This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Chlorthalidone and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (32)
Life Threatening Events (2)
Disability (1)
Reports by Reaction Type
Hypokalaemia (7),
Rhabdomyolysis (4),
Blood Creatinine Increased (4),
Blood Pressure Increased (4),
Hyponatraemia (4),
Dizziness (3),
Nausea (3),
Muscular Weakness (3),
Confusional State (2),
Drug Interaction (2),
Fatigue (2),
Blood Sodium Decreased (2)
Below are a few examples of reports where side effects / adverse reactions may be related to Chlorthalidone. For a complete list or a specific selection of reports, please use the links above.
Possible Chlorthalidone side effects in 64 year old male
Reported by a pharmacist from United States on 2012-08-09
Patient: 64 year old male, weighing 75.2 kg (165.4 pounds)
Reactions: Hyponatraemia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Chlorthalidone
Possible Chlorthalidone side effects in 64 year old male
Reported by a pharmacist from United States on 2012-08-09
Patient: 64 year old male, weighing 72.3 kg (159.1 pounds)
Reactions: Hyponatraemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Chlorthalidone
Possible Chlorthalidone side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-19
Patient: female
Reactions: Hypotension
Drug(s) suspected as cause:
Chlorthalidone
Possible Chlorthalidone side effects in male
Reported by a consumer/non-health professional from United States on 2012-06-28
Patient: male
Reactions: Type 2 Diabetes Mellitus, Blood Creatinine Increased
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Simvastatin
Dosage: 10mg once a day po
Administration route: Oral
Indication: Hypertension
Chlorthalidone
Dosage: 12.5mg once a day po
Administration route: Oral
Indication: Hypertension
Other drugs received by patient: Metformin HCL; Glypocide
Possible Chlorthalidone side effects in 78 year old male
Reported by a pharmacist from United States on 2012-05-25
Patient: 78 year old male, weighing 70.0 kg (154.0 pounds)
Reactions: Blood Pressure Increased, Blood Urea Increased, Hyponatraemia, Hypokalaemia, Blood Glucose Decreased, Carbon Dioxide Decreased, Blood Creatinine Increased, Asthenia, Decreased Appetite
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Chlorthalidone
Possible Chlorthalidone side effects in 51 year old male
Reported by a health professional (non-physician/pharmacist) on 2012-05-24
Patient: 51 year old male
Reactions: in-Stent Arterial Restenosis, Condition Aggravated, Renal Artery Occlusion, Renal Artery Stenosis, Pulmonary Congestion, Blood Pressure Inadequately Controlled, Oedema Peripheral, Blood Sodium Decreased, Renal Failure Acute, Blood Glucose Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Amlodipine
Dosage: 10 mg (10 mg, 1 in 1 d)
Indication: Product Used FOR Unknown Indication
Ramipril
Dosage: 5 mg (5 mg, 1 in 1 d)
Indication: Product Used FOR Unknown Indication
Bisoprolol Fumarate
Dosage: 5 mg (5 mg, 1 in 1 d)
Indication: Product Used FOR Unknown Indication
Chlorthalidone
Dosage: 50 mg (50 mg, 1 in 1 d)
Indication: Product Used FOR Unknown Indication
Possible Chlorthalidone side effects in 86 year old female
Reported by a consumer/non-health professional from United States on 2012-05-23
Patient: 86 year old female, weighing 59.9 kg (131.7 pounds)
Reactions: Vomiting, Blood Potassium Decreased, Dehydration, Asthenia, Blood Sodium Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Chlorthalidone
Possible Chlorthalidone side effects in 48 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-03-28
Patient: 48 year old male
Reactions: Rhabdomyolysis, Withdrawal Syndrome, Hypokalaemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Spironolactone
Dosage: increased to 100mg daily in 2009
Indication: Hypertension
Start date: 2006-01-01
Chlorthalidone
Dosage: titrated to 50mg
Indication: Hypertension
Start date: 2009-01-01
Other drugs received by patient: Lisinopril; Lercanidipine
Possible Chlorthalidone side effects in 48 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-03-28
Patient: 48 year old male
Reactions: Rhabdomyolysis, Withdrawal Syndrome, Hypokalaemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Chlorthalidone
Dosage: titrated to 50mg
Indication: Hypertension
Start date: 2009-01-01
Spironolactone
Dosage: increased to 100mg daily in 2009
Indication: Hypertension
