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Activase (Alteplase) - Life Threatening Events - Suspected Cause - Side Effect Reports

 
 



Index of reports > Life Threatening Events (41)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Activase (Alteplase) life threatening events. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 41   Next >>

Possible Activase side effects in male

Reported by a physician from Germany on 2012-08-27

Patient: male, weighing 100.0 kg (220.0 pounds)

Reactions: Angioedema, Tongue Oedema, Macroglossia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase
    Indication: Cerebrovascular Accident

Ramipril
    Administration route: Oral
    Indication: Hypertension

Other drugs received by patient: Insulin; Spiriva; Bayotensin; Fluticasone Propionate / Salmeterol



Possible Activase side effects in 43 year old male

Reported by a physician from United States on 2012-08-24

Patient: 43 year old male

Reactions: Ventricular Extrasystoles, Metabolic Acidosis, Atrioventricular Block Complete, Hypoxia, Cardiac Arrest, Pulseless Electrical Activity

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Activase



Possible Activase side effects in male

Reported by a physician from Germany on 2012-08-15

Patient: male, weighing 90.0 kg (198.0 pounds)

Reactions: Angioedema, Cerebral Infarction, Respiratory Failure, Brain Oedema, Endotracheal Intubation

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Activase



Possible Activase side effects in 61 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-08-09

Patient: 61 year old male, weighing 70.0 kg (154.0 pounds)

Reactions: Anaphylactic Reaction, Endotracheal Intubation

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase
    Indication: Cerebral Infarction
    Start date: 2012-01-31
    End date: 2012-01-31

Activase
    Start date: 2012-01-31
    End date: 2012-01-31



Possible Activase side effects in male

Reported by a physician from United States on 2012-08-09

Patient: male

Reactions: Death

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Activase

Activase
    Indication: Cerebrovascular Disorder

Activase
    Indication: Convulsion

Activase
    Indication: Cerebrovascular Accident



Possible Activase side effects in female

Reported by a physician from Sweden on 2012-07-25

Patient: female

Reactions: Hypersensitivity, Dyspnoea, Oedema Mouth, Swollen Tongue

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase

Other drugs received by patient: Enalapril Maleate; Simvastatin



Possible Activase side effects in female

Reported by a health professional (non-physician/pharmacist) from Sweden on 2012-07-25

Patient: female

Reactions: Respiratory Rate Decreased, Hypersensitivity, Oxygen Saturation Abnormal, Swollen Tongue

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase

Other drugs received by patient: Enalapril Maleate; Metformin Hydrochloride; Atenolol; Losartan Potassium; Levothyroxine Sodium



Possible Activase side effects in male

Reported by a physician from Germany on 2012-07-23

Patient: male, weighing 94.0 kg (206.8 pounds)

Reactions: Pruritus, Cardiovascular Insufficiency, Aphasia, Anaphylactic Shock, Rash

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase
    Indication: Cerebral Ischaemia

Activase
    Indication: Thrombolysis
    Start date: 2012-06-21

Activase
    Indication: Cerebral Artery Occlusion

Iodine Contrast
    Indication: Angiogram
    Start date: 2012-06-21

Other drugs received by patient: Ramipril; Bisoprolol Fumarate



Possible Activase side effects in 61 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-17

Patient: 61 year old female

Reactions: LIP Swelling, Angioedema, Choking, Swollen Tongue, Paraesthesia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase

Other drugs received by patient: Ranitidine; Zolmitriptan; Atorvastatin; Budesonide; Diltiazem HCL; Perindopril Erbumine; Formoterol Fumarate; Lansoprazole; Zolmitriptan



Possible Activase side effects in female

Reported by a physician from Sweden on 2012-07-11

Patient: female

Reactions: Hypersensitivity, Dyspnoea, Oedema Mouth, Swollen Tongue

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase

Other drugs received by patient: Enalapril Maleate; Simvastatin



Possible Activase side effects in female

Reported by a health professional (non-physician/pharmacist) from Sweden on 2012-07-09

Patient: female

Reactions: Respiratory Rate Decreased, Hypersensitivity, Oxygen Saturation Abnormal, Swollen Tongue

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase

Other drugs received by patient: Enalapril Maleate; Levothyroxine Sodium; Losartan Potassium; Metformin HCL; Atenolol



Possible Activase side effects in

Reported by a health professional (non-physician/pharmacist) from Sweden on 2012-07-02

Patient:

