Does desipramine cause weight gain?

Question

i am on desipramine  25mg,    topiramate 100mg, trazodone100mg, and  escitalopram 20mg

Answer 1

It appear that major weight gain with desipramine is uncommon. People who respond to it reportedly experience modest weight gain sometimes, but that may be related to the lifting of depression rather than desipramine itself.

See http://www.ncbi.nlm.nih.gov/pubmed/3804981

In any case, if you are experiencing any significant weight changed, you need to talk to your doctor about it.