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Actoplus MET (Pioglitazone / Metformin) - Side Effect Reports to FDA

 
 



This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Actoplus MET (Pioglitazone / Metformin) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.

Reports by Event Outcome

All Cases (40)
Death (2)
Disability (2)

Reports by Reaction Type

Bladder Cancer (26)Bladder Transitional Cell Carcinoma (3)Metastases To Lymph Nodes (2)Blood Glucose Abnormal (2)Intervertebral Disc Degeneration (2)Myocardial Infarction (2)Renal Disorder (2)Ischaemic Stroke (2)Urinary Tract Infection (2)Volvulus (2)Impaired Healing (2)Abdominal Hernia (1)

Below are a few examples of reports where side effects / adverse reactions may be related to Actoplus MET (Pioglitazone / Metformin). For a complete list or a specific selection of reports, please use the links above.

Possible Actoplus MET side effects in 52 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-10

Patient: 52 year old male, weighing 82.6 kg (181.6 pounds)

Reactions: Bladder Transitional Cell Carcinoma

Drug(s) suspected as cause:
Actos
    Dosage: 15 mg, 30 mg
    Indication: Type 2 Diabetes Mellitus
    Start date: 2011-04-01
    End date: 2011-08-01

Actos
    Dosage: 15 mg, 30 mg
    Indication: Type 2 Diabetes Mellitus
    Start date: 2007-05-01
    End date: 2007-12-01

Actoplus MET
    Indication: Type 2 Diabetes Mellitus
    Start date: 2008-05-01
    End date: 2010-01-01

Other drugs received by patient: Metformin HCL; Janumet; Metformin Hydrochloride



Possible Actoplus MET side effects in 52 year old male

Reported by a consumer/non-health professional from United States on 2012-07-25

Patient: 52 year old male, weighing 82.6 kg (181.6 pounds)

Reactions: Bladder Cancer

Drug(s) suspected as cause:
Actoplus MET
    Indication: Type 2 Diabetes Mellitus
    Start date: 2008-05-01
    End date: 2010-01-01

Actos
    Dosage: 15 mg, 30 mg
    Indication: Type 2 Diabetes Mellitus
    Start date: 2011-04-01
    End date: 2011-08-01

Actos
    Dosage: 15 mg, 30 mg
    Indication: Type 2 Diabetes Mellitus
    Start date: 2007-05-01
    End date: 2007-12-01

Other drugs received by patient: Janumet



Possible Actoplus MET side effects in female

Reported by a individual with unspecified qualification from United States on 2012-07-07

Patient: female

Reactions: Obesity Surgery

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in

Reported by a physician from United States on 2012-06-07

Patient:

Reactions: Trisomy 21, Maternal Drugs Affecting Foetus

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 60 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-01

Patient: 60 year old male, weighing 88.3 kg (194.2 pounds)

Reactions: Lymphadenopathy, Metastases To Lymph Nodes

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Actoplus MET

Other drugs received by patient: Tricor; Tradjenta (Drug Used IN Diabetes ); Lotrel; Pristiq



Possible Actoplus MET side effects in 60 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-04

Patient: 60 year old male, weighing 88.3 kg (194.2 pounds)

Reactions: Tongue Neoplasm Malignant Stage Unspecified, Metastases To Lymph Nodes

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Actoplus MET

Other drugs received by patient: Pristiq; Tricor; Tradjenta (Drug Used IN Diabetes); Lotrel



Possible Actoplus MET side effects in male

Reported by a physician from United States on 2012-04-04

Patient: male, weighing 103.9 kg (228.5 pounds)

Reactions: Bladder Cancer

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in male

Reported by a physician from United States on 2012-04-04

Patient: male, weighing 103.9 kg (228.5 pounds)

Reactions: Bladder Cancer

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 59 year old male

Reported by a physician from United States on 2012-03-29

Patient: 59 year old male

Reactions: Bladder Cancer

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 64 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-23

Patient: 64 year old female

Reactions: Small Intestinal Obstruction, Renal Disorder, Volvulus, Renal Failure Chronic, Umbilical Hernia, Blood Glucose Abnormal

