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Zyvox (Linezolid) - Summary

 


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ZYVOX SUMMARY

ZYVOX®
(linezolid) injection
(linezolid) tablets
(linezolid) for oral suspension

ZYVOX I.V. Injection, ZYVOX Tablets, and ZYVOX for Oral Suspension contain linezolid, which is a synthetic antibacterial agent of the oxazolidinone class.

ZYVOX formulations are indicated in the treatment of the following infections caused by susceptible strains of the designated microorganisms (see PRECAUTIONS, Pediatric Use and DOSAGE AND ADMINISTRATION).

Vancomycin-Resistant Enterococcus faecium infections, including cases with concurrent bacteremia (see CLINICAL STUDIES).

Nosocomial pneumonia caused by Staphylococcus aureus (methicillin-susceptible and -resistant strains), or Streptococcus pneumoniae (including multi-drug resistant strains [MDRSP]). Combination therapy may be clinically indicated if the documented or presumptive pathogens include Gram-negative organisms (see CLINICAL STUDIES).

Complicated skin and skin structure infections, including diabetic foot infections, without concomitant osteomyelitis, caused by Staphylococcus aureus (methicillin-susceptible and -resistant strains), Streptococcus pyogenes, or Streptococcus agalactiae. ZYVOX has not been studied in the treatment of decubitus ulcers. Combination therapy may be clinically indicated if the documented or presumptive pathogens include Gram-negative organisms (see CLINICAL STUDIES).

Uncomplicated skin and skin structure infections caused by Staphylococcus aureus (methicillin-susceptible only) or Streptococcus pyogenes.

Community-acquired pneumonia caused by Streptococcus pneumoniae (including multi-drug resistant strains [MDRSP] *), including cases with concurrent bacteremia, or Staphylococcus aureus (methicillin-susceptible strains only).

To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZYVOX and other antibacterial drugs, ZYVOX should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.


*MDRSP refers to isolates resistant to two or more of the following antibiotics: penicillin, second-generation cephalosporins, macrolides, tetracycline, and trimethoprim/sulfamethoxazole.


See all Zyvox indications & dosage >>

ZYVOX NEWS HIGHLIGHTS

Media Articles Related to Zyvox (Linezolid)

Zyvox® shows cost savings for treatment of skin infections
Source: The Doctors Lounge - Infections

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Published Studies Related to Zyvox (Linezolid)

Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a Phase 3, multicentre, double-blind, randomized study. [2008.09]

Linezolid for the treatment of infections caused by Gram-positive pathogens in China. [2008.09]

Linezolid pharmacokinetic/pharmacodynamic profile in critically ill septic patients: intermittent versus continuous infusion. [2008.02]

Economic evaluation of linezolid versus teicoplanin for the treatment of infections caused by gram-positive microorganisms in Spain. [2007.08]

Cost-effectiveness analysis of linezolid compared with vancomycin for the treatment of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus. [2006.08]

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Clinical Trials Related to Zyvox (Linezolid)

Drug Use Investigation of Linezolid (Regulatory Post Marketing Commitment Plan) [Enrolling by invitation]

Linezolid Pharmacokinetics (PK) in Multi-Drug Resistant (MDR)/Extensively-Drug Resistant (XDR) Tuberculosis (TB) [Not yet recruiting]

Study to Evaluate Eye Function in Patients Taking Linezolid for Two Months or Greater [Recruiting]

Pharmacokinetics of Linezolid in Children With Cystic Fibrosis [Recruiting]

Pilot Study Examining the Safety and Tolerability of Low Dose Linezolid in the Treatment of Multi-Drug Resistant Tuberculosis [Not yet recruiting]

more >>

ZYVOX PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Zyvox has an overall score of 9. The effectiveness score is 10 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
 

Zyvox review by 48 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   MRSA
Dosage & duration:   600 mg taken twice a day for the period of 10 days
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   It cured the MRSA. Major downside was high price. The resulting yeast infection was a bit irritating but not unexpected.I would highly recmmend zyvox to anyone with this particular strain of MRSA.
Side effects:   Yeast infection and minor queasiness.
Comments:   Pill form, 2 a day. It was pretty simple. I had been receiving it in the hospital as a drip (liquid).

See all Zyvox reviews / ratings >>

Page last updated: 2008-11-03

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