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Alkeran (Melphalan) - Febrile Neutropenia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Febrile Neutropenia (9)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Alkeran (Melphalan) where reactions include febrile neutropenia. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Alkeran side effects in female

Reported by a physician from Italy on 2012-08-08

Patient: female

Reactions: White Blood Cell Count Decreased, Staphylococcal Infection, Urticaria, Febrile Neutropenia, Bacterial Sepsis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alkeran
    Dosage: 24mg per day
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2009-11-18
    End date: 2009-12-20

Thalidomide
    Dosage: 2100mg per day
    Administration route: Oral
    Indication: Multiple Myeloma
    Start date: 2009-11-18
    End date: 2009-12-20

Other drugs received by patient: Allopurinol; Aspirin; Lansoprazole; Prednisone TAB



Possible Alkeran side effects in female

Reported by a physician from Japan on 2012-01-12

Patient: female, weighing 50.0 kg (110.0 pounds)

Reactions: Jaundice, Stomatitis, Graft Versus Host Disease, Febrile Neutropenia, Rash, Pyrexia, Erythema, Haematotoxicity, Diarrhoea, Sepsis, Bacterial Infection, Infection

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Alkeran
    Dosage: 70mgm2 per day
    Indication: Stem Cell Transplant
    Start date: 2008-08-25
    End date: 2008-08-25

Unknown Drug
    Dosage: 300mgm2 per day
    Indication: Stem Cell Transplant
    Start date: 2008-09-01
    End date: 2008-09-01

Cyclophosphamide
    Dosage: 60mgk per day
    Indication: Stem Cell Transplant
    Start date: 2008-09-05
    End date: 2008-09-06

Other drugs received by patient: Cyclosporine



Possible Alkeran side effects in male

Reported by a physician from Japan on 2012-01-12

Patient: male, weighing 12.0 kg (26.4 pounds)

Reactions: Stomatitis, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Febrile Neutropenia, Rash, Pyrexia, Mucosal Inflammation, Diarrhoea, Aspartate Aminotransferase Increased, Bacterial Infection

Drug(s) suspected as cause:
Alkeran
    Dosage: 70mgm2 per day
    Indication: Cord Blood Transplant Therapy
    Start date: 2010-01-09
    End date: 2010-01-10

Unknown Drug
    Dosage: 300mgm2 per day
    Indication: Cord Blood Transplant Therapy
    Start date: 2010-01-11
    End date: 2010-01-12

Other drugs received by patient: Tacrolimus



Possible Alkeran side effects in 17 year old male

Reported by a physician from Japan on 2011-12-29

Patient: 17 year old male

Reactions: Posterior Reversible Encephalopathy Syndrome, Febrile Neutropenia, Muscle Spasms

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytarabine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-07

Methotrexate
    Start date: 2011-06-14
    End date: 2011-06-14

Cytarabine
    Start date: 2011-06-14
    End date: 2011-06-19

Pinorubin
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-08

Alkeran
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-20

Cytarabine
    Start date: 2011-06-07
    End date: 2011-06-12

Cytarabine
    Start date: 2011-06-14
    End date: 2011-06-14

Cyclophosphamide
    Start date: 2011-06-14
    End date: 2011-06-14

Antibiotic
    Indication: Febrile Neutropenia
    Start date: 2011-06-16
    End date: 2011-06-23

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-07

Methotrexate
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-07

Other drugs received by patient: Urso 250; Prednisolone; Hydrocortone



Possible Alkeran side effects in 51 year old male

Reported by a physician from Japan on 2011-12-19

Patient: 51 year old male, weighing 60.0 kg (132.0 pounds)

Reactions: White Blood Cell Count Decreased, Neoplasm Progression, Cytomegalovirus Viraemia, Febrile Neutropenia, Gamma-Glutamyltransferase Increased, Neoplasm Malignant, Sepsis, Bone Marrow Failure, Meningitis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Alkeran
    Dosage: 100 mg, daily
    Start date: 2011-04-03
    End date: 2011-04-04

Fludara
    Dosage: 39 mg, daily
    Start date: 2011-03-30
    End date: 2011-04-03

Prednisolone
    Dosage: 30 mg, daily
    Start date: 2011-02-15
    End date: 2011-07-12

Exjade
    Dosage: 500 mg, daily
    Administration route: Oral
    Indication: Iron Overload
    Start date: 2011-01-07
    End date: 2011-01-11

Exjade
    Dosage: 1000 mg, daily
    Start date: 2011-01-12
    End date: 2011-03-29

