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Wellbutrin XL (Bupropion) - Reviews, Ratings, Comments by Patients

 

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Below are Wellbutrin XL (Bupropion) reviews, ratings, comments submitted by patients and caregivers. This information is not vetted and should not be cosidered as clinical evidence.
 

Wellbutrin XL review by 44 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   300 mg initially increased to 450 mg/day taken 1 time daily for the period of 6 years at 300 mg, 1 year at 450 mg
Other conditions:   none
Other drugs taken:   Lexapro and birth control
  
Reported Results
Benefits:   elevation of mood and clarity of thought. Progress stalled out at 300 mg, but with increase to 450 mg can tell the difference. I'm able to finally think and plan ahead and chip away at all the clutter I've not been able to deal with which accumulated while depressed.
Side effects:   none at 300 mg. Possible tinnitus from increase to 450 mg, not evaluated by an audiologist yet though. Did experience weight loss (7 lbs.) at 450 mg dosage.
Comments:   Initial treatment included therapy and Lexapro in addition to Wellbutrin XL. Now only on the Wellbutrin XL. I see the psychiatrist every 4 months for re-evaluation.

 

Wellbutrin XL review by 44 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   300 mg initially increased to 450 mg/day taken 1 time daily for the period of 6 years at 300 mg, 1 year at 450 mg
Other conditions:   none
Other drugs taken:   Lexapro and birth control
  
Reported Results
Benefits:   elevation of mood and clarity of thought. Progress stalled out at 300 mg, but with increase to 450 mg can tell the difference. I'm able to finally think and plan ahead and chip away at all the clutter I've not been able to deal with which accumulated while depressed.
Side effects:   none at 300 mg. Possible tinnitus from increase to 450 mg, not evaluated by an audiologist yet though. Did experience weight loss (7 lbs.) at 450 mg dosage.
Comments:   Initial treatment included therapy and Lexapro in addition to Wellbutrin XL. Now only on the Wellbutrin XL. I see the psychiatrist every 4 months for re-evaluation.

 

Wellbutrin XL review by 44 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   300 mg initially increased to 450 mg/day taken 1 time daily for the period of 6 years at 300 mg, 1 year at 450 mg
Other conditions:   none
Other drugs taken:   Lexapro and birth control
  
Reported Results
Benefits:   elevation of mood and clarity of thought. Progress stalled out at 300 mg, but with increase to 450 mg can tell the difference. I'm able to finally think and plan ahead and chip away at all the clutter I've not been able to deal with which accumulated while depressed.
Side effects:   none at 300 mg. Possible tinnitus from increase to 450 mg, not evaluated by an audiologist yet though. Did experience weight loss (7 lbs.) at 450 mg dosage.
Comments:   Initial treatment included therapy and Lexapro in addition to Wellbutrin XL. Now only on the Wellbutrin XL. I see the psychiatrist every 4 months for re-evaluation.

 

Wellbutrin XL review by 53 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Depression
Dosage & duration:   300 mg taken one daily for the period of 3 years
Other conditions:   Thyrodectomy
Other drugs taken:   Levothyroxine
  
Reported Results
Benefits:   Remarkable improvement in productivity (no down time) and feeling of well-being.
Side effects:   Constipation, sleeplessness
Comments:   Treatment started at 150 mg, which showed some improvement At 300 mg the improvement showed more dramatic results Before treatment: periods of deep depression, confusion, feeling of helplessness, unability to go to work. After treatment: remarkably fewer periods of light depression, able to work.

 

Wellbutrin XL review by 47 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   SADD
Dosage & duration:   150 mg taken 1x/day for the period of 3 weeks
Other conditions:   none
Other drugs taken:   Synthroid
  
Reported Results
Benefits:   Started to fell seasonal depression clear with about a week.
Side effects:   I was very dizzy on this med.
Comments:   I tried to stay on the drug long enough for side effects to pass, but unfortunately afer I fainted at church, I figured it wasn't worth it. I do believe if I had been able to wait out the side effects, it would have helped to seasonal depression.

