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Carbidopa and Levodopa (Carbidopa / Levodopa) - Side Effect Reports to FDA

 
 



This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Carbidopa and Levodopa (Carbidopa / Levodopa) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.

Reports by Event Outcome

All Cases (77)
Death (2)
Life Threatening Events (2)
Disability (2)

Reports by Reaction Type

Dyskinesia (16)Hallucination, Visual (12)Tremor (10)Agitation (9)Confusional State (9)Fall (9)Gait Disturbance (9)Respiratory Disorder (6)Muscle Rigidity (6)Delirium (6)Dysphonia (6)Mobility Decreased (6)

Below are a few examples of reports where side effects / adverse reactions may be related to Carbidopa and Levodopa (Carbidopa / Levodopa). For a complete list or a specific selection of reports, please use the links above.

Possible Carbidopa and Levodopa side effects in female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-21

Patient: female

Reactions: Death, Confusional State, Drug Effect Decreased, Hallucination, Visual, Motor Dysfunction

Adverse event resulted in: death

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: unk
    Indication: Parkinsonism

Carbidopa and Levodopa
    Dosage: 125 mg, tid



Possible Carbidopa and Levodopa side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-10

Patient: 65 year old female

Reactions: Burning Mouth Syndrome

Drug(s) suspected as cause:
Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in 9 year old male

Reported by a physician from United States on 2012-08-09

Patient: 9 year old male

Reactions: Off Label Use, Agitation, Ileus, Dehydration, Neuroleptic Malignant Syndrome, Transaminases Increased, Respiratory Distress

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Indication: Off Label Use

Carbidopa and Levodopa
    Indication: Dystonia

Other drugs received by patient: Baclofen; Trihexyphenidyl HCL; Clonazepam



Possible Carbidopa and Levodopa side effects in 9 year old male

Reported by a physician from United States on 2012-08-08

Patient: 9 year old male

Reactions: Agitation, Ileus, Neuroleptic Malignant Syndrome, Transaminases Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: 1 df = 10mg levodopa/100mg carbidopa
    Indication: Dystonia

Carbidopa and Levodopa

Other drugs received by patient: Baclofen; Clonazepam



Possible Carbidopa and Levodopa side effects in female

Reported by a pharmacist from Germany on 2012-08-08

Patient: female

Reactions: Aggression

Drug(s) suspected as cause:
Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in 9 year old male

Reported by a physician from United States on 2012-08-03

Patient: 9 year old male

Reactions: Agitation, Ileus, Neuroleptic Malignant Syndrome, Transaminases Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa

Other drugs received by patient: Baclofen; Clonazepam



Possible Carbidopa and Levodopa side effects in male

Reported by a physician from Japan on 2012-08-01

Patient: male

Reactions: Mania, Dopamine Dysregulation Syndrome, Dyskinesia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: 250mg daily
    Indication: Parkinson's Disease

Droxidopa
    Dosage: 200mg
    Indication: Orthostatic Hypotension

Droxidopa
    Dosage: 200mg
    Indication: Dizziness

Other drugs received by patient: Pramipexole Dihychloride



Possible Carbidopa and Levodopa side effects in 61 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-01

Patient: 61 year old male

Reactions: Dyspnoea, Blood Pressure Systolic Increased, Fall, Fatigue, Skin Discolouration, Dehydration, Pigmentation Disorder, Asthenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: for several years
    Indication: Parkinson's Disease

Minocycline Hydrochloride
    Dosage: 100 mg, 2 in 1 d, oral; for several years
    Administration route: Oral
    Indication: Acne



Possible Carbidopa and Levodopa side effects in 65 year old male

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-07-24

Patient: 65 year old male

Reactions: Irritability, Pathological Gambling, Compulsive Shopping

Drug(s) suspected as cause:
Benserazide, Levodopa
    Dosage: 1000 mg/day
    Indication: Parkinson's Disease

Cabergoline
    Dosage: 8 mg, per day
    Indication: Parkinson's Disease

Carbidopa and Levodopa
    Indication: Parkinson's Disease

Pramipexole Dihychloride
    Dosage: 1.2 mg, per day

Pramipexole Dihychloride
    Dosage: 3.05 mg/day
    Indication: Parkinson's Disease