Reactions: Hypersensitivity, Upper Airway Obstruction

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase



Possible Activase side effects in male

Reported by a physician from Japan on 2012-06-21

Patient: male

Reactions: Pneumonia Aspiration, Hepatic Function Abnormal, Haemorrhagic Cerebral Infarction

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase
    Indication: Embolic Stroke
    Start date: 2011-12-25
    End date: 2011-12-25

Ampicillin Sodium / Sulbactam Sodium
    Dosage: brand name: picillibacta
    Indication: Pneumonia Aspiration
    End date: 2012-01-06

Aspirin
    Administration route: Oral
    Indication: Embolic Stroke
    Start date: 2011-12-25
    End date: 2012-01-04

Hangekobokuto
    Administration route: Oral
    Indication: Mental Impairment
    Start date: 2011-12-29
    End date: 2012-01-08

Radicut
    Indication: Embolic Stroke
    Start date: 2011-12-25
    End date: 2012-01-04

Symmetrel
    Administration route: Oral
    Indication: Mental Impairment
    Start date: 2011-12-29
    End date: 2012-01-06

Other drugs received by patient: Heparin Sodium; Bisoprolol Fumarate; Laxoberon; Vancomycin; Lansoprazole; Amlodipine; Gasmotin; Vancomycin; Enalapril Maleate; Warfarin Sodium; Vancomycin; Glyceol; Warfarin Potassium; Amlodipine; Nicardipine HCL; Lansoprazole; Cefazolin Sodium; Amlodipine; Amlodipine; Warfarin Sodium; Warfarin Sodium; Glyceol; Warfarin Sodium; Warfarin Sodium; Verapamil HCL



Possible Activase side effects in female

Reported by a health professional (non-physician/pharmacist) from Sweden on 2012-06-06

Patient: female

Reactions: Angioedema, Tongue Oedema, Anaphylactic Shock

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase

Other drugs received by patient: Potassium Chloride; Ramipril; Levothyroxine Sodium; Aspirin; Targiniq; Arcoxia; Esidrix



Possible Activase side effects in 80 year old female

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-06-01

Patient: 80 year old female

Reactions: Dyspnoea, Angioedema

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase



Possible Activase side effects in 65 year old female

Reported by a pharmacist from United States on 2012-05-17

Patient: 65 year old female, weighing 94.0 kg (206.8 pounds)

Reactions: Angioedema, Anaphylactic Reaction, Blood Pressure Decreased

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Activase



Possible Activase side effects in 64 year old male

Reported by a consumer/non-health professional from United States on 2012-05-15

Patient: 64 year old male

Reactions: Blood Pressure Increased, Overdose, Haemorrhage, Dysphonia, Cerebral Infarction, Haemorrhage Intracranial, Drug Administration Error, Hemiplegia, Ill-Defined Disorder, Arrhythmia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Activase



Possible Activase side effects in 48 year old female

Reported by a physician from Canada on 2012-05-04

Patient: 48 year old female, weighing 70.0 kg (154.0 pounds)

Reactions: Chest Discomfort, Suffocation Feeling, Blood Pressure Immeasurable, Hyperhidrosis, Shock

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase
    Dosage: dose: 5mg iv; 45ml iv drop
    Indication: Cerebral Infarction
    Start date: 2012-04-14
    End date: 2012-04-14

Nitroglycerin
    Dosage: dose: 20mg/ 10 d/ min
    Indication: Cerebral Infarction
    Start date: 2012-04-14
    End date: 2012-04-14



Possible Activase side effects in female

Reported by a physician from China on 2012-05-03

Patient: female, weighing 70.0 kg (154.0 pounds)

Reactions: Chest Discomfort, Suffocation Feeling, Blood Pressure Immeasurable, Hyperhidrosis, Shock

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase
    Indication: Cerebral Infarction
    Start date: 2012-04-14
    End date: 2012-04-14

Activase

Nitroglycerin
    Indication: Cerebral Infarction
    Start date: 2012-04-14
    End date: 2012-04-14



Possible Activase side effects in 75 year old male

Reported by a health professional (non-physician/pharmacist) from Sweden on 2012-04-24

Patient: 75 year old male

Reactions: Cerebral Haemorrhage

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Activase



Possible Activase side effects in 25 year old female

Reported by a physician from United Kingdom on 2012-04-13

Patient: 25 year old female

Reactions: Phaeochromocytoma, Pulmonary Embolism, Cardiac Arrest, Pulseless Electrical Activity

