Media Articles Related to Zymar (Gatifloxacin Ophthalmic)
Pink Eye (Conjunctivitis) Symptoms, Causes and Treatments
Source: MedicineNet Eye Allergy Specialty [2016.06.01]
Title: Pink Eye (Conjunctivitis) Symptoms, Causes and Treatments
Created: 6/26/2008 12:00:00 AM
Last Editorial Review: 6/1/2016 12:00:00 AM
Published Studies Related to Zymar (Gatifloxacin Ophthalmic)
Aqueous humour penetration of moxifloxocin and gatifloxacin eye drops in different dosing regimens before phacoemulsification surgery. [2011.09]
AIM: To compare the aqueous humour penetration of moxifloxacin 0.5% and gatifloxacin 0.3% eye drops administered in two different dosing regimens during phacoemulsification surgery... CONCLUSION: Moxifloxacin, given in the same dosage, penetrated the aqueous humour better then gatifloxacin during cataract surgery. The penetration of both antibiotics increased significantly when the dosage of the agent was doubled.
A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children. [2011.08]
CONCLUSIONS: We conclude that in Vietnam, where nalidixic acid resistant Shigellae are highly prevalent, ciprofloxacin and gatifloxacin are similarly effective for the treatment of acute shigellosis.
Human aqueous humor concentrations of besifloxacin, moxifloxacin, and gatifloxacin after topical ocular application. [2011.06]
PURPOSE: To determine the concentrations of besifloxacin, moxifloxacin, and gatifloxacin in human aqueous humor after topical instillation of commercially available besifloxacin ophthalmic suspension 0.6%, moxifloxacin ophthalmic solution 0.5%, and gatifloxacin ophthalmic solution 0.3%, and to assess these concentrations relative to the minimum inhibitory concentration for 90% of strains (MIC(90)) for each drug against bacterial pathogens identified in recent cases of postoperative endophthalmitis. SETTING: Six clinical sites, United States. DESIGN: Randomized open-label controlled clinical trial... CONCLUSIONS: Based on the aqueous humor drug concentrations measured in this study, it is unlikely that any of the fluoroquinolones tested would be therapeutically effective in the aqueous humor against the most frequently identified drug-resistant staphylococcal isolates from recent cases of postoperative endophthalmitis. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes. Copyright (c) 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
Gatifloxacin versus chloramphenicol for uncomplicated enteric fever: an open-label, randomised, controlled trial. [2011.06]
BACKGROUND: We aimed to investigate whether gatifloxacin, a new generation and affordable fluoroquinolone, is better than chloramphenicol for the treatment of uncomplicated enteric fever in children and adults... INTERPRETATION: Although no more efficacious than chloramphenicol, gatifloxacin should be the preferred treatment for enteric fever in developing countries because of its shorter treatment duration and fewer adverse events. FUNDING: Wellcome Trust. Copyright (c) 2011 Elsevier Ltd. All rights reserved.
A prospective randomized evaluation of topical gatifloxacin on conjunctival flora in patients undergoing intravitreal injections. [2009.08]
PURPOSE: We sought to assess the efficacy of 3-day topical gatifloxacin use in combination with povidone-iodine (PVI) versus PVI alone in eliminating conjunctival bacterial flora in patients scheduled to undergo intravitreal (IVT) injection. DESIGN: Prospective, randomized single-blind clinical trial. PARTICIPANTS: We included 129 patients scheduled to undergo 273 IVT injections at California Vitreoretinal Center at Stanford University... CONCLUSIONS: Although 3-day topical gatifloxacin use is effective in reducing the frequency of conjunctival bacterial growth relative to untreated eyes, antibiotic use confers no additional benefit in combination with PVI than eyes receiving PVI alone. This supports that topical PVI is an effective preinjection monotherapy for infection prophylaxis in the setting of IVT injections.
Clinical Trials Related to Zymar (Gatifloxacin Ophthalmic)
One Hour Preoperative Gatifloxacin [Completed]
Assessment of the Concentrations of Besifloxacin, Moxifloxacin, or Gatifloxacin in the Aqueous Humor of Subjects [Completed]
This study is being conducted to assess the concentration of besifloxacin, moxifloxacin, or
gatifloxacin in aqueous humor samples collected following topical instillation of the
associated formulation in subjects undergoing cataract surgery.
Non-Inferiority of Gatifloxacin/Prednisolone Association vs Isolated Administration in Prevention of Ocular Infection/Inflammation [Completed]
The purpose of the study is to evaluate the safety and tolerance of the 0. 3% gatifloxacin
and 1. 0% prednisolone acetate association in eye drops in the prevention of infection and
inflammation after refractive surgery (Lasik) and also demonstrate the non-inferiority of
the efficacy of this association compared to the administration of 0. 3% gatifloxacin and
1. 0% prednisolone acetate as isolated eye drops formulations. The study treatment is
randomized, double-masked, with 2 parallel arms. Each patient's participation lasts 29 days,
with 15 days of study treatment administration after the ocular surgery is performed.
Candidates for the study are patients with indication for ocular refractive surgery (Lasik)
for correction of visual acuity.
Effectiveness Study of Zymar Versus Vigamox for Preoperative Sterilization of the Ocular Surface After Loading Dose [Active, not recruiting]
The purpose of this study is to analyze the effect of Zymar and Vigamox on ocular surface
bacteria. We believe that Zymar will eradicate more ocular surface bacteria than Vigamox.
Effect of Moxifloxacin Versus Gatifloxacin on Corneal Epithelium Following Pterygium Excision [Not yet recruiting]
The purpose of this study is to determine whether there is a difference in corneal
epithelial healing rate and/or toxicity following pterygium excision, between eyes treated
post-operatively by moxifloxacin(VIGAMOX)versus gatifloxacin (ZYMAR).
Reports of Suspected Zymar (Gatifloxacin Ophthalmic) Side Effects
Toxic Anterior Segment Syndrome (7),
Chest Discomfort (1),
Rash Papular (1),