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Mechanism of action of tobrex

asked Aug 7, 2012 by anonymous
edited Aug 10, 2012 by cassandra

1 Answer

0 votes
Tobrex (Tobramycin) is aminoglycoside antibiotic. It has the following mechanism of action:

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.
answered Aug 10, 2012 by cassandra (1,840 points)