Index of reports
> Cases with Febrile Neutropenia (9)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Alkeran (Melphalan) where reactions include febrile neutropenia. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Alkeran side effects in female
Reported by a physician from Italy on 2012-08-08
Patient: female
Reactions: White Blood Cell Count Decreased, Staphylococcal Infection, Urticaria, Febrile Neutropenia, Bacterial Sepsis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Alkeran
Dosage: 24mg per day
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2009-11-18
End date: 2009-12-20
Thalidomide
Dosage: 2100mg per day
Administration route: Oral
Indication: Multiple Myeloma
Start date: 2009-11-18
End date: 2009-12-20
Other drugs received by patient: Allopurinol; Aspirin; Lansoprazole; Prednisone TAB
Possible Alkeran side effects in female
Reported by a physician from Japan on 2012-01-12
Patient: female, weighing 50.0 kg (110.0 pounds)
Reactions: Jaundice, Stomatitis, Graft Versus Host Disease, Febrile Neutropenia, Rash, Pyrexia, Erythema, Haematotoxicity, Diarrhoea, Sepsis, Bacterial Infection, Infection
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Alkeran
Dosage: 70mgm2 per day
Indication: Stem Cell Transplant
Start date: 2008-08-25
End date: 2008-08-25
Unknown Drug
Dosage: 300mgm2 per day
Indication: Stem Cell Transplant
Start date: 2008-09-01
End date: 2008-09-01
Cyclophosphamide
Dosage: 60mgk per day
Indication: Stem Cell Transplant
Start date: 2008-09-05
End date: 2008-09-06
Other drugs received by patient: Cyclosporine
Possible Alkeran side effects in male
Reported by a physician from Japan on 2012-01-12
Patient: male, weighing 12.0 kg (26.4 pounds)
Reactions: Stomatitis, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Febrile Neutropenia, Rash, Pyrexia, Mucosal Inflammation, Diarrhoea, Aspartate Aminotransferase Increased, Bacterial Infection
Drug(s) suspected as cause:
Alkeran
Dosage: 70mgm2 per day
Indication: Cord Blood Transplant Therapy
Start date: 2010-01-09
End date: 2010-01-10
Unknown Drug
Dosage: 300mgm2 per day
Indication: Cord Blood Transplant Therapy
Start date: 2010-01-11
End date: 2010-01-12
Other drugs received by patient: Tacrolimus
Possible Alkeran side effects in 17 year old male
Reported by a physician from Japan on 2011-12-29
Patient: 17 year old male
Reactions: Posterior Reversible Encephalopathy Syndrome, Febrile Neutropenia, Muscle Spasms
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cytarabine
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-07
Methotrexate
Start date: 2011-06-14
End date: 2011-06-14
Cytarabine
Start date: 2011-06-14
End date: 2011-06-19
Pinorubin
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-08
Alkeran
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-20
Cytarabine
Start date: 2011-06-07
End date: 2011-06-12
Cytarabine
Start date: 2011-06-14
End date: 2011-06-14
Cyclophosphamide
Start date: 2011-06-14
End date: 2011-06-14
Antibiotic
Indication: Febrile Neutropenia
Start date: 2011-06-16
End date: 2011-06-23
Cyclophosphamide
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-07
Methotrexate
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-07
Other drugs received by patient: Urso 250; Prednisolone; Hydrocortone
Possible Alkeran side effects in 51 year old male
Reported by a physician from Japan on 2011-12-19
Patient: 51 year old male, weighing 60.0 kg (132.0 pounds)
Reactions: White Blood Cell Count Decreased, Neoplasm Progression, Cytomegalovirus Viraemia, Febrile Neutropenia, Gamma-Glutamyltransferase Increased, Neoplasm Malignant, Sepsis, Bone Marrow Failure, Meningitis
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Alkeran
Dosage: 100 mg, daily
Start date: 2011-04-03
End date: 2011-04-04
Fludara
Dosage: 39 mg, daily
Start date: 2011-03-30
End date: 2011-04-03
Prednisolone
Dosage: 30 mg, daily
Start date: 2011-02-15
End date: 2011-07-12
Exjade
Dosage: 500 mg, daily
Administration route: Oral
Indication: Iron Overload
Start date: 2011-01-07
End date: 2011-01-11
Exjade
Dosage: 1000 mg, daily
Start date: 2011-01-12
End date: 2011-03-29
Prograf
Dosage: 1 mg, daily
Start date: 2011-04-05
