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Below are Differin (Adapalene) reviews, ratings, comments submitted by patients and caregivers. Based on a total of 17 ratings/reviews, Differin has an overall score of 6.82. The effectiveness score is 6.59 and the side effect score is 8.24. The scores are on ten point scale: 10 - best, 1 - worst. This information is not vetted and should not be cosidered as clinical evidence. | | Differin review by 36 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Ineffective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | 0.1% (dosage frequency: once daily) for the period of once daily / one month |
| Other conditions: | | none |
| Other drugs taken: | | no other drugs | | |
Reported Results |
| Benefits: | | Benefits were intended to be no facial acne |
| Side effects: | | There were no side effects noticed |
| Comments: | | Was to be applied externally to the affected area every night at bedtime afer washing. |
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| | Differin review by 46 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | 0.1% (dosage frequency: daily) for the period of 8 yrs |
| Other conditions: | | none |
| Other drugs taken: | | metrogel | | |
Reported Results |
| Benefits: | | fewer breakouts (due to both Adapalene and Metrogel) and quicker healing time attributed to Adapalene. |
| Side effects: | | some minor burning that disappeared in a few days. |
| Comments: | | Used at bed time daily. |
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| | Differin review by 37 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Acne |
| Dosage & duration: | | gel .3% (dosage frequency: 2 times a day) for the period of 4 weeks |
| Other conditions: | | enlarged pores |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The pimples become dry. At first there was formation of new pimples, but then pimples started gradually go away; overall the skin started looking healthier and cleaner. |
| Side effects: | | some bearable feeling of heat/burning |
| Comments: | | applied the gel in the morning and at night on nose, cheeks, forehead, and chin. |
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| | Differin review by 24 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | very oily skin |
| Dosage & duration: | | .1% (dosage frequency: every second night) for the period of 6 months |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | differin made my skin less oily and shiney and had a very small effect on my large pore size |
| Side effects: | | at the start my skin was very red. after a long period of using differin my skin started to become more oily again,but not as oily as before i started using it. also got small patches of peeling skin especially around the nose |
| Comments: | | after washing face at night i applied a thin layer over entire face every second night and washed it off in the morining |
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| | Differin review by 36 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | thin layers on affected skin area (dosage frequency: every other night) for the period of one month |
| Other conditions: | | dermatitis |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | purging of the skin, some clearing acne. |
| Side effects: | | Initial break-out, drying, peeling of the applied skin area. |
| Comments: | | differin was prescribed to treat moderate facial cystlic acne. it is applied once every other night on affected area. For the first month, the acne that were underneath the skin surface were pushed out, thus created the appearance of a break-out. However, this break out resolved over time and healed quicker than previous break-out experienced before using the medication. Drying and Peeling and all the typical side-affect of retinoid were observed. |
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| | Differin review by 28 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Highly Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | 1x/day (dosage frequency: 1x/day) for the period of 3months |
| Other conditions: | | na |
| Other drugs taken: | | na | | |
Reported Results |
| Benefits: | | The acne I had on my face in the t-zone area disappeared within a week. |
| Side effects: | | The treatment side effects included drying of the skin in the areas that the product was applied. |
| Comments: | | I was directed to apply Differin to my face once per day after cleansing. I was directed to use as needed after the acne cleared up and discontinue the use of the product if irritation occurred. |
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| | Differin review by 38 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | 10mg taken every day for the period of 6 months |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | Exfoliates the skin. It is said to prevent or treat acne and acne scars. whether this is true is questionable. |
| Side effects: | | the drug induced some dryness and flakiness especially around the nose area and chin area. this side effect can go away after a while |
| Comments: | | the product is a gel that is put on every night. it supposedly prevents new blemishes and promotes exfoliation. the results for the blemishes were not satisfactory. |
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| | Differin review by 19 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | 0.1 (dosage frequency: daily) for the period of daily |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | my acne calmed down by 75%.still had some break outs when not used on time,but still nothing else would stop the break outs.everything I used just made it worse and mt skin was very dry and inflamed.those problems went away.my skin isn't dry it is back to normal even in the winter when its dry out. |
| Side effects: | | none |
| Comments: | | used every day after washing face.rubbed in until absorbed,and at night. |
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| | Differin review by 24 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | daily (dosage frequency: daily) for the period of three months |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | There were little to no benefits to using differin to treat acne. while it may have helped exfoliation, it did little to treat current and to prevent future acne. instead of differin, using a separate skin exfoliation product in addition to an over the counter acne treatment might have been more beneficial. My acne worsened using Differin -- some say it is because the impurities are being purged from beneath the outer layers of the skin. I don't know if I completely buy this theory though I would have believed it if it showed some improvement after three months. Unfortunately, it did not. |
| Side effects: | | There were no side effects to the treatment except that it worsened my breakouts. However, it did nothing to take down the flares even after three months of treatment. Soon after I stopped using it, my skin improved. So now, I choose to use an exfoliation product and a separate over the counter acne treatment product. |
