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Zyprexa (Olanzapine) - Summary

 


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ZYPREXA SUMMARY

ZYPREXA (olanzapine) is a psychotropic agent that belongs to the thienobenzodiazepine class.

ZYPREXA is indicated for the following:

SCHIZOPHRENIA

Oral ZYPREXA is indicated for the treatment of schizophrenia.

The efficacy of ZYPREXA was established in short-term (6-week) controlled trials of schizophrenic inpatients (see CLINICAL PHARMACOLOGY).

The effectiveness of oral ZYPREXA at maintaining a treatment response in schizophrenic patients who had been stable on ZYPREXA for approximately 8 weeks and were then followed for a period of up to 8 months has been demonstrated in a placebo-controlled trial (see CLINICAL PHARMACOLOGY). Nevertheless, the physician who elects to use ZYPREXA for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient (see DOSAGE AND ADMINISTRATION).

BIPOLAR DISORDER

Acute Monotherapy -- Oral ZYPREXA is indicated for the treatment of acute mixed or manic episodes associated with Bipolar I Disorder.

The efficacy of ZYPREXA was established in two placebo-controlled trials (one 3-week and one 4-week) with patients meeting DSM-IV criteria for Bipolar I Disorder who currently displayed an acute manic or mixed episode with or without psychotic features (see CLINICAL PHARMACOLOGY).

Maintenance Monotherapy -- The benefit of maintaining bipolar patients on monotherapy with oral ZYPREXA after achieving a responder status for an average duration of two weeks was demonstrated in a controlled trial (see Clinical Efficacy Data under CLINICAL PHARMACOLOGY). The physician who elects to use ZYPREXA for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient (see DOSAGE AND ADMINISTRATION).

Combination Therapy -- The combination of oral ZYPREXA with lithium or valproate is indicated for the short-term treatment of acute manic episodes associated with Bipolar I Disorder.

The efficacy of ZYPREXA in combination with lithium or valproate was established in two placebo-controlled (6-week) trials with patients meeting DSM-IV criteria for Bipolar I Disorder who currently displayed an acute manic or mixed episode with or without psychotic features (see CLINICAL PHARMACOLOGY).

AGITATION ASSOCIATED WITH SCHIZOPHRENIA AND BIPOLAR I MANIA

ZYPREXA IntraMuscular is indicated for the treatment of agitation associated with schizophrenia and bipolar I mania. "Psychomotor agitation" is defined in DSM-IV as "excessive motor activity associated with a feeling of inner tension." Patients experiencing agitation often manifest behaviors that interfere with their diagnosis and care, e.g., threatening behaviors, escalating or urgently distressing behavior, or self-exhausting behavior, leading clinicians to the use of intramuscular antipsychotic medications to achieve immediate control of the agitation.

The efficacy of ZYPREXA IntraMuscular for the treatment of agitation associated with schizophrenia and bipolar I mania was established in 3 short-term (24 hours) placebo-controlled trials in agitated inpatients with schizophrenia or Bipolar I Disorder (manic or mixed episodes) (see CLINICAL PHARMACOLOGY).


See all Zyprexa indications & dosage >>

ZYPREXA NEWS HIGHLIGHTS

Media Articles Related to Zyprexa (Olanzapine)

Zyprexa in schizophrenia shown to prevent brain loss
Source: The Doctors Lounge - Psychiatry

Teens At Risk For Psychosis The Focus Of Pivotal Emory Study
Source: Schizophrenia News From Medical News Today [2008.11.12]

Psychosis Rates Higher In Immigrant Groups In London
Source: Schizophrenia News From Medical News Today [2008.11.06]

Rates Of Psychosis Higher Among Minority Groups In Britain
Source: Schizophrenia News From Medical News Today [2008.11.04]

At Least 20% Of Psychosis Patients Make Suicide Attempt During Their Lifetime
Source: Schizophrenia News From Medical News Today [2008.10.30]

more >>

Published Studies Related to Zyprexa (Olanzapine)

Olanzapine in the treatment of low body weight and obsessive thinking in women with anorexia nervosa: a randomized, double-blind, placebo-controlled trial. [2008.10]

Clozapine versus "high-dose" olanzapine in refractory early-onset schizophrenia: an open-label extension study. [2008.08]

Standard and higher dose of olanzapine in patients with schizophrenia or schizoaffective disorder: a randomized, double-blind, fixed-dose study. [2008.08]

A multicenter, randomized, double-blind study of the effects of aripiprazole in overweight subjects with schizophrenia or schizoaffective disorder switched from olanzapine. [2008.07]

Assessment of strategies for switching patients from olanzapine to risperidone: a randomized, open-label, rater-blinded study. [2008.06.30]

more >>

Clinical Trials Related to Zyprexa (Olanzapine)

Comparison of Intramuscular Olanzapine Depot to Oral Olanzapine and Low-Dose Depot in Patients With Schizophrenia [Completed]

Effects of Modafinil on Olanzapine Weight Gain [Completed]

Olanzapine Pamoate Depot Versus Oral Olanzapine on Treatment Outcomes in Outpatients With Schizophrenia [Active, not recruiting]

PET Imaging and Olanzapine Treatment in Borderline Personality Disorder [Active, not recruiting]

Fasting Study of Olanzapine Tablets 20 mg and Zyprexa® Tablets 20 mg [Terminated]

more >>

ZYPREXA PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 2 ratings/reviews, Zyprexa has an overall score of 6.50. The effectiveness score is 9 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst.
 

Zyprexa review by care giver of 81 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   agitation management r/t Lewy Body Syndrome Demen
Dosage & duration:   20mg taken x1 / daily for the period of 5 years
Other conditions:   B/P ,Diabetes, obesity, SVT's,osteoporosis
Other drugs taken:   ASA, Cardia, Fosamax, glyburide,Lorazepam, Metformin, Namenda,Razadyne, Simvastatin, Zetia, Plavix
  
Reported Results
Benefits:   The Zyprexa minimized agitative outbursts
Side effects:   The pt developed severe "gait freezing" , gait shuffling, severe muscle weakness, and gereral stupor
Comments:   Since many of these s/s are also s/s of the disease-Lewy Body Syndrome Demenia, it took research and experimentation by me and the MD to realize that it was the med adn not the disease in this case. The pt has been taken off the drug and no longer has these pronounced s/s.

 

Zyprexa review by 20 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   depression
Dosage & duration:   10mg taken every night for the period of six years
Other conditions:   anorexia nervosa
Other drugs taken:   Lamictal, birth control (Jolessa)
  
Reported Results
Benefits:   Went from severely depressed before starting the medication to almost entirely free of depression a week after starting the medication; helped with insomnia.
Side effects:   drowsiness in the beginning, but I quickly got used to it.
Comments:   I entered a hospuital six years ago for suicidality; I wasn't sleeping, I wasn't eating (I had anorexia nervosa), and I was extremely depressed. I started taking 10mg of Zyprexa the first night I was there. I was really drowsy all the next day, but it waned over a few days (now it doesn't affect my energy level at all.) In about a week, my depression just lifted. This medicine has worked miracles for me- I've been depression-free since starting it- and I wouldn't go off it for any reason.

See all Zyprexa reviews / ratings >>

Page last updated: 2008-11-12

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