This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Carbidopa and Levodopa (Carbidopa / Levodopa) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (77)
Death (2)
Life Threatening Events (2)
Disability (2)
Reports by Reaction Type
Dyskinesia (16),
Hallucination, Visual (12),
Tremor (10),
Agitation (9),
Confusional State (9),
Fall (9),
Gait Disturbance (9),
Respiratory Disorder (6),
Muscle Rigidity (6),
Delirium (6),
Dysphonia (6),
Mobility Decreased (6)
Below are a few examples of reports where side effects / adverse reactions may be related to Carbidopa and Levodopa (Carbidopa / Levodopa). For a complete list or a specific selection of reports, please use the links above.
Possible Carbidopa and Levodopa side effects in female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-21
Patient: female
Reactions: Death, Confusional State, Drug Effect Decreased, Hallucination, Visual, Motor Dysfunction
Adverse event resulted in: death
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: unk
Indication: Parkinsonism
Carbidopa and Levodopa
Dosage: 125 mg, tid
Possible Carbidopa and Levodopa side effects in 65 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-10
Patient: 65 year old female
Reactions: Burning Mouth Syndrome
Drug(s) suspected as cause:
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in 9 year old male
Reported by a physician from United States on 2012-08-09
Patient: 9 year old male
Reactions: Off Label Use, Agitation, Ileus, Dehydration, Neuroleptic Malignant Syndrome, Transaminases Increased, Respiratory Distress
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Indication: Off Label Use
Carbidopa and Levodopa
Indication: Dystonia
Other drugs received by patient: Baclofen; Trihexyphenidyl HCL; Clonazepam
Possible Carbidopa and Levodopa side effects in 9 year old male
Reported by a physician from United States on 2012-08-08
Patient: 9 year old male
Reactions: Agitation, Ileus, Neuroleptic Malignant Syndrome, Transaminases Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: 1 df = 10mg levodopa/100mg carbidopa
Indication: Dystonia
Carbidopa and Levodopa
Other drugs received by patient: Baclofen; Clonazepam
Possible Carbidopa and Levodopa side effects in female
Reported by a pharmacist from Germany on 2012-08-08
Patient: female
Reactions: Aggression
Drug(s) suspected as cause:
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in 9 year old male
Reported by a physician from United States on 2012-08-03
Patient: 9 year old male
Reactions: Agitation, Ileus, Neuroleptic Malignant Syndrome, Transaminases Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Other drugs received by patient: Baclofen; Clonazepam
Possible Carbidopa and Levodopa side effects in male
Reported by a physician from Japan on 2012-08-01
Patient: male
Reactions: Mania, Dopamine Dysregulation Syndrome, Dyskinesia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: 250mg daily
Indication: Parkinson's Disease
Droxidopa
Dosage: 200mg
Indication: Orthostatic Hypotension
Droxidopa
Dosage: 200mg
Indication: Dizziness
Other drugs received by patient: Pramipexole Dihychloride
Possible Carbidopa and Levodopa side effects in 61 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-01
Patient: 61 year old male
Reactions: Dyspnoea, Blood Pressure Systolic Increased, Fall, Fatigue, Skin Discolouration, Dehydration, Pigmentation Disorder, Asthenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: for several years
Indication: Parkinson's Disease
Minocycline Hydrochloride
Dosage: 100 mg, 2 in 1 d, oral; for several years
Administration route: Oral
Indication: Acne
Possible Carbidopa and Levodopa side effects in 65 year old male
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-07-24
Patient: 65 year old male
Reactions: Irritability, Pathological Gambling, Compulsive Shopping
Drug(s) suspected as cause:
Benserazide, Levodopa
Dosage: 1000 mg/day
Indication: Parkinson's Disease
Cabergoline
Dosage: 8 mg, per day
Indication: Parkinson's Disease
Carbidopa and Levodopa
Indication: Parkinson's Disease
Pramipexole Dihychloride
Dosage: 1.2 mg, per day
Pramipexole Dihychloride
Dosage: 3.05 mg/day
Indication: Parkinson's Disease
