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Anafranil (Clomipramine) - Cytolytic Hepatitis - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Cytolytic Hepatitis (12)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Anafranil (Clomipramine) where reactions include cytolytic hepatitis. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Anafranil side effects in 73 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-24

Patient: 73 year old female

Reactions: Dermo-Hypodermitis, Fungal Oesophagitis, Shock Haemorrhagic, Cytolytic Hepatitis, Cholestasis, Necrotising Fasciitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Aldactone
    Dosage: 50 mg, 1x/day
    Administration route: Oral
    End date: 2012-06-26

Anafranil
    Dosage: 75 mg, 1x/day
    Administration route: Oral
    Indication: Depression
    Start date: 2012-05-01
    End date: 2012-06-26

Levofloxacin
    Dosage: 500 mg, 2x/day
    Administration route: Oral
    Start date: 2012-05-25
    End date: 2012-06-26

Orbenin CAP
    Dosage: 3 g, 3x/day
    Start date: 2012-05-25
    End date: 2012-06-26

Other drugs received by patient: Humalog; Lyrica; Lasix; Oxycodone Hydrochloride; Ketoprofen; Penicillin G Sodium; Clindamycin HCL; Nexium; Prednisone TAB; Oxycontin; Glucophage



Possible Anafranil side effects in female

Reported by a consumer/non-health professional from France on 2012-08-16

Patient: female

Reactions: Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Anafranil
    Dosage: 150 mg, unknown
    Administration route: Oral
    Indication: Major Depression
    Start date: 2012-06-22
    End date: 2012-07-04

Anafranil
    Dosage: 75 mg, unknown
    Administration route: Oral
    Start date: 2012-07-05

Anafranil
    Dosage: unk unk, unknown
    Start date: 2012-06-20
    End date: 2012-06-21

Avastin
    Dosage: 25 mg/ml, 1x/week
    Indication: Breast Cancer Recurrent
    Start date: 2012-02-01
    End date: 2012-07-16

Largactil / 00011902 /
    Dosage: 150 - 250 df 4% drops, unknown
    Administration route: Oral
    Indication: Major Depression
    Start date: 2012-06-20
    End date: 2012-06-28

Midodrine Hydrochloride
    Dosage: 15 mg (6 tablets), unknown
    Administration route: Oral
    Indication: Orthostatic Hypotension
    Start date: 2012-06-22
    End date: 2012-07-02

Midodrine Hydrochloride
    Dosage: 30 mg (12 tablets), unknown
    Administration route: Oral
    Start date: 2012-07-03
    End date: 2012-07-16

Ondansetron
    Dosage: 1 df, 1x/week
    Administration route: Oral
    Indication: Procedural Vomiting
    Start date: 2012-02-01
    End date: 2012-07-16

Taxol
    Dosage: 1 df, 1x/week
    Indication: Breast Cancer Recurrent
    Start date: 2012-02-01
    End date: 2012-07-16

Zyprexa
    Dosage: 10 mg, unknown
    Administration route: Oral
    Indication: Major Depression
    Start date: 2012-06-28
    End date: 2012-07-16

Other drugs received by patient: Corticosteroid NOS; Esomeprazole



Possible Anafranil side effects in 65 year old female

Reported by a physician from France on 2012-08-02

Patient: 65 year old female

Reactions: Cytolytic Hepatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Anafranil
    Start date: 2012-07-05

Anafranil
    Dosage: 25 mg/ 2 ml
    Indication: Major Depression
    Start date: 2012-06-20

Anafranil
    Administration route: Oral
    Start date: 2012-06-22

Avastin
    Indication: Breast Cancer
    End date: 2012-07-16

Chlorpromazine HCL
    Indication: Major Depression
    Start date: 2012-06-20
    End date: 2012-06-28

Midodrine Hydrochloride
    End date: 2012-07-16

Midodrine Hydrochloride
    Administration route: Oral
    Indication: Orthostatic Hypotension
    Start date: 2012-06-22

Taxol
    Indication: Breast Cancer Recurrent
    End date: 2012-07-16

Zofran
    Administration route: Oral
    Indication: Vomiting
    End date: 2012-07-16

Zyprexa
    Administration route: Oral
    Indication: Major Depression
    Start date: 2012-06-28
    End date: 2012-07-16



Possible Anafranil side effects in female

Reported by a consumer/non-health professional from Denmark on 2012-08-01

Patient: female

Reactions: Cytolytic Hepatitis

Drug(s) suspected as cause:
Anafranil
    Dosage: 150 mg, unknown
    Indication: Major Depression
    Start date: 2012-06-22
    End date: 2012-07-04

Anafranil
    Dosage: 75 mg, unknown
    Administration route: Oral
    Start date: 2012-07-05

Avastin
    Dosage: 1 df, 1x/week
    Indication: Breast Cancer
    Start date: 2012-02-01
    End date: 2012-07-16

