This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Alphagan (Brimonidine) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (33)
Life Threatening Events (2)
Disability (3)
Reports by Reaction Type
Drug Hypersensitivity (6),
Ocular Hyperaemia (6),
Eye Pain (5),
Dizziness (4),
Eyelid Oedema (3),
Eye Irritation (3),
Erythema (3),
Malaise (3),
DRY Mouth (3),
Eye Pruritus (3),
Insomnia (3),
Lacrimation Increased (3)
Below are a few examples of reports where side effects / adverse reactions may be related to Alphagan (Brimonidine). For a complete list or a specific selection of reports, please use the links above.
Possible Alphagan side effects in 76 year old female
Reported by a physician from Japan on 2012-08-13
Patient: 76 year old female
Reactions: Depression, Suicidal Ideation
Drug(s) suspected as cause:
Alphagan
Other drugs received by patient: Zolpidem; Indapamide; Diclod; Cravit Daiichi; Dogmatyl; Ketas; Dogmatyl; Rebamipide; Tapros; Atelec; Candesartan Cilexetil
Possible Alphagan side effects in 86 year old male
Reported by a consumer/non-health professional from United Kingdom on 2012-07-31
Patient: 86 year old male, weighing 56.0 kg (123.2 pounds)
Reactions: Depersonalisation, Amnesia, Hallucination
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Alphagan
Dosage: 1 gtt, bid
Indication: Glaucoma
Start date: 2012-02-20
End date: 2012-03-05
Alphagan
Indication: Intraocular Pressure Increased
Other drugs received by patient: Isosorbide Mononitrate; Acetaminophen; Timolol Maleate; Simvastatin; Alendronate Sodium; Ramipril; Aspirin; Calcium Carbonate; Lumigan
Possible Alphagan side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-30
Patient: female
Reactions: Hypersensitivity, Skin Exfoliation, Eye Swelling, Scleral Hyperaemia, Erythema
Drug(s) suspected as cause:
Alphagan
Dosage: 2 gtt, bid
Indication: Intraocular Pressure Increased
Start date: 2011-11-01
Lumigan
Dosage: 2 gtt, bid
Indication: Intraocular Pressure Increased
Start date: 2011-11-01
Possible Alphagan side effects in
Reported by a consumer/non-health professional from United States on 2012-07-26
Patient:
Reactions: Ocular Hyperaemia
Drug(s) suspected as cause:
Alphagan
Cosopt
Dosage: unk
Xalatan
Possible Alphagan side effects in 49 year old female
Reported by a physician from Japan on 2012-07-18
Patient: 49 year old female
Reactions: Eyelid Oedema, Malaise, Pyrexia, Oedema Mouth, Lacrimation Increased, Erythema, Stevens-Johnson Syndrome
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Alphagan
Other drugs received by patient: Azopt; Lumigan
Possible Alphagan side effects in female
Reported by a consumer/non-health professional from Brazil on 2012-07-13
Patient: female, weighing 65.0 kg (143.0 pounds)
Reactions: Photosensitivity Reaction, Eye Irritation, Drug Ineffective, Wrong Drug Administered, Pain, Injury Corneal, Speech Disorder, Malaise, Dizziness, Eye Operation Complication, Eye Movement Disorder, Drug Dispensing Error, Fluid Retention, Blood Pressure Increased, Ear Disorder, Drug Hypersensitivity, Cerebrovascular Accident, Insomnia, Visual Impairment, Memory Impairment
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Alphagan
Dosage: 1 drop every 12 hours
Diovan
Dosage: 1 tablet (160 mg) in the morning and 1 tablet (160 mg) at night
Indication: Hypertension
Start date: 2005-01-01