Start date: 2006-01-01
Other drugs received by patient: Lercanidipine; Lisinopril
Possible Chlorthalidone side effects in 48 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-03-28
Patient: 48 year old male
Reactions: Rhabdomyolysis, Pain, Condition Aggravated, Muscular Weakness, Adrenal Adenoma, Gynaecomastia, Hypokalaemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Chlorthalidone
Dosage: 25 mg, unk
Chlorthalidone
Dosage: titrated upto 50 mg, unk
Indication: Sodium Retention
Other drugs received by patient: Spironolactone; Lisinopril; Lercanidipine
Possible Chlorthalidone side effects in 60 year old male
Reported by a consumer/non-health professional from United States on 2012-03-26
Patient: 60 year old male, weighing 72.6 kg (159.7 pounds)
Reactions: Heart Rate Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Varenicline
Administration route: Oral
Indication: Smoking Cessation Therapy
Start date: 2012-02-06
End date: 2012-02-09
Chlorthalidone
Administration route: Oral
Other drugs received by patient: Carvedilol; Lisinopril; Atorvastatin; Amlodipine Besylate
Possible Chlorthalidone side effects in 75 year old male
Reported by a consumer/non-health professional from United States on 2012-03-22
Patient: 75 year old male
Reactions: Abdominal Discomfort, Constipation
Drug(s) suspected as cause:
Chlorthalidone
Other drugs received by patient: Lisinopril; Ramipril; Metformin HCL; Carvedilol; Amlodipine
Possible Chlorthalidone side effects in 68 year old male
Reported by a consumer/non-health professional from United States on 2012-03-22
Patient: 68 year old male
Reactions: Anxiety, Heart Rate Increased
Drug(s) suspected as cause:
Chlorthalidone
Other drugs received by patient: Lisinopril; Xanax
Possible Chlorthalidone side effects in female
Reported by a physician from United States on 2012-03-22
Patient: female
Reactions: Skin Exfoliation
Drug(s) suspected as cause:
Chlorthalidone
Administration route: Oral
Indication: Diuretic Therapy
End date: 2011-05-19
Azilsartan Medoxomil
Administration route: Oral
Indication: Hypertension
Start date: 2011-01-01
Possible Chlorthalidone side effects in 63 year old female
Reported by a consumer/non-health professional from United States on 2012-03-22
Patient: 63 year old female, weighing 63.5 kg (139.7 pounds)
Reactions: Abdominal Discomfort, Diarrhoea, Functional Gastrointestinal Disorder, Diabetes Mellitus, Drug Interaction
Drug(s) suspected as cause:
Chlorthalidone
Other drugs received by patient possibly interacting with the suspect drug: Estring
Indication: Vaginal Abscess
End date: 2011-11-05
Other drugs received by patient: Vitamin D; Multi-Vitamin; Calcium Carbonate; Magnesium
Possible Chlorthalidone side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-22
Patient: female
Reactions: Blood Pressure Systolic Decreased, Fatigue, Hypotension
Drug(s) suspected as cause:
Azilsartan Medoxomil
Administration route: Oral
Indication: Hypertension
Start date: 2011-04-01
Chlorthalidone
Administration route: Oral
Indication: Hypertension
End date: 2011-01-01
Chlorthalidone
Administration route: Oral
Start date: 2011-01-01
Possible Chlorthalidone side effects in female
Reported by a consumer/non-health professional from Brazil on 2012-03-14
Patient: female, weighing 51.0 kg (112.2 pounds)
Reactions: Labyrinthitis, Fatigue, Wrong Technique in Drug Usage Process, Dizziness, Abdominal Distension, Blood Pressure Fluctuation, Blood Pressure Decreased
Drug(s) suspected as cause:
Chlorthalidone
Dosage: 1 df
Administration route: Oral
Hygroton
Dosage: 1 df (12.5 mg)
Administration route: Oral
Indication: Hypertension
End date: 2012-03-04
Hygroton
Dosage: 0.5 df (25 mg)
Administration route: Oral
Hygroton
Dosage: 1 df (25 mg)
Administration route: Oral
Possible Chlorthalidone side effects in male
Reported by a physician from United States on 2012-03-07
Patient: male, weighing 95.3 kg (209.6 pounds)
Reactions: Mineral Metabolism Disorder, Prostatic Specific Antigen Increased, Blood Urea Increased, Blood Potassium Decreased, Hyperphagia, Diarrhoea, Urinary Retention, Blood Creatinine Increased, Blood Glucose Increased
Drug(s) suspected as cause:
Chlorthalidone
Dosage: 25 - 50 mg
Administration route: Oral
Indication: Hypertension
Start date: 2007-01-01
End date: 2011-12-21
Prednisone TAB
Administration route: Oral
Indication: Prostate Cancer
