year old male, weighing 70.0 kg (154.0 pounds)

Reactions: Blood Pressure Increased, Blood Urea Increased, Hyponatraemia, Hypokalaemia, Blood Glucose Decreased, Carbon Dioxide Decreased, Blood Creatinine Increased, Asthenia, Decreased Appetite

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Chlorthalidone



Possible Chlorthalidone side effects in 51 year old male

Reported by a health professional (non-physician/pharmacist) on 2012-05-24

Patient: 51 year old male

Reactions: in-Stent Arterial Restenosis, Condition Aggravated, Renal Artery Occlusion, Renal Artery Stenosis, Pulmonary Congestion, Blood Pressure Inadequately Controlled, Oedema Peripheral, Blood Sodium Decreased, Renal Failure Acute, Blood Glucose Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Amlodipine
    Dosage: 10 mg (10 mg, 1 in 1 d)
    Indication: Product Used FOR Unknown Indication

Ramipril
    Dosage: 5 mg (5 mg, 1 in 1 d)
    Indication: Product Used FOR Unknown Indication

Bisoprolol Fumarate
    Dosage: 5 mg (5 mg, 1 in 1 d)
    Indication: Product Used FOR Unknown Indication

Chlorthalidone
    Dosage: 50 mg (50 mg, 1 in 1 d)
    Indication: Product Used FOR Unknown Indication



Possible Chlorthalidone side effects in 86 year old female

Reported by a consumer/non-health professional from United States on 2012-05-23

Patient: 86 year old female, weighing 59.9 kg (131.7 pounds)

Reactions: Vomiting, Blood Potassium Decreased, Dehydration, Asthenia, Blood Sodium Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Chlorthalidone



Possible Chlorthalidone side effects in 48 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-03-28

Patient: 48 year old male

Reactions: Rhabdomyolysis, Withdrawal Syndrome, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Spironolactone
    Dosage: increased to 100mg daily in 2009
    Indication: Hypertension
    Start date: 2006-01-01

Chlorthalidone
    Dosage: titrated to 50mg
    Indication: Hypertension
    Start date: 2009-01-01

Other drugs received by patient: Lisinopril; Lercanidipine



Possible Chlorthalidone side effects in 48 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-03-28

Patient: 48 year old male

Reactions: Rhabdomyolysis, Withdrawal Syndrome, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Chlorthalidone
    Dosage: titrated to 50mg
    Indication: Hypertension
    Start date: 2009-01-01

Spironolactone
    Dosage: increased to 100mg daily in 2009
    Indication: Hypertension
    Start date: 2006-01-01

Other drugs received by patient: Lercanidipine; Lisinopril



Possible Chlorthalidone side effects in 48 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-03-28

Patient: 48 year old male

Reactions: Rhabdomyolysis, Pain, Condition Aggravated, Muscular Weakness, Adrenal Adenoma, Gynaecomastia, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Chlorthalidone
    Dosage: 25 mg, unk

Chlorthalidone
    Dosage: titrated upto 50 mg, unk
    Indication: Sodium Retention

Other drugs received by patient: Spironolactone; Lisinopril; Lercanidipine



Possible Chlorthalidone side effects in 60 year old male

Reported by a consumer/non-health professional from United States on 2012-03-26

Patient: 60 year old male, weighing 72.6 kg (159.7 pounds)

Reactions: Heart Rate Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Varenicline
    Administration route: Oral
    Indication: Smoking Cessation Therapy
    Start date: 2012-02-06
    End date: 2012-02-09

Chlorthalidone
    Administration route: Oral

Other drugs received by patient: Carvedilol; Lisinopril; Atorvastatin; Amlodipine Besylate



Possible Chlorthalidone side effects in 75 year old male

Reported by a consumer/non-health professional from United States on 2012-03-22

Patient: 75 year old male

Reactions: Abdominal Discomfort, Constipation

Drug(s) suspected as cause:
Chlorthalidone

Other drugs received by patient: Lisinopril; Ramipril; Metformin HCL; Carvedilol; Amlodipine