| Comments: | | differin did not help prevent acne or get rid of current acne. it worsened the condition though it was explained that as it helped the skin exfoliate, the impurities beneath the outer skin surfaced. however, there were no improvements after three months of application. |
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| | Differin review by 31 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | mild acne |
| Dosage & duration: | | 0.1% (dosage frequency: every night after washing my face) for the period of 6 months |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The acne has decreased and I have not had major skin irritation or sunburn like I know other acne treatments can cause. |
| Side effects: | | Mild dry skin that improves with the use of cream. |
| Comments: | | I was prescribed the medication for moderate acne. I have been using it every night, a pea-sized amount all over my face except eyes, 30 minutes after washing and drying my face with a mild soap. I wait unitl it dries before going to bed, so it won't smear off. I use a moisturizing cream the next day with SPF of at least 15. |
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| | Differin review by 19 year old male patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Acne |
| Dosage & duration: | | 0.1% (dosage frequency: nightly) for the period of 15 weeks |
| Other conditions: | | none |
| Other drugs taken: | | Minocycline | | |
Reported Results |
| Benefits: | | Dramatic reduction in papules and pustules. |
| Side effects: | | Some redness and slight dryness was perceived. Nosystemic side effects were noted, as adapalene is not very well absorbed by the body |
| Comments: | | Application nightly after washing. The first 2 weeks were unpleasant as irritation and breakouts where the most severe, after 4 weeks significant improvement was noted, optimal effectiveness being achieved by the 10th week. |
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| | Differin review by 28 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | 0.03 (dosage frequency: nightly) for the period of 6 months |
| Other conditions: | | none |
| Other drugs taken: | | birth control | | |
Reported Results |
| Benefits: | | The treatment easy and convenient and effective for skin turnover to prevent acne. |
| Side effects: | | Differin was drying and particularly the 3% solution. |
| Comments: | | You are to apply nightly to acne spots but I found it worked better as a preventive measure all over face once your face is used to the drying. Differin worsens any open wounds but is a great preventive measure |
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| | Differin review by 27 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | .3 (dosage frequency: once daily) for the period of 8 months so far |
| Other conditions: | | some fine lines |
| Other drugs taken: | | yazmin and soledyne | | |
Reported Results |
| Benefits: | | my acne cleared up within a few months, and now it is gone. |
| Side effects: | | You cannot wax your eyebrows! It thins your skin, so you can't wax. |
| Comments: | | I used the gel once at night. I also took an antibiotic and yazmin. I believe I will continue to use the differin even after I stop the antibiotic, just for it's benifits. |
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| | Differin review by 34 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | .01% (dosage frequency: daily) for the period of 3 months |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The Differin resulted in decreased body acne on the face and back. i also felt smoother, cleaner skin |
| Side effects: | | dry skin and skin irritation |
| Comments: | | Apply the Differin cream at night after cleasing skin. The dryness decreased after about 3 weeks of daily use. The facial acne was cleared up about 70% and the back acne was cleared up about 50%. |
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| | Differin review by 29 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | 0.1% (dosage frequency: nightly) for the period of commenced a week ago |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | will see with time photo damage reduction. Sun exposure ++ growing up in South Africa so fine lines and facial scar due to dog bite. I have some medical training so am interested to see if any skin improvement |
| Side effects: | | none so far |
| Comments: | | taken for mild acne but curious about photo damage reduction. Will take for next year and see |
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| | Differin review by 36 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | acne |
| Dosage & duration: | | topical 1X/day (dosage frequency: once daily) for the period of still using (6 months) |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | I have noticed a reduction in acne breakouts, particularly painful cysts. I have also noticed improved skin appearance with more even skin tone. |
| Side effects: | | I initially experienced mild facial redness, which lasted the first three days of treatment. |
| Comments: | | I apply Differin gel once per day to treat facial acne. I have noticed a considerable reduction in acne breakouts. |
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| | Differin review by 29 year old male patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Elarge pores blackheads around nose & cheeks |
| Dosage & duration: | | .3% (dosage frequency: once nightly) for the period of 3 months |
| Other conditions: | | None |
| Other drugs taken: | | None | | |
Reported Results |
| Benefits: | | The Differin did seem to help clear up the occasional blemishes I would get. made a slight improvement in the size of blackheads on my nose and cheeks but didn't aleviate them entirely. |
| Side effects: | | My skin became more sensitive although this happened after about a week of use not in the beginning. There were times when my skin felt warm. My skin peeled a little bit and felt and appeared dry. There was some periodic itching. My skin became more sensitive and something like a scrape would hurt. Additionally and most noticeably even though I avoided my eye area the differin would make the skin around my eyes sore, red and flaky. I'm not sure how it spread to my eyes when I avoided rubbing it in anywhere close, but it did. |
| Comments: | | I was directed to apply once or twice a week and build up to once per night as tolerated. I was able to tolerate once per night application for the entire course of treatment. There were some negative side effects (itching, sensitivity, warmth, and redness especially around my eyes) and not much in the way of positive side effects. I am now considering asking my dermatologist for a different prescription. |
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