Start date: 2011-10-15
Chlorthalidone
Dosage: 25 - 50 mg
Administration route: Oral
Indication: Diuretic Therapy
Start date: 2007-01-01
End date: 2011-12-21
Zytiga
Administration route: Oral
Indication: Prostate Cancer
Start date: 2011-10-15
End date: 2011-12-21
Prednisone TAB
Dosage: dose tapered; lowered every 4 days reducing dose
Administration route: Oral
Start date: 2011-12-21
End date: 2011-12-24
Other drugs received by patient: Metformin HCL; Vasotec; Metformin HCL; Potassium Citrate; Potassium Citrate; Hydrochlorothiazide; Norvasc; Potassium Citrate; Potassium Citrate
Possible Chlorthalidone side effects in male
Reported by a consumer/non-health professional from United States on 2012-02-27
Patient: male, weighing 72.6 kg (159.6 pounds)
Reactions: Heart Rate Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Chantix
Dosage: 0.5 mg, daily
Administration route: Oral
Indication: Smoking Cessation Therapy
Start date: 2012-02-06
End date: 2012-02-01
Chlorthalidone
Dosage: 12.5 mg, daily
Administration route: Oral
Chantix
Dosage: 0.5 mg, 2x/day
Administration route: Oral
Start date: 2012-02-01
End date: 2012-02-09
Other drugs received by patient: Amlodipine Besilate; Atorvastatin; Lisinopril; Carvedilol
Possible Chlorthalidone side effects in 82 year old female
Reported by a individual with unspecified qualification from Spain on 2012-02-27
Patient: 82 year old female
Reactions: Vomiting, Nausea, Drug Interaction, Hyponatraemia, Disorientation, Fall, Hypokalaemia, Bradyphrenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Chlorthalidone
Dosage: 50 mg (50 mg, 1 in 1 d), oral
Administration route: Oral
Indication: Hypertension
Start date: 2011-08-01
End date: 2011-09-02
Olmetec Plus (Hydrochlorothiazide, Olmesartan Medoxomil) Tablet
Dosage: 20/12.5 mg (1 in 1 d), oral
Administration route: Oral
Indication: Hypertension
Start date: 2011-05-06
End date: 2011-09-02
Cymbalta
Dosage: 30 mg 930 mg, 1in 1 d, oral
Administration route: Oral
Indication: Hypertension
Start date: 2011-08-29
End date: 2011-09-02
Other drugs received by patient: Ibuprofen (Ibuprofen) (Tablet); Captopril; Dusplatin (Mebeverine) (Tablet)
Possible Chlorthalidone side effects in 49 year old male
Reported by a physician from United States on 2012-02-24
Patient: 49 year old male
Reactions: Erectile Dysfunction
Drug(s) suspected as cause:
Hydrochlorothiazide
Dosage: 25mg daily
Indication: Hypertension
Chlorthalidone
Indication: Hypertension
Losartan Potassium
Dosage: 25mg daily
Indication: Hypertension
Atenolol
Dosage: 50mg daily
Indication: Hypertension
Nebivolol
Indication: Hypertension
Aliskiren
Indication: Hypertension
Possible Chlorthalidone side effects in 47 year old female
Reported by a individual with unspecified qualification from Brazil on 2012-02-22
Patient: 47 year old female
Reactions: Blood Pressure Increased, Thyroid Neoplasm
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Chlorthalidone
Dosage: 25 mg,per oral
Administration route: Oral
Indication: Hypertension
Start date: 2011-11-01
Spironolactone
Dosage: 50 mg,per oral
Administration route: Oral
Indication: Hypertension
Start date: 2011-11-01
Amlodipine Besylate and Olmesartan Medoxomil
Dosage: 40/5 mg (1 in 1 d),per oral ; 40/10 mg (1 in 1 d),per oral
Administration route: Oral
Indication: Hypertension
Start date: 2011-11-01
End date: 2011-11-01
Amlodipine Besylate and Olmesartan Medoxomil
Dosage: 40/5 mg (1 in 1 d),per oral ; 40/10 mg (1 in 1 d),per oral
Administration route: Oral
Indication: Hypertension
Start date: 2011-11-01
Other drugs received by patient: Ciprofibrate (Ciprofibrate) (Ciprofibrate)
Possible Chlorthalidone side effects in 47 year old female
Reported by a consumer/non-health professional from Brazil on 2012-02-20
Patient: 47 year old female
Reactions: Blood Pressure Increased, Thyroid Neoplasm
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Amlodipine Besylate and Olmesartan Medoxomil
Dosage: 40/5 mg 1 in 1 day
Administration route: Oral
Indication: Hypertension
Start date: 2011-11-01
Amlodipine Besylate and Olmesartan Medoxomil
Dosage: 40/10 mg, 1 in 1 day
Administration route: Oral
Start date: 2011-11-01
Spironolactone
Dosage: 50 mg, unk
Administration route: Oral
Indication: Hypertension
Start date: 2011-11-01
Chlorthalidone
Dosage: 25 mg, unk
Administration route: Oral
Indication: Hypertension
Start date: 2011-11-01