Other drugs received by patient: Entacapone



Possible Carbidopa and Levodopa side effects in

Reported by a health professional (non-physician/pharmacist) from Norway on 2012-07-22

Patient:

Reactions: Overdose, Mental Disorder, Device Dislocation, Cerebrovascular Accident, Gastritis

Adverse event resulted in: death

Drug(s) suspected as cause:
Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in 25 year old female

Reported by a physician from United States on 2012-07-20

Patient: 25 year old female

Reactions: General Physical Health Deterioration

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: maximal dose 4?50 mg/100 mg

Sapropterin
    Dosage: lower than 700 mg

Sapropterin
    Dosage: dose: 20 mg/kg



Possible Carbidopa and Levodopa side effects in 24 year old male

Reported by a physician from United States on 2012-07-20

Patient: 24 year old male

Reactions: Muscular Weakness

Drug(s) suspected as cause:
Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in 73 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-09

Patient: 73 year old male

Reactions: Hallucination, Athetosis, Delirium

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-06

Patient: male

Reactions: ON and Off Phenomenon, Dyskinesia, Orthostatic Hypotension, Freezing Phenomenon, Somnolence, Fall, Hallucination, Tactile, Gait Disturbance

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Indication: Parkinson's Disease

Pramipexole Dihychloride
    Indication: Parkinson's Disease

Rasagiline
    Indication: Parkinson's Disease



Possible Carbidopa and Levodopa side effects in 70 year old male

Reported by a physician from Germany on 2012-07-06

Patient: 70 year old male

Reactions: Therapeutic Response Decreased, Bezoar, Pica, Trichotillomania

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: pump rate 5.4 ml/hour + morning dose of 10ml and extra doses of 3ml as needed; switched off at night
    Indication: Parkinson's Disease

Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-06

Patient: female

Reactions: ON and Off Phenomenon, Hallucination, Visual, Dyskinesia, Orthostatic Hypotension, Freezing Phenomenon, Gait Disturbance, Fall

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Indication: Parkinson's Disease

Pramipexole Dihychloride
    Indication: Parkinson's Disease



Possible Carbidopa and Levodopa side effects in 78 year old male

Reported by a health professional (non-physician/pharmacist) from Austria on 2012-07-03

Patient: 78 year old male

Reactions: Feeding Tube Complication, Device Occlusion, Device Malfunction

Drug(s) suspected as cause:
Carbidopa and Levodopa

Other drugs received by patient: Levodopa



Possible Carbidopa and Levodopa side effects in 70 year old male

Reported by a physician from Germany on 2012-06-27

Patient: 70 year old male

Reactions: Therapeutic Response Decreased, ON and Off Phenomenon, Affect Lability, Bezoar, Pica, Trichotillomania

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: the patient additionally took 300mg before going to sleep and during nighttime waking periods

Carbidopa and Levodopa
    Dosage: pump rate 5.4 ml/hour + morning dose of 10ml and extra doses of 3ml as needed; switched off at night
    Indication: Parkinson's Disease



Possible Carbidopa and Levodopa side effects in female

Reported by a physician from Germany on 2012-06-26

Patient: female

Reactions: Impulse-Control Disorder, Kleptomania, Pathological Gambling

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: daily dose: 750 mg
    Administration route: Oral
    Indication: Parkinson's Disease

Madopar LT
    Dosage: 5x1
    Administration route: Oral
    Indication: Parkinson's Disease

Neupro
    Dosage: 8 mg/24 hour
    Indication: Parkinson's Disease

Requip
    Dosage: single dose 8
    Administration route: Oral
    Indication: Parkinson's Disease

Tasmar
    Administration route: Oral
    Indication: Parkinson's Disease

Other drugs received by patient: PK-Merz; Lactulose



Possible Carbidopa and Levodopa side effects in female

Reported by a physician from Germany on 2012-06-26

Patient: female

Reactions: Impulse-Control Disorder, Kleptomania, Pathological Gambling, Theft

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: 125mg unknown
    Administration route: Oral
    Indication: Parkinson's Disease

Madopar
    Dosage: 125mg five times per day
    Administration route: Oral
    Indication: Parkinson's Disease