End date: 2011-07-14
Other drugs received by patient: Neoral; Magmitt Kenei; Levofloxacin; Omeprazole; BIO Three; Sulfamethoxazole and Trimethoprim; Clarithromycin; Itraconazole; Urso 250; Zolpidem
Possible Alkeran side effects in 17 year old male
Reported by a consumer/non-health professional from Japan on 2011-12-09
Patient: 17 year old male
Reactions: Posterior Reversible Encephalopathy Syndrome, Febrile Neutropenia, Convulsion
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cyclophosphamide
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-07
Methotrexate
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-07
Cyclophosphamide
Start date: 2011-06-14
End date: 2011-06-14
Alkeran
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-20
Cytarabine
Start date: 2011-06-14
End date: 2011-06-19
Methotrexate
Start date: 2011-06-14
End date: 2011-06-14
Antibiotic
Indication: Febrile Neutropenia
Start date: 2011-06-16
End date: 2011-06-23
Pinorubin
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-08
Cytarabine
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-07
Cytarabine
Start date: 2011-06-07
End date: 2011-06-12
Cytarabine
Start date: 2011-06-14
End date: 2011-06-14
Other drugs received by patient: Hydrocortone; Prednisolone; Urso 250
Possible Alkeran side effects in 17 year old male
Reported by a consumer/non-health professional from Japan on 2011-11-09
Patient: 17 year old male
Reactions: Posterior Reversible Encephalopathy Syndrome, Febrile Neutropenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Methotrexate
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-07
Cytarabine
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-07
Methotrexate
Start date: 2011-06-14
End date: 2011-06-14
Cyclophosphamide
Start date: 2011-06-14
End date: 2011-06-14
Pinorubin
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-08
Alkeran
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-20
Antibiotic
Indication: Febrile Neutropenia
Start date: 2011-06-16
End date: 2011-06-23
Cytarabine
Start date: 2011-06-07
End date: 2011-06-12
Cyclophosphamide
Indication: Acute Lymphocytic Leukaemia
Start date: 2011-06-07
End date: 2011-06-07
Cytarabine
Start date: 2011-06-14
End date: 2011-06-19
Cytarabine
Start date: 2011-06-14
End date: 2011-06-14
Other drugs received by patient: Hydrocortone; Prednisolone; Urso 250
Possible Alkeran side effects in 51 year old male
Reported by a physician from Japan on 2011-11-01
Patient: 51 year old male, weighing 60.0 kg (132.0 pounds)
Reactions: White Blood Cell Count Decreased, Febrile Neutropenia, Cytomegalovirus Viraemia, Neoplasm Progression, Neoplasm Malignant, Gamma-Glutamyltransferase Increased, Sepsis, Bone Marrow Failure, Meningitis
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Prograf
Exjade
Dosage: 500 mg, daily
Administration route: Oral
Indication: Iron Overload
Start date: 2011-01-07
End date: 2011-01-11
Exjade
Dosage: 1000 mg, daily
Start date: 2011-01-12
End date: 2011-03-29
Fludara
Alkeran
Prednisolone
Other drugs received by patient: BIO Three; Magmitt Kenei; Omeprazole; Levofloxacin; Zolpidem; Clarithromycin; Neoral; Urso 250; Sulfamethoxazole; Itraconazole
Possible Alkeran side effects in female
Reported by a physician from Japan on 2011-10-10
Patient: female, weighing 49.0 kg (107.8 pounds)
Reactions: Viral Haemorrhagic Cystitis, C-Reactive Protein Increased, Diarrhoea, RED Blood Cells Urine Positive, Cytomegalovirus Viraemia, Febrile Neutropenia, Blood Immunoglobulin G Decreased, Hypokalaemia
Drug(s) suspected as cause:
Alkeran
Dosage: 130mgm2 per day
Indication: Stem Cell Transplant
Start date: 2010-10-14
End date: 2010-10-14
Etoposide
Dosage: 500mgm2 per day
Indication: Stem Cell Transplant
Start date: 2010-10-11
End date: 2010-10-13
Cyclophosphamide
Dosage: 60mgk per day
Indication: Stem Cell Transplant
Start date: 2010-10-11
End date: 2010-10-12
Rituxan
Dosage: 375mgm2 per day
Indication: Stem Cell Transplant
Start date: 2010-10-10
End date: 2010-10-10
Other drugs received by patient: Bactrim; Emend; BIO Three; Urso 250; Bactrim; Fluconazole; Emend; Famotidine; Mucosta; Ciprofloxacin HCL
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