Other drugs received by patient: Entacapone
Possible Carbidopa and Levodopa side effects in
Reported by a health professional (non-physician/pharmacist) from Norway on 2012-07-22
Patient:
Reactions: Overdose, Mental Disorder, Device Dislocation, Cerebrovascular Accident, Gastritis
Adverse event resulted in: death
Drug(s) suspected as cause:
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in 25 year old female
Reported by a physician from United States on 2012-07-20
Patient: 25 year old female
Reactions: General Physical Health Deterioration
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: maximal dose 4?50 mg/100 mg
Sapropterin
Dosage: lower than 700 mg
Sapropterin
Dosage: dose: 20 mg/kg
Possible Carbidopa and Levodopa side effects in 24 year old male
Reported by a physician from United States on 2012-07-20
Patient: 24 year old male
Reactions: Muscular Weakness
Drug(s) suspected as cause:
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in 73 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-09
Patient: 73 year old male
Reactions: Hallucination, Athetosis, Delirium
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-06
Patient: male
Reactions: ON and Off Phenomenon, Dyskinesia, Orthostatic Hypotension, Freezing Phenomenon, Somnolence, Fall, Hallucination, Tactile, Gait Disturbance
Drug(s) suspected as cause:
Carbidopa and Levodopa
Indication: Parkinson's Disease
Pramipexole Dihychloride
Indication: Parkinson's Disease
Rasagiline
Indication: Parkinson's Disease
Possible Carbidopa and Levodopa side effects in 70 year old male
Reported by a physician from Germany on 2012-07-06
Patient: 70 year old male
Reactions: Therapeutic Response Decreased, Bezoar, Pica, Trichotillomania
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: pump rate 5.4 ml/hour + morning dose of 10ml and extra doses of 3ml as needed; switched off at night
Indication: Parkinson's Disease
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-06
Patient: female
Reactions: ON and Off Phenomenon, Hallucination, Visual, Dyskinesia, Orthostatic Hypotension, Freezing Phenomenon, Gait Disturbance, Fall
Drug(s) suspected as cause:
Carbidopa and Levodopa
Indication: Parkinson's Disease
Pramipexole Dihychloride
Indication: Parkinson's Disease
Possible Carbidopa and Levodopa side effects in 78 year old male
Reported by a health professional (non-physician/pharmacist) from Austria on 2012-07-03
Patient: 78 year old male
Reactions: Feeding Tube Complication, Device Occlusion, Device Malfunction
Drug(s) suspected as cause:
Carbidopa and Levodopa
Other drugs received by patient: Levodopa
Possible Carbidopa and Levodopa side effects in 70 year old male
Reported by a physician from Germany on 2012-06-27
Patient: 70 year old male
Reactions: Therapeutic Response Decreased, ON and Off Phenomenon, Affect Lability, Bezoar, Pica, Trichotillomania
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: the patient additionally took 300mg before going to sleep and during nighttime waking periods
Carbidopa and Levodopa
Dosage: pump rate 5.4 ml/hour + morning dose of 10ml and extra doses of 3ml as needed; switched off at night
Indication: Parkinson's Disease
Possible Carbidopa and Levodopa side effects in female
Reported by a physician from Germany on 2012-06-26
Patient: female
Reactions: Impulse-Control Disorder, Kleptomania, Pathological Gambling
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: daily dose: 750 mg
Administration route: Oral
Indication: Parkinson's Disease
Madopar LT
Dosage: 5x1
Administration route: Oral
Indication: Parkinson's Disease
Neupro
Dosage: 8 mg/24 hour
Indication: Parkinson's Disease
Requip
Dosage: single dose 8
Administration route: Oral
Indication: Parkinson's Disease
Tasmar
Administration route: Oral
Indication: Parkinson's Disease
Other drugs received by patient: PK-Merz; Lactulose
Possible Carbidopa and Levodopa side effects in female
Reported by a physician from Germany on 2012-06-26
Patient: female
Reactions: Impulse-Control Disorder, Kleptomania, Pathological Gambling, Theft
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: 125mg unknown
Administration route: Oral
Indication: Parkinson's Disease
Madopar
Dosage: 125mg five times per day
