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Alkeran (Melphalan) - Myelodysplastic Syndrome - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Myelodysplastic Syndrome (11)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Alkeran (Melphalan) where reactions include myelodysplastic syndrome. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Alkeran side effects in 60 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-09

Patient: 60 year old female

Reactions: Myelofibrosis, Acute Myeloid Leukaemia, Myelodysplastic Syndrome, Idiopathic Thrombocytopenic Purpura

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Alkeran
    Dosage: intravenous (not otherwise specified)
    Indication: Multiple Myeloma

Bicnu
    Dosage: intravenous (not otherwise specified)
    Indication: Multiple Myeloma

Cyclophosphamide
    Dosage: intravenous (not otherwise specified)
    Indication: Multiple Myeloma

Dexamethasone
    Dosage: 4 years, intravenous (not otherwise specified)
    Indication: Multiple Myeloma

Doxorubicin Hydrochloride
    Dosage: intravenous (not otherwise specified)
    Indication: Multiple Myeloma

Prednisone
    Dosage: intravenous (not otherwise specified)
    Indication: Multiple Myeloma

Velcade
    Dosage: intravenous (not otherwise specified)
    Indication: Multiple Myeloma
    Start date: 2008-05-05

Velcade
    Dosage: intravenous (not otherwise specified)
    Indication: Multiple Myeloma
    Start date: 2008-05-19

Velcade
    Dosage: intravenous (not otherwise specified)
    Indication: Multiple Myeloma
    Start date: 2008-04-08

Vepesid
    Dosage: intravenous (not otherwise sepcified)
    Indication: Multiple Myeloma

Vincristine Sulfate
    Dosage: intravenous (not otherwise specified)
    Indication: Multiple Myeloma

Other drugs received by patient: Neupogen; Corticosteroids



Possible Alkeran side effects in female

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-01

Patient: female

Reactions: Acute Myeloid Leukaemia, Myelodysplastic Syndrome

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Alkeran
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Bicnu
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Cyclophosphamide
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Dexamethasone
    Start date: 2008-04-08

Dexamethasone
    Start date: 2008-06-01
    End date: 2008-01-01

Dexamethasone
    Indication: Multiple Myeloma
    Start date: 2008-05-05

Dexamethasone
    Start date: 2008-05-19

Doxorubicin Hydrochloride
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Prednisone
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Velcade
    Indication: Multiple Myeloma
    Start date: 2008-04-08
    End date: 2008-09-01

Vepesid
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Vincristine
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01



Possible Alkeran side effects in female

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-01

Patient: female

Reactions: Acute Myeloid Leukaemia, Myelodysplastic Syndrome

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Alkeran
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Bicnu
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Cyclophosphamide
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Dexamethasone
    Indication: Multiple Myeloma
    Start date: 2004-01-01
    End date: 2008-01-01

Dexamethasone
    Start date: 2008-04-08
    End date: 2008-09-01

Doxorubicin Hydrochloride
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Prednisone
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Velcade
    Indication: Multiple Myeloma
    Start date: 2008-04-08
    End date: 2008-06-01

Vepesid
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01

Vincristine
    Indication: Multiple Myeloma
    Start date: 2000-01-01
    End date: 2000-01-01



Possible Alkeran side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-01

Patient: female

Reactions: Myelodysplastic Syndrome, Multiple Myeloma

Adverse event resulted in: death

Drug(s) suspected as cause:
Alkeran
    Indication: Multiple Myeloma

Bortezomib
    Indication: Multiple Myeloma

Cisplatin
    Indication: Multiple Myeloma

Cyclophosphamide
    Indication: Multiple Myeloma

Dexamethasone
    Indication: Multiple Myeloma

Doxorubicin HCL
    Indication: Multiple Myeloma

Etoposide
    Indication: Multiple Myeloma

Lenalidomide
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-04-09
    End date: 2008-01-29

Thalomid
    Administration route: Oral
    Indication: Multiple Myeloma

Vincristine
    Indication: Multiple Myeloma



Possible Alkeran side effects in female

Reported by a health professional (non-physician/pharmacist) from France on 2011-12-07

Patient: female

Reactions: Myelodysplastic Syndrome

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Alkeran
    Dosage: 16 milligram
    Administration route: Oral
    Start date: 2007-10-01
    End date: 2008-01-01

Alkeran
    Dosage: 200 mg/m2 depending on cycle
    Administration route: Oral
    Start date: 2003-10-01
    End date: 2003-10-01

Cyclophosphamide
    Dosage: 4ug/m2 depending on cylce
    Start date: 2003-05-27
    End date: 2003-05-27

Dexamethasone
    Administration route: Oral
    Start date: 2003-02-01
    End date: 2003-08-01

Dexamethasone
    Dosage: depending on cycle
    Administration route: Oral
    Start date: 2009-12-12
    End date: 2010-10-01