 

Wellbutrin XL review by 44 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   300 mg initially increased to 450 mg/day taken 1 time daily for the period of 6 years at 300 mg, 1 year at 450 mg
Other conditions:   none
Other drugs taken:   Lexapro and birth control
  
Reported Results
Benefits:   Elevation of mood and clarity of thought. Progress stalled out at 300 mg, but with increase to 450 mg can tell the difference. I'm able to finally think and plan ahead and chip away at all the clutter I've not been able to deal with which accumulated while depressed.
Side effects:   None at 300 mg. Possible tinnitus from increase to 450 mg, not evaluated by an audiologist yet though. Did experience weight loss (7 lbs.) at 450 mg dosage.
Comments:   Initial treatment included therapy and Lexapro in addition to Wellbutrin XL. Now only on the Wellbutrin XL. I see the psychiatrist every 4 months for re-evaluation

 

Wellbutrin XL review by 49 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   anti-depressant
Dosage & duration:   350 (dosage frequency: once a day) for the period of 2 years
Other conditions:   n/a
Other drugs taken:   none
  
Reported Results
Benefits:   The biggest benefit was when I quit smoking, because I had been taking it for a while...it proved to assist with the cravings...it's probably why I was able to quit in the first place.
Side effects:   Made me kind of grumpy and a little weight gain.
Comments:   Started taking anti-depressant when my Mother passed away. Started a low-dose and increased over a period of 3 months. I believe Wellbuterin was very beneficial and did not have major side effects. I stopped taking them 2 months ago and haven't had any withdrawal symptoms.

 

Wellbutrin XL review by 38 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Chronic depression
Dosage & duration:   300 mg taken once a day for the period of two years
Other conditions:   ADD
Other drugs taken:   Dexedrine
  
Reported Results
Benefits:   Significant improvement in mood, affect, energy, libido, and overall mental status. Significant reduction in anxiety, moodiness, and certain obsessive compulsive traits.
Side effects:   None
Comments:   Patient suffering from severe depression prior to medication. Had taken Wellbutrin SR in the past with moderate side effects and moderate improvement in depression. Attending psychiatrist prescribed Wellbutrin XL at a higher dose in conjunction with Dexedrine for ADD. Marked improvement in depression and ADD symptoms. Patient still taking medication.

 

Wellbutrin XL review by 33 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Depression
Dosage & duration:   150 mg taken daily for the period of past 7 months
Other conditions:   dysmenorhea
Other drugs taken:   loestrin fe 24
  
Reported Results
Benefits:   This drug definately does have an effect on depression. I went on a trip and while I had enough for the duration of the trip, I ran out the day I returned and was unable to get the refill for several days. I noticed a significant change in my mood and affect and began experiencing symptoms of depression again. Although I tried to keep a "stiff upper lip" my husband noticed the change.
Side effects:   At the beginning of treatment I noticed a slightly elevated heart rate and I felt a bit jittery. However, I do consume a fairly high amount of caffeine during the day and I was told to expect this by my doctor. Another effect that I didn't really connect to the medication was a lack of motivation. I did not attribute this specifically to the medication until I had a conversation with my best friend who had also taken Wellbutrin at one point. She asked me specifically if I had experienced diminshed motivation while on the drug and it "clicked" with me. I am not entirely certain if this can be attributed solely to the medication since this is also a symptom of depression.
Comments:   Overall, I feel that my treatment with this drug has been successful. I have not experienced any sexual side effects (which I know can occur with some antidepressants). My libido is exactly the same as it was before my depression and before I began taking this drug. I know that this drug can also cause a decrease in appetite as well as the urge to smoke. My husband and I both smoke and I do smoke less when he is not home. He is not on any medications and so he will frequently ask me if I want to go outside with him and smoke. Usually (not always) I say yes for the companionship but sometimes I decline. When he is not home I will smoke approximately 4 cigarettes in an 8-9 hour period (I used to be a pack-a-day smoker). Overall, I feel that this is a useful drug for depression. I began taking it after my father died. He battled cancer for 3 years and I took care of him the entire time. His loss was debilitating to me. No pill is going to change what I went through or how I feel, but this drug has helped me explore some of the painful feelings that go along with his death without "coming unglued". My doctor prescribed this for me and at the same time switched me from Ortho-Tricyclen (which I was highly loyal to) to Loestrin Fe 24. I must say that between these two drugs, physically I feel ten years younger (I am 33 but I feel 23 again). Overall I would rate this drug as successful for me and will continue on it as long as my doctor and I feel is appropriate for me.

