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Zyrtec (Cetirizine Hydrochloride) - Summary

 
 



ZYRTEC SUMMARY

ZYRTEC®
(cetirizine hydrochloride)
Tablets, Chewable Tablets and Syrup
For Oral Use

Cetirizine hydrochloride, the active component of ZYRTEC® tablets and syrup, is an orally active and selective H1-receptor antagonist.

ZYRTEC is indicated for the following:

Seasonal Allergic Rhinitis: ZYRTEC is indicated for the relief of symptoms associated with seasonal allergic rhinitis due to allergens such as ragweed, grass and tree pollens in adults and children 2 years of age and older. Symptoms treated effectively include sneezing, rhinorrhea, nasal pruritus, ocular pruritus, tearing, and redness of the eyes.

Perennial Allergic Rhinitis: ZYRTEC is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens such as dust mites, animal dander and molds in adults and children 6 months of age and older. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, and tearing.

Chronic Urticaria: ZYRTEC is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 months of age and older. It significantly reduces the occurrence, severity, and duration of hives and significantly reduces pruritus.


See all Zyrtec indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Zyrtec (Cetirizine)

Comparison of the sedating effects of levocetirizine and cetirizine: a randomized, double-blind, placebo-controlled trial. [2011.12]
BACKGROUND: Compared with placebo, levocetirizine has been found to be less sedating than cetirizine in separate trials. However, whether levocetirizine is less sedating than its parent drug cetirizine has not yet been studied in a randomized trial. OBJECTIVE: To determine whether levocetirizine is less sedating than cetirizine... CONCLUSIONS: In patients with a perceived history of sedation with cetirizine, most were able to tolerate levocetirizine. However, this controlled trial also suggests that many of these patients would tolerate cetirizine if given in a masked manner. Therefore, patients with a history of mild to moderate sedation with cetirizine are unlikely to experience a different sedation profile with levocetirizine. Copyright (c) 2011 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo in the treatment of perennial allergic rhinitiss. [2011.11.30]
Abstract Objective: Bilastine is a non-sedating second-generation H(1) antihistamine with proven efficacy and safety in the treatment of patients with seasonal allergic rhinitis and urticaria. The objective of this study was to demonstrate the efficacy and safety of bilastine in patients with perennial allergic rhinitis (PAR)...

A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. [2011.03]
Post-burn pruritis is a very distressing symptom having a reported incidence between 80 and 100%. The mainstay of management of post-burn itch has been with antihistaminics and emollients but the treatment is ineffective in a very large percentage of patients... There is now a need to relook at the antipruritic protocols in burn management.

Pharmacokinetics and effects of cetirizine in horses with insect bite hypersensitivity. [2011.03]
Horses with insect bite hypersensitivity (IBH) have difficulty in completely avoiding allergens, so effective treatment options are required. A randomised, placebo controlled and double blinded field study was conducted to determine the pharmacokinetics and efficacy in reducing dermatitis of the antihistamine cetirizine given orally at 0.4 mg/kg twice daily for 3 weeks...

Anti-inflammatory activity and clinical efficacy of a 3-month levocetirizine therapy in mite-allergic children. [2011.02]
The non-sedating third generation antihistamine levocetirizine has ample evidence of efficacy in allergic rhinitis... This suggests that during treatment of mite-allergic children with levocetirizine the early improvement in nasal symptoms is due to the antihistamine activity, while more time is needed to achieve an effect on allergic inflammation.

more studies >>

Clinical Trials Related to Zyrtec (Cetirizine)

Food Study of Cetirizine HCl Tablets 10 mg and ZyrtecŪ 10 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's cetirizine HCl tablets to Pfizer's ZyrtecŪ tablets following a single, oral 10 mg (1 x 10 mg) dose administered under fed conditions.

