Index of reports
> Cases with Cholestasis (9)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Anafranil (Clomipramine) where reactions include cholestasis. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Anafranil side effects in 73 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-24
Patient: 73 year old female
Reactions: Dermo-Hypodermitis, Fungal Oesophagitis, Shock Haemorrhagic, Cytolytic Hepatitis, Cholestasis, Necrotising Fasciitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Aldactone
Dosage: 50 mg, 1x/day
Administration route: Oral
End date: 2012-06-26
Anafranil
Dosage: 75 mg, 1x/day
Administration route: Oral
Indication: Depression
Start date: 2012-05-01
End date: 2012-06-26
Levofloxacin
Dosage: 500 mg, 2x/day
Administration route: Oral
Start date: 2012-05-25
End date: 2012-06-26
Orbenin CAP
Dosage: 3 g, 3x/day
Start date: 2012-05-25
End date: 2012-06-26
Other drugs received by patient: Humalog; Lyrica; Lasix; Oxycodone Hydrochloride; Ketoprofen; Penicillin G Sodium; Clindamycin HCL; Nexium; Prednisone TAB; Oxycontin; Glucophage
Possible Anafranil side effects in 65 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-21
Patient: 65 year old female
Reactions: Urticaria, Hepatocellular Injury, Cholestasis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Anafranil
Dosage: 150 mg, 1x/day
Administration route: Oral
Indication: Major Depression
Start date: 2012-06-22
Avastin
Dosage: unk
Indication: Breast Cancer
Start date: 2012-02-01
End date: 2012-07-16
Chlorpromazine HCL
Dosage: 200 drop(s)
Administration route: Oral
Indication: Major Depression
Start date: 2012-06-20
End date: 2012-06-28
Midodrine Hydrochloride
Dosage: unk
Administration route: Oral
Indication: Orthostatic Hypotension
Start date: 2012-06-22
End date: 2012-07-16
Paclitaxel
Dosage: unk
Indication: Breast Cancer Recurrent
Start date: 2012-02-01
End date: 2012-07-16
Zofran
Dosage: 8 mg, weekly
Administration route: Oral
Indication: Vomiting
Start date: 2012-02-01
End date: 2012-07-16
Zyprexa
Dosage: 10 mg, 1x/day
Administration route: Oral
Indication: Major Depression
Start date: 2012-06-28
End date: 2012-07-16
Other drugs received by patient: Nexium
Possible Anafranil side effects in 65 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-08
Patient: 65 year old female
Reactions: Hepatocellular Injury, Urticaria, Cholestasis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Anafranil
Dosage: 150 mg, 1x/day
Administration route: Oral
Indication: Major Depression
Start date: 2012-06-22
Avastin
Dosage: unk
Indication: Breast Cancer
Start date: 2012-02-01
End date: 2012-07-16
Chlorpromazine HCL
Dosage: 200 drop(s)
Administration route: Oral
Indication: Major Depression
Start date: 2012-06-20
End date: 2012-06-28
Midodrine Hydrochloride
Dosage: unk
Administration route: Oral
Indication: Orthostatic Hypotension
Start date: 2012-06-22
End date: 2012-07-16
Paclitaxel
Dosage: unk
Indication: Breast Cancer Recurrent
Start date: 2012-02-01
End date: 2012-07-16
Zofran
Dosage: unk
Administration route: Oral
Indication: Vomiting
Start date: 2012-02-01
End date: 2012-07-16
Zyprexa
Dosage: 10 mg, unk
Administration route: Oral
Indication: Major Depression
Start date: 2012-06-28
End date: 2012-07-16
Other drugs received by patient: Esomeprazole
Possible Anafranil side effects in female
Reported by a physician from France on 2012-08-02
Patient: female
Reactions: Urticaria, Hepatocellular Injury, Cholestasis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Anafranil
Dosage: 150mg per day
Administration route: Oral
Indication: Major Depression
Start date: 2012-06-22
Avastin
Dosage: 25mgml weekly
Indication: Breast Cancer
Start date: 2012-02-01
End date: 2012-07-16
Chlorpromazine HCL
Dosage: 200drop per day
Administration route: Oral
Indication: Major Depression
Start date: 2012-06-20
End date: 2012-06-28
Midodrine Hydrochloride
Administration route: Oral
Indication: Orthostatic Hypotension
Start date: 2012-06-22
End date: 2012-07-16
Taxol
Indication: Breast Cancer Recurrent
Start date: 2012-02-01
End date: 2012-07-16
Zofran
Dosage: 8mg weekly
Administration route: Oral
Indication: Vomiting
Start date: 2012-02-01
End date: 2012-07-16
Zyprexa
Dosage: 10mg per day
Administration route: Oral
Indication: Major Depression
Start date: 2012-06-28
End date: 2012-07-16
Other drugs received by patient: Nexium; Corticoid
Possible Anafranil side effects in 73 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-27
Patient: 73 year old female
Reactions: Dermo-Hypodermitis, Cytolytic Hepatitis, Cholestasis, Necrotising Fasciitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Aldactone
Dosage: 50 mg, 1x/day
Administration route: Oral
End date: 2012-06-26
Anafranil
Dosage: 75 mg, 1x/day
Administration route: Oral
Indication: Depression
Start date: 2012-05-01
End date: 2012-06-26
Levofloxacin
Dosage: 500 mg, 2x/day
Administration route: Oral
Start date: 2012-05-25
End date: 2012-06-26
Orbenin CAP