Neupro
    Dosage: 8mg per day
    Indication: Parkinson's Disease

Requip
    Dosage: 8mg three times per day
    Administration route: Oral
    Indication: Parkinson's Disease

Tasmar
    Dosage: 100mg three times per day
    Administration route: Oral
    Indication: Parkinson's Disease

Other drugs received by patient: Lactulose; L-Dopa; PK-Merz



Possible Carbidopa and Levodopa side effects in 73 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-18

Patient: 73 year old male

Reactions: Confusional State, Dyskinesia, Dementia, General Physical Health Deterioration, Toxicity To Various Agents, Delirium, Fall, Treatment Noncompliance, Overdose, Hallucination, Visual, Athetosis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in 73 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-08

Patient: 73 year old male

Reactions: Athetosis, Delirium

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in 73 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-30

Patient: 73 year old male

Reactions: Confusional State, Hallucination, Visual, Toxicity To Various Agents, Athetosis, Delirium

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in 30 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-10

Patient: 30 year old male

Reactions: Paradoxical Drug Reaction, Drug Ineffective, Sedation, Gait Disturbance, Fall

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Indication: Product Used FOR Unknown Indication

Risperidone
    Dosage: 0.5mg
    Indication: Chorea

Tetrabenazine (Tetrabenazine)
    Dosage: 12.5 mg, bid,
    Indication: Product Used FOR Unknown Indication



Possible Carbidopa and Levodopa side effects in 64 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-08

Patient: 64 year old male

Reactions: ON and Off Phenomenon, Dyskinesia

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: carbidopa/levodopa 25/100 mg 2 times daily
    Indication: Parkinson's Disease

Carbidopa / Levodopa / Entacapone
    Dosage: carbidopa/levodopa/entacapone 31.25/125/200 mg every 4 hours (4 times daily)
    Indication: Parkinson's Disease

Pramipexole Dihydrochloride
    Dosage: 4 mg
    Indication: Parkinson's Disease

Other drugs received by patient: Clonazepam; Aspirin; Lansoprazole



Possible Carbidopa and Levodopa side effects in male

Reported by a physician from Brazil on 2012-04-30

Patient: male

Reactions: Dopamine Dysregulation Syndrome, Intentional Overdose

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Carbidopa and Levodopa
    Dosage: levodopa/carbidopa 250/25mg per tablet; up to 12tabs/day approx 12y after diagnosis
    Administration route: Oral
    Indication: Parkinson's Disease

Levodopa
    Indication: Parkinson's Disease

Other drugs received by patient: Amantadine HCL; Clonazepam; Amitriptyline HCL



Possible Carbidopa and Levodopa side effects in female

Reported by a consumer/non-health professional from United States on 2012-04-30

Patient: female

Reactions: Abasia, Musculoskeletal Stiffness, Mobility Decreased

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in 66 year old male

Reported by a health professional (non-physician/pharmacist) from Australia on 2012-04-24

Patient: 66 year old male

Reactions: Respiratory Disorder, Tachypnoea, Cerebral Atrophy, Tremor

Drug(s) suspected as cause:
Carbidopa and Levodopa

Other drugs received by patient: Amantadine HCL; Selegiline; Bromocriptine Mesylate; Biperiden Hydrochloride TAB



Possible Carbidopa and Levodopa side effects in 78 year old male

Reported by a health professional (non-physician/pharmacist) from Australia on 2012-04-23

Patient: 78 year old male

Reactions: Respiratory Disorder, Dyskinesia, Tachypnoea, Cerebral Ischaemia

Drug(s) suspected as cause:
Carbidopa and Levodopa



Possible Carbidopa and Levodopa side effects in 78 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-18

Patient: 78 year old male

Reactions: Hallucination, Tactile, Hallucination, Visual, Oedema Peripheral

Drug(s) suspected as cause:
Amantadine HCL
    Indication: Parkinson's Disease

Carbidopa and Levodopa
    Dosage: carbidopa/levodopa 25/100 mg qid
    Indication: Parkinson's Disease

Pramipexole Dihydrochloride
    Dosage: 2.25 mg
    Indication: Parkinson's Disease

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