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Avastin (Bevacizumab) - Side Effect Reports to FDA

 
 



This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Avastin (Bevacizumab) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.

Reports by Event Outcome

All Cases (4689)
Death (1648)
Life Threatening Events (302)
Disability (145)

Reports by Reaction Type

Death (741)Disease Progression (373)Diarrhoea (250)Nausea (230)Hypertension (209)Vomiting (207)Fatigue (156)General Physical Health Deterioration (149)Anaemia (139)Decreased Appetite (132)Abdominal Pain (131)Dyspnoea (130)

Below are a few examples of reports where side effects / adverse reactions may be related to Avastin (Bevacizumab). For a complete list or a specific selection of reports, please use the links above.

Possible Avastin side effects in female

Reported by a consumer/non-health professional from United States on 2012-08-27

Patient: female

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Tarceva
    Indication: Metastases To Nervous System

Avastin
    Indication: Product Used FOR Unknown Indication

Tarceva
    Indication: Lung Neoplasm Malignant



Possible Avastin side effects in

Reported by a physician from Japan on 2012-08-27

Patient:

Reactions: Cerebral Infarction

Drug(s) suspected as cause:
Xeloda
    Dosage: dosage is uncertain.
    Administration route: Oral
    Indication: Large Intestine Carcinoma

Oxaliplatin
    Dosage: dosage is uncertain.
    Indication: Large Intestine Carcinoma

Avastin
    Indication: Large Intestine Carcinoma



Possible Avastin side effects in 62 year old female

Reported by a physician from United States on 2012-08-27

Patient: 62 year old female

Reactions: Mucosal Inflammation, Fatigue, Diarrhoea, Mental Status Changes, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Xeloda
    Indication: Colorectal Cancer Metastatic

Avastin
    Indication: Colorectal Cancer Metastatic



Possible Avastin side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Tarceva
    Indication: Malignant Respiratory Tract Neoplasm

Avastin
    Indication: Product Used FOR Unknown Indication



Possible Avastin side effects in

Reported by a individual with unspecified qualification from United States on 2012-08-27

Patient:

Reactions: Electrocardiogram QT Prolonged, Proctitis, Rhabdomyolysis, Gastrointestinal Haemorrhage, Hyperbilirubinaemia, Hypokalaemia, Neuropathy Peripheral, Intestinal Perforation, Fatigue, Proteinuria, Thrombocytopenia, Azotaemia, Hypovolaemia, Blood Alkaline Phosphatase Increased, Fistula, Stomatitis, Hyperglycaemia, Hyponatraemia, Hyperlipidaemia, Hypophosphataemia, Diarrhoea, Hypoalbuminaemia, Neutropenia, Abscess, Vaginal Infection, Hypertension

Drug(s) suspected as cause:
Avastin
    Indication: Colorectal Cancer Metastatic

Everolimus
    Administration route: Oral
    Indication: Colorectal Cancer Metastatic



Possible Avastin side effects in female

Reported by a physician from United States on 2012-08-27

Patient: female

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Tarceva
    Indication: Lung Neoplasm Malignant

Avastin
    Indication: Product Used FOR Unknown Indication



Possible Avastin side effects in 73 year old

Reported by a physician from Canada on 2012-08-27

Patient: 73 year old

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin



Possible Avastin side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Indication: Lung Neoplasm Malignant

Tarceva
    Indication: Lung Neoplasm Malignant



Possible Avastin side effects in

Reported by a physician from Spain on 2012-08-27

Patient:

Reactions: Drug Intolerance

Drug(s) suspected as cause:
Avastin



Possible Avastin side effects in female

Reported by a physician from France on 2012-08-27

Patient: female, weighing 54.0 kg (118.8 pounds)

Reactions: Skin Mass, Disease Progression

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Avastin

Other drugs received by patient: Cyclophosphamide



Possible Avastin side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male

Reactions: Disease Progression

Drug(s) suspected as cause:
Avastin
    Indication: Haematological Malignancy

Avastin
    Indication: Malignant Respiratory Tract Neoplasm

Tarceva
    Indication: Product Used FOR Unknown Indication



Possible Avastin side effects in female

Reported by a physician from Canada on 2012-08-27

Patient: female, weighing 86.0 kg (189.2 pounds)

Reactions: Angina Unstable, Proteinuria

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Lucentis
    Indication: Product Used FOR Unknown Indication

Avastin
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Metoprolol Tartrate; Risedronate Sodium; Diovan; Lansoprazole; Novolin 70 / 30; Plavix; Lipitor; Amlodipine; Gabapentin; Calcium Carbonate



Possible Avastin side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male

Reactions: Disease Progression

Drug(s) suspected as cause:
Avastin
    Indication: Lung Neoplasm Malignant
    Start date: 2005-11-01

Tarceva
    Indication: Product Used FOR Unknown Indication
    Start date: 2005-06-01

Other drugs received by patient: Carboplatin; Taxotere; Taxol



Possible Avastin side effects in 73 year old male

Reported by a physician from France on 2012-08-27

Patient: 73 year old male, weighing 71.0 kg (156.2 pounds)

Reactions: Folliculitis, Rash

Drug(s) suspected as cause:
Fluorouracil
    Indication: Colorectal Cancer
    Start date: 2012-05-22
    End date: 2012-06-27

Avastin
    Indication: Colorectal Cancer
    Start date: 2012-05-22
    End date: 2012-06-06