Largactil / 00011901 /
    Dosage: 250 df, unknown (150-250 df 4% drops for oral use)
    Administration route: Oral
    Indication: Major Depression
    Start date: 2012-06-20
    End date: 2012-06-28

Midodrine Hydrochloride
    Dosage: 30 mg, unknown
    Administration route: Oral
    Start date: 2012-07-03
    End date: 2012-07-16

Midodrine Hydrochloride
    Dosage: 15 mg, unknown
    Administration route: Oral
    Indication: Orthostatic Hypotension
    Start date: 2012-06-22
    End date: 2012-07-02

Ondansetron
    Dosage: 1 df, 1x/week
    Indication: Procedural Vomiting
    Start date: 2012-02-01
    End date: 2012-07-16

Taxol
    Dosage: 1 df, 1x/week
    Indication: Breast Cancer
    Start date: 2012-02-01
    End date: 2012-07-16

Zyprexa
    Dosage: 10 mg, unknown
    Administration route: Oral
    Indication: Major Depression
    Start date: 2012-06-28
    End date: 2012-07-16

Other drugs received by patient: Esomeprazole; Corticosteroid NOS



Possible Anafranil side effects in 73 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-27

Patient: 73 year old female

Reactions: Dermo-Hypodermitis, Cytolytic Hepatitis, Cholestasis, Necrotising Fasciitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Aldactone
    Dosage: 50 mg, 1x/day
    Administration route: Oral
    End date: 2012-06-26

Anafranil
    Dosage: 75 mg, 1x/day
    Administration route: Oral
    Indication: Depression
    Start date: 2012-05-01
    End date: 2012-06-26

Levofloxacin
    Dosage: 500 mg, 2x/day
    Administration route: Oral
    Start date: 2012-05-25
    End date: 2012-06-26

Orbenin CAP
    Dosage: 3 g, 3x/day
    Start date: 2012-05-25
    End date: 2012-06-26

Other drugs received by patient: Humalog; Ketoprofen; Oxycodone HCL; Penicillin G Sodium; Nexium; Lyrica; Clindamycin HCL; Glucophage; Prednisone TAB; Oxycontin; Lasix



Possible Anafranil side effects in 73 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-25

Patient: 73 year old female

Reactions: Cytolytic Hepatitis, Cholestasis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Aldactone
    Dosage: 50 mg, 1x/day
    Administration route: Oral
    End date: 2012-06-26

Anafranil
    Dosage: 75 mg, 1x/day
    Administration route: Oral
    Indication: Depression
    Start date: 2012-05-01
    End date: 2012-06-26

Levofloxacin
    Dosage: 500 mg, 2x/day
    Administration route: Oral
    Start date: 2012-05-25
    End date: 2012-06-26

Orbenin CAP
    Dosage: 3 g, 3x/day
    Start date: 2012-05-25
    End date: 2012-06-26

Other drugs received by patient: Lasix; Nexium; Clindamycin HCL; Oxycodone HCL; Prednisone TAB; Humalog; Lyrica; Ketoprofen; Penicillin G Sodium; Oxycontin; Glucophage



Possible Anafranil side effects in 52 year old male

Reported by a consumer/non-health professional from Italy on 2012-04-18

Patient: 52 year old male

Reactions: Jaundice, Liver Injury, Cytolytic Hepatitis, Blood Albumin Decreased, Hepatic Failure, Condition Aggravated, Alcoholic Liver Disease, Ascites, Hepatosplenomegaly, Hepatic Cirrhosis, Prothrombin Level Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alprazolam
    Dosage: 0.25 mg, tid
    Administration route: Oral
    Indication: Mental Disorder
    End date: 2012-01-21

Anafranil
    Dosage: 0.25 mg, tid
    Administration route: Oral
    Indication: Depression
    Start date: 2012-01-01
    End date: 2012-01-21

Escitalopram
    Dosage: 20 mg, daily
    Administration route: Oral
    Indication: Depression
    Start date: 2011-10-01
    End date: 2012-01-01

Rasilez HCT
    Dosage: 1 df, daily
    Administration route: Oral
    Indication: Hypertension
    End date: 2012-01-21

Zyprexa
    Dosage: 5 mg, daily
    Administration route: Oral
    Indication: Depression
    Start date: 2011-11-23
    End date: 2012-01-05

Other drugs received by patient: Prazepam



Possible Anafranil side effects in 52 year old male

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-04-18

Patient: 52 year old male

Reactions: Jaundice, Liver Injury, Cytolytic Hepatitis, Condition Aggravated, Blood Albumin Decreased, Hepatic Failure, Alcoholic Liver Disease, Ascites, Hepatosplenomegaly, Hepatic Cirrhosis, Prothrombin Level Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alprazolam
    Dosage: 0.25 mg, tid
    Administration route: Oral
    Indication: Mental Disorder
    End date: 2012-01-21

Anafranil
    Dosage: 0.25 mg, tid
    Administration route: Oral
    Indication: Depression
    Start date: 2012-01-01
    End date: 2012-01-21