Fasting Study of Cetirizine HCl Tablets 10 mg and ZyrtecŪ Tablets 10 mg [Completed]
"The objective of this study was to investigate the bioequivalence of Mylan cetirizine HCl 10 mg tablets to Pfizer's ZyrtecŪ 10 mg tablets following a single, oral 10 mg (1 x 10 mg) dose administration under fasting conditions.

Randomized Phase III Study to Evaluate the Efficacy and Safety of XyzalŪ (Levocetirizine) vs ZyrtecŪ (Cetirizine) in Subjects With Dermatitis and Eczema [Completed]
Korean double-blind non-inferiority study to asses the efficacy (as measured by the responder rate of pruritus severity score by the patient at visit 4 or end-of-treatment visit over the 2 weeks treatment period) and safety of XyzalŪ to ZyrtecŪ in subjects suffering from dermatitis and eczema with pruritus symptoms

Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis [Recruiting]
The aim of this study is to compare the effect of montelukast and cetirizine on allergic inflammation measured by exhaled nitric oxide concentration in children with seasonal allergic rhinitis.

Study of Bronchodilation Effects of Cetirizine [Not yet recruiting]
Primary Objective :

To compare the acute bronchodilatory effects of cetirizine 10 mg tablet and nebulized levalbuterol using impulse oscillometry technique in asthmatic subjects aged 18 to 65 years old who have allergic rhinitis and show clinical evidence of bronchial hyper-reactivity.

Secondary Objective:

To assess the bronchodilatory effects of cetirizine 10 mg tablet versus placebo after two weeks of therapy using impulse oscillometry technique in subjects 18 to 65 years old who have allergic rhinitis and show clinical evidence of bronchial hyper-reactivity.

more trials >>

Reports of Suspected Zyrtec (Cetirizine) Side Effects

Withdrawal Syndrome (32)OFF Label USE (28)Urticaria (26)Wrong Drug Administered (26)Pruritus (25)Dizziness (16)Depression (14)Insomnia (13)Somnolence (12)Overdose (12)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 32 ratings/reviews, Zyrtec has an overall score of 7.78. The effectiveness score is 8.75 and the side effect score is 7.81. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Zyrtec review by care giver of 16 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   hives, itching, swelling due to allergies
Dosage & duration:   1 teaspoon daily (dosage frequency: once a day) for the period of 5 years
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   No allergic reactions while taking daily doses of Zyrtec and no side effects at all.
Side effects:   None
Comments:   My son had been having terrible problems with allergies. The cause is still unknown. Constant hives, itching and worst of all his lips & eyes would swell excessively to the point where he couldn't leave the house. He was prescribed Zyrtec 5 years ago and the only time he has a reaction is when he forgets to take his daily dose. It has been wonderful. Absolutely no side effects.

 

Zyrtec review by 38 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   allergies
Dosage & duration:   10 mg taken 1/day for the period of as needed for months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   helped decrease reactions to common allergens. I have hay fever every spring and Zyrtec helped with the common symptoms of hay fever. Helped decrease sneezing, runny nose and decreased reactivity to allergens experienced during the spring season when my allergies are the worst.
Side effects:   dry nose, slight bleeding of nose. Otherwise, no other symptoms, no drowsiness, no nausea or any other side effects
Comments:   took as symptoms of seasonal allergies started. Used primarily 1 pill per day maybe 3-5 times per week from April to September.

 

Zyrtec review by 28 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Rhinitis
Dosage & duration:   2 times 10 mg/day taken 60 times (about a month worth of doses) for the period of about a month
Other conditions:   AV reentry tachycardia
Other drugs taken:   Cardizem
  
Reported Results
Benefits:   My allergy symptoms got much better. But thats what one would expect. There is not much more to say, i am just filling the "50 words", so go on reading.
Side effects:   Very high blood pressure
Comments:   Since taking Zyrtec, my bloodpressure rose very high. First i did not recognize this was because of the Zyrtec, but discontinuing the drug brought back normal blood pressure.

See all Zyrtec reviews / ratings >>

Page last updated: 2011-12-09

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