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Index of reports
> Cases with Coma ()
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Alprazolam where reactions include coma. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Alprazolam side effects in 76 year old female
Reported by a physician from Italy on 2012-08-08
Patient: 76 year old female
Reactions: Hepatitis C Antibody Positive, Drug Screen Positive, Encephalopathy, Coma, Sopor, Drug Abuse, Heart Rate Increased, Senile Dementia, Hepatic Cirrhosis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Sereprile
Dosage: 2 df, daily
Administration route: Oral
Indication: Senile Psychosis
Start date: 2012-06-28
End date: 2012-07-23
Alprazolam
Dosage: 0.25 mg, daily
Administration route: Oral
Start date: 2012-07-18
End date: 2012-07-23
Other drugs received by patient: Konakion; Nexium; Lasix; Rifaximin; Aldactone
Possible Alprazolam side effects in female
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-08-07
Patient: female
Reactions: Coma, Drug Abuse, Sopor
Drug(s) suspected as cause:
Sereprile
Administration route: Oral
Indication: Senile Dementia
Start date: 2012-06-28
End date: 2012-07-23
Alprazolam
Start date: 2012-07-18
End date: 2012-07-23
Other drugs received by patient: Konakion; Konakion; Lasix; Nexium; Rifaximin; Aldactone
Possible Alprazolam side effects in 76 year old female
Reported by a physician from Italy on 2012-08-03
Patient: 76 year old female
Reactions: Drug Screen Positive, Heart Rate Increased, Coma, Drug Abuse, Sopor
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Sereprile
Dosage: 2 df, daily
Administration route: Oral
Indication: Senile Psychosis
Start date: 2012-06-28
End date: 2012-07-23
Alprazolam
Dosage: 0.25 mg, daily
Administration route: Oral
Start date: 2012-07-18
End date: 2012-07-23
Other drugs received by patient: Aldactone; Rifaximin; Lasix; Nexium; Konakion
Possible Alprazolam side effects in 69 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-27
Patient: 69 year old female
Reactions: Metabolic Acidosis, Pneumonia Aspiration, Hypothermia, Incorrect Dose Administered, Disseminated Intravascular Coagulation, Coma, Continuous Haemodiafiltration, Lactic Acidosis, Toxicity To Various Agents, Multi-Organ Failure, Shock, Renal Failure Acute
Adverse event resulted in: death
Drug(s) suspected as cause:
Glucovance
Dosage: 60 tablets
Indication: Product Used FOR Unknown Indication
Alprazolam
Dosage: 0.50 mg, 60 tabs
Indication: Product Used FOR Unknown Indication
Tercian (Cyamemazine)
Dosage: 25 mg, 60 tabs
Indication: Product Used FOR Unknown Indication
Lithium Carbonate
Dosage: 400 mg, 60 tabs
Indication: Product Used FOR Unknown Indication
Metfformin Hydrochloride
Dosage: 30 gm
Indication: Product Used FOR Unknown Indication
Effexor
Dosage: 75 mg, 30 tablets
Indication: Product Used FOR Unknown Indication
Possible Alprazolam side effects in 69 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-23
Patient: 69 year old female
Reactions: Hypotension, Disseminated Intravascular Coagulation, Coma, Lactic Acidosis, Toxicity To Various Agents, Multi-Organ Failure, Hypoxia, Bradycardia, Shock, Renal Failure Acute
Adverse event resulted in: death
Drug(s) suspected as cause:
Alprazolam
Dosage: 0.50 mg, 60 tabs
Tercian
Dosage: 25 mg, 60 tabs
Lithium Carbonate
Dosage: 400 mg, 60 tabs
Glucovance
Dosage: 60 tablets