Dosage: 3 g, 3x/day
Start date: 2012-05-25
End date: 2012-06-26
Other drugs received by patient: Humalog; Ketoprofen; Oxycodone HCL; Penicillin G Sodium; Nexium; Lyrica; Clindamycin HCL; Glucophage; Prednisone TAB; Oxycontin; Lasix
Possible Anafranil side effects in 73 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-25
Patient: 73 year old female
Reactions: Cytolytic Hepatitis, Cholestasis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Aldactone
Dosage: 50 mg, 1x/day
Administration route: Oral
End date: 2012-06-26
Anafranil
Dosage: 75 mg, 1x/day
Administration route: Oral
Indication: Depression
Start date: 2012-05-01
End date: 2012-06-26
Levofloxacin
Dosage: 500 mg, 2x/day
Administration route: Oral
Start date: 2012-05-25
End date: 2012-06-26
Orbenin CAP
Dosage: 3 g, 3x/day
Start date: 2012-05-25
End date: 2012-06-26
Other drugs received by patient: Lasix; Nexium; Clindamycin HCL; Oxycodone HCL; Prednisone TAB; Humalog; Lyrica; Ketoprofen; Penicillin G Sodium; Oxycontin; Glucophage
Possible Anafranil side effects in male
Reported by a health professional (non-physician/pharmacist) from France on 2012-04-09
Patient: male
Reactions: Cholestasis, Pulmonary Arterial Hypertension, Scleroderma, DRY Skin, Salivary Gland Disorder, C-Reactive Protein Increased, Sialoadenitis, Nodule, Borrelia Infection, Hypergammaglobulinaemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acetaminophen
Administration route: Oral
Start date: 2010-11-01
Acetaminophen
Dosage: 3 g, daily
Administration route: Oral
Start date: 2005-01-01
Anafranil
Dosage: 100 mg, daily
Administration route: Oral
Start date: 2011-04-02
Celiprolol
Dosage: 200 mg, daily
Administration route: Oral
Start date: 2005-01-01
Morphine Sulfate
Administration route: Oral
Start date: 2006-07-01
Morphine Sulfate
Administration route: Oral
Start date: 2010-11-01
Morphine Sulfate
Start date: 2010-11-01
Morphine Sulfate
Administration route: Oral
Start date: 2006-10-01
Motilium
Administration route: Oral
Start date: 2006-07-01
Omeprazole
Administration route: Oral
Start date: 2005-01-01
Pamidronic Acid
Dosage: 60 mg, unk
Start date: 2011-12-12
End date: 2011-12-12
Pamidronic Acid
Dosage: 60 mg, unk
Start date: 2011-11-02
Pamidronic Acid
Dosage: 60 mg, unk
Start date: 2011-10-17
Pamidronic Acid
Dosage: 60 mg, unk
Start date: 2011-11-14
Voltaren
Dosage: 75 mg, daily
Administration route: Oral
Start date: 2010-11-01
Possible Anafranil side effects in male
Reported by a health professional (non-physician/pharmacist) from France on 2012-04-03
Patient: male
Reactions: Cholestasis, Pulmonary Arterial Hypertension, Scleroderma, DRY Skin, Monoclonal Gammopathy, C-Reactive Protein Increased, Salivary Gland Enlargement, Borrelia Infection, Nodule
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acetaminophen
Administration route: Oral
Start date: 2010-11-01
Acetaminophen
Dosage: 3 g, daily
Administration route: Oral
Start date: 2005-01-01
Anafranil
Dosage: 100 mg, daily
Administration route: Oral
Start date: 2011-04-02
Celiprolol
Dosage: 200 mg, daily
Administration route: Oral
Start date: 2005-01-01
Morphine Sulfate
Start date: 2010-11-01
Morphine Sulfate
Administration route: Oral
Start date: 2006-10-01
Morphine Sulfate
Administration route: Oral
Start date: 2010-11-01
Morphine Sulfate
Administration route: Oral
Start date: 2006-07-01
Motilium
Administration route: Oral
Start date: 2006-07-01
Omeprazole
Administration route: Oral
Start date: 2005-01-01
Pamidronic Acid
Dosage: 60 mg, unk
Start date: 2011-11-14
Pamidronic Acid
Dosage: 60 mg, unk
Start date: 2011-11-02
Pamidronic Acid
Dosage: 60 mg, unk
Start date: 2011-10-17
Pamidronic Acid
Dosage: 60 mg, unk
Start date: 2011-12-12
End date: 2011-12-12
Voltaren
Dosage: 75 mg, daily
Administration route: Oral
Start date: 2010-11-01
Possible Anafranil side effects in 48 year old male
Reported by a physician from France on 2012-04-02
Patient: 48 year old male
Reactions: Blood Alkaline Phosphatase Increased, Biliary Cirrhosis Primary, Renal Cancer, Pancytopenia, Pulmonary Arterial Hypertension, Cholestasis, Scleroderma, Gamma-Glutamyltransferase Increased, C-Reactive Protein Increased, Sialoadenitis, Hypergammaglobulinaemia, Lyme Disease, Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acetaminophen
Administration route: Oral
Start date: 2005-01-01
Anafranil
Dosage: 100 mg daily ( 25 mg in the meroning and 75 mg in the evening)
Administration route: Oral
Start date: 2011-04-02
Celiprolol
Administration route: Oral
Start date: 2005-01-01
Morphine Sulfate
Administration route: Oral
Start date: 2006-10-01
Morphine Sulfate
Administration route: Oral
Start date: 2006-07-01
Motilium
Administration route: Oral
Start date: 2006-07-01
Omeprazole
Administration route: Oral
Start date: 2005-01-01
Pamidronate Disodium
Start date: 2011-10-17
End date: 2011-12-12
Voltaren
Administration route: Oral
Start date: 2010-11-01
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