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Alimta (Pemetrexed) - Side Effect Reports to FDA

 
 



This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Alimta (Pemetrexed) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.

Reports by Event Outcome

All Cases (816)
Death (298)
Life Threatening Events (73)
Disability (24)

Reports by Reaction Type

Death (116)Neoplasm Progression (81)Thrombocytopenia (53)Dyspnoea (49)Diarrhoea (49)Interstitial Lung Disease (47)Anaemia (45)Pancytopenia (37)Neutropenia (34)Pyrexia (33)Pneumonia (33)Nausea (32)

Below are a few examples of reports where side effects / adverse reactions may be related to Alimta (Pemetrexed). For a complete list or a specific selection of reports, please use the links above.

Possible Alimta side effects in 68 year old male

Reported by a consumer/non-health professional from Japan on 2012-08-27

Patient: 68 year old male

Reactions: Interstitial Lung Disease

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta



Possible Alimta side effects in 85 year old female

Reported by a physician from Japan on 2012-08-27

Patient: 85 year old female

Reactions: Respiratory Failure, Interstitial Lung Disease

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Panvitan; Fresmin



Possible Alimta side effects in male

Reported by a consumer/non-health professional from Japan on 2012-08-27

Patient: male, weighing 80.0 kg (176.0 pounds)

Reactions: Off Label Use, White Blood Cell Count Decreased, Neoplasm Progression, Metastases To Bone, Nephrotic Syndrome, Acute Prerenal Failure

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Alimta
    Dosage: 750 mg, every 3 weeks
    Indication: Pleural Mesothelioma Malignant
    Start date: 2009-03-12
    End date: 2009-09-24

Gemzar
    Dosage: unk
    Start date: 2010-05-28
    End date: 2010-06-04

Other drugs received by patient: Amlodipine; Vitamin B12; Panvitan; Calblock; Amlodipine; Cisplatin



Possible Alimta side effects in 63 year old female

Reported by a physician from Japan on 2012-08-27

Patient: 63 year old female

Reactions: Pseudomembranous Colitis

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta



Possible Alimta side effects in female

Reported by a physician from France on 2012-08-24

Patient: female

Reactions: Hepatocellular Injury, Cholestasis, Rash

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Carboplatin; Iressa



Possible Alimta side effects in female

Reported by a physician from Italy on 2012-08-24

Patient: female

Reactions: Lung Disorder, Haemorrhage, Anaemia, Petechiae, Neoplasm Progression, Thrombocytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Folic Acid; Dexamethasone Sodium Phosphate; Dobetin; Benzodiazepine Related Drugs



Possible Alimta side effects in male

Reported by a consumer/non-health professional from Netherlands on 2012-08-23

Patient: male

Reactions: Pulmonary Toxicity, Death

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Omeprazole; Cisplatin; Hydroxocobalamine; Folic Acid



Possible Alimta side effects in 78 year old female

Reported by a consumer/non-health professional from Spain on 2012-08-22

Patient: 78 year old female, weighing 59.0 kg (129.8 pounds)

Reactions: Hepatotoxicity

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Zometa; Folic Acid; Vitamin B-12; Lorazepam; Venoruton; Pantoprazole; Dexamethasone; Magnesium; Escitalopram; Emportal



Possible Alimta side effects in male

Reported by a physician from United States on 2012-08-21

Patient: male

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta



Possible Alimta side effects in 66 year old female

Reported by a consumer/non-health professional from Germany on 2012-08-17

Patient: 66 year old female

Reactions: Blood Bilirubin Increased, Jaundice, Liver Function Test Abnormal

Drug(s) suspected as cause:
Alimta



Possible Alimta side effects in male

Reported by a physician from Japan on 2012-08-16

Patient: male, weighing 86.0 kg (189.2 pounds)

Reactions: Pruritus, Neoplasm Malignant, Hypophagia, Bone Marrow Failure, Febrile Neutropenia, Condition Aggravated

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Granisetron; Panvitan; Vitamin B12; Dexamethasone Sodium Phosphate



Possible Alimta side effects in 58 year old female

Reported by a consumer/non-health professional from Brazil on 2012-08-16

Patient: 58 year old female

Reactions: Abdominal Pain, Toxicity To Various Agents

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Carboplatin



Possible Alimta side effects in 70 year old male

Reported by a consumer/non-health professional from Japan on 2012-08-15

Patient: 70 year old male

Reactions: Hypersensitivity, C-Reactive Protein Increased, Pyrexia, Neutrophil Count Decreased, Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Vitamin B-12; Folic Acid



Possible Alimta side effects in female

Reported by a physician from France on 2012-08-15

Patient: female

Reactions: Dyspnoea, Nausea, Rash, Hyperhidrosis, Syncope, Epigastric Discomfort, Rash Erythematous, Conjunctival Hyperaemia, Bronchospasm