Drug(s) suspected as cause:
Januvia
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2010-01-21
    End date: 2011-12-01

Actoplus MET

Other drugs received by patient: Oxybutynin; Tramadol Hydrochloride; Insulin; Nortriptyline; Lisinopril; Furosemide; Procardia



Possible Actoplus MET side effects in male

Reported by a physician from United States on 2012-03-06

Patient: male

Reactions: Bladder Cancer

Adverse event resulted in: death

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 64 year old female

Reported by a consumer/non-health professional from United States on 2012-02-27

Patient: 64 year old female

Reactions: Renal Disorder, Volvulus, Renal Impairment, Blood Glucose Abnormal

Drug(s) suspected as cause:
Actoplus MET

Januvia
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2009-01-01
    End date: 2011-12-01

Other drugs received by patient: Insulin



Possible Actoplus MET side effects in 85 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-02-24

Patient: 85 year old male, weighing 63.7 kg (140.2 pounds)

Reactions: Bladder Transitional Cell Carcinoma

Drug(s) suspected as cause:
Actoplus MET

Other drugs received by patient: Metoprolol Tartrate; Ascorbic Acid; Nexium (Esomeprazole Magnesiuim); Iron (Iron); Diovan; Alprazolam; Lipitor; Exforge; Plavix



Possible Actoplus MET side effects in 59 year old male

Reported by a consumer/non-health professional from United States on 2012-02-22

Patient: 59 year old male

Reactions: Bladder Cancer

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 72 year old male

Reported by a consumer/non-health professional from United States on 2012-02-22

Patient: 72 year old male

Reactions: Bladder Cancer

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 61 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-02-16

Patient: 61 year old male, weighing 121.6 kg (267.4 pounds)

Reactions: Bladder Cancer

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 70 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-02-15

Patient: 70 year old male

Reactions: Bladder Cancer

Drug(s) suspected as cause:
Actos
    Dosage: 1 in 1 d
    Start date: 2011-03-31
    End date: 2011-07-11

Actoplus MET
    Dosage: 30/1000 mg
    Indication: Type 2 Diabetes Mellitus
    Start date: 2011-07-11
    End date: 2011-11-01

Other drugs received by patient: Flomax; Enalapril Maleate; Lovastatin; Hydrochlorothiazide; Lortab; Metformin HCL; Glyburide; Ibuprofen



Possible Actoplus MET side effects in 32 year old male

Reported by a physician from United States on 2012-01-30

Patient: 32 year old male

Reactions: Bladder Cancer

Drug(s) suspected as cause:
Actos
    Dosage: 15 mg, 1 in 1 d, per oral
    Administration route: Oral

Actoplus MET



Possible Actoplus MET side effects in 50 year old male

Reported by a physician from United States on 2012-01-25

Patient: 50 year old male

Reactions: Urinary Tract Infection, Ischaemic Stroke, Panic Disorder, Cardiac Valve Disease, Road Traffic Accident, Impaired Healing, Arthralgia, Gastrointestinal Disorder, Intervertebral Disc Degeneration, Memory Impairment, Bone Disorder, Depression, Bone Density Decreased, Myocardial Infarction, Attention Deficit / Hyperactivity Disorder

Drug(s) suspected as cause:
Actoplus MET
    Dosage: 100 mg/200 mg; 15 mg/500 mg
    Indication: Diabetes Mellitus Management

Vioxx
    Dosage: 25 mci

Actos
    Dosage: 15 mg
    Indication: Diabetes Mellitus Management

Unspecified Nsaid's (Nsaid's)

Other drugs received by patient: Cymbalta; Metformin HCL; Naproxen; Prilosec; Cyclobenzaprine Hydrochloride; Aciphex; Cialis; Paroxetine ER (Paroxetine); Simvastatin; Glucotrol XL; Viagra; Nexium; Janumet (Metformin Hydrocloride, Sitagliptin Phosphate); Fortamet; Glipizide; Cephalexin; Lipitor; Cozaar; Pristiq; Glumetza; Glucophage; Claritin-D (Pseudoepherdrinesulfate, Loratadine); Paxil; Vytorin; Mobic; Ambein C IV (Zolpidem Tartrate); Celebrex; Bextra (Parecoxib Sodium); Aspirin; Prozac; Palgic (Carbinoxamide Maleate)