Prograf
    Dosage: 1 mg, daily
    Start date: 2011-04-05
    End date: 2011-07-14

Other drugs received by patient: Neoral; Magmitt Kenei; Levofloxacin; Omeprazole; BIO Three; Sulfamethoxazole and Trimethoprim; Clarithromycin; Itraconazole; Urso 250; Zolpidem



Possible Alkeran side effects in 17 year old male

Reported by a consumer/non-health professional from Japan on 2011-12-09

Patient: 17 year old male

Reactions: Posterior Reversible Encephalopathy Syndrome, Febrile Neutropenia, Convulsion

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-07

Methotrexate
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-07

Cyclophosphamide
    Start date: 2011-06-14
    End date: 2011-06-14

Alkeran
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-20

Cytarabine
    Start date: 2011-06-14
    End date: 2011-06-19

Methotrexate
    Start date: 2011-06-14
    End date: 2011-06-14

Antibiotic
    Indication: Febrile Neutropenia
    Start date: 2011-06-16
    End date: 2011-06-23

Pinorubin
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-08

Cytarabine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-07

Cytarabine
    Start date: 2011-06-07
    End date: 2011-06-12

Cytarabine
    Start date: 2011-06-14
    End date: 2011-06-14

Other drugs received by patient: Hydrocortone; Prednisolone; Urso 250



Possible Alkeran side effects in 17 year old male

Reported by a consumer/non-health professional from Japan on 2011-11-09

Patient: 17 year old male

Reactions: Posterior Reversible Encephalopathy Syndrome, Febrile Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-07

Cytarabine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-07

Methotrexate
    Start date: 2011-06-14
    End date: 2011-06-14

Cyclophosphamide
    Start date: 2011-06-14
    End date: 2011-06-14

Pinorubin
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-08

Alkeran
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-20

Antibiotic
    Indication: Febrile Neutropenia
    Start date: 2011-06-16
    End date: 2011-06-23

Cytarabine
    Start date: 2011-06-07
    End date: 2011-06-12

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-07

Cytarabine
    Start date: 2011-06-14
    End date: 2011-06-19

Cytarabine
    Start date: 2011-06-14
    End date: 2011-06-14

Other drugs received by patient: Hydrocortone; Prednisolone; Urso 250



Possible Alkeran side effects in 51 year old male

Reported by a physician from Japan on 2011-11-01

Patient: 51 year old male, weighing 60.0 kg (132.0 pounds)

Reactions: White Blood Cell Count Decreased, Febrile Neutropenia, Cytomegalovirus Viraemia, Neoplasm Progression, Neoplasm Malignant, Gamma-Glutamyltransferase Increased, Sepsis, Bone Marrow Failure, Meningitis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Prograf

Exjade
    Dosage: 500 mg, daily
    Administration route: Oral
    Indication: Iron Overload
    Start date: 2011-01-07
    End date: 2011-01-11

Exjade
    Dosage: 1000 mg, daily
    Start date: 2011-01-12
    End date: 2011-03-29

Fludara

Alkeran

Prednisolone

Other drugs received by patient: BIO Three; Magmitt Kenei; Omeprazole; Levofloxacin; Zolpidem; Clarithromycin; Neoral; Urso 250; Sulfamethoxazole; Itraconazole



Possible Alkeran side effects in female

Reported by a physician from Japan on 2011-10-10

Patient: female, weighing 49.0 kg (107.8 pounds)

Reactions: Viral Haemorrhagic Cystitis, C-Reactive Protein Increased, Diarrhoea, RED Blood Cells Urine Positive, Cytomegalovirus Viraemia, Febrile Neutropenia, Blood Immunoglobulin G Decreased, Hypokalaemia

Drug(s) suspected as cause:
Alkeran
    Dosage: 130mgm2 per day
    Indication: Stem Cell Transplant
    Start date: 2010-10-14
    End date: 2010-10-14

Etoposide
    Dosage: 500mgm2 per day
    Indication: Stem Cell Transplant
    Start date: 2010-10-11
    End date: 2010-10-13

Cyclophosphamide
    Dosage: 60mgk per day
    Indication: Stem Cell Transplant
    Start date: 2010-10-11
    End date: 2010-10-12

Rituxan
    Dosage: 375mgm2 per day
    Indication: Stem Cell Transplant
    Start date: 2010-10-10
    End date: 2010-10-10

Other drugs received by patient: Bactrim; Emend; BIO Three; Urso 250; Bactrim; Fluconazole; Emend; Famotidine; Mucosta; Ciprofloxacin HCL

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