Hydergine
Dosage: 6 mg, at night
Indication: Oxygen Supplementation
Start date: 2010-11-10
Zoden
Dosage: 400 mg, unk
Other drugs received by patient: Trisorb; Omeprazole; Liposic; Liposic; Amlodipine; Aspirin; Metformin Hydrochloride; Trisorb; Enalapril Maleate; Simvastatin; Olcadil
Possible Alphagan side effects in 65 year old
Reported by a physician from Japan on 2012-07-13
Patient: 65 year old
Reactions: Abasia, Dizziness
Drug(s) suspected as cause:
Alphagan
Other drugs received by patient: Xalcom; Hyalein; Softear
Possible Alphagan side effects in female
Reported by a physician from United States on 2012-06-21
Patient: female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Alphagan
Dosage: unk
Bromfenac
Dosage: unk
Caffeine
Dosage: unk
Codeine Sulfate
Dosage: unk
Lumigan
Dosage: unk
Morphine Sulfate
Dosage: unk
Nevanac
Dosage: unk
Possible Alphagan side effects in male
Reported by a consumer/non-health professional from United States on 2012-06-21
Patient: male
Reactions: Dyspnoea, Blood Pressure Fluctuation
Drug(s) suspected as cause:
Alphagan
Dosage: unk
Indication: Product Used FOR Unknown Indication
Cosopt
Indication: Product Used FOR Unknown Indication
Lumigan
Indication: Product Used FOR Unknown Indication
Possible Alphagan side effects in 75 year old female
Reported by a consumer/non-health professional from United States on 2012-06-21
Patient: 75 year old female
Reactions: Chromatopsia, Ocular Hyperaemia, Ocular Discomfort, DRY Eye
Drug(s) suspected as cause:
Alphagan
Dosage: unk
Indication: Glaucoma
Lumigan
Dosage: unk
Indication: Glaucoma
Start date: 2011-11-01
End date: 2012-04-01
Other drugs received by patient: Fish OIL; Hypertension Medication Unspecified; Vitamins Unspecified; Preservision Lutein EYE Vita.+min.sup.softg.
Possible Alphagan side effects in 58 year old male
Reported by a consumer/non-health professional from Germany on 2012-06-05
Patient: 58 year old male
Reactions: Dizziness, Scotoma, Depression
Drug(s) suspected as cause:
Alphagan
Dosage: (ophthalmic)
Indication: Intraocular Pressure Increased
Azopt
Dosage: (ophthalmic)
Indication: Intraocular Pressure Increased
Xalatan
Dosage: (ophthalmic)
Indication: Intraocular Pressure Increased
Possible Alphagan side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-04
Patient: female, weighing 63.5 kg (139.7 pounds)
Reactions: Eyelid Margin Crusting, Eyelid Oedema, Ocular Hyperaemia, Visual Impairment, DRY Mouth, Lacrimation Increased, Instillation Site Pain, Eye Pain
Drug(s) suspected as cause:
Alphagan
Dosage: one drop each eye twice a day ophthalmic
Indication: Glaucoma
Start date: 2012-06-01
End date: 2012-06-01
Lumigan
Dosage: one drop each eye once a day ophthalmic
Indication: Glaucoma
Start date: 2012-05-29
End date: 2012-05-29
Possible Alphagan side effects in female
Reported by a physician from United States on 2012-05-18
Patient: female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Alphagan
Dosage: unk
Bromfenac
Dosage: unk
Caffeine
Dosage: unk
Codeine Sulfate
Dosage: unk
Lumigan
Dosage: unk
Morphine Sulfate
Dosage: unk
Nevanac
Dosage: unk
Possible Alphagan side effects in 68 year old male
Reported by a physician from Korea, Republic of on 2012-05-15
Patient: 68 year old male
Reactions: Eye Oedema, Headache, Corneal Opacity, Eye Pain, Intraocular Pressure Test Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acetazolamide