Metformin HCL
Dosage: 30 g, unk
Effexor
Dosage: 75 mg, 30 tablets
Possible Alprazolam side effects in 56 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-13
Patient: 56 year old female
Reactions: Hepatic Encephalopathy, Cytolytic Hepatitis, Coma, Septic Shock, Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Duragesic-100
End date: 2011-10-06
Morphine Sulfate
Indication: Neuroblastoma
End date: 2011-10-06
Duragesic-100
Indication: Neuroblastoma
Alprazolam
Indication: Product Used FOR Unknown Indication
End date: 2011-10-06
Other drugs received by patient: Acetaminophen; Prozac
Possible Alprazolam side effects in 56 year old female
Reported by a physician from France on 2012-07-13
Patient: 56 year old female
Reactions: Cytolytic Hepatitis, Coma, Septic Shock, Renal Failure Acute
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Duragesic-100
Dosage: 1df=25 to 50 mg
Indication: Neuroblastoma
End date: 2011-10-06
Cisplatin
Dosage: 2nd course on 20-sep-2011
Indication: Neuroblastoma
Start date: 2011-08-31
Alprazolam
End date: 2011-10-06
Morphine Sulfate
Indication: Neuroblastoma
End date: 2011-10-06
Acetaminophen
Indication: Pain
Other drugs received by patient: Prozac
Possible Alprazolam side effects in 63 year old female
Reported by a physician from United States on 2012-07-11
Patient: 63 year old female, weighing 55.0 kg (121.0 pounds)
Reactions: Coma, Multiple Drug Overdose Intentional, Suicide Attempt
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tylenol TAB
Indication: Product Used FOR Unknown Indication
Ibuprofen
Indication: Product Used FOR Unknown Indication
Tylenol TAB
Alprazolam
Indication: Product Used FOR Unknown Indication
Doxepin
Indication: Product Used FOR Unknown Indication
Possible Alprazolam side effects in 63 year old female
Reported by a physician from United States on 2012-07-10
Patient: 63 year old female, weighing 55.0 kg (121.0 pounds)
Reactions: Multiple Drug Overdose Intentional, Suicide Attempt, Coma
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Alprazolam
Dosage: unk
Indication: Product Used FOR Unknown Indication
Doxepin HCL
Dosage: unk
Indication: Product Used FOR Unknown Indication
Ibuprofen
Dosage: unk
Indication: Product Used FOR Unknown Indication
Acetaminophen
Dosage: unk
Indication: Product Used FOR Unknown Indication
Possible Alprazolam side effects in 36 year old female
Reported by a physician from Taiwan, Province of China on 2012-05-25
Patient: 36 year old female
Reactions: Disseminated Intravascular Coagulation, Coma, Muscle Rigidity, Hyperhidrosis, Ecchymosis, Circulatory Collapse, Mouth Haemorrhage, Hypotension, General Physical Health Deterioration, Toxicity To Various Agents, Tremor, Electrocardiogram QT Prolonged, Rhabdomyolysis, Hyperthermia, Ventricular Arrhythmia, Intentional Drug Misuse, Extensor Plantar Response, Shift To THE Left, Electrocardiogram QRS Complex Prolonged, Thrombocytopenia, Oxygen Saturation Decreased, Blood Glucose Increased, Hypertonia, Mydriasis, Hyperreflexia, Muscle Twitching, Renal Failure, Respiratory Failure, Bradycardia, Sinus Tachycardia, Blood Pressure Decreased, Leukocytosis
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Moclobemide (Moclobemide)
Dosage: 4500 mg;1x
Alprazolam
Dosage: 15 mg;1x
Lorazepam
Dosage: 10 mg;1x
Estazolam
Dosage: 20 mg;1x
Midazolam HCL
Dosage: 75 mg;1x
Bromazepam (Bromazepam)