Possible Chlorthalidone side effects in 68 year old male

Reported by a consumer/non-health professional from United States on 2012-03-22

Patient: 68 year old male

Reactions: Anxiety, Heart Rate Increased

Drug(s) suspected as cause:
Chlorthalidone

Other drugs received by patient: Lisinopril; Xanax



Possible Chlorthalidone side effects in female

Reported by a physician from United States on 2012-03-22

Patient: female

Reactions: Skin Exfoliation

Drug(s) suspected as cause:
Chlorthalidone
    Administration route: Oral
    Indication: Diuretic Therapy
    End date: 2011-05-19

Azilsartan Medoxomil
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-01-01



Possible Chlorthalidone side effects in 63 year old female

Reported by a consumer/non-health professional from United States on 2012-03-22

Patient: 63 year old female, weighing 63.5 kg (139.7 pounds)

Reactions: Abdominal Discomfort, Diarrhoea, Functional Gastrointestinal Disorder, Diabetes Mellitus, Drug Interaction

Drug(s) suspected as cause:
Chlorthalidone

Other drugs received by patient possibly interacting with the suspect drug:
Estring
    Indication: Vaginal Abscess
    End date: 2011-11-05

Other drugs received by patient: Vitamin D; Multi-Vitamin; Calcium Carbonate; Magnesium



Possible Chlorthalidone side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-22

Patient: female

Reactions: Blood Pressure Systolic Decreased, Fatigue, Hypotension

Drug(s) suspected as cause:
Azilsartan Medoxomil
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-04-01

Chlorthalidone
    Administration route: Oral
    Indication: Hypertension
    End date: 2011-01-01

Chlorthalidone
    Administration route: Oral
    Start date: 2011-01-01



Possible Chlorthalidone side effects in female

Reported by a consumer/non-health professional from Brazil on 2012-03-14

Patient: female, weighing 51.0 kg (112.2 pounds)

Reactions: Labyrinthitis, Fatigue, Wrong Technique in Drug Usage Process, Dizziness, Abdominal Distension, Blood Pressure Fluctuation, Blood Pressure Decreased

Drug(s) suspected as cause:
Chlorthalidone
    Dosage: 1 df
    Administration route: Oral

Hygroton
    Dosage: 1 df (12.5 mg)
    Administration route: Oral
    Indication: Hypertension
    End date: 2012-03-04

Hygroton
    Dosage: 0.5 df (25 mg)
    Administration route: Oral

Hygroton
    Dosage: 1 df (25 mg)
    Administration route: Oral



Possible Chlorthalidone side effects in male

Reported by a physician from United States on 2012-03-07

Patient: male, weighing 95.3 kg (209.6 pounds)

Reactions: Mineral Metabolism Disorder, Prostatic Specific Antigen Increased, Blood Urea Increased, Blood Potassium Decreased, Hyperphagia, Diarrhoea, Urinary Retention, Blood Creatinine Increased, Blood Glucose Increased

Drug(s) suspected as cause:
Chlorthalidone
    Dosage: 25 - 50 mg
    Administration route: Oral
    Indication: Hypertension
    Start date: 2007-01-01
    End date: 2011-12-21

Prednisone TAB
    Administration route: Oral
    Indication: Prostate Cancer
    Start date: 2011-10-15

Chlorthalidone
    Dosage: 25 - 50 mg
    Administration route: Oral
    Indication: Diuretic Therapy
    Start date: 2007-01-01
    End date: 2011-12-21

Zytiga
    Administration route: Oral
    Indication: Prostate Cancer
    Start date: 2011-10-15
    End date: 2011-12-21

Prednisone TAB
    Dosage: dose tapered; lowered every 4 days reducing dose
    Administration route: Oral
    Start date: 2011-12-21
    End date: 2011-12-24

Other drugs received by patient: Metformin HCL; Vasotec; Metformin HCL; Potassium Citrate; Potassium Citrate; Hydrochlorothiazide; Norvasc; Potassium Citrate; Potassium Citrate



Possible Chlorthalidone side effects in male

Reported by a consumer/non-health professional from United States on 2012-02-27

Patient: male, weighing 72.6 kg (159.6 pounds)

Reactions: Heart Rate Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Chantix
    Dosage: 0.5 mg, daily
    Administration route: Oral
    Indication: Smoking Cessation Therapy
    Start date: 2012-02-06
    End date: 2012-02-01

