Is it best to take Prozac in the morning or at bedtime?

Question

It doesn't seem to make me tired, like all the other anti-depressants did.

Thank you, Sarah

Answer 1

In most Prozac studies, it was administered once a day on the morning -- so this is the typical way it is taken.

It is worth noting though that Prozac (fluoxetine) has a very long half-life in the bloodstream and so the effect of each dose is quite protracted. As a result, it is likely to make relatively modest difference at what time of the day Prozac is taken because each dose stays in the body for up to several days.

Answer 2

All of the SSRIs can be either activating or sedating. The effect is different for different people. Try taking it in the morning, if you find that it makes you sleepy or fatigued, take it before bed and see if that makes a difference.