Dosage: 60 mg;1x
Fluoxetine Hydrochloride
Dosage: 200 mg;1x
Alprazolam
Dosage: 300 mg;1x
Possible Alprazolam side effects in 36 year old female
Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2012-05-11
Patient: 36 year old female
Reactions: Electrocardiogram QT Prolonged, Blood Creatine Phosphokinase Increased, Disseminated Intravascular Coagulation, Coma, Ventricular Arrhythmia, Drug Interaction, Serotonin Syndrome, Extensor Plantar Response, Electrocardiogram QRS Complex Prolonged, Circulatory Collapse, Multiple Drug Overdose Intentional, Thrombocytopenia, Oxygen Saturation Decreased, Blood Glucose Increased, Mouth Haemorrhage, Toxicity To Various Agents, Blood Creatine Increased, Bradycardia, Sinus Tachycardia, Leukocytosis
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Lorazepam
Dosage: 10 mg,
Indication: Product Used FOR Unknown Indication
Fluoxetine
Dosage: 200 mg
Indication: Product Used FOR Unknown Indication
Bromazepam (Formulation Unknown) (Generic) (Bromazepam)
Dosage: 60 mg,
Indication: Product Used FOR Unknown Indication
Alprazolam
Dosage: 15 mg,
Indication: Product Used FOR Unknown Indication
Midazolam
Dosage: 75 mg,
Indication: Product Used FOR Unknown Indication
Estazolam
Dosage: 20 mg
Indication: Product Used FOR Unknown Indication
Propranolol Hydrochloride
Dosage: 300 mg
Indication: Product Used FOR Unknown Indication
Moclobemide (Formulation Unknown) (Moclobemide)
Dosage: 4500 mg
Indication: Product Used FOR Unknown Indication
Possible Alprazolam side effects in female
Reported by a physician from United States on 2012-05-08
Patient: female
Reactions: Overdose, Coma, Drug Interaction
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Alprazolam
Indication: Product Used FOR Unknown Indication
Xyrem
Dosage: oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Other drugs received by patient: Unspecified Benzodiazepine
Possible Alprazolam side effects in 55 year old female
Reported by a consumer/non-health professional from China on 2012-04-17
Patient: 55 year old female
Reactions: Abdominal Discomfort, Coma
Drug(s) suspected as cause:
Glucobay
Dosage: 270 df, once
Administration route: Oral
Indication: Depression
Start date: 2012-04-04
Alprazolam
Dosage: 100 df, once
Administration route: Oral
Indication: Depression
Start date: 2012-04-04
Possible Alprazolam side effects in 63 year old female
Reported by a physician from United States on 2012-04-11
Patient: 63 year old female, weighing 55.0 kg (121.0 pounds)
Reactions: Coma, Multiple Drug Overdose Intentional, Suicide Attempt
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Ibuprofen
Indication: Product Used FOR Unknown Indication
Acetaminophen
Indication: Product Used FOR Unknown Indication
Doxepin HCL
Indication: Product Used FOR Unknown Indication
Alprazolam
Indication: Product Used FOR Unknown Indication
Possible Alprazolam side effects in 63 year old female
Reported by a physician from United States on 2012-04-04
Patient: 63 year old female, weighing 55.0 kg (121.0 pounds)
Reactions: Multiple Drug Overdose Intentional, Suicide Attempt, Coma
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tylenol TAB
Alprazolam
Indication: Product Used FOR Unknown Indication
Doxepin HCL
Indication: Product Used FOR Unknown Indication
Tylenol TAB
Indication: Product Used FOR Unknown Indication
Ibuprofen