Possible Actoplus MET side effects in 56 year old

Reported by a physician from United States on 2012-01-20

Patient: 56 year old

Reactions: Bladder Cancer

Adverse event resulted in: death

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 47 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-17

Patient: 47 year old male, weighing 129.7 kg (285.4 pounds)

Reactions: Mantle Cell Lymphoma Stage IV, Body Height Decreased, Weight Decreased, Ulcer, Blood Pressure Decreased, RIB Fracture, Loss of Consciousness

Drug(s) suspected as cause:
Actoplus MET
    Dosage: 2 in 1 d, 15/850, per oral 1 in 1 d, 15/850, per oral
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2009-01-09
    End date: 2011-07-09

Actoplus MET
    Dosage: 2 in 1 d, 15/850, per oral 1 in 1 d, 15/850, per oral
    Administration route: Oral
    Indication: Type 2 Diabetes Mellitus
    Start date: 2011-07-09

Other drugs received by patient: Digoxin; Dexilant; Plavix; Pravastatin; Celebrex; Lasix; Aspirin; Potassium Chloride; Coreg; Ambien



Possible Actoplus MET side effects in 79 year old male

Reported by a consumer/non-health professional from United States on 2012-01-17

Patient: 79 year old male, weighing 103.0 kg (226.5 pounds)

Reactions: Abdominal Pain, Bladder Cancer

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in male

Reported by a consumer/non-health professional from United States on 2012-01-10

Patient: male

Reactions: Impaired Healing, Ischaemic Stroke, Intervertebral Disc Degeneration, Myocardial Infarction

Drug(s) suspected as cause:
Actos
    Indication: Type 2 Diabetes Mellitus

Actoplus MET
    Dosage: 100 mg/200 mg
    Indication: Type 2 Diabetes Mellitus



Possible Actoplus MET side effects in female

Reported by a physician from United States on 2011-12-15

Patient: female

Reactions: Renal Cell Carcinoma, Bladder Cancer

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 69 year old male

Reported by a consumer/non-health professional from United States on 2011-12-12

Patient: 69 year old male, weighing 81.6 kg (179.6 pounds)

Reactions: Cholelithiasis, Abdominal Hernia, Post Procedural Complication, Procedural Site Reaction, Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Actoplus MET

Other drugs received by patient: Naproxen; Vicodin; Lisinopril; Fluocinolone Cream (Fluocinolone Acetonide); Proair Inhaler (Fluticasone Propionate); Flomax



Possible Actoplus MET side effects in 79 year old female

Reported by a physician from United States on 2011-12-09

Patient: 79 year old female

Reactions: Bladder Cancer

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 61 year old male

Reported by a physician from United States on 2011-12-01

Patient: 61 year old male, weighing 121.6 kg (267.4 pounds)

Reactions: Bladder Transitional Cell Carcinoma Stage II

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in 73 year old male

Reported by a physician from United States on 2011-11-15

Patient: 73 year old male, weighing 94.6 kg (208.1 pounds)

Reactions: Bladder Cancer

Drug(s) suspected as cause:
Actoplus MET



Possible Actoplus MET side effects in male

Reported by a physician from United States on 2011-11-14

Patient: male

Reactions: Bladder Cancer

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Actos
    Dosage: 15 mg, 1 in 1 d
    Indication: Diabetes Mellitus
    Start date: 2005-10-06
    End date: 2008-03-11

Actoplus MET
    Dosage: 15 mg/850 mg, 2 in 1 d
    Indication: Diabetes Mellitus
    Start date: 2008-07-20
    End date: 2010-02-17



Possible Actoplus MET side effects in 85 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-14

Patient: 85 year old male, weighing 63.7 kg (140.2 pounds)

Reactions: Blood Iron Decreased, Haemorrhage, Bladder Cancer

Drug(s) suspected as cause:
Lipitor

Actoplus MET
    Dosage: 2 in 1 d, per oral
    Administration route: Oral

Other drugs received by patient: Metoprolol Tartrate; Diovan; Exforge

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