 

Wellbutrin XL review by 45 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Depression
Dosage & duration:   400mg taken once daily for the period of 4 years
Other conditions:   None
Other drugs taken:   Topamax
  
Reported Results
Benefits:   Marked adjustment in level of depression within one month. Continued benefits through following years of usage.
Side effects:   No side effects were experienced.
Comments:   Wellbutrin XL was used in conjunction with talk therapy to great effect. Dosage has been maintained over the years with frequency of talk therapy decreasing and alleviation of depression has been maintained.

 

Wellbutrin XL review by 41 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Post trauma depression
Dosage & duration:   300mg/day taken every day for the period of April 15, 2005 to present
Other conditions:   Anxiety
Other drugs taken:   Vitamins
  
Reported Results
Benefits:   Taking Wellbutrin has reduced my depression 8 fold. I was better able to cope with every day decisions, events that stressed me with out crying or having angry episodes. My moods have become stabilized since about a month after the start of taking this medicine.
Side effects:   I tried two other medications prior to using Wellbutrin and was quite pleased! I had mild dry mouth for about a month and actually lost the weight i gained from prior meds and a bit more. I still have shaking hands but it is not any worse than a cup of coffee. I have found that my tolerance to alcohol has increased, and lately my lower back has been hurting in the area of my kidneys, but i also have lower back spasms so i could be projecting worry that the combination of Wellbutrin and wine are doing major damage to my liver and kidneys!
Comments:   I started taking 150mg of Wellbutrin from April 15 to 30 in 2005 and then increased to 300mg. I tried to take 450mg about a year ago because I felt the medicine did not seem to be working as well, but I wound up not benefiting from that dose. I also tried to add Lexapro and gained so much weight I had to stop that medicine. I was given a generic version for about a month and I believe the pills were expired or tainted because the smelled rancid and my behavior patterns went haywire!

 

Wellbutrin XL review by 44 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   300 mg initially increased to 450 mg/day taken 1 time daily for the period of 6 years at 300 mg, 1 year at 450 mg
Other conditions:   none
Other drugs taken:   Lexapro and birth control
  
Reported Results
Benefits:   elevation of mood and clarity of thought. Progress stalled out at 300 mg, but with increase to 450 mg can tell the difference. I'm able to finally think and plan ahead and chip away at all the clutter I've not been able to deal with which accumulated while depressed.
Side effects:   none at 300 mg. Possible tinnitus from increase to 450 mg, not evaluated by an audiologist yet though. Did experience weight loss (7 lbs.) at 450 mg dosage.
Comments:   Inital treatment included therapy and Lexapro in addition to Wellbutrin XL. Now only on the Wellbutrin XL. I see the psychiatrist every 4 months for re-evaluation.

 

Wellbutrin XL review by 54 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Dysthymia ( chronic, low grade depression )
Dosage & duration:   150 mg taken once a day for the period of 8 years
Other conditions:   normal tension glaucoma
Other drugs taken:   Armour Thyroid
  
Reported Results
Benefits:   It lifted my depression without any noticeable side effects which I had experienced with every other anti-depressant I had taken.
Side effects:   None.
Comments:   I had been prescribed 300 mg which is a normal dosage, but fond it made me sleepless. So after talking with my doctor, we agreed to let me try half the dosage. I'm especially sensitive to medications and always feel overdosed at the 'standard' dosage. I've been taking Wellbutrin for the last 8 years and only recenyly felt the need to boost it up to 300 mg as the depression seemed to be inching up. It worked for me and I will maintain the 300 mg through the winter months. I think this is a wonderful drug, if nothing else works for you, give it a try.