Indication: Product Used FOR Unknown Indication
Possible Alprazolam side effects in 36 year old female
Reported by a physician from Taiwan, Province of China on 2012-04-02
Patient: 36 year old female
Reactions: Electrocardiogram QT Prolonged, Disseminated Intravascular Coagulation, Ventricular Arrhythmia, Coma, Serotonin Syndrome, Shift To THE Left, Electrocardiogram QRS Complex Prolonged, Multiple Drug Overdose Intentional, Circulatory Collapse, Blood Creatinine Increased, Thrombocytopenia, Blood Glucose Increased, Antidepressant Drug Level Below Therapeutic, Renal Failure, Respiratory Failure, Bradycardia, Sinus Tachycardia, Blood Pressure Decreased
Adverse event resulted in: death
Drug(s) suspected as cause:
Lorazepam
Dosage: 1 mg
Lorazepam
Dosage: 10 mg
Fluoxetine
Dosage: 20 mg
Estazolam
Dosage: 20 mg
Midazolam
Dosage: 7.5 mg
Fluoxetine
Dosage: 200 mg
Estazolam
Dosage: 2 mg
Midazolam
Dosage: 75 mg
Bromazepam
Dosage: 60 mg
Alprazolam
Dosage: 1.5 mg
Moclobemide
Dosage: 4500 mg
Propranolol
Dosage: 30 mg
Propranolol
Dosage: 300 mg
Moclobemide
Dosage: 450 mg
Alprazolam
Dosage: 15 mg
Bromazepam
Dosage: 6 mg
Possible Alprazolam side effects in 47 year old female
Reported by a physician from Spain on 2012-03-28
Patient: 47 year old female
Reactions: Intentional Overdose, Coma
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Seroquel
Dosage: 1g
Administration route: Oral
Start date: 2011-09-07
End date: 2011-09-07
Acetaminophen
Dosage: 6.5 g
Administration route: Oral
Indication: Pain
Start date: 2011-09-07
End date: 2011-09-07
Alcohol
Seroquel
Administration route: Oral
Indication: Suicide Attempt
Start date: 2011-04-01
End date: 2011-09-06
Seroquel
Dosage: 1g
Administration route: Oral
Start date: 2011-09-07
End date: 2011-09-07
Seroquel
Administration route: Oral
Indication: Depression
Start date: 2011-04-01
End date: 2011-09-06
Topiramate
Administration route: Oral
Indication: Depression
Start date: 2011-04-01
End date: 2011-09-07
Alprazolam
Dosage: 20 mg
Administration route: Oral
Indication: Suicide Attempt
Start date: 2011-09-07
End date: 2011-09-07
Other drugs received by patient: Venlafaxien
Possible Alprazolam side effects in 36 year old female
Reported by a physician from Taiwan, Province of China on 2012-03-26
Patient: 36 year old female
Reactions: Unresponsive To Stimuli, Disseminated Intravascular Coagulation, Coma, Serotonin Syndrome, Muscle Rigidity, Hyperhidrosis, Ecchymosis, Circulatory Collapse, Pupillary Reflex Impaired, Respiratory Rate Increased, Mouth Haemorrhage, Hypotension, Tremor, Antidepressant Drug Level Below Therapeutic, Electrocardiogram QT Prolonged, Rhabdomyolysis, Hyperthermia, Chills, Blood PH Decreased, Ventricular Arrhythmia, Extensor Plantar Response, PO2 Decreased, Shift To THE Left, Electrocardiogram QRS Complex Prolonged, Completed Suicide, Multiple Drug Overdose Intentional, Blood Glucose Increased, Hypertonia, Oxygen Saturation Decreased, Mydriasis, Hyperreflexia, Muscle Twitching, Renal Failure, Bradycardia, Sinus Tachycardia, Leukocytosis
Adverse event resulted in: death
Drug(s) suspected as cause:
Alprazolam
Dosage: 15 mg, 1 x not the prescribed amount) (2 mg, qd, at bedtime)
Indication: Product Used FOR Unknown Indication
Midazolam HCL
Dosage: 75 mg, 1 x not the prescribed amount) (6 mg, at bedtime)
Indication: Product Used FOR Unknown Indication
Bromazepam (Bromazepam)
