Question

Levaquin and Augmentin (amoxi-clav), are they the same?

Answer 1

No, Amoxi-clav is the same as Augmentin. Levaquin is different.

Levaquin's active ingredient is levofloxacin and Augmentin's active ingredients are amoxicillin and clavulinate. Levaquin and Augmentin are both braod spectrum antibiotics, so, against many (but not all) bacterial species they will be both effective. However, have different structure and different mechanisms of action. Therefore they have different resistance patterns. They spectra of effectiveness overlap but to mot coincide.

They  also have different side effects profiles. For example,  levofloxacin and other floxins (but not Augmentin or amoxi-clav) reportedly increase the risk of tendonitis and tendon rupture.