 

Wellbutrin XL review by 53 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   lose weight
Dosage & duration:   300mg taken 1x day for the period of 2 weeks
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Positive- increased libido
Side effects:   Negative- 1)significant increase in breast pain on one side, leading to bloody discharge after only 2 weeks of taking drug 2)'coursing' feeling through veins on same side as breast pain 3)humongous hard pimple formed near nose.
Comments:   Discontinued treatment due to side effects. I would consider taking again if the negative side effects were noted in literature as temporary and insignificant over the long term

 

Wellbutrin XL review by 48 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   300 mg taken once a day for the period of still taking it
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I dont have days that seem so dark that there is no hope for the future any more. If I am up set about something I can still function and not spend time hibernating and not functioning. I sleep regularly where before I had nights where I would not get any sleep at all. Activities are more enjoyable. I enjoy life more.
Side effects:   have not noticed any side effects the only effects I notice are positive. Has not effected my sex drive and satisfaction that other anti depressants have in the past. Don't have problems with a dry mouth like other anti depressants have in the past. I don't have problems with going to sleep like I did with other anti depressants.
Comments:   take one tablet once a day every day for the rest of my life. take one tablet once a day for the rest of my life. take one tablet a day before breakfast wait 30 minutes before eating. take with one glass of water seems to work beter if I take it in the morning before I have anything to eat and wait 30 minutes before having breakfast.

 

Wellbutrin XL review by 31 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   150 mg taken daily for the period of 1 year
Other conditions:   anxiety
Other drugs taken:   Lexapro
  
Reported Results
Benefits:   Aided in decreasing symptoms of depression, and also reduced craving for cigarettes as a bonus. Noticeably less lethargy.
Side effects:   Side effects were generally positive, including help with smoking cessation as well as increased libido, which had decreased on Lexapro.
Comments:   In conjunction with taking Lexapro for anxiety, Wellbutrin XL was taken (150 mg/day) to reduce depression and balance the side effects of Lexapro, including lethargy, weight gain and sexual dysfunction. Lexapro was taken in evening, Wellbutrin XL in the morning.

 

Wellbutrin XL review by 50 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   300mg taken one tablet per day for the period of 2001-currently
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   The drug caused the depression to recede to the point that I was able to function normally. The libido lowering effects of a prior antidepressent (SSRI) were alleviated completely. I was able to lose excess weight gained during treatment with the other SSRI
Side effects:   Occasionally I would have trouble falling asleep and staying asleep if I took the drug too late in the day. I began to take it upon wakening daily to counter those effects.
Comments:   I took one tablet per day 300 mg of the Wellbutrin XL.

 

Wellbutrin XL review by 56 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   150mg taken every am for the period of on going
Other conditions:   thyroid, high cholesterol
Other drugs taken:   Synthroid 25mg Simvastaton 20mg
  
Reported Results
Benefits:   Yes, I had taken Prozac for fourteen to fifteen years for the treatment of depession and experienced a loss of sexual desire. I tried the Wellbutrin XL in the hopes that it would not produce this side effect starting about 18 months ago. The Wellbutrin XL does not have this side effect in my experience.
Side effects:   I have not noticed side effects. I was hoping that a good side effect would be that it would help me quit smoking. It hasn't.
Comments:   I don't have any details. Have thought about asking my doctor to up the dosage when I was having a bout of feeling "down" but it passed and I didn't.

 

Wellbutrin XL review by 43 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   300 mg taken once daily for the period of approx six months
Other conditions:   none
Other drugs taken:   clonazepam
  
Reported Results
Benefits:   Greatly benefitted depression. I started to take this just before my child was born, having had post partum depression with another baby, and I was anticipating my life to be at least as hectic, if not more hectic, when this child was born as when the older child was born. I was very pleased with the antidepressant effects. I never experienced any depression at all once this baby was born. I did not experience hypomania like I did with sertraline, which was a huge concern of mine. I just did not become depressed when this baby was born.
Side effects:   Wellbutrin can make me feel anxious, which is why I have a prescription for clonazepam whenever I am taking wellbutrin. The worst side effect was the cost. I have no health insurance and wellbutrin xl is very expensive. I did not notice weight loss, as some others have, nor did I ever notice an increase in my libido. I tolerated it very well.
Comments:   I started to take wellbutrin xl at about six months of pregnancy and continued for approx six months, when the baby was about three months old. I usually took it in the morning, but often times forgot and took it later in the day. None of this seemed to affect how well it worked. Were it not for the fact that it is so expensive and that it can be toxic to the body, I would take it every day. (Please do not reveal my email address. I really value my privacy. Thank you.)

