NEWS HIGHLIGHTSMedia Articles Related to Zymar (Gatifloxacin Ophthalmic)
Bacterial Conjunctivitis Drug Besivance Approved
Source: MedicineNet Pink Eye Specialty [2009.06.01]
Title: Bacterial Conjunctivitis Drug Besivance Approved
Category: Health News
Created: 6/1/2009
Last Editorial Review: 6/1/2009
Pink Eye Pictures Slideshow: Pink Eye (Conjunctivitis)
Source: MedicineNet Eye Allergy Specialty [2008.06.27]
Title: Pink Eye Pictures Slideshow: Pink Eye (Conjunctivitis)
Category: Slideshows
Created: 6/26/2008
Last Editorial Review: 6/27/2008
Published Studies Related to Zymar (Gatifloxacin Ophthalmic)
A prospective randomized evaluation of topical gatifloxacin on conjunctival flora in patients undergoing intravitreal injections. [2009.08]
PURPOSE: We sought to assess the efficacy of 3-day topical gatifloxacin use in combination with povidone-iodine (PVI) versus PVI alone in eliminating conjunctival bacterial flora in patients scheduled to undergo intravitreal (IVT) injection. DESIGN: Prospective, randomized single-blind clinical trial. PARTICIPANTS: We included 129 patients scheduled to undergo 273 IVT injections at California Vitreoretinal Center at Stanford University... CONCLUSIONS: Although 3-day topical gatifloxacin use is effective in reducing the frequency of conjunctival bacterial growth relative to untreated eyes, antibiotic use confers no additional benefit in combination with PVI than eyes receiving PVI alone. This supports that topical PVI is an effective preinjection monotherapy for infection prophylaxis in the setting of IVT injections.
Aqueous humor penetration of gatifloxacin and moxifloxacin eyedrops given in different concentrations in a wick before cataract surgery. [2008.05]
PURPOSE: To determine whether the penetration into the aqueous humor of gatifloxacin (Zymar) and moxifloxacin (Vigamox) eyedrops was affected by altering their concentrations in the dilating mixture in which the wick used to dilate the pupil before cataract surgery was soaked. SETTING: Pasqua Hospital, Regina, Saskatchewan, Canada... CONCLUSIONS: Moxifloxacin penetrated the aqueous humor better than gatifloxacin when given in a wick soaked in the dilating mixture before cataract surgery. Only the penetration of moxifloxacin increased significantly when the volume of the antibiotic in the dilating mixture was doubled. In both groups, only moxifloxacin reached and exceeded the minimum inhibitory concentration levels for the most common ocular pathogens causing endophthalmitis.
Population pharmacokinetics of levofloxacin, gatifloxacin, and moxifloxacin in adults with pulmonary tuberculosis. [2008.03]
The objective of this study was to determine the population pharmacokinetic parameters of levofloxacin, gatifloxacin, and moxifloxacin following multiple oral doses. Twenty-nine patients with tuberculosis at the University Hospital in Vitoria, Brazil, participated... All three quinolones showed favorable pharmacokinetic and pharmacodynamic indices, with the most favorable results in this population being seen with levofloxacin at the comparative doses used.
An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever. [2007.06.27]
OBJECTIVE: To assess the efficacy of gatifloxacin versus cefixime in the treatment of uncomplicated culture positive enteric fever... CONCLUSIONS: Based on this study, gatifloxacin is a better treatment for uncomplicated enteric fever as compared to cefixime. TRIAL REGISTRATION: Current Controlled Trials ISRCTN75784880.
The effect of moxifloxacin and gatifloxacin on long-term visual outcomes following photorefractive keratectomy. [2007.04]
PURPOSE: To compare the effect of gatifloxacin and moxifloxacin on visual outcomes after photorefractive keratectomy (PRK)... CONCLUSIONS: At 6 months after PRK, there was no significant difference in visual outcomes with either antibiotic.
Clinical Trials Related to Zymar (Gatifloxacin Ophthalmic)
Effectiveness Study of Zymar Versus Vigamox for Preoperative Sterilization of the Ocular Surface After Loading Dose [Active, not recruiting]
The purpose of this study is to analyze the effect of Zymar and Vigamox on ocular surface
bacteria. We believe that Zymar will eradicate more ocular surface bacteria than Vigamox.
Preoperative Topical Gatifloxacin on Anterior Chamber Cultures After Cataract Surgery [Suspended]
Postoperative endophthalmitis, a possible severe complication of cataract surgery, is an
infection of the anterior chamber of the eye caused by bacterial contamination and
colonization through surgical incisions. Bacteria are thought to originate mainly from the
patient’s skin and studies show that bacteria are commonly found in the anterior chamber
following surgery. However, innate immune defences are usually able to control and eliminate
bacterial growth before postoperative endophthalmitis occurs. Also, due to the low incidence
of postoperative endophthalmitis, it is difficult to accurately evaluate preventative
methods. This study will examine the efficacy of topical preoperative administration of
gatifloxacin (a new fourth generation fluoroquinolone antibiotic) on reduction of bacterial
contamination of the anterior chamber following cataract surgery. If the antibiotic is shown
to lower bacteria count in cultures from anterior chamber fluid, it has the potential to
lower the incidence of postoperative endophthalmitis.
Patients undergoing cataract surgery will be notified and asked to participate in the study
by the physician in advance of the surgery, provided they do not possess any exclusion
criteria. The participants will be randomly split into two groups; one group will receive
topical application of gatifloxacin prior to surgery, while the other group will receive no
eye drops. During surgery, a small sample of anterior chamber fluid will be removed from the
eye and cultured in both broth and enrichment media for all subjects. Bacterial growth, i. e.,
colony forming units (CFUs), will be used as an indicator of the bacterial contamination of
the fluid.
Prospective Randomized Comparison of Zymar(Gatifloxacin) and Vigamox (Moxifloxacin) in Killing Conjunctival Bacterial Flora Following a One-Hour Application [Recruiting]
Topical ophthalmic antibiotics are common prescribed just prior to eye surgery to lower the
risk of infection. Previous studies have suggested that antibiotics containing a
preservative (Zymar) kill bacteria much quicker than those without a preservative (Vigamox).
The purpose of this research is to compare how quickly to the two commonly prescribed
antibiotics eliminate bacteria from the eye surface.
Effect of Moxifloxacin Versus Gatifloxacin on Corneal Epithelium Following Pterygium Excision [Not yet recruiting]
The purpose of this study is to determine whether there is a difference in corneal
epithelial healing rate and/or toxicity following pterygium excision, between eyes treated
post-operatively by moxifloxacin(VIGAMOX)versus gatifloxacin (ZYMAR).
EBA-Early Bactericidal Activity [Completed]
This study will look at the ability of 4 antibiotics to kill the bacteria that cause
tuberculosis (TB). The antibiotics to be studied are linezolid, gatifloxacin, levofloxacin,
and moxifloxacin. They are all approved by the Brazilian health authorities to treat
infections caused by other germs but are not approved to treat TB in Brazil or anywhere else.
Seventy HIV-negative adults, aged 18-65 years, who have been newly diagnosed with pulmonary
(lung) TB, will participate in this study. Study volunteers will be given one of the 4 study
drugs or a comparison antibiotic, isozianid. Isoniazid has been used around the world to
treat tuberculosis and is being given in this study as a standard drug. Volunteers will stay
in the hospital for 10 days and be given a study antibiotic 7 of those days. Blood and spit
samples will be taken. Six weeks later, volunteers will return for a final health check. All
volunteers will receive 6 months of standard tuberculosis treatment outside of the hospital.
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