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Activase
    Dosage: 100 mg
    Indication: Pulmonary Embolism
    Start date: 2011-10-01
    End date: 2011-10-01

Propranolol
    Dosage: 20 mg
    Indication: Anxiety
    Start date: 2011-10-01

Other drugs received by patient: Midazolam; Morphine; Suxamethonium



Possible Activase side effects in male

Reported by a physician from Germany on 2012-04-11

Patient: male, weighing 80.0 kg (176.0 pounds)

Reactions: Brain Death, Tracheal Oedema, Angioedema, Dyspnoea, Respiratory Failure, Cyanosis

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Activase
    Indication: Cerebral Infarction
    Start date: 2012-02-07

Activase

Lisinopril
    Administration route: Oral
    Indication: Hypertension

Other drugs received by patient: Levothyroxine Sodium; Moviprep; Aspirin; Diamox; Simvastatin



Possible Activase side effects in 25 year old female

Reported by a physician from United Kingdom on 2012-03-30

Patient: 25 year old female

Reactions: Phaeochromocytoma, Cardiac Arrest, Pulseless Electrical Activity

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Activase
    Dosage: 100 mg
    Indication: Pulmonary Embolism
    Start date: 2011-10-01
    End date: 2011-10-01

Propranolol
    Dosage: 20 mg
    Indication: Anxiety
    Start date: 2011-10-01

Other drugs received by patient: Midazolam; Suxamethonium; Morphine



Possible Activase side effects in female

Reported by a physician from United Kingdom on 2012-03-26

Patient: female

Reactions: Phaeochromocytoma, Cardiac Arrest, Pulseless Electrical Activity

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Activase
    Dosage: 2 doses administered-one hour apart
    Indication: Pulmonary Embolism
    Start date: 2011-10-01
    End date: 2011-10-01

Propranolol
    Dosage: (taken in the morning, prior to events onset)
    Indication: Anxiety
    Start date: 2011-10-01

Other drugs received by patient: Midazolam; Suxamethonium; Morphine



Possible Activase side effects in 25 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-03-22

Patient: 25 year old female

Reactions: Electrocardiogram QT Prolonged, Metabolic Acidosis, Phaeochromocytoma, Neutrophil Count Increased, Haemorrhage, Haemoglobin Decreased, Pulmonary Congestion, Pleural Effusion, Hypoxia, Cardiac Arrest, Arteriosclerosis, Electrocardiogram ST Segment Elevation, Sinus Tachycardia, Pulseless Electrical Activity, White Blood Cell Count Increased

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Activase
    Dosage: 50 mg, bid
    Indication: Pulmonary Embolism
    Start date: 2011-10-01

Propranolol
    Dosage: 10 mg, unk
    Indication: Anxiety
    Start date: 2011-10-01

Other drugs received by patient: Suxamethonium; Morphine; Midazolam



Possible Activase side effects in 70 year old male

Reported by a physician from Germany on 2012-03-09

Patient: 70 year old male, weighing 90.0 kg (198.0 pounds)

Reactions: Angioedema, Brain Oedema, Endotracheal Intubation

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Activase



Possible Activase side effects in male

Reported by a physician from Denmark on 2012-03-06

Patient: male, weighing 110.0 kg (242.0 pounds)

Reactions: Angioedema, Anaphylactic Shock

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Activase



Possible Activase side effects in 65 year old male

Reported by a physician from Sweden on 2012-03-02

Patient: 65 year old male

Reactions: Renal Failure, Hepatic Failure, Blood Pressure Decreased

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Activase

Other drugs received by patient: Cozaar; Aspirin; Metoprolol Succinate; Furosemide; Insulin



Possible Activase side effects in female

Reported by a health professional (non-physician/pharmacist) from Australia on 2012-03-02

Patient: female

Reactions: Dyspnoea, Swollen Tongue, Haematoma

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Activase



Possible Activase side effects in male

Reported by a physician from Germany on 2012-02-29

Patient: male, weighing 80.0 kg (176.0 pounds)

Reactions: Tracheal Oedema, Brain Death, Angioedema, Dyspnoea, Cyanosis, Respiratory Failure

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Activase

Activase
    Indication: Cerebral Infarction
    Start date: 2012-02-07

Lisinopril
    Administration route: Oral
    Indication: Hypertension

Other drugs received by patient: Diamox SRC; Moviprep; L-Thyrox; Simvastatin



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