 

Wellbutrin XL review by 52 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   300 mg taken once a day for the period of 12 years
Other conditions:   Adult ADHD, hypothyroid
Other drugs taken:   Levothyroxine
  
Reported Results
Benefits:   Within 3-4 weeks I had no depression and less hyperactivity; I was better able to organize my work and accomplish daily tasks; it regulated my sleep cycle. I told my husband that this must be what 'normal' (non-depressed, non-ADHD) adults feel like.
Side effects:   A small amount of shaking, mainly felt when drinking from a cup. It's not supposed to affect weight and hunger, but I have gained some weight, though I don't know if or how the medicine contributed.
Comments:   Before using Wellbutrin I had trouble getting to sleep, then trouble getting up in the morning. I was very irritable, depressed and frustrated. I always felt groggy and could not 'get it together' until late in the day. When my treatment began, I started by taking one 150 mg pill first thing in the morning for a week. Then I took one 150 mg pill in am and one 150 mg pill in pm (this was before XL came out). The third week and from then on I took 300 mg in morning. I felt so much better that I was not bothered by the slight let down in the evening. However,I didn't feel really well consistently all day until the XL formula came out. I have tried the generic and I don't feel as well and I had constant stomach aches to the point that I was having pain near my gall bladder and was considering being evaluated for gallstones. All of this cleared up when I went back to Wellbutrin XL and I have not had a problem since.

 

Wellbutrin XL review by 38 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression/dysthymia
Dosage & duration:   300 mg per day taken once daily for the period of 4 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Wellbutrin has been very effective for my low-grade depression. I have tried many other antidepressants in the past and have found them to be ineffective and/or causing too many side effects (weight gain, sexual side effects, fatigue, etc.). Wellbutrin actually helps me maintain my weight and has minimal sexual side effects.
Side effects:   Side effects included mild nausea and shakiness. These side effects disappeared after about two weeks.
Comments:   I have been on Wellbutrin for four years and will probably continue use for several more years.

 

Wellbutrin XL review by 36 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Low energy and depression
Dosage & duration:   50mg taken 1'x a day for the period of 4 years
Other conditions:   hypothyroidism, depression
Other drugs taken:   synthroid, zoloft
  
Reported Results
Benefits:   I became a happier person and felt like living and being active again. I was a better mother and wife. I could focus and was not lethargic or sad.
Side effects:   The side effects mostly were related to low sex drive.
Comments:   I was diagnosed with hypothyroidism and then depression. I was treated first for the hypothyroidism and then the depression. The Zoloft worked but I still felt like I had a lower than normal energy level. My doctor added in the Wellbutrin to give me the energy boost.

 

Wellbutrin XL review by 34 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   depression, fatigue
Dosage & duration:   300mg taken once per day for the period of 2 years and going
Other conditions:   n/a
Other drugs taken:   n/a
  
Reported Results
Benefits:   Wellbutrin XL made a real difference in my life. I had a tendency to get unnerved and anxious at the smallest things and since taking Wellbutrin, my husband has noticed a huge difference in my disposition. I was not a majorly depressed person, just mildly depressed and fatigued, and also becoming uninterested in activities that I used to enjoy. Wellbutrin definitely made me feel happier and more interested in life. As far as the rumor goes of Wellbutrin enhancing sexual desire - I have not noticed a diffence in myself in that regard.
Side effects:   I have to take the pill at night. If I take the pill in the morning, I notice that I get a headache about 2p.
Comments:   I take 300mg once a day and I've been on Wellbutrin for 2 years now and my doctor said there is no reason to stop taking it.

 

Wellbutrin XL review by 37 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Depression
Dosage & duration:   150 mg taken once a day for the period of 5 years
Other conditions:   Anxiety
Other drugs taken:   Prozac
  
Reported Results
Benefits:   The Wellbutrin with 20 mg of Prozac daily as an adjunct alleviated most symptoms of depression. Better sleep as a result, and more energy throughout the day.
Side effects:   Jitters, trembling hands.
Comments:   I had been taking Prozac with other medications for 10 years and it had stopped working for me. After being prescribed Wellbutrin with it, I found I felt so much better. However, when I tried to stop taking Prozac entirely and stay just on the Wellbutrin, my depression returned. I have been on this cocktail now for 5 years and believe it has helped me immensly.
 


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