Dosage: 60 mg 1x, not the prescribed amount), (5 mg, qd, a bedtime)
Indication: Product Used FOR Unknown Indication
Lorazepam
Dosage: 10 mg, 1x, not the prescribed amount), (1 mg, qd at bedtime)
Indication: Product Used FOR Unknown Indication
Moclobemide (Moclobemide)
Dosage: 4500 mg 1x, not the presribed amount, (150 mg, tid)
Indication: Product Used FOR Unknown Indication
Propranolol
Dosage: 300 mg, 1 x not the prescribed amount, (10 mg, tid)
Indication: Product Used FOR Unknown Indication
Estazolam
Dosage: 20 mg, 1 x, not the prescribed amount (2 mg, qd, at bedtime)
Indication: Product Used FOR Unknown Indication
Midazolam HCL
Dosage: 75 mg 1x, not the prescribed amount, 7.5 mg qd, at bedtime
Indication: Product Used FOR Unknown Indication
Fluoxetine
Dosage: 200 mg, 1 x not the prescribed amount), (20 mg, qd)
Indication: Product Used FOR Unknown Indication
Possible Alprazolam side effects in 47 year old female
Reported by a physician from Spain on 2012-03-23
Patient: 47 year old female
Reactions: Intentional Overdose, Coma
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Alprazolam
Dosage: 20 mg, 1x/day
Administration route: Oral
Indication: Suicide Attempt
Start date: 2011-09-07
End date: 2011-09-07
Acetaminophen
Dosage: 6.5 g, 1x/day
Administration route: Oral
Indication: Pain
Start date: 2011-09-07
End date: 2011-09-07
Venlafaxine HCL
Dosage: unk
Quetiapine
Dosage: 100 mg, 1x/day
Administration route: Oral
Indication: Depression
Start date: 2011-04-01
End date: 2011-09-06
Topiramate
Dosage: 100 mg, 1x/day
Administration route: Oral
Indication: Depression
Start date: 2011-04-01
End date: 2011-09-07
Seroquel
Dosage: 1 g, 1x/day
Administration route: Oral
Indication: Suicide Attempt
Start date: 2011-09-07
End date: 2011-09-07
Possible Alprazolam side effects in 36 year old female
Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2012-03-05
Patient: 36 year old female
Reactions: Drug Level Increased, Hyperthermia, Intentional Overdose, Chills, Disseminated Intravascular Coagulation, Coma, Ventricular Arrhythmia, Serotonin Syndrome, Hyperhidrosis, Extensor Plantar Response, Muscle Rigidity, Ecchymosis, Circulatory Collapse, Thrombocytopenia, Blood Glucose Increased, Pupillary Reflex Impaired, Mydriasis, Mouth Haemorrhage, Hypotension, Hyperreflexia, Muscle Twitching, Convulsion, Tremor, Bradycardia, Leukocytosis, Sinus Tachycardia
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Bromazepam
Dosage: 60 mg, unk
Lorazepam
Dosage: 10 mg, unk
Moclobemide
Dosage: 4500 mg, unk
Alprazolam
Dosage: 15 mg, unk
Fluoxetine
Dosage: 200 mg, unk
Midazolam
Dosage: 75 mg, unk
Estazolam
Dosage: 20 mg, unk
Propranolol
Dosage: 300 mg, unk
Possible Alprazolam side effects in 36 year old female
Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2012-01-20
Patient: 36 year old female
Reactions: Electrocardiogram QT Prolonged, Rhabdomyolysis, Intentional Overdose, Unresponsive To Stimuli, Disseminated Intravascular Coagulation, Chills, Blood PH Decreased, Ventricular Arrhythmia, Coma, Serotonin Syndrome, Hyperhidrosis, Muscle Rigidity, Electrocardiogram QRS Complex Prolonged, Completed Suicide, Multiple Drug Overdose Intentional, Circulatory Collapse, Blood Glucose Increased, Pupillary Reflex Impaired, Respiratory Rate Increased, Mydriasis, Hypotension, Muscle Twitching, Convulsion, Tremor, Renal Failure, Respiratory Failure, Nervous System Disorder, Bradycardia, Leukocytosis, Sinus Tachycardia