Other drugs received by patient: Ciprofibrate
Possible Chlorthalidone side effects in 45 year old male
Reported by a physician from United States on 2012-02-01
Patient: 45 year old male
Reactions: Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozapine
Administration route: Oral
Indication: Schizophrenia, Paranoid Type
Chlorthalidone
Other drugs received by patient: Carvedilol; Lisinopril; Thiazide Derivatives; Olanzapine; Metformin HCL; Simvastatin
Possible Chlorthalidone side effects in 75 year old male
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-01-23
Patient: 75 year old male
Reactions: Presyncope
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Chlorthalidone
Dosage: unk
Indication: Product Used FOR Unknown Indication
Altace
Dosage: 1.25 mg, 1x/day
Administration route: Oral
Indication: Hypertension
Start date: 2009-01-01
End date: 2010-05-08
Possible Chlorthalidone side effects in 59 year old male
Reported by a pharmacist from United States on 2012-01-17
Patient: 59 year old male, weighing 63.6 kg (139.9 pounds)
Reactions: Rhabdomyolysis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Chlorthalidone
Possible Chlorthalidone side effects in 87 year old female
Reported by a health professional (non-physician/pharmacist) from Australia on 2011-12-19
Patient: 87 year old female
Reactions: Syncope, Nausea, Orthostatic Hypotension, Dizziness
Drug(s) suspected as cause:
Lercanidipine
Dosage: 20 mg, qd
Administration route: Oral
Indication: Essential Hypertension
Amiodarone Hydrochloride
Dosage: 100 mg, unk
Administration route: Oral
Indication: Arrhythmia
Start date: 2011-03-30
Perindopril Erbumine
Dosage: 8 mg, unk
Administration route: Oral
Indication: Essential Hypertension
Start date: 2011-03-30
Atacand
Dosage: 1 df, unk
Administration route: Oral
Indication: Essential Hypertension
End date: 2011-03-30
Chlorthalidone
Dosage: 25 mg, unk
Administration route: Oral
Indication: Essential Hypertension
Start date: 2011-03-30
Levothyroxine Sodium
Dosage: 100 ug, unk
Administration route: Oral
Indication: Myxoedema
Atenolol
Dosage: 50 mg, unk
Administration route: Oral
Indication: Essential Hypertension
End date: 2011-03-16
Methyldopa
Dosage: 4 df, unk
Administration route: Oral
Indication: Essential Hypertension
Start date: 2011-03-16
Other drugs received by patient: Simvastatin; Acetylsalicylic Acid SRT; Amoxicillin
Possible Chlorthalidone side effects in 87 year old female
Reported by a physician from Japan on 2011-11-30
Patient: 87 year old female
Reactions: Syncope, Nausea, Dizziness, Orthostatic Hypotension
Drug(s) suspected as cause:
Perindopril Erbumine
Administration route: Oral
Indication: Essential Hypertension
Start date: 2011-03-30
Atenolol
Administration route: Oral
Indication: Essential Hypertension
Start date: 2011-03-16
Amiodarone HCL
Administration route: Oral
Indication: Arrhythmia
Start date: 2011-03-30
Levothyroxine Sodium
Administration route: Oral
Indication: Myxoedema
Lercanidipine
Administration route: Oral
Indication: Essential Hypertension
Chlorthalidone
Administration route: Oral
Indication: Essential Hypertension
Start date: 2011-03-30
Atacand
Administration route: Oral
Indication: Essential Hypertension
Start date: 2011-03-30
Methyldopa
Administration route: Oral
Indication: Essential Hypertension
Start date: 2011-03-16
Other drugs received by patient: Amoxicillin; Acetylsalicylic Acid SRT; Simvastatin
Possible Chlorthalidone side effects in 49 year old female
Reported by a consumer/non-health professional from United States on 2011-11-29
Patient: 49 year old female
Reactions: Abdominal Pain
Drug(s) suspected as cause:
Chlorthalidone
Indication: Blood Pressure Increased
Start date: 2010-11-03
Amlodipine Besylate
Indication: Hypertension
Start date: 2010-11-03
Other drugs received by patient: Iron; Paroxetine HCL
Possible Chlorthalidone side effects in 88 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-18
Patient: 88 year old female
Reactions: Blood Pressure Increased, Haemoglobin Decreased, Presyncope, Blood Potassium Increased, Nodal Rhythm, Bradycardia, Blood Creatinine Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Metoprolol Tartrate
Dosage: 50 mg, bid
Hydralazine HCL
Dosage: 50 mg, bid
Lisinopril
Dosage: 40 mg, unk
Diltiazem HCL
Dosage: 180 mg, unk
Chlorthalidone
Dosage: 25 mg, unk
Clonidine
Dosage: 0.3 mg, weekly patch
|