Administration route: Oral
Indication: Parkinson's Disease
Neupro
Dosage: 8mg per day
Indication: Parkinson's Disease
Requip
Dosage: 8mg three times per day
Administration route: Oral
Indication: Parkinson's Disease
Tasmar
Dosage: 100mg three times per day
Administration route: Oral
Indication: Parkinson's Disease
Other drugs received by patient: Lactulose; L-Dopa; PK-Merz
Possible Carbidopa and Levodopa side effects in 73 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-18
Patient: 73 year old male
Reactions: Confusional State, Dyskinesia, Dementia, General Physical Health Deterioration, Toxicity To Various Agents, Delirium, Fall, Treatment Noncompliance, Overdose, Hallucination, Visual, Athetosis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in 73 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-08
Patient: 73 year old male
Reactions: Athetosis, Delirium
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in 73 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-30
Patient: 73 year old male
Reactions: Confusional State, Hallucination, Visual, Toxicity To Various Agents, Athetosis, Delirium
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in 30 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-10
Patient: 30 year old male
Reactions: Paradoxical Drug Reaction, Drug Ineffective, Sedation, Gait Disturbance, Fall
Drug(s) suspected as cause:
Carbidopa and Levodopa
Indication: Product Used FOR Unknown Indication
Risperidone
Dosage: 0.5mg
Indication: Chorea
Tetrabenazine (Tetrabenazine)
Dosage: 12.5 mg, bid,
Indication: Product Used FOR Unknown Indication
Possible Carbidopa and Levodopa side effects in 64 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-08
Patient: 64 year old male
Reactions: ON and Off Phenomenon, Dyskinesia
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: carbidopa/levodopa 25/100 mg 2 times daily
Indication: Parkinson's Disease
Carbidopa / Levodopa / Entacapone
Dosage: carbidopa/levodopa/entacapone 31.25/125/200 mg every 4 hours (4 times daily)
Indication: Parkinson's Disease
Pramipexole Dihydrochloride
Dosage: 4 mg
Indication: Parkinson's Disease
Other drugs received by patient: Clonazepam; Aspirin; Lansoprazole
Possible Carbidopa and Levodopa side effects in male
Reported by a physician from Brazil on 2012-04-30
Patient: male
Reactions: Dopamine Dysregulation Syndrome, Intentional Overdose
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carbidopa and Levodopa
Dosage: levodopa/carbidopa 250/25mg per tablet; up to 12tabs/day approx 12y after diagnosis
Administration route: Oral
Indication: Parkinson's Disease
Levodopa
Indication: Parkinson's Disease
Other drugs received by patient: Amantadine HCL; Clonazepam; Amitriptyline HCL
Possible Carbidopa and Levodopa side effects in female
Reported by a consumer/non-health professional from United States on 2012-04-30
Patient: female
Reactions: Abasia, Musculoskeletal Stiffness, Mobility Decreased
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in 66 year old male
Reported by a health professional (non-physician/pharmacist) from Australia on 2012-04-24
Patient: 66 year old male
Reactions: Respiratory Disorder, Tachypnoea, Cerebral Atrophy, Tremor
Drug(s) suspected as cause:
Carbidopa and Levodopa
Other drugs received by patient: Amantadine HCL; Selegiline; Bromocriptine Mesylate; Biperiden Hydrochloride TAB
Possible Carbidopa and Levodopa side effects in 78 year old male
Reported by a health professional (non-physician/pharmacist) from Australia on 2012-04-23
Patient: 78 year old male
Reactions: Respiratory Disorder, Dyskinesia, Tachypnoea, Cerebral Ischaemia
Drug(s) suspected as cause:
Carbidopa and Levodopa
Possible Carbidopa and Levodopa side effects in 78 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-18
Patient: 78 year old male
Reactions: Hallucination, Tactile, Hallucination, Visual, Oedema Peripheral
Drug(s) suspected as cause:
Amantadine HCL
Indication: Parkinson's Disease
Carbidopa and Levodopa
Dosage: carbidopa/levodopa 25/100 mg qid
Indication: Parkinson's Disease
Pramipexole Dihydrochloride
Dosage: 2.25 mg
Indication: Parkinson's Disease
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