Could zofran come up as a benzo in a urine drug screening?

Answer 1

This is very unlikely. It is structurally different from benzodiazepines.

Answer 2

There should not be any false positives as a result of Zofran they  can be caused by Benadryl or anything that contains its active ingredient Diphenhydramine, such as Tylenol PM, Advil PM or generic equivalents.

There are also herbal remedies, such as those for weight loss and relaxation or sleep that have been found to contain Benzodiazepines as undeclared drug ingredients.