Dosage: 250 mg tablet, one tab 4x/day
Alphagan
Dosage: unk
Indication: Intraocular Pressure Test Abnormal
Cosopt
Dosage: unk
Indication: Intraocular Pressure Test Abnormal
Diamox
Dosage: ^1t^ four times daily
Indication: Intraocular Pressure Test Abnormal
Xalatan
Dosage: unk
Indication: Intraocular Pressure Test Abnormal
Possible Alphagan side effects in male
Reported by a consumer/non-health professional from United States on 2012-04-20
Patient: male
Reactions: Drug Dose Omission, Eye Discharge, DRY Eye, Cerebrovascular Accident, Open Angle Glaucoma
Drug(s) suspected as cause:
Alphagan
Other drugs received by patient: Xalatan
Possible Alphagan side effects in female
Reported by a physician from United States on 2012-04-12
Patient: female
Reactions: Aphakia, Sight Disability, Glaucoma, Nystagmus
Drug(s) suspected as cause:
Alphagan
Dosage: unk (daily)
Indication: Glaucoma
Trusopt
Dosage: unk (daily)
Indication: Glaucoma
Xalatan
Dosage: 0.005 %, unk (1 drop each eye at night) daily
Indication: Glaucoma
Possible Alphagan side effects in female
Reported by a physician from United States on 2012-03-27
Patient: female
Reactions: Alopecia
Drug(s) suspected as cause:
Alphagan
Dosage: unk
Azopt
Dosage: 1 gtt, 2x/day (left eye)
Indication: Glaucoma
Istalol
Dosage: unk
Xalatan
Dosage: unk
Possible Alphagan side effects in female
Reported by a physician from United States on 2012-03-23
Patient: female, weighing 52.2 kg (114.7 pounds)
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Alphagan
Dosage: unk
Azopt
Dosage: unk
Celexa
Dosage: unk
Ciprofloxacin
Dosage: unk
Codeine Sulfate
Dosage: unk
Darvon
Dosage: unk
E.E.S.
Dosage: unk
Ergomar
Dosage: unk
Gemfibrozil
Dosage: unk
Lipitor
Dosage: unk
Minitran
Dosage: unk
Phenergan
Dosage: unk
Tetanus Toxoid
Dosage: unk
Tetracycline HCL
Dosage: unk
Timoptic
Dosage: unk
Valium
Dosage: unk
Velocef
Dosage: unk
Vicodin
Dosage: unk
Possible Alphagan side effects in female
Reported by a physician from United States on 2012-03-23
Patient: female, weighing 52.2 kg (114.7 pounds)
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Alphagan
Dosage: unk
Azopt
Dosage: unk
Celexa
Dosage: unk
Ciprofloxacin
Dosage: unk
Codeine
Dosage: unk
Darvon
Dosage: unk
E.E.S.
Dosage: unk
Ergomar
Dosage: unk
Gemfibrozil
Dosage: unk
Lipitor
Dosage: unk
Minitran
Dosage: unk
Phenergan HCL
Dosage: unk
Tetanus Toxoid
Dosage: unk
Timoptic
Dosage: unk
Tobramycin
Dosage: unk
Valium
Dosage: unk
Velocef
Dosage: unk
Vicodin
Dosage: unk
Possible Alphagan side effects in 96 year old female
Reported by a consumer/non-health professional from United States on 2012-03-22
Patient: 96 year old female
Reactions: Thrombosis, Restless Legs Syndrome, DRY Mouth, Insomnia, Incorrect Dose Administered
Drug(s) suspected as cause:
Alphagan
Dosage: 1 gtt, tid
Indication: Intraocular Pressure Increased
Start date: 2012-03-13
Lumigan
Dosage: unk
Indication: Intraocular Pressure Increased
Possible Alphagan side effects in female
Reported by a consumer/non-health professional from United States on 2012-02-15
Patient: female
Reactions: Conjunctival Irritation, Drug Hypersensitivity
Drug(s) suspected as cause:
Alphagan
Dosage: 1 gtt os bid prior to march 2007
Indication: Open Angle Glaucoma
Pilopine HS
Dosage: 1 gtt os qhs