Doxorubicin HCL
    Start date: 2003-02-01
    End date: 2003-01-01

Granocyte
    Dosage: 800 ug, depending on cycle
    Start date: 2011-06-12
    End date: 2011-06-18

Mozobil
    Dosage: depending on cycle
    Start date: 2011-06-13
    End date: 2011-06-16

Prednisolone
    Dosage: 170 milligram
    Administration route: Oral
    Start date: 2007-10-01
    End date: 2008-01-01

Revlimid
    Dosage: 25 milligram
    Administration route: Oral
    Start date: 2009-12-12
    End date: 2010-10-01

Velcade
    Dosage: depending on cycle
    Start date: 2007-10-01
    End date: 2008-01-01

Vincristine
    Start date: 2003-02-01
    End date: 2003-08-01



Possible Alkeran side effects in 59 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2011-12-06

Patient: 59 year old female

Reactions: Myelodysplastic Syndrome

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Alkeran
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-10-01
    End date: 2008-01-01

Alkeran
    Administration route: Oral
    Start date: 2003-10-01
    End date: 2003-10-01

Cyclophosphamide
    Indication: Haematopoietic Stem Cell Mobilisation
    Start date: 2003-05-27
    End date: 2003-05-27

Dexamethasone
    Administration route: Oral
    Start date: 2003-02-01
    End date: 2003-08-01

Dexamethasone
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2009-12-12
    End date: 2010-10-01

Doxorubicin HCL
    Indication: Multiple Myeloma
    Start date: 2003-02-01
    End date: 2003-08-01

Lenalidomide
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2009-12-12
    End date: 2010-10-01

Lenograstim
    Indication: Haematopoietic Stem Cell Mobilisation
    Start date: 2011-06-12
    End date: 2011-06-18

Plerixafor
    Indication: Haematopoietic Stem Cell Mobilisation
    Start date: 2011-06-13
    End date: 2011-06-16

Prednisolone
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-10-01
    End date: 2008-01-01

Velcade
    Indication: Multiple Myeloma
    Start date: 2007-10-01
    End date: 2008-01-01

Vincristine Sulfate
    Indication: Multiple Myeloma
    Start date: 2003-02-01
    End date: 2003-08-01



Possible Alkeran side effects in 58 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-12-05

Patient: 58 year old male

Reactions: Myelodysplastic Syndrome

Drug(s) suspected as cause:
Alkeran
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-06-05

Cyclophosphamide
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-01-01

Doxorubicin HCL
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-09-27

Etoposide
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-08-28

Velcade
    Indication: Multiple Myeloma
    Start date: 2007-05-04
    End date: 2007-09-27

Other drugs received by patient: Dexamethasone



Possible Alkeran side effects in 58 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-11-30

Patient: 58 year old male

Reactions: Myeloma Recurrence, Neoplasm Malignant, Myelodysplastic Syndrome, Transplant, Herpes Zoster

Drug(s) suspected as cause:
Alkeran
    Dosage: 125 mg, unk
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-06-05

Cyclophosphamide
    Administration route: Oral
    Indication: Multiple Myeloma

Doxorubicin HCL
    Dosage: unk
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-09-27

Etoposide
    Dosage: unk
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-08-28

Velcade
    Dosage: unk
    Indication: Multiple Myeloma
    Start date: 2007-05-04
    End date: 2007-07-10

Velcade
    Dosage: unk
    Start date: 2007-07-31
    End date: 2007-09-27



Possible Alkeran side effects in 85 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-23

Patient: 85 year old male

Reactions: Myelodysplastic Syndrome, Multiple Myeloma

Drug(s) suspected as cause:
Alkeran

Revlimid
    Dosage: 25mg per day
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2009-02-01
    End date: 2009-01-01

Other drugs received by patient: Velcade; Prednisone TAB



Possible Alkeran side effects in 58 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-10-25

Patient: 58 year old male

Reactions: Myelodysplastic Syndrome

Drug(s) suspected as cause:
Alkeran
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-06-05

Cyclophosphamide
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-01-01

Doxorubicin HCL
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-09-27

Etoposide
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-08-28

Velcade
    Indication: Multiple Myeloma
    Start date: 2007-05-04
    End date: 2007-09-27

Other drugs received by patient: Dexamethasone



Possible Alkeran side effects in 58 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-10-24

Patient: 58 year old male

Reactions: Neoplasm Malignant, Myelodysplastic Syndrome

Drug(s) suspected as cause:
Alkeran
    Dosage: 125 mg, unk
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-06-05

Cyclophosphamide
    Administration route: Oral
    Indication: Multiple Myeloma

Doxorubicin HCL
    Dosage: unk
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-09-27

Etoposide
    Dosage: unk
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2007-08-28

Velcade
    Dosage: unk
    Indication: Multiple Myeloma
    Start date: 2007-05-04
    End date: 2007-07-10

Velcade
    Dosage: unk
    Start date: 2007-07-31
    End date: 2007-09-27

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