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: B12-Vitamiin; Methylprednisolone; Polaramine; Avastin; Pravastatin; Acetaminophen; Zofran; Folic Acid; Enalapril Maleate



Possible Alimta side effects in female

Reported by a consumer/non-health professional from Belgium on 2012-08-15

Patient: female, weighing 64.0 kg (140.8 pounds)

Reactions: Death, Off Label Use, Dyspnoea Exertional, Interstitial Lung Disease

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Alimta
    Dosage: 500 mg/m2, unknown

Alimta
    Dosage: 500 mg/m2, unknown
    Indication: Thymoma Malignant
    Start date: 2012-01-31

Other drugs received by patient: Dexamethasone; Bisoprolol Fumarate; Vitamin B-12; Folic Acid



Possible Alimta side effects in male

Reported by a physician from Japan on 2012-08-15

Patient: male, weighing 61.7 kg (135.7 pounds)

Reactions: C-Reactive Protein Increased, Platelet Count Decreased, Pyrexia, Loss of Consciousness, White Blood Cell Count Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Vitamin B12; Panvitan



Possible Alimta side effects in 65 year old male

Reported by a physician from Japan on 2012-08-14

Patient: 65 year old male

Reactions: Death, Renal Disorder, Lung Disorder, Bone Marrow Failure

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Avastin; Carboplatin



Possible Alimta side effects in 47 year old female

Reported by a consumer/non-health professional from Morocco on 2012-08-14

Patient: 47 year old female

Reactions: Rash Generalised, Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Vitamins NOS; Cisplatin; Corticosteroid NOS



Possible Alimta side effects in male

Reported by a physician from France on 2012-08-13

Patient: male

Reactions: Carcinoembryonic Antigen Increased, Anaemia, Thrombocytopenia, Streptococcal Infection, Renal Failure Chronic

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alimta



Possible Alimta side effects in male

Reported by a consumer/non-health professional from Italy on 2012-08-13

Patient: male

Reactions: Diarrhoea, Hypotension, Depressed Level of Consciousness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Carboplatin



Possible Alimta side effects in 79 year old female

Reported by a physician from Japan on 2012-08-13

Patient: 79 year old female

Reactions: Interstitial Lung Disease, Rash

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Vitamin B12 / 00056201 /; Folic Acid



Possible Alimta side effects in male

Reported by a physician from France on 2012-08-13

Patient: male

Reactions: Neoplasm Progression, Purpura

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Digoxin; Flecainide Acetate; Janumet; Paroxetine HCL; Previscan; Carboplatin; Atorvastatin; Innohep; Tamsulosin HCL; Permixon



Possible Alimta side effects in 65 year old male

Reported by a consumer/non-health professional from United States on 2012-08-13

Patient: 65 year old male, weighing 67.0 kg (147.4 pounds)

Reactions: Weight Decreased, Mucosal Inflammation, Vomiting

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alimta
    Dosage: last dose on 9jul12,375mg/m2
    Indication: non-Small Cell Lung Cancer Stage III
    Start date: 2012-05-21

Cisplatin
    Dosage: last dose on 9jul12,50mg/m2
    Indication: non-Small Cell Lung Cancer Stage III
    Start date: 2012-05-21

Other drugs received by patient: Dexamethasone; Kytril; Antepsin; Isosorbide Dinitrate; Folic Acid; Vitamin B-12



Possible Alimta side effects in male

Reported by a physician from Belgium on 2012-08-13

Patient: male

Reactions: Capillary Leak Syndrome, Pleural Effusion, Generalised Oedema

Drug(s) suspected as cause:
Alimta



Possible Alimta side effects in

Reported by a consumer/non-health professional from United States on 2012-08-13

Patient:

Reactions: Death, Neoplasm Progression

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta



Possible Alimta side effects in male

Reported by a physician from United States on 2012-08-10

Patient: male

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta



Possible Alimta side effects in male

Reported by a consumer/non-health professional from Netherlands on 2012-08-10

Patient: male

Reactions: Pulmonary Toxicity

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alimta

Other drugs received by patient: Folic Acid; Cisplatin; Hydroxocobalamine; Omeprazole



Possible Alimta side effects in female

Reported by a consumer/non-health professional from United States on 2012-08-10

Patient: female

Reactions: Neoplasm Progression

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta



Possible Alimta side effects in male

Reported by a consumer/non-health professional from United States on 2012-08-10

Patient: male, weighing 92.0 kg (202.4 pounds)

Reactions: Mental Disorder, Gait Disturbance

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Alimta
    Dosage: 500 mg/m2, every 21 days
    Indication: Lung Cancer Metastatic
    Start date: 2011-07-20
    End date: 2011-07-27

Gemzar
    Dosage: 1000 mg/m2, unk
    Indication: Lung Cancer Metastatic



Possible Alimta side effects in male

Reported by a consumer/non-health professional from United States on 2012-08-10

Patient: male

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Alimta

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