Indication: Open Angle Glaucoma
Start date: 2007-04-03
End date: 2009-09-01
Possible Alphagan side effects in female
Reported by a consumer/non-health professional from United States on 2012-02-06
Patient: female, weighing 65.3 kg (143.7 pounds)
Reactions: Insomnia, DRY Mouth, Eye Pruritus
Drug(s) suspected as cause:
Alphagan
Dosage: drops twice daily
Indication: Glaucoma
Start date: 2006-10-01
End date: 2006-12-01
Alphagan
Dosage: drops twice daily
Indication: Glaucoma
Start date: 2012-01-01
Possible Alphagan side effects in 74 year old female
Reported by a consumer/non-health professional from United Kingdom on 2012-01-20
Patient: 74 year old female
Reactions: Eye Inflammation, Iridocyclitis
Drug(s) suspected as cause:
Alphagan
Other drugs received by patient: Cosopt; Lumigan; Diamox SRC
Possible Alphagan side effects in male
Reported by a physician from United States on 2012-01-19
Patient: male
Reactions: Ocular Hyperaemia
Drug(s) suspected as cause:
Alphagan
Dosage: daily
Indication: Glaucoma
Xalatan
Dosage: daily
Indication: Glaucoma
Start date: 2011-01-01
Possible Alphagan side effects in 75 year old female
Reported by a consumer/non-health professional from Brazil on 2012-01-09
Patient: 75 year old female
Reactions: Ocular Hyperaemia, Eye Allergy, Eye Pain, Eye Pruritus
Drug(s) suspected as cause:
Alphagan
Dosage: 2 gtt, bid
Indication: Glaucoma
End date: 2011-11-04
Alphagan
Indication: Cataract
Possible Alphagan side effects in 59 year old female
Reported by a pharmacist from Croatia (Local Name: Hrvatska) on 2011-12-26
Patient: 59 year old female
Reactions: Eyelid Oedema, Swelling Face, Angioedema, Pharyngeal Oedema, DRY Eye, Erythema
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Alphagan
Dosage: unk, 2x/day
Ramipril
Dosage: 2.5 mg, 1x/day
Administration route: Oral
Other drugs received by patient: Bisoprolol Fumarate; Levothyroxine Sodium
Possible Alphagan side effects in 82 year old female
Reported by a individual with unspecified qualification from United States on 2011-12-22
Patient: 82 year old female, weighing 52.6 kg (115.8 pounds)
Reactions: Confusional State, Headache, Disorientation, Loss of Consciousness, Abdominal Pain Upper, Impaired Driving Ability, Malaise, Sensation of Foreign Body, Dizziness, Cough, Gastric Disorder, Dysacusis, Gastrointestinal Disorder, Immune System Disorder, Gait Disturbance, Infection, Influenza Like Illness
Drug(s) suspected as cause:
Alphagan
Possible Alphagan side effects in
Reported by a physician from United Kingdom on 2011-12-21
Patient:
Reactions: Uveitis
Drug(s) suspected as cause:
Alphagan
Possible Alphagan side effects in 75 year old female
Reported by a consumer/non-health professional from Brazil on 2011-12-21
Patient: 75 year old female
Reactions: Ocular Hyperaemia, Blindness Transient, Eye Pruritus, Eye Pain
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Alphagan
Dosage: 2 gtt, bid
Indication: Glaucoma
End date: 2011-11-04
Alphagan
Indication: Cataract
Possible Alphagan side effects in female
Reported by a consumer/non-health professional from United States on 2011-12-21
Patient: female
Reactions: Alopecia
Drug(s) suspected as cause:
Alphagan
Dosage: unk
Azopt
Dosage: 1 gtt, 2x/day (left eye)
Indication: Glaucoma
Istalol
Dosage: unk
Xalatan
Dosage: unk
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