Chlorthalidone
    Dosage: 12.5 mg, daily
    Administration route: Oral

Chantix
    Dosage: 0.5 mg, 2x/day
    Administration route: Oral
    Start date: 2012-02-01
    End date: 2012-02-09

Other drugs received by patient: Amlodipine Besilate; Atorvastatin; Lisinopril; Carvedilol



Possible Chlorthalidone side effects in 82 year old female

Reported by a individual with unspecified qualification from Spain on 2012-02-27

Patient: 82 year old female

Reactions: Vomiting, Nausea, Drug Interaction, Hyponatraemia, Disorientation, Fall, Hypokalaemia, Bradyphrenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Chlorthalidone
    Dosage: 50 mg (50 mg, 1 in 1 d), oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-08-01
    End date: 2011-09-02

Olmetec Plus (Hydrochlorothiazide, Olmesartan Medoxomil) Tablet
    Dosage: 20/12.5 mg (1 in 1 d), oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-05-06
    End date: 2011-09-02

Cymbalta
    Dosage: 30 mg 930 mg, 1in 1 d, oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-08-29
    End date: 2011-09-02

Other drugs received by patient: Ibuprofen (Ibuprofen) (Tablet); Captopril; Dusplatin (Mebeverine) (Tablet)



Possible Chlorthalidone side effects in 49 year old male

Reported by a physician from United States on 2012-02-24

Patient: 49 year old male

Reactions: Erectile Dysfunction

Drug(s) suspected as cause:
Hydrochlorothiazide
    Dosage: 25mg daily
    Indication: Hypertension

Chlorthalidone
    Indication: Hypertension

Losartan Potassium
    Dosage: 25mg daily
    Indication: Hypertension

Atenolol
    Dosage: 50mg daily
    Indication: Hypertension

Nebivolol
    Indication: Hypertension

Aliskiren
    Indication: Hypertension



Possible Chlorthalidone side effects in 47 year old female

Reported by a individual with unspecified qualification from Brazil on 2012-02-22

Patient: 47 year old female

Reactions: Blood Pressure Increased, Thyroid Neoplasm

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Chlorthalidone
    Dosage: 25 mg,per oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-11-01

Spironolactone
    Dosage: 50 mg,per oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-11-01

Amlodipine Besylate and Olmesartan Medoxomil
    Dosage: 40/5 mg (1 in 1 d),per oral ; 40/10 mg (1 in 1 d),per oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-11-01
    End date: 2011-11-01

Amlodipine Besylate and Olmesartan Medoxomil
    Dosage: 40/5 mg (1 in 1 d),per oral ; 40/10 mg (1 in 1 d),per oral
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-11-01

Other drugs received by patient: Ciprofibrate (Ciprofibrate) (Ciprofibrate)



Possible Chlorthalidone side effects in 47 year old female

Reported by a consumer/non-health professional from Brazil on 2012-02-20

Patient: 47 year old female

Reactions: Blood Pressure Increased, Thyroid Neoplasm

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Amlodipine Besylate and Olmesartan Medoxomil
    Dosage: 40/5 mg 1 in 1 day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-11-01

Amlodipine Besylate and Olmesartan Medoxomil
    Dosage: 40/10 mg, 1 in 1 day
    Administration route: Oral
    Start date: 2011-11-01

Spironolactone
    Dosage: 50 mg, unk
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-11-01

Chlorthalidone
    Dosage: 25 mg, unk
    Administration route: Oral
    Indication: Hypertension
    Start date: 2011-11-01

Other drugs received by patient: Ciprofibrate



Possible Chlorthalidone side effects in 45 year old male

Reported by a physician from United States on 2012-02-01

Patient: 45 year old male

Reactions: Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Administration route: Oral
    Indication: Schizophrenia, Paranoid Type

Chlorthalidone

Other drugs received by patient: Carvedilol; Lisinopril; Thiazide Derivatives; Olanzapine; Metformin HCL; Simvastatin



Possible Chlorthalidone side effects in 75 year old male

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-01-23

Patient: 75 year old male

Reactions: Presyncope

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Chlorthalidone
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Altace
    Dosage: 1.25 mg, 1x/day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2009-01-01
    End date: 2010-05-08