Escitalopram
    Dosage: 20 mg, daily
    Administration route: Oral
    Indication: Depression
    Start date: 2011-10-01
    End date: 2012-01-01

Rasilez HCT
    Dosage: 1 df, daily
    Administration route: Oral
    Indication: Hypertension
    End date: 2012-01-21

Zyprexa
    Dosage: 5 mg, daily
    Administration route: Oral
    Indication: Depression
    Start date: 2011-11-23
    End date: 2012-01-05

Other drugs received by patient: Prazepam



Possible Anafranil side effects in 52 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-04-12

Patient: 52 year old male

Reactions: Liver Injury, Jaundice, Cytolytic Hepatitis, Condition Aggravated, Hepatic Failure, Blood Albumin Decreased, Prothrombin Time Prolonged, Alcoholic Liver Disease, Ascites, Hepatic Enzyme Increased, Gynaecomastia, Spider Vein, Hepatomegaly, Hepatosplenomegaly, Hepatic Cirrhosis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alprazolam
    Dosage: 0.25 mg, tid
    End date: 2012-01-21

Anafranil
    Dosage: 37.5 mg, qd
    End date: 2012-01-21

Escitalopram
    Dosage: 20 mg, qd
    Indication: Depression
    End date: 2012-01-01

Rasilez HCT
    Dosage: 1 df, unk
    Administration route: Oral
    Indication: Hypertension
    End date: 2012-01-21

Zyprexa
    Dosage: 5 mg, qd
    Indication: Depression
    End date: 2012-01-05

Other drugs received by patient: Prazepam



Possible Anafranil side effects in 52 year old male

Reported by a physician from France on 2012-04-12

Patient: 52 year old male

Reactions: Liver Injury, Jaundice, Cytolytic Hepatitis, Condition Aggravated, Hepatic Failure, Alcoholic Liver Disease, Ascites, Hepatic Enzyme Increased, Gynaecomastia, Hepatomegaly, Hepatic Cirrhosis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alprazolam
    Dosage: 0.25 mg, tid
    End date: 2012-01-21

Anafranil
    Dosage: 37.5 mg, qd
    End date: 2012-01-21

Escitalopram Oxalate
    Dosage: 20 mg, qd
    Indication: Depression
    End date: 2012-01-01

Rasilez HCT
    Dosage: 1 df, unk
    Administration route: Oral
    Indication: Hypertension
    End date: 2012-01-21

Zyprexa
    Dosage: 5 mg, qd
    Indication: Depression
    End date: 2012-01-05

Other drugs received by patient: Prazepam



Possible Anafranil side effects in 52 year old male

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-04-12

Patient: 52 year old male

Reactions: Liver Injury, Jaundice, Cytolytic Hepatitis, Condition Aggravated, Blood Albumin Decreased, Hepatic Failure, Alcoholic Liver Disease, Ascites, Prothrombin Level Decreased, Hepatic Cirrhosis, Hepatosplenomegaly

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alprazolam
    Dosage: 0.25 mg, tid
    Administration route: Oral
    Indication: Mental Disorder
    End date: 2012-01-21

Anafranil
    Dosage: 0.25 mg, tid
    Administration route: Oral
    Indication: Depression
    Start date: 2012-01-01
    End date: 2012-01-21

Escitalopram
    Dosage: 20 mg, daily
    Administration route: Oral
    Indication: Depression
    Start date: 2011-10-01
    End date: 2012-01-01

Rasilez HCT
    Dosage: 1 df, daily
    Administration route: Oral
    Indication: Hypertension
    End date: 2012-01-21

Zyprexa
    Dosage: 5 mg, daily
    Administration route: Oral
    Indication: Depression
    Start date: 2011-11-23
    End date: 2012-01-05

Other drugs received by patient: Prazepam



Possible Anafranil side effects in 52 year old male

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-04-12

Patient: 52 year old male

Reactions: Liver Injury, Jaundice, Cytolytic Hepatitis, Blood Albumin Decreased, Condition Aggravated, Hepatic Failure, Alcoholic Liver Disease, Ascites, Hepatosplenomegaly, Hepatic Cirrhosis, Prothrombin Level Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alprazolam
    Dosage: 0.25 mg, tid
    Administration route: Oral
    Indication: Mental Disorder
    End date: 2012-01-21

Anafranil
    Dosage: 0.25 mg, tid
    Administration route: Oral
    Indication: Depression
    Start date: 2012-01-01
    End date: 2012-01-21

Escitalopram
    Dosage: 20 mg, daily
    Administration route: Oral
    Indication: Depression
    Start date: 2011-10-01
    End date: 2012-01-01

Rasilez HCT
    Dosage: 1 df, daily
    Administration route: Oral
    Indication: Hypertension
    End date: 2012-01-21

Zyprexa
    Dosage: 5 mg, daily
    Administration route: Oral
    Indication: Depression
    Start date: 2011-11-23
    End date: 2012-01-05

Other drugs received by patient: Prazepam

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