Adverse event resulted in: death
Drug(s) suspected as cause:
Alprazolam
Dosage: 15 mg
Lorazepam
Dosage: 10 mg
Estazolam
Dosage: 2 mg, 1x/day
Moclobemide
Dosage: 150 mg, 3x/day
Estazolam
Dosage: 20 mg
Bromazepam
Dosage: 6 mg, 1x/day
Midazolam
Dosage: 7.5 mg, at bedtime
Propranolol HCL
Dosage: 10 mg, 3x/day
Propranolol HCL
Dosage: 300 mg
Moclobemide
Dosage: 4,500 mg
Fluoxetine
Dosage: 20 mg, 1x/day
Alprazolam
Dosage: 0.5 mg, 3x/day
Lorazepam
Dosage: 1 mg, 1x/day
Fluoxetine
Dosage: 200 mg
Bromazepam
Dosage: 60 mg
Midazolam
Dosage: 75 mg
Possible Alprazolam side effects in 25 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-17
Patient: 25 year old male
Reactions: Hypothermia, Intentional Overdose, Hypotension, Coma, Atrioventricular Block Second Degree, Brain Stem Syndrome, Suicide Attempt, Areflexia
Drug(s) suspected as cause:
Alprazolam
Dosage: (30 mg 1x)
Indication: Product Used FOR Unknown Indication
Baclofen
Dosage: (720 mg 1x)
Indication: Product Used FOR Unknown Indication
Possible Alprazolam side effects in female
Reported by a physician from Greece on 2011-12-27
Patient: female
Reactions: Miosis, Hypotension, Tachycardia, Suicide Attempt, Coma
Drug(s) suspected as cause:
Alprazolam
Dosage: unk
Indication: Product Used FOR Unknown Indication
Start date: 2011-12-01
Ibuprofen
Dosage: 17 tablets; total amount :10200
Indication: Product Used FOR Unknown Indication
Start date: 2011-12-01
Pantozol / 01263204 /
Dosage: unknown amount
Indication: Product Used FOR Unknown Indication
Start date: 2011-12-01
Levothyroxine Sodium
Dosage: 12 tablets
Indication: Product Used FOR Unknown Indication
Start date: 2011-12-01
Ferrous Sulfate TAB
Dosage: unk
Indication: Product Used FOR Unknown Indication
Start date: 2011-12-01
Diazepam
Dosage: 250 mg
Indication: Product Used FOR Unknown Indication
Start date: 2011-12-01
Possible Alprazolam side effects in 23 year old male
Reported by a consumer/non-health professional from Sweden on 2011-12-22
Patient: 23 year old male
Reactions: Mania, Condition Aggravated, Suicide Attempt, Coma
Drug(s) suspected as cause:
Alprazolam
Dosage: 2mg, unk
Alprazolam
Dosage: 2 mg, 3x/day
Possible Alprazolam side effects in 37 year old male
Reported by a health professional (non-physician/pharmacist) on 2011-10-12
Patient: 37 year old male
Reactions: Pneumonia Aspiration, Coma, Intentional Drug Misuse, Toxicity To Various Agents
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Paroxetine HCL
Dosage: unknown
Indication: Product Used FOR Unknown Indication
End date: 2009-02-04
Alprazolam
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2009-02-05
End date: 2009-02-05
Alprazolam
Dosage: unknown
Indication: Product Used FOR Unknown Indication
End date: 2009-02-04
Atarax
Dosage: unknown
Indication: Product Used FOR Unknown Indication
End date: 2009-02-04
Atarax
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2009-02-05
End date: 2009-02-05
Paroxetine HCL
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2009-02-05
End date: 2009-02-05
Lormetazepam (Lormetazepam)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2009-02-05
End date: 2009-02-05
Lormetazepam (Lormetazepam)
Dosage: unknown
Indication: Product Used FOR Unknown Indication
End date: 2009-02-04
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