Possible Chlorthalidone side effects in 59 year old male

Reported by a pharmacist from United States on 2012-01-17

Patient: 59 year old male, weighing 63.6 kg (139.9 pounds)

Reactions: Rhabdomyolysis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Chlorthalidone



Possible Chlorthalidone side effects in 87 year old female

Reported by a health professional (non-physician/pharmacist) from Australia on 2011-12-19

Patient: 87 year old female

Reactions: Syncope, Nausea, Orthostatic Hypotension, Dizziness

Drug(s) suspected as cause:
Lercanidipine
    Dosage: 20 mg, qd
    Administration route: Oral
    Indication: Essential Hypertension

Amiodarone Hydrochloride
    Dosage: 100 mg, unk
    Administration route: Oral
    Indication: Arrhythmia
    Start date: 2011-03-30

Perindopril Erbumine
    Dosage: 8 mg, unk
    Administration route: Oral
    Indication: Essential Hypertension
    Start date: 2011-03-30

Atacand
    Dosage: 1 df, unk
    Administration route: Oral
    Indication: Essential Hypertension
    End date: 2011-03-30

Chlorthalidone
    Dosage: 25 mg, unk
    Administration route: Oral
    Indication: Essential Hypertension
    Start date: 2011-03-30

Levothyroxine Sodium
    Dosage: 100 ug, unk
    Administration route: Oral
    Indication: Myxoedema

Atenolol
    Dosage: 50 mg, unk
    Administration route: Oral
    Indication: Essential Hypertension
    End date: 2011-03-16

Methyldopa
    Dosage: 4 df, unk
    Administration route: Oral
    Indication: Essential Hypertension
    Start date: 2011-03-16

Other drugs received by patient: Simvastatin; Acetylsalicylic Acid SRT; Amoxicillin



Possible Chlorthalidone side effects in 87 year old female

Reported by a physician from Japan on 2011-11-30

Patient: 87 year old female

Reactions: Syncope, Nausea, Dizziness, Orthostatic Hypotension

Drug(s) suspected as cause:
Perindopril Erbumine
    Administration route: Oral
    Indication: Essential Hypertension
    Start date: 2011-03-30

Atenolol
    Administration route: Oral
    Indication: Essential Hypertension
    Start date: 2011-03-16

Amiodarone HCL
    Administration route: Oral
    Indication: Arrhythmia
    Start date: 2011-03-30

Levothyroxine Sodium
    Administration route: Oral
    Indication: Myxoedema

Lercanidipine
    Administration route: Oral
    Indication: Essential Hypertension

Chlorthalidone
    Administration route: Oral
    Indication: Essential Hypertension
    Start date: 2011-03-30

Atacand
    Administration route: Oral
    Indication: Essential Hypertension
    Start date: 2011-03-30

Methyldopa
    Administration route: Oral
    Indication: Essential Hypertension
    Start date: 2011-03-16

Other drugs received by patient: Amoxicillin; Acetylsalicylic Acid SRT; Simvastatin



Possible Chlorthalidone side effects in 49 year old female

Reported by a consumer/non-health professional from United States on 2011-11-29

Patient: 49 year old female

Reactions: Abdominal Pain

Drug(s) suspected as cause:
Chlorthalidone
    Indication: Blood Pressure Increased
    Start date: 2010-11-03

Amlodipine Besylate
    Indication: Hypertension
    Start date: 2010-11-03

Other drugs received by patient: Iron; Paroxetine HCL



Possible Chlorthalidone side effects in 88 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-18

Patient: 88 year old female

Reactions: Blood Pressure Increased, Haemoglobin Decreased, Presyncope, Blood Potassium Increased, Nodal Rhythm, Bradycardia, Blood Creatinine Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Metoprolol Tartrate
    Dosage: 50 mg, bid

Hydralazine HCL
    Dosage: 50 mg, bid

Lisinopril
    Dosage: 40 mg, unk

Diltiazem HCL
    Dosage: 180 mg, unk

Chlorthalidone
    Dosage: 25 mg, unk

Clonidine
    Dosage: 0.3 mg, weekly patch

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