Other drugs received by patient: Leucovorin Calcium



Possible Avastin side effects in 41 year old male

Reported by a physician from Austria on 2012-08-27

Patient: 41 year old male

Reactions: Neoplasm Progression, General Physical Health Deterioration

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Indication: Brain Neoplasm Malignant

Irinotecan Hydrochloride
    Indication: Brain Neoplasm Malignant



Possible Avastin side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male

Reactions: Rash, Deep Vein Thrombosis, Disease Progression

Drug(s) suspected as cause:
Avastin
    Indication: Renal Cancer
    Start date: 2004-08-01

Tarceva
    Indication: Renal Cancer
    Start date: 2004-12-26

Other drugs received by patient: Aredia; Thalidomide; Proleukin; Zometa



Possible Avastin side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male

Reactions: Disease Progression

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Indication: Pancreatic Carcinoma

Xeloda
    Indication: Pancreatic Carcinoma

Tarceva
    Indication: Pancreatic Carcinoma



Possible Avastin side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male

Reactions: Disease Progression

Drug(s) suspected as cause:
Tarceva
    Indication: Renal Cancer

Avastin
    Indication: Renal Cancer



Possible Avastin side effects in male

Reported by a physician from Netherlands on 2012-08-27

Patient: male

Reactions: Dyspnoea, Respiratory Failure, Cardiac Arrest

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Avastin
    Indication: Colorectal Cancer
    Start date: 2010-12-06

Oxaliplatin
    Indication: Colorectal Cancer
    Start date: 2010-12-06

Xeloda
    Administration route: Oral
    Indication: Colorectal Cancer
    Start date: 2010-12-06

Other drugs received by patient: Glyburide; Rosuvastatin; Augmentin '500'; Telmisartan



Possible Avastin side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male, weighing 76.7 kg (168.7 pounds)

Reactions: Pneumonia, Pyrexia, Convulsion

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Avastin
    Indication: Glioblastoma Multiforme
    Start date: 2010-04-27
    End date: 2012-05-09

Bortezomib
    Indication: Glioblastoma Multiforme
    Start date: 2010-04-27
    End date: 2010-07-13

Other drugs received by patient: Keppra; Ascorbic Acid; Celexa; Zinc Sulfate; Finasteride; Provigil



Possible Avastin side effects in female

Reported by a consumer/non-health professional from Australia on 2012-08-27

Patient: female

Reactions: Disease Progression

Drug(s) suspected as cause:
Avastin



Possible Avastin side effects in male

Reported by a physician from Japan on 2012-08-27

Patient: male, weighing 59.0 kg (129.8 pounds)

Reactions: White Blood Cell Count Decreased, Gastrointestinal Haemorrhage, Dyspnoea, Haemoptysis, Cardio-Respiratory Arrest, Depressed Level of Consciousness, Pulmonary Thrombosis, Epistaxis, Oxygen Saturation Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Aspirin
    Dosage: dose form: enteric coating drug
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Warfarin Sodium
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Avastin
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-08-10
    End date: 2010-08-10

Other drugs received by patient: Amaryl; Transamine CAP; Carboplatin; Coniel; Allopurinol; Lasix; Adona; Candesartan Cilexetil; Aldactone; Basen; Gosha-Jinki-GAN; Paclitaxel



Possible Avastin side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male

Reactions: Brain Neoplasm

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin

Tarceva
    Indication: Product Used FOR Unknown Indication

Avastin
    Indication: Brain Neoplasm Malignant



Possible Avastin side effects in female

Reported by a physician from United States on 2012-08-27

Patient: female, weighing 84.9 kg (186.8 pounds)

Reactions: Breast Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-06-15
    End date: 2012-08-01

Avastin
    Dosage: last dose prior to event - 27/jul/2012
    Indication: Breast Cancer
    Start date: 2012-06-15

Cyclophosphamide
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-06-15
    End date: 2012-08-01



Possible Avastin side effects in female

Reported by a physician from United States on 2012-08-27

Patient: female

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin



Possible Avastin side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Indication: Bile Duct Cancer

Tarceva
    Indication: Product Used FOR Unknown Indication



Possible Avastin side effects in male

Reported by a physician from Algeria on 2012-08-27

Patient: male

Reactions: Disease Progression

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Indication: Glioblastoma

Irinotecan Hydrochloride
    Indication: Glioblastoma



Possible Avastin side effects in female

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-27

Patient: female

Reactions: Glioblastoma, White Blood Cell Count Decreased, Monocyte Count Decreased, Nausea, Alopecia, Platelet Count Decreased, Neutrophil Count Decreased

Drug(s) suspected as cause:
Avastin
    Indication: Glioblastoma
    Start date: 2012-03-23

Avastin
    Start date: 2012-07-25

Avastin
    Start date: 2012-04-04

Avastin
    Start date: 2012-05-06

Other drugs received by patient: Valproic Acid



Possible Avastin side effects in

Reported by a physician from Netherlands on 2012-08-27

Patient:

Reactions: Disease Progression

Drug(s) suspected as cause:
Carboplatin
    Indication: non-Small Cell Lung Cancer

Pemetrexed
    Indication: non-Small Cell Lung Cancer

Avastin
    Indication: non-Small Cell Lung Cancer



Possible Avastin side effects in female

Reported by a physician from United States on 2012-08-27

Patient: female

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Indication: Hepatic Neoplasm Malignant

Avastin
    Indication: Renal Cancer

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